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  <entry>
    <source releaseDate="2022-02-04">
      <names>
        <shortLabel>IntAct</shortLabel>
        <fullName>European Bioinformatics Institute</fullName>
        <alias type="synonym" typeAc="MI:1041">IntAct</alias>
        <alias type="synonym" typeAc="MI:1041">intact</alias>
      </names>
      <bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
      </bibref>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0469" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-10" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="22121220" refType="method reference" refTypeAc="MI:0357"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="19850723" refType="method reference" refTypeAc="MI:0357"/>
      </xref>
      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
        <attribute name="search-url" nameAc="MI:0615">http://www.ebi.ac.uk/intact/query/${ac}</attribute>
        <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
        <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact</attribute>
        <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Interaction of FIE, a polycomb protein, with pRb: a possible mechanism regulating endosperm development.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="15221456" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1992820" refType="identity" refTypeAc="MI:0356"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Interaction of FIE, a polycomb protein, with pRb: a possible mechanism regulating endosperm development.</attribute>
            <attribute name="journal" nameAc="MI:0885">Mol. Genet. Genomics (1617-4615)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2004</attribute>
            <attribute name="author-list" nameAc="MI:0636">Mosquna A., Katz A., Shochat S., Grafi G., Ohad N.</attribute>
            <attribute name="dataset" nameAc="MI:0875">Chromatin - Epigenetic interactions resulting in chromatin modulation</attribute>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="15221456" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="-1">
            <names>
              <shortLabel>in vitro</shortLabel>
              <fullName>In vitro</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>pull down</shortLabel>
            <fullName>pull down</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0096" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1223" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Mosquna A., Katz A., Shochat S., Grafi G., Ohad N.</attribute>
          <attribute name="dataset" nameAc="MI:0875">Chromatin - Epigenetic interactions resulting in chromatin modulation</attribute>
          <attribute name="accepted">Accepted 2010-JAN-10 by SKERRIEN (applied to all records created before 2005-Sep-01).</attribute>
          <attribute name="journal" nameAc="MI:0885">Mol. Genet. Genomics (1617-4615)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2004</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>rbr1_arath</shortLabel>
          <fullName>Retinoblastoma-related protein 1</fullName>
          <alias type="gene name" typeAc="MI:0301">RBR1</alias>
          <alias type="locus name" typeAc="MI:0305">At3g12280</alias>
          <alias type="gene name synonym" typeAc="MI:0302">RBR</alias>
          <alias type="orf name" typeAc="MI:0306">F28J15.11</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q9LKZ3" version="TrEMBL_34" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q93ZS5" version="SP_38" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9C7C9" version="SP_38" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9LHH8" version="SP_38" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensemblplants" id="AT3G12280.1" version="SP_155" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-398590" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_566417.3"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-33046N"/>
          <secondaryRef db="ensemblplants" id="AT3G12280" version="SP_155" refType="gene"/>
          <secondaryRef db="ensemblplants" id="AT3G12280.1" version="SP_155" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000082" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000785" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000977" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001558" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001708" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003677" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005667" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006349" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006357" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007129" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008356" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009553" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009555" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009567" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010090" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010377" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0022619" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030154" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032875" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0048229" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0048366" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051726" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051783" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0061629" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1903866" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000036" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000134" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000653" version="SP_155"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002719" version="SP_155"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002720" version="SP_155"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR024599" version="SP_155"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR028309" version="SP_155"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036915" version="SP_155"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="3702">
