IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency. Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency. Bioorg. Med. Chem. Lett. (0960-894X) 2003 Gwaltney SL., O'Connor SJ., Nelson LT., Sullivan GM., Imade H., Wang W., Hasvold L., Li Q., Cohen J., Gu WZ., Tahir SK., Bauch J., Marsh K., Ng SC., Frost DJ., Zhang H., Muchmore S., Jakob CG., Stoll V., Hutchins C., Rosenberg SH., Sham HL. PDBe - Data obtained from the Protein Data Bank Europe stephen.gwaltney@syrrx.com in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Gwaltney SL., O'Connor SJ., Nelson LT., Sullivan GM., Imade H., Wang W., Hasvold L., Li Q., Cohen J., Gu WZ., Tahir SK., Bauch J., Marsh K., Ng SC., Frost DJ., Zhang H., Muchmore S., Jakob CG., Stoll V., Hutchins C., Rosenberg SH., Sham HL. PDBe - Data obtained from the Protein Data Bank Europe stephen.gwaltney@syrrx.com Bioorg. Med. Chem. Lett. (0960-894X) 2003 fnta_rat Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha CAAX farnesyltransferase subunit alpha Ras proteins prenyltransferase subunit alpha FTase-alpha Type I protein geranyl-geranyltransferase subunit alpha Fnta protein protein rat Rattus norvegicus (Rat) Rat MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV DIP protein Q04631 original sequence version: 124 DIP protein Q04631 original sequence version: 118 DIP protein Q04631 original sequence version: 130 DFFFECC1B88BC080 fntb_rat Protein farnesyltransferase subunit beta CAAX farnesyltransferase subunit beta Ras proteins prenyltransferase subunit beta Fntb protein protein rat Rattus norvegicus (Rat) Rat MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD DIP protein Q02293 original sequence version: 136 DIP protein Q02293 original sequence version: 142 41A9D6D79CD319A8 fnta-fntb-7 1 3 unspecified role unspecified role neutral component neutral component region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm 2 unspecified role unspecified role neutral component neutral component region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm direct interaction direct interaction dimeric, multimeric working 67.100%, free 62.500% 3.2A