IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B. MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B. Cancer cell 2016 imex curation Hu J., Sun T., Wang H., Chen Z., Wang S., Yuan L., Liu T., Li HR., Wang P., Feng Y., Wang Q., McLendon RE., Friedman AH., Keir ST., Bigner DD., Rathmell J., Fu XD., Li QJ., Wang H., Wang XF. Cancer - Interactions investigated in the context of cancer I have not created a new cell line for "110040" as the term "glioma- initiating-cell" has no Brenda XRef, limited usage, and no other publication appears to use the cell line "110040". The cells are processed to extract Cd133+ cells. Cell line D456MG appears to be a paediatric GBM cell line, mentioned in the literature, but also further processed here, and also always as a xenograft - original references go back to . ~1990 - earlier than pmid:8194169 - so I have not been able to see if this cell line had an independant existence or is only a xenograft. I have created a cell_type for it, but decided not to use it. Or maybe host organism should be "Mouse"? xiao.fan.wang@duke.edu 11-Apr-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-glioblastoma Homo sapiens glioblastoma glioblastoma Glioblastoma Glioblastoma is the same as 'Glioblastoma multiforme' (GBM) -is the same as Astrocytoma Grade 4. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Hu J., Sun T., Wang H., Chen Z., Wang S., Yuan L., Liu T., Li HR., Wang P., Feng Y., Wang Q., McLendon RE., Friedman AH., Keir ST., Bigner DD., Rathmell J., Fu XD., Li QJ., Wang H., Wang XF. Cancer - Interactions investigated in the context of cancer I have not created a new cell line for "110040" as the term "glioma- initiating-cell" has no Brenda XRef, limited usage, and no other publication appears to use the cell line "110040". The cells are processed to extract Cd133+ cells. Cell line D456MG appears to be a paediatric GBM cell line, mentioned in the literature, but also further processed here, and also always as a xenograft - original references go back to . ~1990 - earlier than pmid:8194169 - so I have not been able to see if this cell line had an independant existence or is only a xenograft. I have created a cell_type for it, but decided not to use it. Or maybe host organism should be "Mouse"? Cell line "10040": Glioma Initiating cells (CD133+) derived from a xenografted cell line isolated from a GBM patient and passaged in nude mice as a subcutaneous xenograft. xiao.fan.wang@duke.edu Accepted 2016-MAR-03 AT 08:15 GMT AT 08:15 GMT by ORCHARD Cancer cell 2016 Only protein-protein interactions imex curation imex curation I have made the comment into a Data-Proc statement - and added where/how I found the other MiRna for completeness. MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B. MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B. Cancer cell 2016 imex curation Hu J., Sun T., Wang H., Chen Z., Wang S., Yuan L., Liu T., Li HR., Wang P., Feng Y., Wang Q., McLendon RE., Friedman AH., Keir ST., Bigner DD., Rathmell J., Fu XD., Li QJ., Wang H., Wang XF. Cancer - Interactions investigated in the context of cancer I have not created a new cell line for "110040" as the term "glioma- initiating-cell" has no Brenda XRef, limited usage, and no other publication appears to use the cell line "110040". The cells are processed to extract Cd133+ cells. Cell line D456MG appears to be a paediatric GBM cell line, mentioned in the literature, but also further processed here, and also always as a xenograft - original references go back to . ~1990 - earlier than pmid:8194169 - so I have not been able to see if this cell line had an independant existence or is only a xenograft. I have created a cell_type for it, but decided not to use it. Or maybe host organism should be "Mouse"? xiao.fan.wang@duke.edu 11-Apr-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-glioblastoma Homo sapiens glioblastoma glioblastoma Glioblastoma Glioblastoma is the same as 'Glioblastoma multiforme' (GBM) -is the same as Astrocytoma Grade 4. ch-ip