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        <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
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          <fullName>Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy.</fullName>
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            <attribute name="publication year" nameAc="MI:0886">2004</attribute>
            <attribute name="author-list" nameAc="MI:0636">Siebold C., Hansen BE., Wyer JR., Harlos K., Esnouf RE., Svejgaard A., Bell JI., Strominger JL., Jones EY., Fugger L.</attribute>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1S9V" version="SP_195"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1UVQ" version="SP_195"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2NNA" version="SP_195"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GG6" version="SP_195"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4OZF" version="SP_195"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4OZG" version="SP_195"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4OZH" version="SP_195"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4OZI" version="SP_195"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-202424" version="SP_195"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-202427" version="SP_195"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-202430" version="SP_195"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-202433" version="SP_195"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2132295" version="SP_195"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-389948" version="SP_195"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-877300" version="SP_195"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MSWKKALRIPGGLRAATVTLMLAMLSTPVAEGRDSPEDFVYQFKAMCYFTNGTERVRYVTRYIYNREEYARFDSDVEVYRAVTPLGPPDAEYWNSQKEVLERTRAELDTVCRHNYQLELRTTLQRRVEPTVTISPSRTEALNHHNLLVCSVTDFYPAQIKVRWFRNDQEETTGVVSTPLIRNGDWTFQILVMLEMTPQHGDVYTCHVEHPSLQNPITVEWRAQSESAQSKMLSGIGGFVLGLIFLGLGLIIHHRSQKGLLH</sequence>
        <attributeList>
          <attribute name="crc64">79B1E571A628CF96</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>dqa1_human</shortLabel>
          <fullName>HLA class II histocompatibility antigen, DQ alpha 1 chain</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">DC-alpha</alias>
          <alias type="gene name synonym" typeAc="MI:0302">HLA-DCA</alias>
          <alias type="gene name synonym" typeAc="MI:0302">DC-1 alpha chain</alias>
          <alias type="gene name synonym" typeAc="MI:0302">MHC class II DQA1</alias>
          <alias type="gene name" typeAc="MI:0301">HLA-DQA1</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P01909" version="SP_73" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O19630" version="SP_73" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q30101" version="SP_73" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UM31" version="SP_73" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000339398" version="SP_198" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000364087" version="SP_198" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000372738" version="SP_198" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000382583" version="SP_198" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000382586" version="SP_198" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000387892" version="SP_198" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000413237" version="SP_198" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000378767" version="SP_198" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1038000" refType="intact-secondary"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q06751" version="SP_63" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q29994" version="SP_63" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q30086" version="SP_63" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5Y7D5" version="SP_63" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O19706" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P01907" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P04225" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P04226" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P79553" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q29876" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q2Q6Y6" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q2Q6Y7" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q2Q6Y8" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q2WCM3" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q30064" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q30067" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q30068" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q30070" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q30071" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q30072" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q30073" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6ICU6" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6PR46" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6QDB1" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q860W2" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q860W4" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9BD37" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9TPM3" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5Y7F5" version="SP_98" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P01908" version="SP_101" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P05536" version="SP_101" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-713389" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_002113.2"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001003" version="SP_198"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003006" version="SP_198"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003597" version="SP_198"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR007110" version="SP_198"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011162" version="SP_198"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013783" version="SP_198"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR014745" version="SP_198"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036179" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1JK8" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1NBN" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1S9V" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1UVQ" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2NNA" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GG6" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4OZF" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4OZG" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4OZH" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4OZI" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5KSA" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5KSB" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5KSU" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5KSV" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6MFF" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6MFG" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6U3M" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6U3N" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-202424" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-202427" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-202430" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-202433" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2132295" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-389948" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-877300" version="SP_198"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071556" version="SP_198"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000196735" version="SP_198" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000206305" version="SP_198" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000232062" version="SP_198" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000343139" version="SP_198" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000374949" version="SP_198" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000383251" version="SP_198" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000395363" version="SP_198" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000399675" version="SP_198" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000399678" version="SP_198" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000418023" version="SP_198" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000444296" version="SP_198" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000139" version="SP_198"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0002250" version="SP_198"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0002504" version="SP_198"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005765" version="SP_198"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" version="SP_198"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005887" version="SP_198"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006955" version="SP_198"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010008" version="SP_198"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0012507" version="SP_198"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" version="SP_198"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030658" version="SP_198"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030666" version="SP_198"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030669" version="SP_198"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032395" version="SP_198"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032588" version="SP_198"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042605" version="SP_198"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042613" version="SP_198"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MILNKALMLGALALTTVMSPCGGEDIVADHVASYGVNLYQSYGPSGQYTHEFDGDEQFYVDLGRKETVWCLPVLRQFRFDPQFALTNIAVLKHNLNSLIKRSNSTAATNEVPEVTVFSKSPVTLGQPNILICLVDNIFPPVVNITWLSNGHSVTEGVSETSFLSKSDHSFFKISYLTLLPSAEESYDCKVEHWGLDKPLLKHWEPEIPAPMSELTETVVCALGLSVGLVGIVVGTVFIIRGLRSVGASRHQGPL</sequence>
