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        <shortLabel>IntAct</shortLabel>
        <fullName>European Bioinformatics Institute</fullName>
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        <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
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        <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
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          <fullName>Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family.</fullName>
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            <attribute name="publication title" nameAc="MI:1091">Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family.</attribute>
            <attribute name="journal" nameAc="MI:0885">J. Biol. Chem. (0021-9258)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2002</attribute>
            <attribute name="author-list" nameAc="MI:0636">Gao L., Cueto MA., Asselbergs F., Atadja P.</attribute>
            <attribute name="dataset" nameAc="MI:0875">Chromatin - Epigenetic interactions resulting in chromatin modulation</attribute>
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              <fullName>Homo sapiens transformed primary embryonal kidney cells</fullName>
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                <shortLabel>293</shortLabel>
                <fullName>Transformed human primary embryonal kidney cells.</fullName>
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              <attributeList>
                <attribute name="comment" nameAc="MI:0612">The Cell type named 293 is synonymous with HEK-293.</attribute>
              </attributeList>
            </cellType>
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        </hostOrganismList>
        <interactionDetectionMethod>
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            <shortLabel>coip</shortLabel>
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            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
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          <attribute name="accepted">Accepted 2010-JAN-10 by SKERRIEN (applied to all records created before 2005-Sep-01).</attribute>
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          </names>
        </organism>
        <sequence>MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNLAEVKKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAPQPAKPRLAERMTTREKKVLEAGMGKVTSASFGEESTPGQTNSETAVVALTQDQPSEAATGGATLAQTISEAAIGGAMLGQTTSEEAVGGATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATLDQTTSEEAPGGTELIQTPLASSTDHQTPPTSPVQGTTPQISPSTLIGSLRTLELGSESQGASESQAPGEENLLGEAAGGQDMADSMLMQGSRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKFGEDMPHPH</sequence>
        <attributeList>
          <attribute name="crc64">6F17731268A33114</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>hda11_human</shortLabel>
          <fullName>Histone deacetylase 11</fullName>
          <alias type="gene name" typeAc="MI:0301">HDAC11</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q96DB2" version="SP_55" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9H6I7" version="SP_55" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9H6X3" version="SP_55" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9NTC9" version="SP_55" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000295757" version="SP_174" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B4DDK1" version="SP_100" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-301713" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_079103.2"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000163517" version="SP_174" refType="gene"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000118" version="SP_174"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004407" version="SP_174"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_174"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" version="SP_174"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006325" version="SP_174"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0014003" version="SP_174"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016575" version="SP_174"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032041" version="SP_174"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0140297" version="SP_174"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000286" version="SP_174"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR023696" version="SP_174"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR023801" version="SP_174"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR037138" version="SP_174"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR044150" version="SP_174"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2122947" version="SP_174"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2644606" version="SP_174"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2894862" version="SP_174"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-350054" version="SP_174"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000295757" version="SP_174" refType="transcript"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011532437.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001129513.1"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP</sequence>
        <attributeList>
          <attribute name="crc64">0D976CAF6EAC7A15</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4">
        <names>
          <shortLabel>hdac6-hdac11-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-297951" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004407" refType="function" refTypeAc="MI:0355"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" refType="component" refTypeAc="MI:0354"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000118" refType="component" refTypeAc="MI:0354"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="6">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="comment" nameAc="MI:0612">HDAC11 is FLAG-tagged.</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>