IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Structure of the histone-core octamer in KCl/phosphate crystals at 2.15 A resolution. Structure of the histone-core octamer in KCl/phosphate crystals at 2.15 A resolution. Acta Crystallogr. D Biol. Crystallogr. (0907-4449) 2003 imex curation Chantalat L., Nicholson JM., Lambert SJ., Reid AJ., Donovan MJ., Reynolds CD., Wood CM., Baldwin JP. Chromatin - Epigenetic interactions resulting in chromatin modulation j.p.baldwin@dl.ac.uk 29-OCT-2007: Contacted by JYOTI. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Chantalat L., Nicholson JM., Lambert SJ., Reid AJ., Donovan MJ., Reynolds CD., Wood CM., Baldwin JP. Chromatin - Epigenetic interactions resulting in chromatin modulation j.p.baldwin@dl.ac.uk Accepted 2007-JUN-22 by DAVET. Acta Crystallogr. D Biol. Crystallogr. (0907-4449) 2003 Only protein-protein interactions imex curation h4_chick Histone H4 H4-I H4-II H4-III H4-IV H4-V H4-VI H4-VII protein protein chick Gallus gallus (Chicken) Chicken MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG A9E5DFD3F8B97598 h2a4_chick Histone H2A-IV protein protein chick Gallus gallus (Chicken) Chicken MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTDSHKAKAK C148297D1C525360 h2b7_chick Histone H2B 7 H2B VII H2B-VII protein protein chick Gallus gallus (Chicken) Chicken MPEPAKSAPAPKKGSKKAVTKTQKKGDKKRKRARKESYSIYVYKVLKQVHPDTGISSKAMSIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK B14EC3822B5DAA97 h32_chick Histone H3.2 H3-I H3-II H3-III H3-IV H3-V H3-VI H3-VII H3-VIII Histone H3 class I protein protein chick Gallus gallus (Chicken) Chicken MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA 6FD8508EA50A0EEC h2b-h3 1 3 unspecified role unspecified role neutral component neutral component glu61 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain asp90 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain glu91 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) 2 unspecified role unspecified role neutral component neutral component glu52 binding region binding-associated region binding region x-ray diffraction x-ray crystallography X-ray x-ray diffraction X-ray certain certain sequence position certain certain certain sequence position certain asp24 binding region binding-associated region binding region x-ray diffraction x-ray crystallography X-ray x-ray diffraction X-ray certain certain sequence position certain certain certain sequence position certain arg36 binding region binding-associated region binding region x-ray diffraction x-ray crystallography X-ray x-ray diffraction X-ray certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) 5 unspecified role unspecified role neutral component neutral component arg53 binding region binding-associated region binding region x-ray diffraction x-ray crystallography X-ray x-ray diffraction X-ray certain certain sequence position certain certain certain sequence position certain arg72 binding region binding-associated region binding region x-ray diffraction x-ray crystallography X-ray x-ray diffraction X-ray certain certain sequence position certain certain certain sequence position certain gln68 binding region binding-associated region binding region x-ray diffraction x-ray crystallography X-ray x-ray diffraction X-ray certain certain sequence position certain certain certain sequence position certain arg83 binding region binding-associated region binding region x-ray diffraction x-ray crystallography X-ray x-ray diffraction X-ray certain certain sequence position certain certain certain sequence position certain arg40 binding region binding-associated region binding region x-ray diffraction x-ray crystallography X-ray x-ray diffraction X-ray certain certain sequence position certain certain certain sequence position certain arg42 binding region binding-associated region binding region x-ray diffraction x-ray crystallography X-ray x-ray diffraction X-ray certain certain sequence position certain certain certain sequence position certain arg63 binding region binding-associated region binding region x-ray diffraction x-ray crystallography X-ray x-ray diffraction X-ray certain certain sequence position certain certain certain sequence position certain arg63 binding region binding-associated region binding region x-ray diffraction x-ray crystallography X-ray x-ray diffraction X-ray certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) 4 unspecified role unspecified role neutral component neutral component val48 binding region binding-associated region binding region x-ray diffraction x-ray crystallography X-ray x-ray diffraction X-ray certain certain sequence position certain certain certain sequence position certain asp51 binding region binding-associated region binding region x-ray diffraction x-ray crystallography X-ray x-ray diffraction X-ray certain certain sequence position certain certain certain sequence position certain glu105 binding region binding-associated region binding region x-ray diffraction x-ray crystallography X-ray x-ray diffraction X-ray certain certain sequence position certain certain certain sequence position certain gln47 binding region binding-associated region binding region x-ray diffraction x-ray crystallography X-ray x-ray diffraction X-ray certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) 8 23 9 22 16 10 20 12 13 21 14 27 17 28 25 18 19 26 physical association physical association working 21.4 percent, free 25.2 percent 2.15 A Table 1, Table 2, Figure 3, Figure 2 the chick erythrocyte histone octamer, described herein, crystallized in space group P65, with one octamer in the asymmetric unit. Only direct interactiosn via salt bridges shown.