IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy. Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy. European heart journal 2013 imex curation van Hengel J., Calore M., Bauce B., Dazzo E., Mazzotti E., De Bortoli M., Lorenzon A., Li Mura IE., Beffagna G., Rigato I., Vleeschouwers M., Tyberghein K., Hulpiau P., van Hamme E., Zaglia T., Corrado D., Basso C., Thiene G., Daliento L., Nava A., van Roy F., Rampazzo A. Rare diseases - Interactions investigated in the context of Rare genetic disease Cardiac - Interactions involving cardiac related proteins alessandra.rampazzo@unipd.it,f.vanroy@dmbr.vib-ugent.be 21-Nov-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-mcf7_az human-mcf7_az mcf7-az non-invasive mammary gland adenocarcinoma cells confocal microscopy confocal microscopy immunostaining immunostaining van Hengel J., Calore M., Bauce B., Dazzo E., Mazzotti E., De Bortoli M., Lorenzon A., Li Mura IE., Beffagna G., Rigato I., Vleeschouwers M., Tyberghein K., Hulpiau P., van Hamme E., Zaglia T., Corrado D., Basso C., Thiene G., Daliento L., Nava A., van Roy F., Rampazzo A. Rare diseases - Interactions investigated in the context of Rare genetic disease Cardiac - Interactions involving cardiac related proteins alessandra.rampazzo@unipd.it,f.vanroy@dmbr.vib-ugent.be Accepted 2019-NOV-01 AT 14:07 GMT AT 14:07 GMT by LIVIAP European heart journal 2013 Only protein-protein interactions imex curation imex curation Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy. Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy. European heart journal 2013 imex curation van Hengel J., Calore M., Bauce B., Dazzo E., Mazzotti E., De Bortoli M., Lorenzon A., Li Mura IE., Beffagna G., Rigato I., Vleeschouwers M., Tyberghein K., Hulpiau P., van Hamme E., Zaglia T., Corrado D., Basso C., Thiene G., Daliento L., Nava A., van Roy F., Rampazzo A. Rare diseases - Interactions investigated in the context of Rare genetic disease Cardiac - Interactions involving cardiac related proteins alessandra.rampazzo@unipd.it,f.vanroy@dmbr.vib-ugent.be 21-Nov-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation mouse-hl-1 Mus musculus hl-1 hl-1 confocal microscopy confocal microscopy immunostaining immunostaining van Hengel J., Calore M., Bauce B., Dazzo E., Mazzotti E., De Bortoli M., Lorenzon A., Li Mura IE., Beffagna G., Rigato I., Vleeschouwers M., Tyberghein K., Hulpiau P., van Hamme E., Zaglia T., Corrado D., Basso C., Thiene G., Daliento L., Nava A., van Roy F., Rampazzo A. Rare diseases - Interactions investigated in the context of Rare genetic disease Cardiac - Interactions involving cardiac related proteins alessandra.rampazzo@unipd.it,f.vanroy@dmbr.vib-ugent.be Accepted 2019-NOV-01 AT 14:07 GMT AT 14:07 GMT by LIVIAP European heart journal 2013 Only protein-protein interactions imex curation imex curation Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy. Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy. European heart journal 2013 imex curation van Hengel J., Calore M., Bauce B., Dazzo E., Mazzotti E., De Bortoli M., Lorenzon A., Li Mura IE., Beffagna G., Rigato I., Vleeschouwers M., Tyberghein K., Hulpiau P., van Hamme E., Zaglia T., Corrado D., Basso C., Thiene G., Daliento L., Nava A., van Roy F., Rampazzo A. Rare diseases - Interactions investigated in the context of Rare genetic disease Cardiac - Interactions involving cardiac related proteins alessandra.rampazzo@unipd.it,f.vanroy@dmbr.vib-ugent.be 21-Nov-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined van Hengel J., Calore M., Bauce B., Dazzo E., Mazzotti E., De Bortoli M., Lorenzon A., Li Mura IE., Beffagna G., Rigato I., Vleeschouwers M., Tyberghein K., Hulpiau P., van Hamme E., Zaglia T., Corrado D., Basso C., Thiene G., Daliento L., Nava A., van Roy F., Rampazzo A. Rare diseases - Interactions investigated in the context of Rare genetic disease Cardiac - Interactions involving cardiac related proteins alessandra.rampazzo@unipd.it,f.vanroy@dmbr.vib-ugent.be Accepted 2019-NOV-01 AT 14:07 GMT AT 14:07 GMT by LIVIAP European heart journal 2013 Only protein-protein interactions imex curation imex curation Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy. Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy. European heart journal 2013 imex curation van Hengel J., Calore M., Bauce B., Dazzo E., Mazzotti E., De Bortoli M., Lorenzon A., Li Mura IE., Beffagna G., Rigato I., Vleeschouwers M., Tyberghein K., Hulpiau P., van Hamme E., Zaglia T., Corrado D., Basso C., Thiene G., Daliento L., Nava A., van Roy F., Rampazzo A. Rare diseases - Interactions investigated in the context of Rare genetic disease Cardiac - Interactions involving cardiac related proteins alessandra.rampazzo@unipd.it,f.vanroy@dmbr.vib-ugent.be 21-Nov-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. anti bait coip anti bait coimmunoprecipitation anti bait coip anti tag western anti tag western blot anti tag western van Hengel J., Calore M., Bauce B., Dazzo E., Mazzotti E., De Bortoli M., Lorenzon A., Li Mura IE., Beffagna G., Rigato I., Vleeschouwers M., Tyberghein K., Hulpiau P., van Hamme E., Zaglia T., Corrado D., Basso C., Thiene G., Daliento L., Nava A., van Roy F., Rampazzo A. Rare diseases - Interactions investigated in the context of Rare genetic disease Cardiac - Interactions involving cardiac related proteins alessandra.rampazzo@unipd.it,f.vanroy@dmbr.vib-ugent.be Accepted 2019-NOV-01 AT 14:07 GMT AT 14:07 GMT by LIVIAP European heart journal 2013 Only protein-protein interactions imex curation imex curation Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy. Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy. European heart journal 2013 imex curation van Hengel J., Calore M., Bauce B., Dazzo E., Mazzotti E., De Bortoli M., Lorenzon A., Li Mura IE., Beffagna G., Rigato I., Vleeschouwers M., Tyberghein K., Hulpiau P., van Hamme E., Zaglia T., Corrado D., Basso C., Thiene G., Daliento L., Nava A., van Roy F., Rampazzo A. Rare diseases - Interactions investigated in the context of Rare genetic disease Cardiac - Interactions involving cardiac related proteins alessandra.rampazzo@unipd.it,f.vanroy@dmbr.vib-ugent.be 21-Nov-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot van Hengel J., Calore M., Bauce B., Dazzo E., Mazzotti E., De Bortoli M., Lorenzon A., Li Mura IE., Beffagna G., Rigato I., Vleeschouwers M., Tyberghein K., Hulpiau P., van Hamme E., Zaglia T., Corrado D., Basso C., Thiene G., Daliento L., Nava A., van Roy F., Rampazzo A. Rare diseases - Interactions investigated in the context of Rare genetic disease Cardiac - Interactions involving cardiac related proteins alessandra.rampazzo@unipd.it,f.vanroy@dmbr.vib-ugent.be Accepted 2019-NOV-01 AT 14:07 GMT AT 14:07 GMT by LIVIAP European heart journal 2013 Only protein-protein interactions imex curation imex curation Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy. Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy. European heart journal 2013 imex curation van Hengel J., Calore M., Bauce B., Dazzo E., Mazzotti E., De Bortoli M., Lorenzon A., Li Mura IE., Beffagna G., Rigato I., Vleeschouwers M., Tyberghein K., Hulpiau P., van Hamme E., Zaglia T., Corrado D., Basso C., Thiene G., Daliento L., Nava A., van Roy F., Rampazzo A. Rare diseases - Interactions investigated in the context of Rare genetic disease Cardiac - Interactions involving cardiac related proteins alessandra.rampazzo@unipd.it,f.vanroy@dmbr.vib-ugent.be 21-Nov-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation rat-cardiac_myocytes_neo rat cardiac myocytes neo neonatal_ventricular_myocyte neonatal ventricular myocyte confocal microscopy confocal microscopy immunostaining immunostaining van Hengel J., Calore M., Bauce B., Dazzo E., Mazzotti E., De Bortoli M., Lorenzon A., Li Mura IE., Beffagna G., Rigato I., Vleeschouwers M., Tyberghein K., Hulpiau P., van Hamme E., Zaglia T., Corrado D., Basso C., Thiene G., Daliento L., Nava A., van Roy F., Rampazzo A. Rare diseases - Interactions investigated in the context of Rare genetic disease Cardiac - Interactions involving cardiac related