IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination. Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination. Cancer cell 2016 imex curation Ham J., Costa C., Sano R., Lochmann TL., Sennott EM., Patel NU., Dastur A., Gomez-Caraballo M., Krytska K., Hata AN., Floros KV., Hughes MT., Jakubik CT., Heisey DA., Ferrell JT., Bristol ML., March RJ., Yates C., Hicks MA., Nakajima W., Gowda M., Windle BE., Dozmorov MG., Garnett MJ., McDermott U., Harada H., Taylor SM., Morgan IM., Benes CH., Engelman JA., Mossé YP., Faber AC. Cancer - Interactions investigated in the context of cancer acfaber@vcu.edu 11-Apr-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-sk-n-dz human-SK-N-DZ;neuroblastoma cell line from a poorly differentiated bone marrow metastasis. Human sk-n-dz SK-N-DZ -neuroblastoma cell line from a poorly differentiated bone marrow metastasis http://www.lgcstandards-atcc.org/products/all/CRL-2149 ch-ip chromatin immunoprecipitation assay ch-ip q-pcr quantitative pcr q-pcr Ham J., Costa C., Sano R., Lochmann TL., Sennott EM., Patel NU., Dastur A., Gomez-Caraballo M., Krytska K., Hata AN., Floros KV., Hughes MT., Jakubik CT., Heisey DA., Ferrell JT., Bristol ML., March RJ., Yates C., Hicks MA., Nakajima W., Gowda M., Windle BE., Dozmorov MG., Garnett MJ., McDermott U., Harada H., Taylor SM., Morgan IM., Benes CH., Engelman JA., Mossé YP., Faber AC. Cancer - Interactions investigated in the context of cancer The GFP-IRES-MCL-1 pLENTI plasmid was found to be of Murine origin -pmid:21613222 (Warr et al., 2011). The provider of the plasmid was a Dr Gordon Shore, as stated in the Faber - 2015 reference (not Faber - 2014 as stated.) acfaber@vcu.edu Accepted 2016-MAR-21 AT 10:05 GMT AT 10:05 GMT by ORCHARD Cancer cell 2016 Only protein-protein interactions imex curation imex curation Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination. Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination. Cancer cell 2016 imex curation Ham J., Costa C., Sano R., Lochmann TL., Sennott EM., Patel NU., Dastur A., Gomez-Caraballo M., Krytska K., Hata AN., Floros KV., Hughes MT., Jakubik CT., Heisey DA., Ferrell JT., Bristol ML., March RJ., Yates C., Hicks MA., Nakajima W., Gowda M., Windle BE., Dozmorov MG., Garnett MJ., McDermott U., Harada H., Taylor SM., Morgan IM., Benes CH., Engelman JA., Mossé YP., Faber AC. Cancer - Interactions investigated in the context of cancer acfaber@vcu.edu 11-Apr-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-kelly human KELLY- Neuroblastoma cell line with ampification of N-MYC Human kelly KELLY- Neuroblastoma cell line with ampification of N-MYC https://www.dsmz.de/catalogues/details/culture/ACC-355.html ch-ip chromatin immunoprecipitation assay ch-ip q-pcr quantitative pcr q-pcr Ham J., Costa C., Sano R., Lochmann TL., Sennott EM., Patel NU., Dastur A., Gomez-Caraballo M., Krytska K., Hata AN., Floros KV., Hughes MT., Jakubik CT., Heisey DA., Ferrell JT., Bristol ML., March RJ., Yates C., Hicks MA., Nakajima W., Gowda M., Windle BE., Dozmorov MG., Garnett MJ., McDermott U., Harada H., Taylor SM., Morgan IM., Benes CH., Engelman JA., Mossé YP., Faber AC. Cancer - Interactions investigated in the context of cancer The GFP-IRES-MCL-1 pLENTI plasmid was found to be of Murine origin -pmid:21613222 (Warr et al., 2011). The provider of the plasmid was a Dr Gordon Shore, as stated in the Faber - 2015 reference (not Faber - 2014 as stated.) acfaber@vcu.edu Accepted 2016-MAR-21 AT 10:05 GMT AT 10:05 GMT by ORCHARD Cancer cell 2016 Only protein-protein interactions imex curation imex curation Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination. Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination. Cancer cell 2016 imex curation Ham J., Costa C., Sano R., Lochmann TL., Sennott EM., Patel NU., Dastur A., Gomez-Caraballo M., Krytska K., Hata AN., Floros KV., Hughes MT., Jakubik CT., Heisey DA., Ferrell JT., Bristol ML., March RJ., Yates C., Hicks MA., Nakajima W., Gowda M., Windle BE., Dozmorov MG., Garnett MJ., McDermott U., Harada H., Taylor SM., Morgan IM., Benes CH., Engelman JA., Mossé YP., Faber AC. Cancer - Interactions investigated in the context of cancer acfaber@vcu.edu 11-Apr-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Ham J., Costa C., Sano R., Lochmann TL., Sennott EM., Patel NU., Dastur A., Gomez-Caraballo M., Krytska K., Hata AN., Floros KV., Hughes MT., Jakubik CT., Heisey DA., Ferrell JT., Bristol ML., March RJ., Yates C., Hicks MA., Nakajima W., Gowda M., Windle BE., Dozmorov MG., Garnett MJ., McDermott U., Harada H., Taylor SM., Morgan IM., Benes CH., Engelman JA., Mossé YP., Faber AC. Cancer - Interactions investigated in the context of cancer Western Blotting was used for Participant Detection, as stated in the main body of the paper in reference to Fig S5G. From the antibody datasheet (eIF4G (cat #2469) it was determined that "eIF4G" refers to the molecule EIF4G1 as this is the only species of EIF4G that has a Gly at residue 188. acfaber@vcu.edu Accepted 2016-MAR-21 AT 10:05 GMT AT 10:05 GMT by ORCHARD Cancer cell 2016 Only protein-protein interactions imex curation imex curation Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination. Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination. Cancer cell 2016 imex curation Ham J., Costa C., Sano R., Lochmann TL., Sennott EM., Patel NU., Dastur A., Gomez-Caraballo M., Krytska K., Hata AN., Floros KV., Hughes MT., Jakubik CT., Heisey DA., Ferrell JT., Bristol ML., March RJ., Yates C., Hicks MA., Nakajima W., Gowda M., Windle BE., Dozmorov MG., Garnett MJ., McDermott U., Harada H., Taylor SM., Morgan IM., Benes CH., Engelman JA., Mossé YP., Faber AC. Cancer - Interactions investigated in the context of cancer acfaber@vcu.edu 11-Apr-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-sk_n_be(2) Human caucasian neuroblastoma cell line sk_n_be(2) Human neuroblastoma cell line anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Ham J., Costa C., Sano R., Lochmann TL., Sennott EM., Patel NU., Dastur A., Gomez-Caraballo M., Krytska K., Hata AN., Floros KV., Hughes MT., Jakubik CT., Heisey DA., Ferrell JT., Bristol ML., March RJ., Yates C., Hicks MA., Nakajima W., Gowda M., Windle BE., Dozmorov MG., Garnett MJ., McDermott U., Harada H., Taylor SM., Morgan IM., Benes CH., Engelman JA., Mossé YP., Faber AC. Cancer - Interactions investigated in the context of cancer acfaber@vcu.edu Accepted 2016-MAR-21 AT 10:05 GMT AT 10:05 GMT by ORCHARD Cancer cell 2016 Only protein-protein interactions imex curation imex curation Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination. Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination. Cancer cell 2016 imex curation Ham J., Costa C., Sano R., Lochmann TL., Sennott EM., Patel NU., Dastur A., Gomez-Caraballo M., Krytska K., Hata AN., Floros KV., Hughes MT., Jakubik CT., Heisey DA., Ferrell JT., Bristol ML., March RJ., Yates C., Hicks MA., Nakajima W., Gowda M., Windle BE., Dozmorov MG., Garnett MJ., McDermott U., Harada H., Taylor SM., Morgan IM., Benes CH., Engelman JA., Mossé YP., Faber AC. Cancer - Interactions investigated in the context of cancer acfaber@vcu.edu 11-Apr-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-sk-n-dz human-SK-N-DZ;neuroblastoma cell line from a poorly differentiated bone marrow metastasis. Human sk-n-dz SK-N-DZ -neuroblastoma cell line from a poorly differentiated bone marrow metastasis http://www.lgcstandards-atcc.org/products/all/CRL-2149 anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Ham J., Costa C., Sano R., Lochmann TL., Sennott EM., Patel NU., Dastur A., Gomez-Caraballo M., Krytska K., Hata AN., Floros KV., Hughes MT., Jakubik CT., Heisey DA., Ferrell JT., Bristol ML., March RJ., Yates C., Hicks MA., Nakajima W., Gowda M., Windle BE., Dozmorov MG., Garnett MJ., McDermott U., Harada H., Taylor SM., Morgan IM., Benes CH., Engelman JA., Mossé YP., Faber AC. Cancer - Interactions investigated in the context of cancer acfaber@vcu.edu Accepted 2016-MAR-21 AT 10:05 GMT AT 10:05 GMT by ORCHARD Cancer cell 2016 Only protein-protein interactions imex curation imex curation mycn_human N-myc proto-oncogene protein MYCN NMYC BHLHE37 Class E basic helix-loop-helix protein 37 protein protein human Homo sapiens Human MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLGGLGGLTPNPVILQDCMWSGFSAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGAASPAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTITVRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC DIP protein P04198 original sequence version: 157 560E885602E30DAD b2l11_human Bcl-2-like protein 11 BCL2L11 BIM Bcl2-interacting mediator of cell death protein protein human Homo sapiens Human MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH DIP protein O43521 original sequence version: 48 DIP protein O43521-1 original sequence version: 71 DIP protein O43521 original sequence version: 132 DIP protein O43521 original sequence version: 143 D75735E469CA6997 4ebp1_human Eukaryotic translation initiation factor 4E-binding protein 1 Phosphorylated heat- and acid-stable protein regulated by insulin 1 EIF4EBP1 protein protein human Homo sapiens Human MSGGSSCSQTPSRAIPATRRVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKRAGGEESQFEMDI DIP protein Q13541 original sequence version: 96 DIP protein Q13541 original sequence version: 103 DIP protein Q13541 original sequence version: 120 DIP protein Q13541 original sequence version: 113 1682A6BA74132966 if4g1_human Eukaryotic translation initiation factor 4 gamma 1 p220 EIF4G1 EIF4G EIF4GI EIF4F protein protein human Homo sapiens Human MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN DIP protein Q04637 original sequence version: 68 DIP protein Q04637 original sequence version: 166 DIP protein Q04637 original sequence version: 160 DIP protein Q04637-1 original sequence version: 94 DIP protein Q04637 original sequence version: 115 DIP protein Q04637 original sequence version: 119 DIP protein Q04637 original sequence version: 146 DIP protein Q04637-1 original sequence version: 148 DIP protein Q04637 original sequence version: 150 324088B60863DA34 if4e_human Eukaryotic translation initiation factor 4E mRNA cap-binding protein eIF-4F 25 kDa subunit EIF4E EIF4EL1 EIF4F protein protein human Homo sapiens Human MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV DIP protein P06730 original sequence version: 164 DIP protein P06730 original sequence version: 127 DIP protein P06730 original sequence version: 126 DIP protein P06730 original sequence version: 135 DIP protein P06730 original sequence version: 151 DIP protein P06730 original sequence version: 155 DIP protein P06730 original sequence version: 160 DIP protein P06730-1 original sequence version: 187 DIP protein P06730 original sequence version: 146 B869B8DE615E699D mdm2_human_gene Human MDM2 gene gene gene human Homo sapiens Human mir17hg_human_gene MIR17HG_human_gene gene gene human Homo sapiens Human 7-methyl-gtp 7-methyl-GTP small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) mcl1_human Induced myeloid leukemia cell differentiation protein Mcl-1 Bcl-2-related protein EAT/mcl1 mcl1/EAT MCL1 BCL2L3 Bcl-2-like protein 3 protein protein human Homo sapiens Human MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR DIP protein Q07820 original sequence version: 85 DIP protein Q07820 original sequence version: 89 DIP protein Q07820 original sequence version: 113 DIP protein Q07820 original sequence version: 168 DIP protein Q07820-1 original sequence version: 113 D85821AC59275F1F apr_human_gene Phorbol-12-myristate-13-acetate-induced protein 1 PMAIP1 NOXA gene gene human Homo sapiens Human mycn-pmaip1-1 2 15 unspecified role unspecified role prey prey promoter_region sufficient to bind sufficient binding region sufficient to bind undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 6 unspecified role unspecified role bait bait association association 2J P04198 increases expression at RNA level of ENSG00000141682 P04198 increases expression at protein level of ENSG00000141682 mycn-mdm2_human_gene-1 2 11 unspecified role unspecified role prey prey region sufficient to bind sufficient binding region sufficient to bind undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 6 unspecified role unspecified role bait bait association association 2J-2 primers given for MDM2 are too short to give a Blat result. mycn-mir17hg_human_gene-1 2 12 unspecified role unspecified role prey prey intron_1_region sufficient to bind sufficient binding region sufficient to bind undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 6 unspecified role unspecified role bait bait association association 2J-3 I had to create an internal entry for MIR17HG_human_gene; presumably as UniProt do not list any Ensembl entry as an XRef, also the Ensembl Transcript table says "no protein" for all 3 transcripts!?? mycn-mdm2_human_gene-2 1 6 unspecified role unspecified role bait bait 11 unspecified role unspecified role prey prey region sufficient to bind sufficient binding region sufficient to bind undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 2J-2 primers given for MDM2 are too short to give a Blat result. mycn-mir17hg_human_gene-2 1 12 unspecified role unspecified role prey prey intron_1_region sufficient to bind sufficient binding region sufficient to bind undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 6 unspecified role unspecified role bait bait association association 2J-3 I had to create an internal entry for MIR17HG_human_gene; presumably as UniProt do not list any Ensembl entry as an XRef, also the Ensembl Transcript table says "no protein" for all 3 transcripts!?? mycn-pmaip1-2 1 15 unspecified role unspecified role prey prey promoter_region sufficient to bind sufficient binding region sufficient to bind undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 6 unspecified role unspecified role bait bait association association 2J P04198 increase expression at RNA level of ENSG00000141682 P04198 increase expression at protein level of ENSG00000141682 mcl1-bcl2l11-11 4 7 unspecified role unspecified role prey prey 14 unspecified role unspecified role bait bait physical association physical association 5E ABT-199 (Venetoclax) -a BCL-2 inhibitor, encouraging apoptosis. MLN8237-an Aurora Kinase A inhibitor mcl1-bcl2l11-10 5 14 unspecified role unspecified role bait bait 7 unspecified role unspecified role prey prey physical association physical association 5E ABT-199 (Venetoclax) -a BCL-2 inhibitor, encouraging apoptosis. MLN8237-an Aurora Kinase A inhibitor 7_methyl_gtp-eif4e-1 3 9 unspecified role unspecified role prey prey human-kelly human KELLY- Neuroblastoma cell line with ampification of N-MYC Human kelly KELLY- Neuroblastoma cell line with ampification of N-MYC https://www.dsmz.de/catalogues/details/culture/ACC-355.html 10 unspecified role unspecified role prey prey human-kelly human KELLY- Neuroblastoma cell line with ampification of N-MYC Human kelly KELLY- Neuroblastoma cell line with ampification of N-MYC https://www.dsmz.de/catalogues/details/culture/ACC-355.html 8 unspecified role unspecified role prey prey human-kelly human KELLY- Neuroblastoma cell line with ampification of N-MYC Human kelly KELLY- Neuroblastoma cell line with ampification of N-MYC https://www.dsmz.de/catalogues/details/culture/ACC-355.html 13 unspecified role unspecified role bait bait association association Supp 5G MLN8237; 4EBP1:eIF4E complex formation is increased MLN8237 (Aurora A inhibitor) ;eIF4G:eIF4E complex formation decreases 7_methyl_gtp-eif4e-2 3 9 unspecified role unspecified role prey prey human-sk_n_be(2) Human caucasian neuroblastoma cell line sk_n_be(2) Human neuroblastoma cell line 10 unspecified role unspecified role prey prey human-sk_n_be(2) Human caucasian neuroblastoma cell line sk_n_be(2) Human neuroblastoma cell line 8 unspecified role unspecified role prey prey human-sk_n_be(2) Human caucasian neuroblastoma cell line sk_n_be(2) Human neuroblastoma cell line 13 unspecified role unspecified role bait bait association association Supp 5G-2 MLN8237; 4EBP1:eIF4E complex formation is increased MLN8237 (Aurora A inhibitor) ;eIF4G:eIF4E complex formation decreases mcl1-bcl2l11-12 4 7 unspecified role unspecified role bait bait 14 unspecified role unspecified role prey prey physical association physical association Supp 6D ABT-199 (Venetoclax) -a BCL-2 inhibitor, encouraging apoptosis. MLN8237-an Aurora Kinase A inhibitor mcl1-bcl2l11-13 5 14 unspecified role unspecified role prey prey 7 unspecified role unspecified role bait bait physical association physical association Supp 6D ABT-199 (Venetoclax) -a BCL-2 inhibitor, encouraging apoptosis. MLN8237-an Aurora Kinase A inhibitor