IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. Cancer Cell (1535-6108) 2012 imex curation Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn 01-March-2013: Contacted by IntAct-Help. Only protein-protein interactions human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn Accepted 2013-FEB-14 by ORCHARD 01-March-2013: Contacted by IntAct-Help. Cancer Cell (1535-6108) 2012 Only protein-protein interactions imex curation CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. Cancer Cell (1535-6108) 2012 imex curation Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn 01-March-2013: Contacted by IntAct-Help. Only protein-protein interactions human-kyse-410 KYSE-410 -Human esophageal squamous cell carcinoma cell line kyse-410 KYSE-410 -Human esophageal squamous cell carcinoma cell line anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn Accepted 2013-FEB-14 by ORCHARD 01-March-2013: Contacted by IntAct-Help. Cancer Cell (1535-6108) 2012 Only protein-protein interactions imex curation CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. Cancer Cell (1535-6108) 2012 imex curation Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn 01-March-2013: Contacted by IntAct-Help. Only protein-protein interactions human-kyse-410 KYSE-410 -Human esophageal squamous cell carcinoma cell line kyse-410 KYSE-410 -Human esophageal squamous cell carcinoma cell line ch-ip chromatin immunoprecipitation assay ch-ip q-pcr quantitative pcr q-pcr Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn Accepted 2013-FEB-14 by ORCHARD 01-March-2013: Contacted by IntAct-Help. Cancer Cell (1535-6108) 2012 Only protein-protein interactions imex curation CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. Cancer Cell (1535-6108) 2012 imex curation Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn 01-March-2013: Contacted by IntAct-Help. Only protein-protein interactions human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column western blot western blot Immuno blot Immuno blot Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do HeLa cell nuclear extracts were fractionated on a DEAE sepharose column followed by gel filtration. These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn Accepted 2013-FEB-14 by ORCHARD 01-March-2013: Contacted by IntAct-Help. Cancer Cell (1535-6108) 2012 Only protein-protein interactions imex curation CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. Cancer Cell (1535-6108) 2012 imex curation Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn 01-March-2013: Contacted by IntAct-Help. Only protein-protein interactions human-kyse-410 KYSE-410 -Human esophageal squamous cell carcinoma cell line kyse-410 KYSE-410 -Human esophageal squamous cell carcinoma cell line ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do Re-ChIP experiment:- sequential immunoprecipitations where the bait of the first IP is prey for the second. This method allows for the identification of multiple (concurrently binding) proteins on a single DNA sequence. These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn Accepted 2013-FEB-14 by ORCHARD 01-March-2013: Contacted by IntAct-Help. Cancer Cell (1535-6108) 2012 Only protein-protein interactions imex curation CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. Cancer Cell (1535-6108) 2012 imex curation Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn 01-March-2013: Contacted by IntAct-Help. Only protein-protein interactions human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 ch-ip chromatin immunoprecipitation assay ch-ip q-pcr quantitative pcr q-pcr Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn Accepted 2013-FEB-14 by ORCHARD 01-March-2013: Contacted by IntAct-Help. Cancer Cell (1535-6108) 2012 Only protein-protein interactions imex curation CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. Cancer Cell (1535-6108) 2012 imex curation Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn 01-March-2013: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn Accepted 2013-FEB-14 by ORCHARD 01-March-2013: Contacted by IntAct-Help. Cancer Cell (1535-6108) 2012 Only protein-protein interactions imex curation CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. Cancer Cell (1535-6108) 2012 imex curation Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn 01-March-2013: Contacted by IntAct-Help. Only protein-protein interactions human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn Accepted 2013-FEB-14 by ORCHARD 01-March-2013: Contacted by IntAct-Help. Cancer Cell (1535-6108) 2012 Only protein-protein interactions imex curation CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. Cancer Cell (1535-6108) 2012 imex curation Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn 01-March-2013: Contacted by IntAct-Help. Only protein-protein interactions human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn Accepted 2013-FEB-14 by ORCHARD 01-March-2013: Contacted by IntAct-Help. Cancer Cell (1535-6108) 2012 Only protein-protein interactions imex curation CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. Cancer Cell (1535-6108) 2012 imex curation Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn 01-March-2013: Contacted by IntAct-Help. Only protein-protein interactions human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 anti tag coip anti tag coimmunoprecipitation anti tag coip sequence tag sequence tag identification sequence tag Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer The peptide identifications for "DDB1" are erroneous: all peptide sequences given in Table S1 correspond to the protein PDIA3_Human -(UniProt P30101), which has few regions of homology with DDB1. The authors have however confirmed that the identification of DDB1 was correct. I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn Accepted 2013-FEB-14 by ORCHARD 01-March-2013: Contacted by IntAct-Help. Cancer Cell (1535-6108) 2012 Only protein-protein interactions imex curation CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. Cancer Cell (1535-6108) 2012 imex curation Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn 01-March-2013: Contacted by IntAct-Help. Only protein-protein interactions human-kyse-410 KYSE-410 -Human esophageal squamous cell carcinoma cell line kyse-410 KYSE-410 -Human esophageal squamous cell carcinoma cell line ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Hu H., Yang Y., Ji Q., Zhao W., Jiang B., Liu R., Yuan J., Liu Q., Li X., Zou Y., Shao C., Shang Y., Wang Y., Gong Y. Cancer - Interactions investigated in the context of cancer I Was waiting for Pablo to finish/SO to re-assign -publication with thousands of chIP-chIP interactions that Pablo volunteered to do/enter into the editor... (The tables involved are S2, S3 + S4. -different antibody target for each.) Date 7/2/13 :- Decided not to add Tables S2/3/4 as the curation effort would be too great - in creating thousands of nucleic acid Preys...not easy/possible for Pablo to do These constructs/proteins have been confirmed by the authors to be of Human origin:- FLAG-CUL4B and deletion mutants, FLAG-RING1B, GST-DDB1,in-vitro-transcribed/translated _RbAp46 and RbAp48, Sf9 produced - purified _His6-H2A_ and mutations. yanwang@tmu.edu.cn, yxg8@sdu.edu.cn Accepted 2013-FEB-14 by ORCHARD 01-March-2013: Contacted by IntAct-Help. Cancer Cell (1535-6108) 2012 Only protein-protein interactions imex curation cd2a2_human_gene Cyclin-dependent kinase inhibitor 2A- CDKN2A gene gene human Homo sapiens Human rbbp4_human Histone-binding protein RBBP4 Retinoblastoma-binding protein 4 Retinoblastoma-binding protein p48 Chromatin assembly factor 1 subunit C Chromatin assembly factor I p48 subunit Nucleosome-remodeling factor subunit RBAP48 RBBP4 RBAP48 protein protein human Homo sapiens Human MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS DIP protein Q09028 original sequence version: 151 DIP protein Q09028 original sequence version: 111 DIP protein Q09028 original sequence version: 116 DIP protein Q09028-1 original sequence version: 130 DIP protein Q09028 original sequence version: 149 DIP protein Q09028 original sequence version: 159 DIP protein Q09028 original sequence version: 131 B71E2D55A444C360 socs1_human_gene SOCS1_HUMAN_GENE gene gene human Homo sapiens Human cabl2_human_gene CABL2_HUMAN_GENE gene gene human Homo sapiens Human runx1_human_gene Human RUNX1 gene : Runt-related transcription factor 1 gene gene human Homo sapiens Human rnh1_human_gene RNH1_HUMAN_GENE gene gene human Homo sapiens Human phf1_human PHD finger protein 1 PCL1 Polycomb-like protein 1 PHF1 protein protein human Homo sapiens Human MAQPPRLSRSGASSLWDPASPAPTSGPRPRLWEGQDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVPGNRLVSCEKCRHAYHQDCHVPRAPAPGEGEGTSWVCRQCVFAIATKRGGALKKGPYARAMLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVCRGGPEKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSDTPKGERSSRLLSALNSHKDRFISGREIKKRKCLFGLHARMPPPVEPPTGDGALTSFPSGQGPGGGVSRPLGKRRRPEPEPLRRRQKGKVEELGPPSAVRNQPEPQEQRERAHLQRALQASVSPPSPSPNQSYQGSSGYNFRPTDARCLPSSPIRMFASFHPSASTAGTSGDSGPPDRSPLELHIGFPTDIPKSAPHSMTASSSSVSSPSPGLPRRSAPPSPLCRSLSPGTGGGVRGGVGYLSRGDPVRVLARRVRPDGSVQYLVEWGGGGIF DIP protein O43189 original sequence version: 124 E81BA9475565957C gal4_yeast_gene YEAST GAL4 Gene gene gene yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast pten_human_gene PTEN_HUMAN_GENE gene gene human Homo sapiens Human e2f1_human_gene Human transcription factor E2F1 gene gene human Homo