MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it FRMPD4 mutations cause X-linked intellectual disability and disrupt dendritic spine morphogenesis. FRMPD4 mutations cause X-linked intellectual disability and disrupt dendritic spine morphogenesis. Human molecular genetics 2018 imex curation Piard J., Hu JH., Campeau PM., Rzonca S., Van Esch H., Vincent E., Han M., Rossignol E., Castaneda J., Chelly J., Skinner C., Kalscheuer VM., Wang R., Lemyre E., Kosinska J., Stawinski P., Bal J., Hoffman DA., Schwartz CE., Van Maldergem L., Wang T., Worley PF. Rare diseases - Interactions investigated in the context of Rare genetic disease Interactions involving GFP-PSD-95 have not been curated as it has not been possible to trace the species origin of GFP-PSD-95 and the authors did not respond to a request for information. twang9@jhmi.edu 29-Mar-2021: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Piard J., Hu JH., Campeau PM., Rzonca S., Van Esch H., Vincent E., Han M., Rossignol E., Castaneda J., Chelly J., Skinner C., Kalscheuer VM., Wang R., Lemyre E., Kosinska J., Stawinski P., Bal J., Hoffman DA., Schwartz CE., Van Maldergem L., Wang T., Worley PF. Rare diseases - Interactions investigated in the context of Rare genetic disease Interactions involving GFP-PSD-95 have not been curated as it has not been possible to trace the species origin of GFP-PSD-95 and the authors did not respond to a request for information. twang9@jhmi.edu Accepted 2021-FEB-05 AT 11:12 GMT AT 11:12 GMT by MGT Human molecular genetics 2018 Only protein-protein interactions imex curation imex curation FRMPD4 mutations cause X-linked intellectual disability and disrupt dendritic spine morphogenesis. FRMPD4 mutations cause X-linked intellectual disability and disrupt dendritic spine morphogenesis. Human molecular genetics 2018 imex curation Piard J., Hu JH., Campeau PM., Rzonca S., Van Esch H., Vincent E., Han M., Rossignol E., Castaneda J., Chelly J., Skinner C., Kalscheuer VM., Wang R., Lemyre E., Kosinska J., Stawinski P., Bal J., Hoffman DA., Schwartz CE., Van Maldergem L., Wang T., Worley PF. Rare diseases - Interactions investigated in the context of Rare genetic disease Interactions involving GFP-PSD-95 have not been curated as it has not been possible to trace the species origin of GFP-PSD-95 and the authors did not respond to a request for information. twang9@jhmi.edu 29-Mar-2021: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. anti bait coip anti bait coimmunoprecipitation anti bait coip anti tag western anti tag western blot anti tag western Piard J., Hu JH., Campeau PM., Rzonca S., Van Esch H., Vincent E., Han M., Rossignol E., Castaneda J., Chelly J., Skinner C., Kalscheuer VM., Wang R., Lemyre E., Kosinska J., Stawinski P., Bal J., Hoffman DA., Schwartz CE., Van Maldergem L., Wang T., Worley PF. Rare diseases - Interactions investigated in the context of Rare genetic disease Interactions involving GFP-PSD-95 have not been curated as it has not been possible to trace the species origin of GFP-PSD-95 and the authors did not respond to a request for information. twang9@jhmi.edu Accepted 2021-FEB-05 AT 11:12 GMT AT 11:12 GMT by MGT Human molecular genetics 2018 Only protein-protein interactions imex curation imex curation q9z214-1 Homer protein homolog 1 1c Vesl-1L Homer1 Homer Vesl PSD-Zip45 VASP/Ena-related gene up-regulated during seizure and LTP 1 protein protein rat Rattus norvegicus (Rat) Rat MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPAQNALPFSHSAGDRTQGLSHASSAISKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVHSHKTELSQTVQELEETLKVKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSELEQRLEKSQSEQDAFRSNLKTLLEILDGKIFELTELRDNLAKLLECS