chromatin immunoprecipitation assay ch-ip q-pcr quantitative pcr q-pcr Hu J., Sun T., Wang H., Chen Z., Wang S., Yuan L., Liu T., Li HR., Wang P., Feng Y., Wang Q., McLendon RE., Friedman AH., Keir ST., Bigner DD., Rathmell J., Fu XD., Li QJ., Wang H., Wang XF. Cancer - Interactions investigated in the context of cancer I have not created a new cell line for "110040" as the term "glioma- initiating-cell" has no Brenda XRef, limited usage, and no other publication appears to use the cell line "110040". The cells are processed to extract Cd133+ cells. Cell line D456MG appears to be a paediatric GBM cell line, mentioned in the literature, but also further processed here, and also always as a xenograft - original references go back to . ~1990 - earlier than pmid:8194169 - so I have not been able to see if this cell line had an independant existence or is only a xenograft. I have created a cell_type for it, but decided not to use it. Or maybe host organism should be "Mouse"? RNA-ChIP Cell line "D456MG": derived from a paediatric glioblastoma biopsy. Glioma Initiating cells (CD133+) derived from this xenografted cell line and passaged in nude mice as a subcutaneous xenograft. xiao.fan.wang@duke.edu Accepted 2016-MAR-03 AT 08:15 GMT AT 08:15 GMT by ORCHARD Cancer cell 2016 Only protein-protein interactions imex curation imex curation I have made the comment into a Data-Proc statement - and added where/how I found the other MiRna for completeness. MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B. MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B. Cancer cell 2016 imex curation Hu J., Sun T., Wang H., Chen Z., Wang S., Yuan L., Liu T., Li HR., Wang P., Feng Y., Wang Q., McLendon RE., Friedman AH., Keir ST., Bigner DD., Rathmell J., Fu XD., Li QJ., Wang H., Wang XF. Cancer - Interactions investigated in the context of cancer I have not created a new cell line for "110040" as the term "glioma- initiating-cell" has no Brenda XRef, limited usage, and no other publication appears to use the cell line "110040". The cells are processed to extract Cd133+ cells. Cell line D456MG appears to be a paediatric GBM cell line, mentioned in the literature, but also further processed here, and also always as a xenograft - original references go back to . ~1990 - earlier than pmid:8194169 - so I have not been able to see if this cell line had an independant existence or is only a xenograft. I have created a cell_type for it, but decided not to use it. Or maybe host organism should be "Mouse"? xiao.fan.wang@duke.edu 11-Apr-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-glioblastoma Homo sapiens glioblastoma glioblastoma Glioblastoma Glioblastoma is the same as 'Glioblastoma multiforme' (GBM) -is the same as Astrocytoma Grade 4. ch-ip chromatin immunoprecipitation assay ch-ip q-pcr quantitative pcr q-pcr Hu J., Sun T., Wang H., Chen Z., Wang S., Yuan L., Liu T., Li HR., Wang P., Feng Y., Wang Q., McLendon RE., Friedman AH., Keir ST., Bigner DD., Rathmell J., Fu XD., Li QJ., Wang H., Wang XF. Cancer - Interactions investigated in the context of cancer Results from Figure 5B have not been included due to lack of antibody specificity. I have not created a new cell line for "110040" as the term "glioma- initiating-cell" has no Brenda XRef, limited usage, and no other publication appears to use the cell line "110040". The cells are processed to extract Cd133+ cells. Cell line D456MG appears to be a paediatric GBM cell line, mentioned in the literature, but also further processed here, and also always as a xenograft - original references go back to . ~1990 - earlier than pmid:8194169 - so I have not been able to see if this cell line had an independant existence or is only a xenograft. I have created a cell_type for it, but decided not to use it. Or maybe host organism should be "Mouse"? RNA-ChIP Cell line "10040": Glioma Initiating cells (CD133+) derived from a xenografted cell line isolated from a GBM patient and passaged in nude mice as a subcutaneous xenograft. An