proteins alessandra.rampazzo@unipd.it,f.vanroy@dmbr.vib-ugent.be Accepted 2019-NOV-01 AT 14:07 GMT AT 14:07 GMT by LIVIAP European heart journal 2013 Only protein-protein interactions imex curation imex curation ctnb1_human Catenin beta-1 Beta-catenin OK/SW-cl.35 PRO2286 CTNNB1 CTNNB protein protein human Homo sapiens Human MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL DIP protein P35222 original sequence version: 187 DIP protein P35222 original sequence version: 188 DIP protein P35222 original sequence version: 180 DIP protein P35222-1 original sequence version: 181 DIP protein P35222 original sequence version: 181 DIP protein P35222 original sequence version: 107 DIP protein P35222-1 original sequence version: 107 DIP protein P35222 original sequence version: 103 DIP protein P35222-1 original sequence version: 103 DIP protein P35222 original sequence version: 175 DIP protein P35222 original sequence version: 136 DIP protein P35222 original sequence version: 135 DIP protein P35222 original sequence version: 131 DIP protein P35222-1 original sequence version: 133 DIP protein P35222 original sequence version: 133 DIP protein P35222 original sequence version: 148 DIP protein P35222-1 original sequence version: 139 DIP protein P35222 original sequence version: 139 DIP protein P35222 original sequence version: 146 DIP protein P35222 original sequence version: 196 DIP protein P35222 original sequence version: 192 DIP protein P35222 original sequence version: 185 DIP protein P35222 original sequence version: 151 DIP protein P35222-1 original sequence version: 151 DIP protein P35222-1 original sequence version: 171 DIP protein P35222-1 original sequence version: 148 DIP protein P35222 original sequence version: 177 DIP protein P35222 original sequence version: 178 DIP protein P35222-1 original sequence version: 178 CB78F165A3EEF86E q9ui47-1 Catenin alpha-3 Alpha T-catenin Cadherin-associated protein CTNNA3 protein protein human Homo sapiens Human MSAETPITLNIDPQDLQVQTFTVEKLLEPLIIQVTTLVNCPQNPSSRKKGRSKRASVLLASVEEATWNLLDKGEKIAQEATVLKDELTASLEEVRKESEALKVSAERFTDDPCFLPKREAVVQAARALLAAVTRLLILADMIDVMCLLQHVSAFQRTFESLKNVANKSDLQKTYQKLGKELENLDYLAFKRQQDLKSPNQRDEIAGARASLKENSPLLHSICSACLEHSDVASLKASKDTVCEEIQNALNVISNASQGIQNMTTPPEPQAATLGSALDELENLIVLNPLTVTEEEIRPSLEKRLEAIISGAALLADSSCTRDLHRERIIAECNAIRQALQDLLSEYMNNAGKKERSNTLNIALDNMCKKTRDLRRQLRKAIIDHVSDSFLDTTVPLLVLIEAAKNGREKEIKEYAAIFHEHTSRLVEVANLACSMSTNEDGIKIVKIAANHLETLCPQIINAALALAARPKSQAVKNTMEMYKRTWENHIHVLTEAVDDITSIDDFLAVSESHILEDVNKCIIALRDQDADNLDRAAGAIRGRAARVAHIVTGEMDSYEPGAYTEGVMRNVNFLTSTVIPEFVTQVNVALEALSKSSLNVLDDNQFVDISKKIYDTIHDIRCSVMMIRTPEELEDVSDLEEEHEVRSHTSIQTEGKTDRAKMTQLPEAEKEKIAEQVADFKKVKSKLDAEIEIWDDTSNDIIVLAKNMCMIMMEMTDFTRGKGPLKHTTDVIYAAKMISESGSRMDVLARQIANQCPDPSCKQDLLAYLEQIKFYSHQLKICSQVKAEIQNLGGELIMSALDSVTSLIQAAKNLMNAVVQTVKMSYIASTKIIRIQSPAGPRHPVVMWRMKAPAKKPLIKREKPEETCAAVRRGSAKKKIHPLQVMSEFRGRQIY 269E6DFB4956BDFE q99959-2 Plakophilin-2 PKP2 A protein protein human Homo sapiens Human MAAPGAPAEYGYIRTVLGQQILGQLDSSSLALPSEAKLKLAGSSGRGGQTVKSLRIQEQVQQTLARKGRSSVGNGNLHRTSSVPEYVYNLHLVENDFVGGRSPVPKTYDMLKAGTTATYEGRWGRGTAQYSSQKSVEERSLRHPLRRLEISPDSSPERAHYTHSDYQYSQRSQAGHTLHHQESRRAALLVPPRYARSEIVGVSRAGTTSRQRHFDTYHRQYQHGSVSDTVFDSIPANPALLTYPRPGTSRSMGNLLEKENYLTAGLTVGQVRPLVPLQPVTQNRASRSSWHQSSFHSTRTLREAGPSVAVDSSGRRAHLTVGQAAAGGSGNLLTERSTFTDSQLGNADMEMTLERAVSMLEADHMLPSRISAAATFIQHECFQKSEARKRVNQLRGILKLLQLLKVQNEDVQRAVCGALRNLVFEDNDNKLEVAELNGVPRLLQVLKQTRDLETKKQITGLLWNLSSNDKLKNLMITEALLTLTENIIIPFSGWPEGDYPKANGLLDFDIFYNVTGCLRNMSSAGADGRKAMRRCDGLIDSLVHYVRGTIADYQPDDKATENCVCILHNLSYQLEAELPEKYSQNIYIQNRNIQTDNNKSIGCFGSRSRKVKEQYQDVPMPEEKSNPKGVEWLWHSIVIRMYLSLIAKSVRNYTQEASLGALQNLTAGSGPMPTSVAQTVVQKESGLQHTRKMLHVGDPSVKKTAISLLRNLSRNLSLQNEIAKETLPDLVSIIPDTVPSTDLLIETTASACYTLNNIIQNSYQNARDLLNTGGIQKIMAISAGDAYASNKASKAASVLLYSLWAHTELHHAYKKAQFKKTDFVNSRTAKAYHSLKD Major isoform in heart. 