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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>HPIDb</shortLabel>
        <fullName>Host Pathogen Interaction database</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1335" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6598961" refType="identity" refTypeAc="MI:0356"/>
      </xref>
      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://www.agbase.msstate.edu/hpi/main.html</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Marek's disease virus Meq transforms chicken cells via the v-Jun transcriptional cascade: a converging transforming pathway for avian oncoviruses.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="16203997" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-10766776" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-26037" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Marek's disease virus Meq transforms chicken cells via the v-Jun transcriptional cascade: a converging transforming pathway for avian oncoviruses.</attribute>
            <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
            <attribute name="publication year" nameAc="MI:0886">2005</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Levy AM., Gilad O., Xia L., Izumiya Y., Choi J., Tsalenko A., Yakhini Z., Witter R., Lee L., Cardona CJ., Kung HJ.</attribute>
            <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
            <attribute name="contact-email" nameAc="MI:0634">hkung@ucdavis.edu</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959">imex curation</attribute>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="16203997" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-26037" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="9031">
            <names>
              <shortLabel>chick-df-1</shortLabel>
              <fullName>df-1_chick embryonic fibroblasts</fullName>
              <alias type="synonym" typeAc="MI:1041">Chicken</alias>
            </names>
            <cellType>
              <names>
                <shortLabel>df-1</shortLabel>
                <fullName>Primary chicken embryonic fibroblasts DF-1</fullName>
              </names>
              <xref>
                <primaryRef db="intact" dbAc="MI:0469" id="IA:2948" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-10888911" refType="identity" refTypeAc="MI:0356"/>
              </xref>
            </cellType>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>anti bait coip</shortLabel>
            <fullName>anti bait coimmunoprecipitation</fullName>
            <alias type="synonym" typeAc="MI:1041">anti bait coip</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0006" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-976" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
            <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
            <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Levy AM., Gilad O., Xia L., Izumiya Y., Choi J., Tsalenko A., Yakhini Z., Witter R., Lee L., Cardona CJ., Kung HJ.</attribute>
          <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
          <attribute name="data-processing" nameAc="MI:0633">The Meq protein used  is from the GA strain of the  Marek's disease virus/Gallid herpesvirus 2, as given in References 2 and 3.  The  Genbank identifier (AAF67210.1)  for this protein was found from Ref 2;   Lee L. et al-2000;pmid:10823954. (in entry GenBank: AF147806.2  -Gallid herpesvirus 2, complete genome, GA strain)&#xd;
It has 99.1% homology with the only reviewed UniProt entry for the Meq protein -Q9DGW5.</attribute>
          <attribute name="contact-email" nameAc="MI:0634">hkung@ucdavis.edu</attribute>
          <attribute name="accepted">Accepted 2015-JUN-25 by MGT</attribute>
          <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
          <attribute name="publication year" nameAc="MI:0886">2005</attribute>
          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>q77q71_9alph</shortLabel>
          <alias type="gene name" typeAc="MI:0301">R-LORF7</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Meq</alias>
          <alias type="gene name synonym" typeAc="MI:0302">meq</alias>
          <alias type="orf name" typeAc="MI:0306">MDV005</alias>
          <alias type="orf name" typeAc="MI:0306">MDV076</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q77Q71" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-10818860" refType="intact-secondary"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-10766689" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000837"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR004827"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0002039" version="TrEMBL_107"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003677" version="TrEMBL_107"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003700" version="TrEMBL_107"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006357" version="TrEMBL_107"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030307" version="TrEMBL_107"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042025" version="TrEMBL_107"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042803" version="TrEMBL_107"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043066" version="TrEMBL_107"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045070" version="TrEMBL_107"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045892" version="TrEMBL_107"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1904187" version="TrEMBL_107"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1990216" version="TrEMBL_107"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10390">
          <names>
            <shortLabel>Gallid herpesvirus 2</shortLabel>
            <fullName>Gallid herpesvirus 2</fullName>
          </names>
        </organism>
        <sequence>MSQEPEPGAMPYSPADDPSPLDLSLGSTSRRKKRKSHDIPNSPSKHPFPDGLSEEEKQKLERRRKRNRDAARRRRRKQTDYVDKLHEACEELQRANEHLRKEIRDLRTECTSLRVQLACHEPVCPMAVPLTVTLGLLTTPHDPVPEPPICTPPPPSPDEPNAPHCSGSQPPICTPPPPDTEELCAQLCSTPPPPISTPHIIYAPGPSPLQPPICTPPPPDAEELCAQLCSTPPPPICTPHSLFCPPQPPSPEGIFPALCPVTEPCTPPSPGTVYAQLCPVGQAPLFTPSPPHPAPEPERLYARLTEDPEQDSLYSGQIYIQFPSDTQSTVWWFPGDGRP</sequence>
        <attributeList>
          <attribute name="crc64">DF16E8F68C88463A</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>jun_chick</shortLabel>
          <fullName>Transcription factor AP-1</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">Proto-oncogene c-Jun</alias>
          <alias type="gene name" typeAc="MI:0301">JUN</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P18870" version="SP_60" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-445826" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001026460.1"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008917"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR005643"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002112"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR004827"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015558"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-GGA-437986"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000976" version="SP_154"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000978" version="SP_154"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000981" version="SP_154"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_154"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005667" version="SP_154"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006357" version="SP_154"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007265" version="SP_154"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030307" version="SP_154"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042127" version="SP_154"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043923" version="SP_154"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051726" version="SP_154"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9031">
          <names>
            <shortLabel>chick</shortLabel>
            <fullName>Gallus gallus (Chicken)</fullName>
            <alias type="synonym" typeAc="MI:1041">Chicken</alias>
          </names>
        </organism>
        <sequence>MSAKMEPTFYEDALNASFAPPESGGYGYNNAKVLKQSMTLNLSDAASSLKPHLRNKNADILTSPDVGLLKLASPELERLIIQSSNGLITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHNQNTLPSVTSAAQPVSGGMAPVSSMAGGGSFNTSLHSEPPVYANLSNFNPNALNSAPNYNANGMGYAPQHHINPQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF</sequence>
        <attributeList>
          <attribute name="crc64">B882DBFACEDDE1B1</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-26037-1">
        <names>
          <shortLabel>meq-cjun-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-10766793" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-26037-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="6">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">4C</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>