UniProt UniProt http://www.uniprot.org The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner. The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner. The Biochemical journal 2004 imex curation Kanaya E., Shiraki T., Jingami H., Kanaya E., Shiraki T., Jingami H. IBD - Inflammatory bowel disease jingami@beri.or.jp 22-Feb-2016: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro pull down pull down anti tag western anti tag western blot anti tag western Kanaya E., Shiraki T., Jingami H., Kanaya E., Shiraki T., Jingami H. IBD - Inflammatory bowel disease jingami@beri.or.jp Accepted 2016-FEB-04 AT 14:32 GMT AT 14:32 GMT by ORCHARD The Biochemical journal 2004 imex curation The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner. The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner. The Biochemical journal 2004 imex curation Kanaya E., Shiraki T., Jingami H., Kanaya E., Shiraki T., Jingami H. IBD - Inflammatory bowel disease jingami@beri.or.jp 22-Feb-2016: Contacted by IntAct-Help. Only protein-protein interactions chlae-cos_7 Cercopithecus aethiops simian cells transformed with SV40 Grivet cos_7 cercopithecus aethiops, by transformation with SV40 anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Kanaya E., Shiraki T., Jingami H., Kanaya E., Shiraki T., Jingami H. IBD - Inflammatory bowel disease jingami@beri.or.jp Accepted 2016-FEB-04 AT 14:32 GMT AT 14:32 GMT by ORCHARD The Biochemical journal 2004 imex curation prgc1_mouse Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Ppargc1a Pgc1 Pgc1a Ppargc1 protein protein mouse Mus musculus Mouse MAWDMCSQDSVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPANIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGAVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHAANHTHRIRTNPAIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCASKKKSHTQPQSQHAQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFKASPKLKPSCKTVVPPPTKRARYSECSGTQGSHSTKKGPEQSELYAQLSKSSGLSRGHEERKTKRPSLRLFGDHDYCQSLNSKTDILINISQELQDSRQLDFKDASCDWQGHICSSTDSGQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPCQAVFDDKSDKTSELRDGDFSNEQFSKLPVFINSGLAMDGLFDDSEDESDKLSYPWDGTQPYSLFDVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEAYEHERLKRDEYRKEHEKRESERAKQRERQKQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDTNSDDFDPASTKSKYDSLDFDSLLKEAQRSLRR DIP protein O70343 original sequence version: 117 DIP protein O70343-1 original sequence version: 120 DIP protein O70343 original sequence version: 120 DIP protein O70343 original sequence version: 67 AE73EE2B3A622B05 q96ri1-2 Bile acid receptor NR1H4 BAR FXR Farnesoid X-activated receptor Farnesol receptor HRR-1 HRR1 Nuclear receptor subfamily 1 group H member 4 RIP14 Retinoid X receptor-interacting protein 14 FXRalpha1(-) FXRalpha2 protein protein human Homo sapiens Human MGSKMNLIEHSHLPTTDEFSFSENLFGVLTEQVAGPLGQNLEVEPYSQYSNVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ Produced by alternative splicing of isoform 3. DIP protein Q96RI1-2 original sequence version: 75 DIP protein Q96RI1-2 original sequence version: 109 0A53D414B9049C4C o70343-1 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Ppargc1a Pgc1 Pgc1a Ppargc1 PGC-1a1 protein protein mouse Mus musculus Mouse MAWDMCSQDSVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPANIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGAVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHAANHTHRIRTNPAIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCASKKKSHTQPQSQHAQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFKASPKLKPSCKTVVPPPTKRARYSECSGTQGSHSTKKGPEQSELYAQLSKSSGLSRGHEERKTKRPSLRLFGDHDYCQSLNSKTDILINISQELQDSRQLDFKDASCDWQGHICSSTDSGQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPCQAVFDDKSDKTSELRDGDFSNEQFSKLPVFINSGLAMDGLFDDSEDESDKLSYPWDGTQPYSLFDVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEAYEHERLKRDEYRKEHEKRESERAKQRERQKQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDTNSDDFDPASTKSKYDSLDFDSLLKEAQRSLRR AE73EE2B3A622B05 chenodeoxycholic acid chenodeoxycholic acid 3alpha,7alpha-Dihydroxy-5beta-cholanic acid 7alpha-hydroxylithocholic acid anthropodeoxycholic acid anthropodesoxycholic acid CDCA chenic acid Chenix Chenodeoxycholic acid Chenodiol gallodesoxycholic acid 3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) ppargc1a-nr1h4-4 2 3 unspecified role unspecified role bait bait nucl transfection nucleic acid transfection nucl transfection region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 4 unspecified role unspecified role prey prey nucl transfection nucleic acid transfection nucl transfection nucl_hrmn_rcpt_lig-bd sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain region his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 6 stimulator stimulator unspecified role unspecified role physical association physical association 6 CHEBI:16755 is required for the binding of Q15788 to Q96RI1-2 ppargc1a-nr1h4-5 1 4 unspecified role unspecified role prey prey nucl transfection nucleic acid transfection nucl transfection nucl_hrmn_rcpt_lig-bd sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain region his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecoli Escherichia coli (strain K12) 5 unspecified role unspecified role bait bait n-terminus gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range region required to bind necessary binding region required to bind certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) physical association physical association 7 CDCA; CHEBI:16755