Molecular Connections Molecular Connections Pvt. Ltd. 2/2, Kariappa Road, Basavanagudi, Bangalore -560 004 www.molecularconnections.com Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers. Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers. Mol. Cancer 2013 imex curation Oshima T., Sato S., Kato J., Ito Y., Watanabe T., Tsuji I., Hori A., Kurokawa T., Kokubo T. Cancer - Interactions investigated in the context of cancer tomofumi.kurokawa@takeda.com 18-Feb-2014: Contacted by IntAct-Help. Only protein-protein interactions Molecular Connections Pvt. Ltd. in vitro In vitro elisa enzyme linked immunosorbent assay ELISA ELISA elisa predetermined predetermined participant predetermined Oshima T., Sato S., Kato J., Ito Y., Watanabe T., Tsuji I., Hori A., Kurokawa T., Kokubo T. Cancer - Interactions investigated in the context of cancer competitive inhibition by anti -Nectin-2 mAbs used for binding studies. tomofumi.kurokawa@takeda.com Accepted 2014-JAN-14 by PPORRAS Mol. Cancer 2013 Only protein-protein interactions imex curation Molecular Connections Pvt. Ltd. Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers. Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers. Mol. Cancer 2013 imex curation Oshima T., Sato S., Kato J., Ito Y., Watanabe T., Tsuji I., Hori A., Kurokawa T., Kokubo T. Cancer - Interactions investigated in the context of cancer tomofumi.kurokawa@takeda.com 18-Feb-2014: Contacted by IntAct-Help. Only protein-protein interactions Molecular Connections Pvt. Ltd. in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Oshima T., Sato S., Kato J., Ito Y., Watanabe T., Tsuji I., Hori A., Kurokawa T., Kokubo T. Cancer - Interactions investigated in the context of cancer competitive inhibition by anti -Nectin-2 mAbs used for binding studies. Species details for nectin-2 and nectin-3 obtained from authors. tomofumi.kurokawa@takeda.com Accepted 2014-JAN-14 by PPORRAS Mol. Cancer 2013 Only protein-protein interactions imex curation Molecular Connections Pvt. Ltd. nect3_human Nectin-3 NECTIN3 CDw113 Nectin cell adhesion molecule 3 PRR3 PVRL3 Poliovirus receptor-related protein 3 protein protein human Homo sapiens Human MARTLRPSPLCPGGGKAQLSSASLLGAGLLLQPPTPPPLLLLLFPLLLFSRLCGALAGPIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTADIEDLATEPKKLPFPLSTLATIKDDTIATIIASVVGGALFIVLVSVLAGIFCYRRRRTFRGDYFAKNYIPPSDMQKESQIDVLQQDELDSYPDSVKKENKNPVNNLIRKDYLEEPEKTQWNNVENLNRFERPMDYYEDLKMGMKFVSDEHYDENEDDLVSHVDGSVISRREWYV 6D1104CCB4A9D731 nect2_human Nectin-2 NECTIN2 HVEB Herpes virus entry mediator B Nectin cell adhesion molecule 2 PRR2 PVRL2 Poliovirus receptor-related protein 2 protein protein human Homo sapiens Human MARAAALLPSRSPPTPLLWPLLLLLLLETGAQDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAGAGATGGIIGGIIAAIIATAVAATGILICRQQRKEQTLQGAEEDEDLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEERSGPLHPGATSLGSPIPVPPGPPAVEDVSLDLEDEEGEEEEEYLDKINPIYDALSYSSPSDSYQGKGFVMSRAMYV DIP protein Q92692 original sequence version: 131 DIP protein Q92692 original sequence version: 134 3AE4F83E92F6F624 pvrl3-pvrl2-1 2 3 unspecified role unspecified role bait bait region fc-igg2 fc-igg2 feature detection feature detection method feature detection undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain human-293f Homo sapiens HEK293F cell line 293f embryonic kidney cell 293f 4 unspecified role unspecified role prey prey region fc-igg1 fc-igg1 feature detection feature detection method feature detection undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain human-293f Homo sapiens HEK293F cell line 293f embryonic kidney cell 293f direct interaction direct interaction 7 pvrl2-pvrl2-6 1 4 unspecified role unspecified role prey prey region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain region fluorescein fluorescein label fluorescein feature detection feature detection method feature detection undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined region fc-igg1 fc-igg1 feature detection feature detection method feature detection undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human-293f Homo sapiens HEK293F cell line 293f embryonic kidney cell 293f 4 unspecified role unspecified role bait bait region fc-igg1 fc-igg1 predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain human-293f Homo sapiens HEK293F cell line 293f embryonic kidney cell 293f direct interaction direct interaction 7