        <attributeList>
          <attribute name="crc64">84E12B5A80E2A028</attribute>
        </attributeList>
      </interactor>
      <interactor id="4">
        <names>
          <shortLabel>orex_human</shortLabel>
          <fullName>Orexin</fullName>
          <alias type="gene name" typeAc="MI:0301">HCRT</alias>
          <alias type="gene name synonym" typeAc="MI:0302">OX</alias>
          <alias type="gene name synonym" typeAc="MI:0302">PPORX</alias>
          <alias type="gene name synonym" typeAc="MI:0302">PPOX</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Hypocretin</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="O43612" version="SP_65" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000293330" version="SP_176" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1037990" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001515.1"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000161610" version="SP_176" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000293330" version="SP_176" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001659" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005184" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005576" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005791" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007200" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007204" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007205" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007218" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007268" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008021" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008156" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030141" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030431" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031771" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031772" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042594" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042755" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043267" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046928" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0048471" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051928" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051970" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051971" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060079" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0098794" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0120162" version="SP_176"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001704" version="SP_176"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1CQ0" version="SP_176"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1R02" version="SP_176"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1UVQ" version="SP_176"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1WSO" version="SP_176"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7L1U" version="SP_176"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-389397" version="SP_176"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-416476" version="SP_176"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MNLPSTKVSWAAVTLLLLLLLLPPALLSSGAAAQPLPDCCRQKTCSCRLYELLHGAGNHAAGILTLGKRRSGPPGLQGRLQRLLQASGNHAAGILTMGRRAGAEPAPRPCLGRRCSAPAAASVAPGGQSGI</sequence>
        <attributeList>
          <attribute name="crc64">139D9C33E39E4EF1</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="5">
        <names>
          <shortLabel>hcrt-hla_dqa1-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="rcsb pdb" dbAc="MI:0460" id="1UVQ" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1038032" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="6">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <featureList>
              <feature id="7">
                <names>
                  <shortLabel>region</shortLabel>
                </names>
                <xref>
                  <primaryRef db="intact" dbAc="MI:0469" id="EBI-1038040" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <featureType>
                  <names>
                    <shortLabel>sufficient to bind</shortLabel>
                    <fullName>sufficient binding region</fullName>
                    <alias type="synonym" typeAc="MI:1041">sufficient to bind</alias>
                  </names>
                  <xref>
                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0442" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608899" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                  </xref>
                </featureType>
                <featureRangeList>
                  <featureRange>
                    <startStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </startStatus>
                    <begin position="35"/>
                    <endStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </endStatus>
                    <end position="230"/>
                  </featureRange>
                </featureRangeList>
              </feature>
            </featureList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="7227">
                <names>
                  <shortLabel>drome</shortLabel>
                  <fullName>Drosophila melanogaster (Fruit fly)</fullName>
                  <alias type="synonym" typeAc="MI:1041">Fruit fly</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
            <stoichiometry value="1"/>
          </participant>
          <participant id="8">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <featureList>
              <feature id="9">
                <names>
                  <shortLabel>region</shortLabel>
                </names>
                <xref>
                  <primaryRef db="intact" dbAc="MI:0469" id="EBI-1038037" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <featureType>
                  <names>
                    <shortLabel>sufficient to bind</shortLabel>
                    <fullName>sufficient binding region</fullName>
                    <alias type="synonym" typeAc="MI:1041">sufficient to bind</alias>
                  </names>
                  <xref>
                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0442" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608899" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                  </xref>
                </featureType>
                <featureRangeList>
                  <featureRange>
                    <startStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </startStatus>
                    <begin position="24"/>
                    <endStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </endStatus>
                    <end position="219"/>
                  </featureRange>
                </featureRangeList>
              </feature>
            </featureList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="7227">
                <names>
                  <shortLabel>drome</shortLabel>
                  <fullName>Drosophila melanogaster (Fruit fly)</fullName>
                  <alias type="synonym" typeAc="MI:1041">Fruit fly</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
            <stoichiometry value="1"/>
          </participant>
          <participant id="10">
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <featureList>
              <feature id="11">
                <names>
                  <shortLabel>region</shortLabel>
                </names>
                <xref>
                  <primaryRef db="intact" dbAc="MI:0469" id="EBI-1038034" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <featureType>
                  <names>
                    <shortLabel>sufficient to bind</shortLabel>
                    <fullName>sufficient binding region</fullName>
                    <alias type="synonym" typeAc="MI:1041">sufficient to bind</alias>
                  </names>
                  <xref>
                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0442" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608899" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                  </xref>
                </featureType>
                <featureRangeList>
                  <featureRange>
                    <startStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </startStatus>
                    <begin position="1"/>
                    <endStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </endStatus>
                    <end position="13"/>
                  </featureRange>
                </featureRangeList>
              </feature>
            </featureList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="7227">
                <names>
                  <shortLabel>drome</shortLabel>
                  <fullName>Drosophila melanogaster (Fruit fly)</fullName>
                  <alias type="synonym" typeAc="MI:1041">Fruit fly</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
            <stoichiometry value="1"/>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="assembly">trimeric, multimeric</attribute>
          <attribute name="3d-r-factors" nameAc="MI:0631">working 81.100%, free 79.500%</attribute>
          <attribute name="3d-resolution" nameAc="MI:0632">1.8A</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>