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    <source releaseDate="2022-02-04">
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        <shortLabel>IntAct</shortLabel>
        <fullName>European Bioinformatics Institute</fullName>
        <alias type="synonym" typeAc="MI:1041">IntAct</alias>
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      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
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        <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
        <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact</attribute>
        <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>p68 Sam is a substrate of the insulin receptor and associates with the SH2 domains of p85 PI3K.</fullName>
        </names>
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            <attribute name="publication title" nameAc="MI:1091">p68 Sam is a substrate of the insulin receptor and associates with the SH2 domains of p85 PI3K.</attribute>
            <attribute name="journal" nameAc="MI:0885">FEBS Lett. (0014-5793)</attribute>
            <attribute name="publication year" nameAc="MI:0886">1999</attribute>
            <attribute name="author-list" nameAc="MI:0636">Sanchez-Margalet V., Najib S.</attribute>
            <attribute name="dataset" nameAc="MI:0875">Synapse - Interactions of proteins with an established role in the presynapse.</attribute>
            <attribute name="contact-email" nameAc="MI:0634">vsanchez@cica.es</attribute>
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            <names>
              <shortLabel>rat-htc</shortLabel>
              <fullName>Rat hepatoma HTC cells</fullName>
            </names>
            <cellType>
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                <shortLabel>htc</shortLabel>
                <fullName>Rat hepatoma HTC cell line</fullName>
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        </hostOrganismList>
        <interactionDetectionMethod>
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            <shortLabel>coip</shortLabel>
            <fullName>coimmunoprecipitation</fullName>
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            <alias type="go synonym" typeAc="MI:0303">CoIp</alias>
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        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
            <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
            <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
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        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Sanchez-Margalet V., Najib S.</attribute>
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          <attribute name="publication year" nameAc="MI:0886">1999</attribute>
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    </experimentList>
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          <shortLabel>khdr1_rat</shortLabel>
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          <alias type="gene name synonym" typeAc="MI:0302">p21 Ras GTPase-activating protein-associated p62</alias>
          <alias type="gene name synonym" typeAc="MI:0302">GAP-associated tyrosine phosphoprotein p62</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Src-associated in mitosis 68 kDa protein</alias>
          <alias type="gene name synonym" typeAc="MI:0302">p68</alias>
          <alias type="gene name" typeAc="MI:0301">Khdrbs1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Sam68</alias>
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            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
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        </interactorType>
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            <shortLabel>rat</shortLabel>
            <fullName>Rattus norvegicus (Rat)</fullName>
            <alias type="synonym" typeAc="MI:1041">Rat</alias>
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        </organism>
        <sequence>MQRRDDPAARLTRSSGRSCSKDPSGAHPSVRLTPSRPSPLPHRSRGGGGGPRGGARASPATQPPPLLPPSNPGPDATVVGSAPTPLLPPSATAAAKMEPENKYLPELMAEKDSLDPSFTHAMQLLSVEIEKIQKGESKKDDEENYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEELRKGGDPKYAHLNMDLHVFIEVFGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQFLELSYLNGVPEPSRGRGVSVRGRGAAPPPPPVPRGRGVGPPRGALVRGTPVRGSITRGATVTRGVPPPPTVRGAPTPRARTAGIQRIPLPPTPAPETYEDYGYDDSYAEQSYEGYEGYYSQSQGESEYYDYGHGELQDSYEAYGQDDWNGTRPSLKAPPARPVKGAYREHPYGRY</sequence>
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          <attribute name="crc64">C41A42831E7DCBC7</attribute>
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      <interactor id="3">
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          <shortLabel>p85a_rat</shortLabel>
          <fullName>Phosphatidylinositol 3-kinase regulatory subunit alpha</fullName>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:1900103" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1903076" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1990578" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000198" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000980" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001452" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008936" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR032498" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035020" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035022" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035591" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036028" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036860" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR044124" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1FU5" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1FU6" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-109704" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-112399" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-114604" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-1250342" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-1257604" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-1266695" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-1433557" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-1660499" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-180292" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-186763" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-1963642" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-198203" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-202424" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-2029485" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-210993" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-2424491" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-2730905" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-388841" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-389357" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-416476" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-430116" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-4420097" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-512988" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-5654689" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-5654695" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-5654710" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-5654720" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-5673001" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-6811558" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-8851907" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-8853659" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-8980692" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9009391" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9013026" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9013106" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9013148" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9013149" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9013404" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9013405" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9013408" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9013409" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9013420" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9013423" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9013424" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9027276" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9035034" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-912526" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-912631" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9607240" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9696264" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9696270" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9696273" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-983695" version="SP_186"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10116">
          <names>
            <shortLabel>rat</shortLabel>
            <fullName>Rattus norvegicus (Rat)</fullName>
            <alias type="synonym" typeAc="MI:1041">Rat</alias>
          </names>
        </organism>
        <sequence>MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEDIGWLNGYNETTGERGDFPGTYVEYIGRKRISPPTPKPRPPRPLPVAPGSSKTEADTEQPVLTLPDLAEQFAPPDVAPPLLIKLLEAIEKKGLECSTLYRTQSSSNPAELRQLLDCDPPSVDLDVFDEHVLADAFKRYLADLPNPVIPVAVYNEMMSLAQEVPSSEDYIQLLKKLIRSPNIPHQYWLTLQYLLKHFFKLSQASSKNLLNARALSEIFSHVLFRFPAASSDNTEHLIKAVELLISAEWSERQPAPALPPKPPKPTSIANNSMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNDTIKIFEEQCHPQERYSKDYIEKFKREGNEKEIQRIMHNHDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVDDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein Q63787 original sequence version: 130</attribute>
          <attribute name="crc64">95C65CF612873B84</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4">
        <names>
          <shortLabel>khdrbs1-pik3r1-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-518469" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008286" refType="process" refTypeAc="MI:0359"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="6">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="agonist" nameAc="MI:0625">Insulin</attribute>
        </attributeList>
      </interaction>
      <interaction id="7">
        <names>
          <shortLabel>khdrbs1-pik3r1-2</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-518474" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008286" refType="process" refTypeAc="MI:0359"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="8">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="9">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="agonist" nameAc="MI:0625">Insulin</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>