          <names>
            <shortLabel>arath</shortLabel>
            <fullName>Arabidopsis thaliana (Mouse-ear cress)</fullName>
            <alias type="synonym" typeAc="MI:1041">Mouse-ear cress</alias>
          </names>
        </organism>
        <sequence>MEEVQPPVTPPIEPNGKRSEASLLDICEKVLSLDGSTCDEALKLFTETKRILSASMSNIGSGTREEVERFWFAFILYSVKRLSVRKEADGLSVSGDNEFNLCQILRALKLNIVDFFKELPQFVVKAGSVLGELYGADWENRLQAKEVQANFVHLSLLSKYYKRGFREFFLTYDANAEKNSANSSTYLLDSYRFGWLLFLALRNHAFSRFKDLVTCSNGVVSILAILIIHVPCRFRNFSIQDSSRFVKKGDKGVDLVASLCKIYDASEDELRIVIDKANNLVETILKKKPSPASECQTDKLDNIDPDGLTYFEDLLEETSISTSLITLEKDYYDGKGELDERVFINEEDSLLGSGSLSAGAVNITGVKRKIDALSSPARTFISPLSPHKSPAAKTNGISGATKLAATPVSTAMTTAKWLRTVISPLLPKPSPGLEHFLKSCDRDITNDVTRRAHIILEAIFPNSSLGAQCGGGSLQAVDLMDDIWAEQRRLEACKLYYRVLEAMCKAEAQILHANNLNSLLTNERFHRCMLACSAELVLATHKTITMLFPAVLERTGITAFDLSKVIESFIRHEDSLPRELRRHLNSLEERLLESMVWEKGSSMYNSLIVARPSLALEINQLGLLAEPMPSLDAIAALINFSDGANHASSVQKHETCPGQNGGIRSPKRLCTDYRSILVERNSFTSPVKDRLLALGNVKSKMLPPPLQSAFASPTRPNPGGGGETCAETGINIFFTKINKLAAVRINGMVERLQLSQQIRESVYCFFQHVLAQRTSLLFSRHIDQIILCCFYGVAKISQMSLTFREIIYNYRKQPQCKPLVFRSVYVDALQCRRQGRIGPDHVDIITFYNEIFIPAVKPLLVELGPVRNDRAVEANNKPEGQCPGSPKVSVFPSVPDMSPKKVSAVHNVYVSPLRGSKMDALISHSTKSYYACVGESTHAYQSPSKDLSAINNRLNNSSSNRKRTLNFDAEAGMVSDSMVANSLNLQNQNQNQNGSDASSSGGAAPLKTEPTDS</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein Q9LKZ3 original sequence version: 38</attribute>
          <attribute name="remark-internal">DIP protein Q9LKZ3 original sequence version: 93</attribute>
          <attribute name="crc64">F3CD279ED508C263</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>fie_arath</shortLabel>
          <fullName>Polycomb group protein FERTILIZATION-INDEPENDENT ENDOSPERM</fullName>
          <alias type="gene name" typeAc="MI:0301">FIE</alias>
          <alias type="gene name synonym" typeAc="MI:0302">FIS3</alias>
          <alias type="locus name" typeAc="MI:0305">At3g20740</alias>
          <alias type="orf name" typeAc="MI:0306">MOE17.5</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Protein FERTILIZATION-INDEPENDENT SEED 3</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q9LT47" version="SP_64" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9XF44" version="SP_64" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensemblplants" id="AT3G20740.1" version="SP_161" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-307146" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_188710.1"/>
          <secondaryRef db="ensemblplants" id="AT3G20740" version="SP_161" refType="gene"/>
          <secondaryRef db="ensemblplants" id="AT3G20740.1" version="SP_161" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000122" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003700" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005677" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006342" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006349" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009409" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016571" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035098" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043078" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070734" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000014" version="SP_161"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001680" version="SP_161"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015943" version="SP_161"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR019775" version="SP_161"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR020472" version="SP_161"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036322" version="SP_161"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-31378N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="3702">
          <names>
            <shortLabel>arath</shortLabel>
            <fullName>Arabidopsis thaliana (Mouse-ear cress)</fullName>
            <alias type="synonym" typeAc="MI:1041">Mouse-ear cress</alias>
          </names>
        </organism>
        <sequence>MSKITLGNESIVGSLTPSNKKSYKVTNRIQEGKKPLYAVVFNFLDARFFDVFVTAGGNRITLYNCLGDGAISALQSYADEDKEESFYTVSWACGVNGNPYVAAGGVKGIIRVIDVNSETIHKSLVGHGDSVNEIRTQPLKPQLVITASKDESVRLWNVETGICILIFAGAGGHRYEVLSVDFHPSDIYRFASCGMDTTIKIWSMKEFWTYVEKSFTWTDDPSKFPTKFVQFPVFTASIHTNYVDCNRWFGDFILSKSVDNEILLWEPQLKENSPGEGASDVLLRYPVPMCDIWFIKFSCDLHLSSVAIGNQEGKVYVWDLKSCPPVLITKLSHNQSKSVIRQTAMSVDGSTILACCEDGTIWRWDVITK</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein Q9LT47 original sequence version: 126</attribute>
          <attribute name="remark-internal">DIP protein Q9LT47 original sequence version: 91</attribute>
          <attribute name="crc64">EDF0989C02B4FD4A</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4">
        <names>
          <shortLabel>fie-rbr1-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-398600" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="-1">
                <names>
                  <shortLabel>in vitro</shortLabel>
                  <fullName>In vitro</fullName>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
          <participant id="6">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="83333">
                <names>
                  <shortLabel>ecoli</shortLabel>
                  <fullName>Escherichia coli (strain K12)</fullName>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>