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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>HPIDb</shortLabel>
        <fullName>Host Pathogen Interaction database</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1335" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6598961" refType="identity" refTypeAc="MI:0356"/>
      </xref>
      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://www.agbase.msstate.edu/hpi/main.html</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Bovine herpesvirus 1 UL49.5 protein inhibits the transporter associated with antigen processing despite complex formation with glycoprotein M.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="16731921" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-11314467" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-26104" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Bovine herpesvirus 1 UL49.5 protein inhibits the transporter associated with antigen processing despite complex formation with glycoprotein M.</attribute>
            <attribute name="journal" nameAc="MI:0885">Journal of virology</attribute>
            <attribute name="publication year" nameAc="MI:0886">2006</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Lipińska AD., Koppers-Lalic D., Rychłowski M., Admiraal P., Rijsewijk FA., Bieńkowska-Szewczyk K., Wiertz EJ.</attribute>
            <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
            <attribute name="data-processing" nameAc="MI:0633">Since no UniProt entries exist for the BHV1 strain Lam (genotype 1.1) used in the study, the reference cooper strain (genotype 1.1) protein accessions Q77CE4 (GN_BHV1C) and P52370 (GM_BHV1C) have been used instead.</attribute>
            <attribute name="contact-email" nameAc="MI:0634">wiertz@lumc.nl</attribute>
            <attribute name="author-announcement">03-Dec-2015: Contacted by IntAct-Help.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959">imex curation</attribute>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="16731921" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-26104" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="9606">
            <names>
              <shortLabel>human-mel_juso</shortLabel>
              <fullName>Homo sapiens</fullName>
            </names>
            <cellType>
              <names>
                <shortLabel>mel_juso</shortLabel>
              </names>
              <xref>
                <primaryRef db="intact" dbAc="MI:0469" id="IA:0940" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2935556" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="6895502" refType="see-also" refTypeAc="MI:0361"/>
              </xref>
            </cellType>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>anti bait coip</shortLabel>
            <fullName>anti bait coimmunoprecipitation</fullName>
            <alias type="synonym" typeAc="MI:1041">anti bait coip</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0006" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-976" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
            <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
            <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Lipińska AD., Koppers-Lalic D., Rychłowski M., Admiraal P., Rijsewijk FA., Bieńkowska-Szewczyk K., Wiertz EJ.</attribute>
          <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
          <attribute name="data-processing" nameAc="MI:0633">Since no UniProt entries exist for the BHV1 strain Lam (genotype 1.1) used in the study, the reference cooper strain (genotype 1.1) protein accessions Q77CE4 (GN_BHV1C) and P52370 (GM_BHV1C) have been used instead.</attribute>
          <attribute name="contact-email" nameAc="MI:0634">wiertz@lumc.nl</attribute>
          <attribute name="accepted">Accepted 2015-NOV-09 AT 09:32 GMT AT 09:32 GMT by MGT</attribute>
          <attribute name="journal" nameAc="MI:0885">Journal of virology</attribute>
          <attribute name="publication year" nameAc="MI:0886">2006</attribute>
          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
          <attribute name="correction comment"/>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>gn_bhv1c</shortLabel>
          <fullName>Envelope glycoprotein N</fullName>
          <alias type="gene name" typeAc="MI:0301">gN</alias>
          <alias type="orf name" typeAc="MI:0306">UL49.5</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q77CE4" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-11303846" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008647"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_045309.1"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" version="SP_56"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019031" version="SP_56"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0033644" version="SP_56"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0039591" version="SP_56"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0039657" version="SP_56"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0044165" version="SP_56"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0044177" version="SP_56"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045862" version="SP_56"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046776" version="SP_56"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046978" version="SP_56"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046979" version="SP_56"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046980" version="SP_56"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0055036" version="SP_56"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0061635" version="SP_56"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0090087" version="SP_56"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1903317" version="SP_56"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1903364" version="SP_56"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR034707"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10323">
          <names>
            <shortLabel>bhv1c</shortLabel>
            <fullName>Bovine herpesvirus 1.1 (strain Cooper)</fullName>
            <alias type="synonym" typeAc="MI:1041">BoHV-1</alias>
            <alias type="synonym" typeAc="MI:1041">Infectious bovine rhinotracheitis virus</alias>
          </names>
        </organism>
        <sequence>MPRSPLIVAVVAAALFAIVRGRDPLLDAMRREGAMDFWSAGCYARGVPLSEPPQALVVFYVALTAVMVAVALYAYGLCFRLMGASGPNKKESRGRG</sequence>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>gm_bhv1c</shortLabel>
          <fullName>Envelope glycoprotein M</fullName>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-11297169" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P52370"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10320">
          <names>
            <shortLabel>Bovine herpesvirus 1</shortLabel>
            <fullName>Bovine herpesvirus 1</fullName>
          </names>
        </organism>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-26104-1">
        <names>
          <shortLabel>gm-gn-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-11314486" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-26104-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="6">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
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                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
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                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">1B</attribute>
        </attributeList>
      </interaction>
      <interaction id="7" imexId="IM-26104-3">
        <names>
          <shortLabel>gm_bhv1c-gn_bhv1c_1-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-11314490" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-26104-3" refType="imex-primary" refTypeAc="MI:0662"/>
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        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="8">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
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            </biologicalRole>
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                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
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                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
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              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="9">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
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                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
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            </biologicalRole>
            <experimentalRoleList>
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                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
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        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
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          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">1B</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
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