identifier for pri-let-7i has been derived from the Ensembl geneID- ENSG00000199179 - primary transcript. This was found from the MirBase hsa-let-7i entry, as Blatting primers given for both pre-let-7i and pri-let-7i in the Supplement did not yield any human genomic sequence match. The identifier for pri_mir_215 was found by blatting primers given in the supplement. xiao.fan.wang@duke.edu Accepted 2016-MAR-03 AT 08:15 GMT AT 08:15 GMT by ORCHARD Cancer cell 2016 Only protein-protein interactions imex curation imex curation I have made the comment into a Data-Proc statement - and added where/how I found the other MiRna for completeness. MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B. MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B. Cancer cell 2016 imex curation Hu J., Sun T., Wang H., Chen Z., Wang S., Yuan L., Liu T., Li HR., Wang P., Feng Y., Wang Q., McLendon RE., Friedman AH., Keir ST., Bigner DD., Rathmell J., Fu XD., Li QJ., Wang H., Wang XF. Cancer - Interactions investigated in the context of cancer I have not created a new cell line for "110040" as the term "glioma- initiating-cell" has no Brenda XRef, limited usage, and no other publication appears to use the cell line "110040". The cells are processed to extract Cd133+ cells. Cell line D456MG appears to be a paediatric GBM cell line, mentioned in the literature, but also further processed here, and also always as a xenograft - original references go back to . ~1990 - earlier than pmid:8194169 - so I have not been able to see if this cell line had an independant existence or is only a xenograft. I have created a cell_type for it, but decided not to use it. Or maybe host organism should be "Mouse"? xiao.fan.wang@duke.edu 11-Apr-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Hu J., Sun T., Wang H., Chen Z., Wang S., Yuan L., Liu T., Li HR., Wang P., Feng Y., Wang Q., McLendon RE., Friedman AH., Keir ST., Bigner DD., Rathmell J., Fu XD., Li QJ., Wang H., Wang XF. Cancer - Interactions investigated in the context of cancer I have not created a new cell line for "110040" as the term "glioma- initiating-cell" has no Brenda XRef, limited usage, and no other publication appears to use the cell line "110040". The cells are processed to extract Cd133+ cells. Cell line D456MG appears to be a paediatric GBM cell line, mentioned in the literature, but also further processed here, and also always as a xenograft - original references go back to . ~1990 - earlier than pmid:8194169 - so I have not been able to see if this cell line had an independant existence or is only a xenograft. I have created a cell_type for it, but decided not to use it. Or maybe host organism should be "Mouse"? xiao.fan.wang@duke.edu Accepted 2016-MAR-03 AT 08:15 GMT AT 08:15 GMT by ORCHARD Cancer cell 2016 Only protein-protein interactions imex curation imex curation I have made the comment into a Data-Proc statement - and added where/how I found the other MiRna for completeness. MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B. MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B. Cancer cell 2016 imex curation Hu J., Sun T., Wang H., Chen Z., Wang S., Yuan L., Liu T., Li HR., Wang P., Feng Y., Wang Q., McLendon RE., Friedman AH., Keir ST., Bigner DD., Rathmell J., Fu XD., Li QJ., Wang H., Wang XF. Cancer - Interactions investigated in the context of cancer I have not created a new cell line for "110040" as the term "glioma- initiating-cell" has no Brenda XRef, limited usage, and no other publication appears to use the cell line "110040". The cells are processed to extract Cd133+ cells. Cell line D456MG appears to be a paediatric GBM cell line, mentioned in the literature, but also further processed here, and also always as a xenograft - original references go back to . ~1990 - earlier than pmid:8194169 - so I have not been able to see if this cell line had an independant existence or is only a xenograft. I have created a cell_type for it, but decided not to use it. Or maybe host organism should be "Mouse"? xiao.fan.wang@duke.edu 11-Apr-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. ch-ip chromatin immunoprecipitation assay ch-ip q-pcr quantitative pcr q-pcr Hu J., Sun T., Wang H., Chen Z., Wang S., Yuan L., Liu T., Li HR., Wang P., Feng Y., Wang Q., McLendon RE., Friedman AH., Keir ST., Bigner DD., Rathmell J., Fu XD., Li QJ., Wang H., Wang XF. Cancer - Interactions investigated in the context of cancer I have not created a new cell line for "110040" as the term "glioma- initiating-cell" has no Brenda XRef, limited usage, and no other publication appears to use the cell line "110040". The cells are processed to extract Cd133+ cells. Cell line D456MG appears to be a paediatric GBM cell line, mentioned in the literature, but also further processed here, and also always as a xenograft - original references go back to . ~1990 - earlier than pmid:8194169 - so I have not been able to see if this cell line had an independant existence or is only a xenograft. I have created a cell_type for it, but decided not to use it. Or maybe host organism should be "Mouse"? RNA-ChIP xiao.fan.wang@duke.edu Accepted 2016-MAR-03 AT 08:15 GMT AT 08:15 GMT by ORCHARD Cancer cell 2016 Only protein-protein interactions imex curation imex curation I have made the comment into a Data-Proc statement - and added where/how I found the other MiRna for completeness. q9nrr4-1 Ribonuclease 3 Protein Drosha Ribonuclease III p241 DROSHA RN3 RNASE3L RNASEN protein protein human Homo sapiens Human MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQGPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPPSFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYDRGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNHRSPSREKKRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMPDKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECESDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIANMLQWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQLDREQFNPDVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHPSHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHMRKKGINTLINIMSRLGQDDPTPSRINHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLCRESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLNYPLHPLQLQEPNTDRQLIETSPVLQKLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEYAITNDKTKRPVALRTKTLADLLESFIAALYIDKDLEYVHTFMNVCFFPRLKEFILNQDWNDPKSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERIGCGKGPSIQQAEMGAAMDALEKYNFPQMAHQKRFIERKYRQELKEMRWEREHQEREPDETEDIKK ED6FDEA09F3B8092 ddx5_human Probable ATP-dependent RNA helicase DDX5 HLR1 DDX5 HELR G17P1 DEAD box protein 5 RNA helicase p68 protein protein human Homo sapiens Human MSGYSSDRDRGRDRGFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGNPTGTYQNGYDSTQQYGSNVPNMHNGMNQQAYAYPATAAAPMIGYPMPTGYSQ DIP protein P17844 original sequence version: 98 DIP protein P17844 original sequence version: 148 DIP protein P17844 original sequence version: 137 DIP protein P17844 original sequence version: 124 DIP protein P17844 original sequence version: 177 DIP protein P17844-1 original sequence version: 177 DIP protein P17844 original sequence version: 179 DIP protein P17844 original sequence version: 182 84DF684FD6871594 epas1_human Endothelial PAS domain-containing protein 1 EPAS1 HIF2A MOP2 Member of PAS protein 2 Basic-helix-loop-helix-PAS protein MOP2 BHLHE73 PASD2 Hypoxia-inducible factor 2-alpha HIF-1-alpha-like factor PAS domain-containing protein 2 Class E basic helix-loop-helix protein 73 protein protein human Homo sapiens Human MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQNFEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSSCSTPNSPEDYYTSLDNDLKIEVIEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDFQLSPICPEERLLAENPQSTPQHCFSAMTNIFQPLAPVAPHSPFLLDKFQQQLESKKTEPEHRPMSSIFFDAGSKASLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWAVGDQRTEFLGAAPLGPPVSPPHVSTFKTRSAKGFGARGPDVLSPAMVALSNKLKLKRQLEYEEQAFQDLSGGDPPGGSTSHLMWKRMKNLRGGSCPLMPDKPLSANVPNDKFTQNPMRGLGHPLRHLPLPQPPSAISPGENSKSRFPPQCYATQYQDYSLSSAHKVSGMASRLLGPSFESYLLPELTRYDCEVNVPVLGSSTLLQGGDLLRALDQAT