8E9553F9B820E8DF plak_human Junction plakoglobin JUP DP3 CTNNG Desmoplakin-3 Desmoplakin III Catenin gamma protein protein human Homo sapiens Human MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTTYTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDYRKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDMDGDYPIDTYSDGLRPPYPTADHMLA DIP protein P14923 original sequence version: 159 3519A0973748BCF4 pkp3_human Plakophilin-3 PKP3 protein protein human Homo sapiens Human MQDGNFLLSALQPEAGVCSLALPSDLQLDRRGAEGPEAERLRAARVQEQVRARLLQLGQQPRHNGAAEPEPEAETARGTSRGQYHTLQAGFSSRSQGLSGDKTSGFRPIAKPAYSPASWSSRSAVDLSCSRRLSSAHNGGSAFGAAGYGGAQPTPPMPTRPVSFHERGGVGSRADYDTLSLRSLRLGPGGLDDRYSLVSEQLEPAATSTYRAFAYERQASSSSSRAGGLDWPEATEVSPSRTIRAPAVRTLQRFQSSHRSRGVGGAVPGAVLEPVARAPSVRSLSLSLADSGHLPDVHGFNSYGSHRTLQRLSSGFDDIDLPSAVKYLMASDPNLQVLGAAYIQHKCYSDAAAKKQARSLQAVPRLVKLFNHANQEVQRHATGAMRNLIYDNADNKLALVEENGIFELLRTLREQDDELRKNVTGILWNLSSSDHLKDRLARDTLEQLTDLVLSPLSGAGGPPLIQQNASEAEIFYNATGFLRNLSSASQATRQKMRECHGLVDALVTSINHALDAGKCEDKSVENAVCVLRNLSYRLYDEMPPSALQRLEGRGRRDLAGAPPGEVVGCFTPQSRRLRELPLAADALTFAEVSKDPKGLEWLWSPQIVGLYNRLLQRCELNRHTTEAAAGALQNITAGDRRWAGVLSRLALEQERILNPLLDRVRTADHHQLRSLTGLIRNLSRNARNKDEMSTKVVSHLIEKLPGSVGEKSPPAEVLVNIIAVLNNLVVASPIAARDLLYFDGLRKLIFIKKKRDSPDSEKSSRAASSLLANLWQYNKLHRDFRAKGYRKEDFLGP D43C7E77FA805E7E ctnb1_mouse Catenin beta-1 Beta-catenin Ctnnb1 Catnb protein protein mouse Mus musculus Mouse MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEALGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL DIP protein Q02248 original sequence version: 128 DIP protein Q02248 original sequence version: 135 DIP protein Q02248 original sequence version: 147 DIP protein Q02248 original sequence version: 187 DIP protein Q02248 original sequence version: 140 D708F170A3FBED6E ctnb1_rat Catenin beta-1 Ctnnb1 Catnb Beta-catenin protein protein rat Rattus norvegicus (Rat) Rat MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGPHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEALGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL DIP protein Q9WU82 original sequence version: 140 DIP protein Q9WU82 original sequence version: 93 DIP protein Q9WU82 original sequence version: 115 9C29186B6DD54B87 ctnna3-pkp3-2 3 11 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed living cell living cell 8 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed living cell living cell Q9UI47-1:p.Val94Asp mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain V D Tue Jun 30 18:10:46 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val94Asp' Q9UI47-1:p.Leu765del mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain L . Tue Jun 30 17:00:22 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu765del' physical association physical association Fig. 3a pkp3-ctnna3-1 3 9 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed living cell living cell 8 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed living cell living cell Q9UI47-1:p.Val94Asp mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain V D Tue Jun 30 18:50:02 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val94Asp' Q9UI47-1:p.Leu765del mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain L . Tue Jun 30 20:02:43 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu765del' physical association physical association Fig. 3a pkp2-ctnna3-1 3 7 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed living cell living cell region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 8 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed living cell living cell Q9UI47-1:p.Val94Asp mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain V D Tue Jun 30 19:41:33 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val94Asp' Q9UI47-1:p.Leu765del mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain L . Tue Jun 30 16:12:19 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu765del' physical association physical association Fig. 3a ctnna3-jup-3 3 10 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed living cell living cell 8 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed living cell living cell Q9UI47-1:p.Val94Asp mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain V D Tue Jun 30 19:29:54 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val94Asp' Q9UI47-1:p.Leu765del mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain L . Tue Jun 30 20:03:56 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu765del' physical association physical association Fig. 3a pkp2-ctnna3-2 3 8 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed living cell living cell Q9UI47-1:p.Val94Asp mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain V D Tue Jun 30 18:40:37 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val94Asp' Q9UI47-1:p.Leu765del mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain L . Tue Jun 30 18:31:04 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu765del' 8 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed living cell living cell Q9UI47-1:p.Val94Asp mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain V D Tue Jun 30 20:06:52 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val94Asp' Q9UI47-1:p.Leu765del mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain L . Tue Jun 30 16:13:52 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu765del' physical association physical association Fig. 3a ctnna3-ctnnb1-1 5 7 unspecified role unspecified role prey prey living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level 8 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed living cell living cell region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q9UI47-1:p.Val94Asp mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain V D Tue Jun 30 18:10:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val94Asp' physical association physical association Figure 4a ctnna3-ctnnb1-2 4 7 unspecified role unspecified role bait bait living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level 8 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed living cell living cell region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q9UI47-1:p.Val94Asp mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain V D Tue Jun 30 19:31:40 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val94Asp' physical association physical association Figure 4a ctnna3-ctnnb1-3 6 13 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level fixed cell fixed cell 8 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed fixed cell fixed cell region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q9UI47-1:p.Val94Asp mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain V D Tue Jun 30 19:19:43 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val94Asp' Q9UI47-1:p.Leu765del mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain L . Tue Jun 30 16:28:42 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu765del' colocalization colocalization Figure 4b ctnna3-ctnnb1-4 2 12 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level fixed cell fixed cell 8 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed fixed cell fixed cell region egfp tag enhanced green fluorescent protein tag enhanced green fluorescent protein EGFP enhanced green fluorescent protein EGFP egfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q9UI47-1:p.Val94Asp mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain V D Tue Jun 30 19:21:26 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val94Asp' Q9UI47-1:p.Leu765del mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain L . Tue Jun 30 16:16:01 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu765del' colocalization colocalization Figure S2 ctnna3-ctnnb1-5 1 7 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed fixed cell fixed cell region myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 8 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed fixed cell fixed cell region egfp tag enhanced green fluorescent protein tag enhanced green fluorescent protein EGFP enhanced green fluorescent protein EGFP egfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q9UI47-1:p.Val94Asp mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain V D Tue Jun 30 19:44:28 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val94Asp' colocalization colocalization Figure S3