IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells. Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells. J. Biol. Chem. (0021-9258) 2004 Fukuda M., Kanno E., Yamamoto A. Synapse - Interactions of proteins with an established role in the presynapse. mnfukuda@brain.riken.go.jp in vitro In vitro coip coimmunoprecipitation co-immunoprecipitation CoIp immunoprecipitation Co-IP co-immunoprecipitation CoIp immunoprecipitation Co-IP coip full dna sequence full identification by DNA sequencing full dna sequence Fukuda M., Kanno E., Yamamoto A. Synapse - Interactions of proteins with an established role in the presynapse. mnfukuda@brain.riken.go.jp Accepted 2010-JAN-10 by SKERRIEN (applied to all records created before 2005-Sep-01). J. Biol. Chem. (0021-9258) 2004 rab8a_mouse Ras-related protein Rab-8A Rab8a Mel Rab8 Oncogene c-mel protein protein mouse Mus musculus Mouse MAKTYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHASADVEKMILGNKCDVNDKRQVSKERGEKLALDYGIKFMETSAKANINVENAFFTLARDIKAKMDKKLEGNSPQGSSHGVKITVEQQKRTSFFRCSLL DIP protein P55258 original sequence version: 143 AC89DC85588FB8F8 rbf1_caeel Rabphilin-1 rbf-1 F37A4.7 protein protein caeel Caenorhabditis elegans MTKSTKLRHCKQKKKKPEKTPKGNPPILITEKSIEDAATTTSTTDALLGSPEGSRSKSRKLKLCCCTAQAATLSPLDPTSYGGIASTSAHNGMVGGLSRDSRAASRTSKRGSSKSLNRPQIDADEPSTSGTNPDRRPSTHFVLDLPVVSTRYLMNDWEIGGTQNKWVCPSDRHLHLRAQLKSGWSVRTATARSPTNSKAQTGSITAAEQEHIQKVLAKAEESKSKEQQRIGKMVDRLEKMRRRATGNGVTHCLLCHTEFGLLASKSYAAMCVDCRKYVCQRNCGVETTDVNQTTGKVETVFLCKICSEAREVLWKKSGAWFYKEMPEFQRPDDRLPYYVPVTTNGTLPNASSAATPLSGTPGGAGPQPMTMPSTSSCQMTTPKWASPGVCNSPGLQMNGGPTSPLPNGTRRNTGHGGIEFPSSSRPSICSVLQAIEPLDRSKSPRPRIQPRWVNEKVMSSMSVDDEEKAASSSDGESFVQSGVPRRALNNKTPVGSTSATTSPAPPPTSTTPTSRREANMERFSRHTHAHANRLYSTDDDDDSSPESRPSTRSTSPRHSLATPSSYAHDTCHDTSLPDADTRSIDSGVVQSDHSNPQQSGLTCSSSSLTPLQQQASHDHHSGGGTPRRISNPDRTTSRVAQSASGTSLVTPPPPISSRTSPDNCNSSPLNVMEHKSSSASTASSGGNRRVGSAEPVLNNHHAMHNNQNHNDINKKLISQTSRAESPLAASSSFLSSPDDDTKQKNRRRDGVGRVNSLQLRTSLDDVAPPVAPISKMNGHIVSSEPTSSTTSNQNHTSVPIPTVPVVPEEEEEKAITASTESASEPGSLGSITLTLTYHSADKKLKMHLIRAKNLKAMDSNGFSDPYVKFHLLPGNTKATKLTSKTIEKTLNPEWNEEMSYYGITEDDKEKKILRVTVLDRDRIGSDFLGETRIALKKLNDNEMKKFNLYLESALPVPQQTKEEENEDRGKINVGLQYNIQQGSLFININRCVELVGMDSTGFSDPYCKVSLTPITSKAHRAKTSTKKRTLNPEWNEQLQFVVPFKDLPKKTLQIGVYDHDLGKHDDYIGGILLSTSAKDERGRQWIKCIENPGTLVEAWHRLELDS 34F1C9D9E3AF495F rp3a_mouse Rabphilin-3A Rph3a Exophilin-1 protein protein mouse Mus musculus Mouse MTDTVVNRWMYPGDGPLQSNDKEQLQAGWSVHPGAQTDRQRKQEELTDEEKEIINRVIARAEKMEAMEQERIGRLVDRLETMRKNVAGDGVNRCILCGEQLGMLGSACVVCEDCKKNVCTKCGVETSNNRPHPVWLCKICLEQREVWKRSGAWFFKGFPKQVLPQPMPIKKTKPQQPAGEPATQEQPTPESRHPARAPARGDMEDRRPPGQKPGPDLTSAPGRGSHGPPTRRASEARMSTAARDSEGWDHAHGGGTGDTSRSPAGLRRANSVQAARPAPAPVPSPAPPQPVQPGPPGGSRATPGPGRFPEQSTEAPPSDPGYPGAVAPAREERTGPAGGFQAAPHTAAPYSQAAPARQPPPAEEEEEEANSYDSDEATTLGALEFSLLYDQDNSNLQCTIIRAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPVWNETLQYHGITEEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKANQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERIGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKKIERWHQLQNENHVSSD D09F8D8D2CBB271E g5ebs5_caeel Small monomeric GTPase CELE_Y87G2A.4 rab27 aex-6 Y87G2A.4 protein protein caeel Caenorhabditis elegans MGDYDYLIKFLALGDSGVGKTSFLHRYTDNTFTGQFISTVGIDFKEKKVVYKSSRGGFGGRGQRVLLQLWDTAGQERFRSLTTAFFRDAMGFILIFDITNEQSFLNIRDWLSQLKVHAYCEQPDIIICGNKADLENRRQVSTARAKQLADQLGLPYFETSACTSTNVEKSVDCLLDLVMQRIQQSVETSSLPLSECRGVSLDGDPSAASSYCANC 1173A2DB0C1D73B8 rab3a_mouse Ras-related protein Rab-3A Rab3a protein protein mouse Mus musculus Mouse MASATDSRYGQKESSDQNFDYMFKILIIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTIYRNDKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDNAQVLLVGNKCDMEDERVVSSERGRQLADHLGFEFFEASAKDNINVKQTFERLVDVICEKMSESLDTADPAVTGAKQGPQLTDQQAPPHQDCAC DIP protein P63011 original sequence version: 100 