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          <fullName>Upregulation of survivin by leptin/STAT3 signaling in MCF-7 cells.</fullName>
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            <attribute name="publication year" nameAc="MI:0886">2008</attribute>
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            <attribute name="remark-internal">I tried to mail the corresponding author to establish the origin of the recombinant leptin from R&amp;D Systems, but I got an error message that the account has been disabled or discontinued; should it still be listed then?</attribute>
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            <attribute name="author-announcement">26-Feb-2015: Contacted by IntAct-Help.</attribute>
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              <shortLabel>human-mcf7</shortLabel>
              <fullName>Homo sapiens  mammary carcinoma cells</fullName>
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          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-452723" version="SP_231"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6783783" version="SP_231"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6785807" version="SP_231"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8849474" version="SP_231"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8854691" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0098685" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0098978" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0099527" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1900017" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1901215" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1902728" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1902895" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1904685" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1905564" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1905618" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000635" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000637" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000737" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2001171" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2001223" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000980" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001217" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008967" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR012345" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013799" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013800" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013801" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015988" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035855" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036535" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036860" version="SP_231"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_003141.2"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_644805.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_998827.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011523447.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011523448.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_005257673.2"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_005257674.2"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_016880461.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_016880464.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-33584N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM</sequence>
        <attributeList>
          <attribute name="crc64">6C00632211C8012D</attribute>
          <attribute name="remark-internal">DIP protein P40763 original sequence version: 157</attribute>
          <attribute name="remark-internal">DIP protein P40763-1 original sequence version: 147</attribute>
          <attribute name="remark-internal">DIP protein P40763-1 original sequence version: 135</attribute>
          <attribute name="remark-internal">DIP protein P40763-1 original sequence version: 157</attribute>
          <attribute name="remark-internal">DIP protein P40763 original sequence version: 165</attribute>
          <attribute name="remark-internal">DIP protein P40763 original sequence version: 182</attribute>
          <attribute name="remark-internal">DIP protein P40763 original sequence version: 135</attribute>
          <attribute name="crc64">6C00632211C8012D</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-23690-1">
        <names>
          <shortLabel>stat3-birc5-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-10062032" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-23690-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <featureList>
              <feature id="6">
                <names>
                  <shortLabel>promoter region</shortLabel>
                </names>
                <xref>
                  <primaryRef db="intact" dbAc="MI:0469" id="EBI-10062037" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <featureType>
                  <names>
                    <shortLabel>binding region</shortLabel>
                    <fullName>binding-associated region</fullName>
                    <alias type="synonym" typeAc="MI:1041">binding region</alias>
                  </names>
                  <xref>
                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0117" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456493" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                  </xref>
                </featureType>
                <featureRangeList>
                  <featureRange>
                    <startStatus>
                      <names>
                        <shortLabel>undetermined</shortLabel>
                        <fullName>undetermined sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">undetermined</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </startStatus>
                    <endStatus>
                      <names>
                        <shortLabel>undetermined</shortLabel>
                        <fullName>undetermined sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">undetermined</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </endStatus>
                  </featureRange>
                </featureRangeList>
              </feature>
            </featureList>
          </participant>
          <participant id="7">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>association</shortLabel>
            <fullName>association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0914" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813191" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">Fig. 4b</attribute>
          <attribute name="agonist" nameAc="MI:0625">leptin (10nM for 30 minutes)</attribute>
          <attribute name="agonist" nameAc="MI:0625">interleukin-6 (IL-6) (20 ng/ml for 30 minutes)</attribute>
          <attribute name="causality statement">P40763 increases expression at RNA level of ENSG00000089685</attribute>
          <attribute name="causality statement">P40763 increases expression at protein level of ENSG00000089685</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>