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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>IntAct</shortLabel>
        <fullName>European Bioinformatics Institute</fullName>
        <alias type="synonym" typeAc="MI:1041">IntAct</alias>
        <alias type="synonym" typeAc="MI:1041">intact</alias>
      </names>
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      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
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        <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
        <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact</attribute>
        <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4.</fullName>
        </names>
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          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="15383288" refType="primary-reference" refTypeAc="MI:0358"/>
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          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4.</attribute>
            <attribute name="journal" nameAc="MI:0885">Mol. Cell (1097-2765)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2004</attribute>
            <attribute name="author-list" nameAc="MI:0636">Yan N., Gu L., Kokel D., Chai J., Li W., Han A., Chen L., Xue D., Shi Y.</attribute>
            <attribute name="dataset" nameAc="MI:0875">Apoptosis - Interactions involving proteins with a function related to apoptosis</attribute>
            <attribute name="dataset" nameAc="MI:0875">PDBe - Data obtained from the Protein Data Bank Europe</attribute>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="15383288" refType="primary-reference" refTypeAc="MI:0358"/>
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        <hostOrganismList>
          <hostOrganism ncbiTaxId="-1">
            <names>
              <shortLabel>in vitro</shortLabel>
              <fullName>In vitro</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>x-ray diffraction</shortLabel>
            <fullName>x-ray crystallography</fullName>
            <alias type="go synonym" typeAc="MI:0303">X-ray</alias>
            <alias type="synonym" typeAc="MI:1041">X-ray</alias>
            <alias type="synonym" typeAc="MI:1041">x-ray diffraction</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0114" refType="identity" refTypeAc="MI:0356"/>
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          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
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        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Yan N., Gu L., Kokel D., Chai J., Li W., Han A., Chen L., Xue D., Shi Y.</attribute>
          <attribute name="dataset" nameAc="MI:0875">Apoptosis - Interactions involving proteins with a function related to apoptosis</attribute>
          <attribute name="accepted"/>
          <attribute name="journal" nameAc="MI:0885">Mol. Cell (1097-2765)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2004</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>ced9_caeel</shortLabel>
          <fullName>Apoptosis regulator ced-9</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">Cell death protein 9</alias>
          <alias type="gene name" typeAc="MI:0301">ced-9</alias>
          <alias type="orf name" typeAc="MI:0306">T07C4.8</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P41958" version="SP_60" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensemblmetazoa" id="T07C4.8.1" version="SP_162" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-494110" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_499284.1"/>
          <secondaryRef db="wormbase" dbAc="MI:0487" id="T07C4.8"/>
          <secondaryRef db="ensemblmetazoa" id="T07C4.8.1" version="SP_162" refType="transcript"/>
          <secondaryRef db="ensemblmetazoa" id="WBGene00000423" version="SP_162" refType="gene"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000422" version="SP_162"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-CEL-9648002"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-250N"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005739" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005741" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006915" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008630" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010636" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0012505" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016485" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030042" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031090" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031333" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0040019" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042803" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043025" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043066" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043069" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043204" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046982" version="SP_162"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0090727" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097192" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0098793" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0140311" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1901046" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1902742" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1905516" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1905808" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2001243" version="SP_162"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002475" version="SP_162"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003093" version="SP_162"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR020717" version="SP_162"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR026298" version="SP_162"/>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2A5Y" version="SP_162"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="6239">
          <names>
            <shortLabel>caeel</shortLabel>
            <fullName>Caenorhabditis elegans</fullName>
          </names>
        </organism>
        <sequence>MTRCTADNSLTNPAYRRRTMATGEMKEFLGIKGTEPTDFGINSDAQDLPSPSRQASTRRMSIGESIDGKINDWEEPRLDIEGFVVDYFTHRIRQNGMEWFGAPGLPCGVQPEHEMMRVMGTIFEKKHAENFETFCEQLLAVPRISFSLYQDVVRTVGNAQTDQCPMSYGRLIGLISFGGFVAAKMMESVELQGQVRNLFVYTSLFIKTRIRNNWKEHNRSWDDFMTLGKQMKEDYERAEAEKVGRRKQNRRWSMIGAGVTAGAIGIVGVVVCGRMMFSLK</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P41958 original sequence version: 125</attribute>
          <attribute name="remark-internal">DIP protein P41958 original sequence version: 83</attribute>