DIP protein Q99814 original sequence version: 115 DIP protein Q99814 original sequence version: 155 DIP protein Q99814 original sequence version: 157 DIP protein Q99814 original sequence version: 137 DIP protein Q99814 original sequence version: 135 4838989598234FC1 rnc_human Ribonuclease 3 Ribonuclease III DROSHA p241 RNASEN RN3 RNASE3L Protein Drosha protein protein human Homo sapiens Human MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQGPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPPSFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYDRGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNHRSPSREKKRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMPDKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECESDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIANMLQWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQLDREQFNPDVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHPSHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHMRKKGINTLINIMSRLGQDDPTPSRINHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLCRESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLNYPLHPLQLQEPNTDRQLIETSPVLQKLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEYAITNDKTKRPVALRTKTLADLLESFIAALYIDKDLEYVHTFMNVCFFPRLKEFILNQDWNDPKSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERIGCGKGPSIQQAEMGAAMDALEKYNFPQMAHQKRFIERKYRQELKEMRWEREHQEREPDETEDIKK DIP protein Q9NRR4 original sequence version: 112 DIP protein Q9NRR4 original sequence version: 70 DIP protein Q9NRR4 original sequence version: 110 DIP protein Q9NRR4 original sequence version: 102 DIP protein Q9NRR4 original sequence version: 121 DIP protein Q9NRR4 original sequence version: 109 ED6FDEA09F3B8092 hif1a_human Hypoxia-inducible factor 1-alpha ARNT-interacting protein Member of PAS protein 1 Basic-helix-loop-helix-PAS protein MOP1 HIF1A MOP1 BHLHE78 PASD8 PAS domain-containing protein 8 Class E basic helix-loop-helix protein 78 protein protein human Homo sapiens Human MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN DIP protein Q16665 original sequence version: 94 DIP protein Q16665 original sequence version: 98 DIP protein Q16665-1 original sequence version: 102 DIP protein Q16665 original sequence version: 102 DIP protein Q16665 original sequence version: 127 DIP protein Q16665 original sequence version: 120 DIP protein Q16665 original sequence version: 169 DIP protein Q16665 original sequence version: 174 DIP protein Q16665-1 original sequence version: 174 DIP protein Q16665-1 original sequence version: 191 DIP protein Q16665 original sequence version: 191 DIP protein Q16665 original sequence version: 179 DIP protein Q16665 original sequence version: 150 DIP protein Q16665 original sequence version: 156 DIP protein Q16665 original sequence version: 177 ABD4F7DAA135BE2D pri_mir_215 mirna micro rna micro RNA micro-RNA micro-rna mirna miRNA human Homo sapiens Human dgcr8_human Microprocessor complex subunit DGCR8 DiGeorge syndrome critical region 8 DGCR8 DGCRK6 C22orf12 LP4941 protein protein human Homo sapiens Human METDESPSPLPCGPAGEAVMESRARPFQALPREQSPPPPLQTSSGAEVMDVGSGGDGQSELPAEDPFNFYGASLLSKGSFSKGRLLIDPNCSGHSPRTARHAPAVRKFSPDLKLLKDVKISVSFTESCRSKDRKVLYTGAERDVRAECGLLLSPVSGDVHACPFGGSVGDGVGIGGESADKKDEENELDQEKRVEYAVLDELEDFTDNLELDEEGAGGFTAKAIVQRDRVDEEALNFPYEDDFDNDVDALLEEGLCAPKKRRTEEKYGGDSDHPSDGETSVQPMMTKIKTVLKSRGRPPTEPLPDGWIMTFHNSGVPVYLHRESRVVTWSRPYFLGTGSIRKHDPPLSSIPCLHYKKMKDNEEREQSSDLTPSGDVSPVKPLSRSAELEFPLDEPDSMGADPGPPDEKDPLGAEAAPGALGQVKAKVEVCKDESVDLEEFRSYLEKRFDFEQVTVKKFRTWAERRQFNREMKRKQAESERPILPANQKLITLSVQDAPTKKEFVINPNGKSEVCILHEYMQRVLKVRPVYNFFECENPSEPFGASVTIDGVTYGSGTASSKKLAKNKAARATLEILIPDFVKQTSEEKPKDSEELEYFNHISIEDSRVYELTSKAGLLSPYQILHECLKRNHGMGDTSIKFEVVPGKNQKSEYVMACGKHTVRGWCKNKRVGKQLASQKILQLLHPHVKNWGSLLRMYGRESSKMVKQETSDKSVIELQQYAKKNKPNLHILSKLQEEMKRLAEEREETRKKPKMSIVASAQPGGEPLCTVDV DIP protein Q8WYQ5 original sequence version: 51 DIP protein Q8WYQ5 original sequence version: 112 DIP protein Q8WYQ5 original sequence version: 103 DIP protein Q8WYQ5 original