IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ LRIG2 promotes the proliferation and cell cycle progression of glioblastoma cells in vitro and in vivo through enhancing PDGFRβ signaling. LRIG2 promotes the proliferation and cell cycle progression of glioblastoma cells in vitro and in vivo through enhancing PDGFRβ signaling. International journal of oncology 2018 imex curation Xiao Q., Dong M., Cheng F., Mao F., Zong W., Wu K., Wang H., Xie R., Wang B., Lei T., Guo D., Xiao Q., Dong M., Cheng F., Mao F., Zong W., Wu K., Wang H., Xie R., Wang B., Lei T., Guo D. Cancer - Interactions investigated in the context of cancer Details of LRIG2 obtained from the stated reference (no 22) pmid:25353163. wbf620@163.com 04-05-20: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-u87 Human U-87 MG glioblastoma cell line u87 anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Xiao Q., Dong M., Cheng F., Mao F., Zong W., Wu K., Wang H., Xie R., Wang B., Lei T., Guo D., Xiao Q., Dong M., Cheng F., Mao F., Zong W., Wu K., Wang H., Xie R., Wang B., Lei T., Guo D. Cancer - Interactions investigated in the context of cancer Details of LRIG2 obtained from the stated reference (no 22) pmid:25353163. wbf620@163.com Accepted 2020-FEB-13 AT 10:18 GMT AT 10:18 GMT by LIVIAP International journal of oncology 2018 Only protein-protein interactions imex curation imex curation LRIG2 promotes the proliferation and cell cycle progression of glioblastoma cells in vitro and in vivo through enhancing PDGFRβ signaling. LRIG2 promotes the proliferation and cell cycle progression of glioblastoma cells in vitro and in vivo through enhancing PDGFRβ signaling. International journal of oncology 2018 imex curation Xiao Q., Dong M., Cheng F., Mao F., Zong W., Wu K., Wang H., Xie R., Wang B., Lei T., Guo D., Xiao Q., Dong M., Cheng F., Mao F., Zong W., Wu K., Wang H., Xie R., Wang B., Lei T., Guo D. Cancer - Interactions investigated in the context of cancer Details of LRIG2 obtained from the stated reference (no 22) pmid:25353163. wbf620@163.com 04-05-20: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-u87 Human U-87 MG glioblastoma cell line u87 anti bait coip anti bait coimmunoprecipitation anti bait coip anti tag western anti tag western blot anti tag western Xiao Q., Dong M., Cheng F., Mao F., Zong W., Wu K., Wang H., Xie R., Wang B., Lei T., Guo D., Xiao Q., Dong M., Cheng F., Mao F., Zong W., Wu K., Wang H., Xie R., Wang B., Lei T., Guo D. Cancer - Interactions investigated in the context of cancer Details of LRIG2 obtained from the stated reference (no 22) pmid:25353163. wbf620@163.com Accepted 2020-FEB-13 AT 10:18 GMT AT 10:18 GMT by LIVIAP International journal of oncology 2018 Only protein-protein interactions imex curation imex curation LRIG2 promotes the proliferation and cell cycle progression of glioblastoma cells in vitro and in vivo through enhancing PDGFRβ signaling. LRIG2 promotes the proliferation and cell cycle progression of glioblastoma cells in vitro and in vivo through enhancing PDGFRβ signaling. International journal of oncology 2018 imex curation Xiao Q., Dong M., Cheng F., Mao F., Zong W., Wu K., Wang H., Xie R., Wang B., Lei T., Guo D., Xiao Q., Dong M., Cheng F., Mao F., Zong W., Wu K., Wang H., Xie R., Wang B., Lei T., Guo D. Cancer - Interactions investigated in the context of cancer Details of LRIG2 obtained from the stated reference (no 22) pmid:25353163. wbf620@163.com 04-05-20: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-u87 Human U-87 MG glioblastoma cell line u87 confocal microscopy confocal microscopy immunocytochemistry immunocytochemistry Xiao Q., Dong M., Cheng F., Mao F., Zong W., Wu K., Wang H., Xie R., Wang B., Lei T., Guo D., Xiao Q., Dong M., Cheng F., Mao F., Zong W., Wu K., Wang H., Xie R., Wang B., Lei T., Guo D. Cancer - Interactions investigated in the context of cancer Details of LRIG2 obtained from the stated reference (no 22) pmid:25353163. wbf620@163.com Accepted 2020-FEB-13 AT 10:18 GMT AT 10:18 GMT by LIVIAP International journal of oncology 2018 Only protein-protein interactions imex curation imex curation pgfrb_human Platelet-derived growth factor receptor beta CD140 antigen-like family member B PDGFRB Beta-type platelet-derived growth factor receptor PDGFR Platelet-derived growth factor receptor 1 Beta platelet-derived growth factor receptor PDGFR1 protein protein human Homo sapiens Human MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL DIP protein P09619 original sequence version: 176 DIP protein P09619 original sequence version: 185 DIP protein P09619 original sequence version: 114 DIP protein P09619 original sequence version: 162 DIP protein P09619 original sequence version: 150 DIP protein P09619 original sequence version: 165 DIP protein P09619 original sequence version: 161 038C15E531D6E89D lrig2_human Leucine-rich repeats and immunoglobulin-like domains protein 2 LRIG2 KIAA0806 LIG2 protein protein human Homo sapiens Human MAPAPLGVPEEQLLGCRSRVLSRLLFIAQTALLLLPAAGAGLCPAPCSCRIPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSHNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSSQSSIGHEDDGWTTVGIVIIVVVCCVVGTSLIWVIVIYHMRRKNEDYSITNTEELNLPADIPSYLSSQGTLSEPQEGYSNSEAGSHQQLMPPANGYIHKGTDGGTGTRVICSDCYDNANIYSRTREYCPYTYIAEEDVLDQTLSSLMVQMPKETYLVHPPQDTTALESLIPSANREPSAFPTNHERISEKKLPSTQMSGETLQRPVWNINRELGLPHPPFSQQPVHESPQLHQNEGLAGREPDCSASSMSCHRLQDHAFDFSRTRNIQDGSEGT CD2903A861DC4887 lrig2-pdgfrb-1 3 5 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed n-terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range 4 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level colocalization colocalization 8A lrig2-pdgfrb-2 1 5 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range 4 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level physical association physical association 8B lrig2-pdgfrb-3 2 5 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed n-terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range 4 unspecified role unspecified role bait bait physiological level physiological level endogenous level endogenous endogenous endogenous level physical association physical association 8B