          <attribute name="crc64">7603675E490DD3EB</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>egl1_caeel</shortLabel>
          <fullName>Programmed cell death activator egl-1</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">Egg-laying defective protein 1</alias>
          <alias type="gene name" typeAc="MI:0301">egl-1</alias>
          <alias type="orf name" typeAc="MI:0306">F23B12.9</alias>
        </names>
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          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q7JLC9" version="SP_35" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensemblmetazoa" id="F23B12.9.1" version="SP_117" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-495949" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_506575.2"/>
          <secondaryRef db="wormbase" dbAc="MI:0487" id="F23B12.9"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR021543"/>
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          <secondaryRef db="ensemblmetazoa" id="WBGene00001170" version="SP_117" refType="gene"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0018991" version="SP_117"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032091" version="SP_117"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0040034" version="SP_117"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043068" version="SP_117"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043231" version="SP_117"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0098793" version="SP_117"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:1904747" version="SP_117"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1905808" version="SP_117"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
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            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="6239">
          <names>
            <shortLabel>caeel</shortLabel>
            <fullName>Caenorhabditis elegans</fullName>
          </names>
        </organism>
        <sequence>MLMLTFASTSSDLLPMSNVFDVQSSVFYNEKNMFYSSSQDFSSCEDSSQFADDSGFFDDSEISSIGYEIGSKLAAMCDDFDAQMMSYSAHASDRSLFHRLLDFFAF</sequence>
        <attributeList>
          <attribute name="crc64">2329D2DB0F019636</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4">
        <names>
          <shortLabel>ced_9-egl_1-3</shortLabel>
        </names>
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        <experimentList>
          <experimentRef>1</experimentRef>
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        <participantList>
          <participant id="5">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
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            </biologicalRole>
            <experimentalRoleList>
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                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
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              </experimentalRole>
            </experimentalRoleList>
            <featureList>
              <feature id="6">
                <names>
                  <shortLabel>region</shortLabel>
                </names>
                <xref>
                  <primaryRef db="intact" dbAc="MI:0469" id="EBI-1040395" refType="identity" refTypeAc="MI:0356"/>
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                <featureType>
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                    <fullName>sufficient binding region</fullName>
                    <alias type="synonym" typeAc="MI:1041">sufficient to bind</alias>
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                </featureType>
                <featureRangeList>
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                    <startStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
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                    </startStatus>
                    <begin position="46"/>
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                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
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                      </xref>
                    </endStatus>
                    <end position="102"/>
                  </featureRange>
                </featureRangeList>
              </feature>
            </featureList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="83333">
                <names>
                  <shortLabel>ecoli</shortLabel>
                  <fullName>Escherichia coli (strain K12)</fullName>
                </names>
              </hostOrganism>
            </hostOrganismList>
            <stoichiometry value="2"/>
          </participant>
          <participant id="7">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
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            </biologicalRole>
            <experimentalRoleList>
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                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
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                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
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            <featureList>
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                  <shortLabel>region</shortLabel>
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                    <fullName>sufficient binding region</fullName>
                    <alias type="synonym" typeAc="MI:1041">sufficient to bind</alias>
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                        <fullName>certain sequence position</fullName>
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                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </startStatus>
                    <begin position="68"/>
                    <endStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </endStatus>
                    <end position="237"/>
                  </featureRange>
                </featureRangeList>
              </feature>
            </featureList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="83333">
                <names>
                  <shortLabel>ecoli</shortLabel>
                  <fullName>Escherichia coli (strain K12)</fullName>
                </names>
              </hostOrganism>
            </hostOrganismList>
            <stoichiometry value="2"/>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>direct interaction</shortLabel>
            <fullName>direct interaction</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="assembly">dimeric, multimeric</attribute>
          <attribute name="3d-r-factors" nameAc="MI:0631">working 78.800%, free 76.500%</attribute>
          <attribute name="3d-resolution" nameAc="MI:0632">2.2A</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>