sequence version: 122 DIP protein Q8WYQ5-1 original sequence version: 111 DIP protein Q8WYQ5 original sequence version: 111 72D962BBE32890EC q16665-1 Hypoxia-inducible factor 1-alpha ARNT-interacting protein Basic-helix-loop-helix-PAS protein MOP1 Class E basic helix-loop-helix protein 78 Member of PAS protein 1 PAS domain-containing protein 8 HIF1A BHLHE78 MOP1 PASD8 protein protein human Homo sapiens Human MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN ABD4F7DAA135BE2D pri_let_7i mirna micro rna micro RNA micro-RNA micro-rna mirna miRNA human Homo sapiens Human hif1a-dgcr8-1 1 12 unspecified role unspecified role prey prey 9 unspecified role unspecified role prey prey 10 unspecified role unspecified role bait bait association association 3A hypoxia hif1a-pri_mir_215-2 3 11 unspecified role unspecified role prey prey 10 unspecified role unspecified role bait bait association association 3B hypoxia drosha-pri_mir_215-1 3 9 unspecified role unspecified role bait bait 11 unspecified role unspecified role prey prey association association 3C hypoxia drosha-pri_mir_215-2 3 11 unspecified role unspecified role prey prey 7 unspecified role unspecified role bait bait association association 3D hypoxia there is an antibody specified in Supplement for DDX5- the only protein with "p68" as an alt name mentioned. hif1a-dgcr8-2 4 6 unspecified role unspecified role bait bait n_terminus myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 13 unspecified role unspecified role prey prey c_terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range undefined mutation mutation mutation certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain Wed Jul 06 16:53:58 BST 2016 Sequence change details about this feature cannot be ascertained or do not fit with the current version of the referenced protein, so they have been deleted as a result of our quality control procedures. The original label was 'pro402ala,pro564ala' physical association physical association Supp. 3D/4A drosha-hif1a-1 5 11 unspecified role unspecified role prey prey 10 unspecified role unspecified role bait bait c_terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range undefined mutation mutation mutation certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain Wed Jul 06 16:54:53 BST 2016 Sequence change details about this feature cannot be ascertained or do not fit with the current version of the referenced protein, so they have been deleted as a result of our quality control procedures. The original label was 'pro402ala,pro564ala' association association Supp. 3E hypoxia hif1a-pri_mir_215-1 2 11 unspecified role unspecified role prey prey 10 unspecified role unspecified role bait bait association association Supp. 3F hypoxia drosha-pri_mir_215-3 2 9 unspecified role unspecified role bait bait 11 unspecified role unspecified role prey prey association association Supp 3G hypoxia hif1a-pri_let_7i-1 3 14 unspecified role unspecified role prey prey 10 unspecified role unspecified role bait bait association association Supp. 3P hypoxia ddx5-pri_let_7i-1 3 14 unspecified role unspecified role prey prey 7 unspecified role unspecified role bait bait association association Supp. 3Q hypoxia drosha-hif1a-2 4 6 unspecified role unspecified role bait bait n_terminus myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 8 unspecified role unspecified role prey prey undefined mutation mutation mutation certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain Wed Jul 06 17:07:21 BST 2016 Sequence change details about this feature cannot be ascertained or do not fit with the current version of the referenced protein, so they have been deleted as a result of our quality control procedures. The original label was 'pro405ala,pro531ala' c_terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range physical association physical association Supp 4A hif1a-dgcr8-3 1 9 unspecified role unspecified role prey prey 8 unspecified role unspecified role bait bait association association Supp 4B hypoxia