DIP protein P63011 original sequence version: 53 1A3E9F8C9D09EB40 rb27a_mouse Ras-related protein Rab-27A Rab27a protein protein mouse Mus musculus Mouse MSDGDYDYLIKFLALGDSGVGKTSVLYQYTDGKFNSKFITTVGIDFREKRVVYRANGPDGAVGRGQRIHLQLWDTAGQERFRSLTTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHAYCENPDIVLCGNKSDLEDQRAVKEEEARELAEKYGIPYFETSAANGTNISHAIEMLLDLIMKRMERCVDKSWIPEGVVRSNGHTSADQLSEEKEKGLCGC DIP protein Q9ERI2 original sequence version: 64 C6857EBDD7F38137 o76901_drome Rab27 EG:80H7.4 Rab27-RB CG14791 18543235 AAF45634 AAF45635 DmRab27 Dmel\CG14791 O76901 dm-Rab27 rab27 Dmel_CG14791 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MRAAPPEPEPLQLAGSGEQFLVLGDSGVGKTCLLYQYTDGRFHTQFISTVGIDFREKRLLYNSRGRRHRIHLQIWDTAGQERFRSLTTAFYRDAMGFLLIFDLTSEKSFLETANWLSQLRTHAYSEDPDVVLCGNKCDLLQLRVVSRDQVAALCRRYRLPYIETSACTGANVKEAVELLVGRVMERIENAACNREFSLLLTQSRCLPNIAYGQPEDLVRLHDRREEPCSRRNCRNC 6F482F0F7C9C050C q9w2r9_drome Rph Dmel\CG11556 rph CG11556 Dmel_CG11556 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MDFQNRNNTANKFVCPSDRQLALRAKLKAGWSSSKTSEPLRPEEQEAIISVIRRNEEIEVAERQRVGRLVERVEKIKQHAVERGPNCCRLCGDTFGILRPQRILCEDCRQSVCTKCSVDINIRYHTSERSREIWLCRICSETREMWKKSGAWFFKGLPKYDMPRSASATPIPNPGPGSMAGDTRAVQSCHATPTRPARVKKLTIRVNDSSSSSSGHSEPEDEVDTGVGIGVGVVGGGMAKGIASTRLQREDSFRLRAYGSIRSFIDGGERKLSNSFFFNRQQSQRPSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSGSNNSGNSQTQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGHDFLGAAKVCLSTVHSTSQYRISVPLGVEDQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKWHCLAPDNPAH 9D89636E64A1590B rph-rab27-1 1 9 unspecified role unspecified role bait bait rat-pc12 Rattus norvegicus PC12 cells pc12 Rat adrenal pheochromocytoma cells 8 unspecified role unspecified role prey prey rbd domain region binding region binding-associated region binding region deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain c-terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range rat-pc12 Rattus norvegicus PC12 cells pc12 Rat adrenal pheochromocytoma cells physical association physical association Rabphilin does not interact with Rab3 and Rab8, contrary to the mouse Rabphilin rbf1-rab27-1 1 3 unspecified role unspecified role bait bait rbd domain region binding region binding-associated region binding region deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain rat-pc12 Rattus norvegicus PC12 cells pc12 Rat adrenal pheochromocytoma cells 5 unspecified role unspecified role prey prey c-terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range rat-pc12 Rattus norvegicus PC12 cells pc12 Rat adrenal pheochromocytoma cells physical association physical association Rabphilin does not interact with Rab3 and Rab8, contrary to the mouse Rabphilin rph3a-rab3a-3 1 4 unspecified role unspecified role bait bait rat-pc12 Rattus norvegicus PC12 cells pc12 Rat adrenal pheochromocytoma cells 6 unspecified role unspecified role prey prey c-terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range rat-pc12 Rattus norvegicus PC12 cells pc12 Rat adrenal pheochromocytoma cells physical association physical association rph3a-rab8a-2 1 2 unspecified role unspecified role prey prey c-terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range rat-pc12 Rattus norvegicus PC12 cells pc12 Rat adrenal pheochromocytoma cells 4 unspecified role unspecified role bait bait rat-pc12 Rattus norvegicus PC12 cells pc12 Rat adrenal pheochromocytoma cells physical association physical association rph3a-rab27a-2 1 7 unspecified role unspecified role prey prey c-terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range rat-pc12 Rattus norvegicus PC12 cells pc12 Rat adrenal pheochromocytoma cells 4 unspecified role unspecified role bait bait rat-pc12 Rattus norvegicus PC12 cells pc12 Rat adrenal pheochromocytoma cells physical association physical association