A6A21CB14207A384 frpd4_human FERM and PDZ domain-containing protein 4 FRMPD4 KIAA0316 PDZD10 PDZK10 PDZ domain-containing protein 10 PSD-95-interacting regulator of spine morphogenesis protein protein human Homo sapiens Human MDVFSFVKIAKLSSHRTKSSGWPPPSGTWGLSQVPPYGWEMTANRDGRDYFINHMTQAIPFDDPRLESCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLTVIQPYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRTEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFSEEESLVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNTATQETGPENKGKHNLLGPDWNCIPQMTTFIGEGEQEAQITYIDSKQKTVEITDSTMCPKEHRHLYIDNAYSSDGLNQQLSQPGEAPCEADYRSLAQRSLLTLSGPETLKKAQESPRGAKVSFIFGDFALDDGISPPTLGYETLLDEGPEMLEKQRNLYIGSANDMKGLDLTPEAEGIQFVENSVYANIGDVKSFQAAEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILNLSGSSDDIIDLTSLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDSQSQAASFPEDKEKGSSLQNDEIPVSLIDAVPTSAEGKCEKGLDNAVVSTLGALEALSVSEEQQTSDNSGVAILRAYSPESSSDSGNETNSSEMTESSELATAQKQSENLSRMFLATHEGYHPLAEEQTEFPASKTPAGGLPPKSSHALAARPATDLPPKVVPSKQLLHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLADGEGKAPPNGNTTGKKQQGTKTAEMEEEASGKFGTVSSRDSQHLSTFNLERTAFRKDSQRWYVATEGGMAEKSGLEAATGKTFPRASGLGAREAEGKEEGAPDGETSDGSGLGQGDRFLTDVTCASSAKDLDNPEDADSSTCDHPSKLPEADESVARLCDYHLAKRMSSLQSEGHFSLQSSQGSSVDAGCGTGSSGSACATPVESPLCPSLGKHLIPDASGKGVNYIPSEERAPGLPNHGATFKELHPQTEGMCPRMTVPALHTAINTEPLFGTLRDGCHRLPKIKETTV 79B73E41B89E2D08 frmpd4-homer1-1 2 4 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed Q14CM0:p.Cys618_Val1322delinsValArgGlnThrThrGluVal NM_014728.3:p.Cys618fs mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain CEADYRSLAQRSLLTLSGPETLKKAQESPRGAKVSFIFGDFALDDGISPPTLGYETLLDEGPEMLEKQRNLYIGSANDMKGLDLTPEAEGIQFVENSVYANIGDVKSFQAAEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILNLSGSSDDIIDLTSLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDSQSQAASFPEDKEKGSSLQNDEIPVSLIDAVPTSAEGKCEKGLDNAVVSTLGALEALSVSEEQQTSDNSGVAILRAYSPESSSDSGNETNSSEMTESSELATAQKQSENLSRMFLATHEGYHPLAEEQTEFPASKTPAGGLPPKSSHALAARPATDLPPKVVPSKQLLHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLADGEGKAPPNGNTTGKKQQGTKTAEMEEEASGKFGTVSSRDSQHLSTFNLERTAFRKDSQRWYVATEGGMAEKSGLEAATGKTFPRASGLGAREAEGKEEGAPDGETSDGSGLGQGDRFLTDVTCASSAKDLDNPEDADSSTCDHPSKLPEADESVARLCDYHLAKRMSSLQSEGHFSLQSSQGSSVDAGCGTGSSGSACATPVESPLCPSLGKHLIPDASGKGVNYIPSEERAPGLPNHGATFKELHPQTEGMCPRMTVPALHTAINTEPLFGTLRDGCHRLPKIKETTV VRQTTEV 3 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed ha tag ha tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association SF1A frmpd4-homer1-2 1 4 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed Q14CM0:p.Cys618_Val1322delinsValArgGlnThrThrGluVal NM_014728.3:p.Cys618fs*8 mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain CEADYRSLAQRSLLTLSGPETLKKAQESPRGAKVSFIFGDFALDDGISPPTLGYETLLDEGPEMLEKQRNLYIGSANDMKGLDLTPEAEGIQFVENSVYANIGDVKSFQAAEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILNLSGSSDDIIDLTSLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDSQSQAASFPEDKEKGSSLQNDEIPVSLIDAVPTSAEGKCEKGLDNAVVSTLGALEALSVSEEQQTSDNSGVAILRAYSPESSSDSGNETNSSEMTESSELATAQKQSENLSRMFLATHEGYHPLAEEQTEFPASKTPAGGLPPKSSHALAARPATDLPPKVVPSKQLLHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLADGEGKAPPNGNTTGKKQQGTKTAEMEEEASGKFGTVSSRDSQHLSTFNLERTAFRKDSQRWYVATEGGMAEKSGLEAATGKTFPRASGLGAREAEGKEEGAPDGETSDGSGLGQGDRFLTDVTCASSAKDLDNPEDADSSTCDHPSKLPEADESVARLCDYHLAKRMSSLQSEGHFSLQSSQGSSVDAGCGTGSSGSACATPVESPLCPSLGKHLIPDASGKGVNYIPSEERAPGLPNHGATFKELHPQTEGMCPRMTVPALHTAINTEPLFGTLRDGCHRLPKIKETTV VRQTTEV myc tag myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 3 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed ha tag ha tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association F3B