sapiens Human ddb1_human DNA damage-binding protein 1 DDB1 Damage-specific DNA-binding protein 1 UV-damaged DNA-binding factor DDB p127 subunit DNA damage-binding protein a UV-damaged DNA-binding protein 1 Xeroderma pigmentosum group E-complementing protein XPE-binding factor HBV X-associated protein 1 XAP1 protein protein human Homo sapiens Human MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVKEVGMYGKIAVMELFRPKGESKDLLFILTAKYNACILEYKQSGESIDIITRAHGNVQDRIGRPSETGIIGIIDPECRMIGLRLYDGLFKVIPLDRDNKELKAFNIRLEELHVIDVKFLYGCQAPTICFVYQDPQGRHVKTYEVSLREKEFNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYLAIAPPIIKQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDLRVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAMETFTNLGPIVDMCVVDLERQGQGQLVTCSGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSDPNRETDDTLVLSFVGQTRVLMLNGEEVEETELMGFVDDQQTFFCGNVAHQQLIQITSASVRLVSQEPKALVSEWKEPQAKNISVASCNSSQVVVAVGRALYYLQIHPQELRQISHTEMEHEVACLDITPLGDSNGLSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSHYLLCALGDGALFYFGLNIETGLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIGTIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRIEVQDTSGGTTALRPSASTQALSSSVSSSKLFSSSTAPHETSFGEEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEEAEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTTEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDDNFLGAENAFNLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLFGTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTERKTEPATGFIDGDLIESFLDISRPKMQEVVANLQYDDGSGMKREATADDLIKVVEELTRIH DIP protein Q16531 original sequence version: 145 DIP protein Q16531 original sequence version: 140 DIP protein Q16531 original sequence version: 99 DIP protein Q16531 original sequence version: 93 DIP protein Q16531 original sequence version: 116 DIP protein Q16531 original sequence version: 111 DIP protein Q16531-1 original sequence version: 163 DIP protein Q16531 original sequence version: 162 DIP protein Q16531 original sequence version: 113 DIP protein Q16531 original sequence version: 132 DIP protein Q16531 original sequence version: 139 DIP protein Q16531 original sequence version: 151 DIP protein Q16531-1 original sequence version: 144 DIP protein Q16531 original sequence version: 155 74D082023E3D846D ring2_human E3 ubiquitin-protein ligase RING2 RING finger protein 2 RING finger protein 1B RING finger protein BAP-1 Protein DinG Huntingtin-interacting protein 2-interacting protein 3 RNF2 BAP1 DING HIPI3 RING1B RING-type E3 ubiquitin transferase RING2 protein protein human Homo sapiens Human MSQAVQTNGTQPLSKTWELSLYELQRTPQEAITDGLEIVVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCADCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEYEAHQERVLARINKHNNQQALSHSIEEGLKIQAMNRLQRGKKQQIENGSGAEDNGDSSHCSNASTHSNQEAGPSNKRTKTSDDSGLELDNNNAAMAIDPVMDGASEIELVFRPHPTLMEKDDSAQTRYIKTSGNATVDHLSKYLAVRLALEELRSKGESNQMNLDTASEKQYTIYIATASGQFTVLNGSFSLELVSEKYWKVNKPMELYYAPTKEHK DIP protein Q99496 original sequence version: 95 DIP protein Q99496 original sequence version: 94 DIP protein Q99496 original sequence version: 96 DIP protein Q99496 original sequence version: 125 DIP protein Q99496 original sequence version: 142 DIP protein Q99496 original sequence version: 159 DIP protein Q99496 original sequence version: 129 DIP protein Q99496 original sequence version: 99 DIP protein Q99496 original sequence version: 118 90EA546E1F4DB7EC siah1_human_gene SIAH1_HUMAN_GENE gene gene human Homo sapiens Human eed_human Polycomb protein EED EED WD protein associating with integrin cytoplasmic tails 1 Embryonic ectoderm development protein protein protein human Homo sapiens Human MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR DIP protein O75530 original sequence version: 70 DIP protein O75530-1 original sequence version: 78 DIP protein O75530 original sequence version: 78 DIP protein O75530 original sequence version: 73 DIP protein O75530-1 original sequence version: 89 DIP protein O75530-1 original sequence version: 87 DIP protein O75530 original sequence version: 77 D2E0A5BA27C0499A csn3_human COP9 signalosome complex subunit 3 COPS3 CSN3 JAB1-containing signalosome subunit 3 protein protein human Homo sapiens Human MASALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS DIP protein Q9UNS2 original sequence version: 82 DIP protein Q9UNS2-1 original sequence version: 122 DIP protein Q9UNS2 original sequence version: 140 1D371050C7D7BF8D hsp7c_human Heat shock cognate 71 kDa protein HSPA8 HSC70 HSP73 HSPA10 Heat shock 70 kDa protein 8 Lipopolysaccharide-associated protein 1 protein protein human Homo sapiens Human MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD 9AA27B210730670C csn5_human COP9 signalosome complex subunit 5 Jun activation domain-binding protein 1 COPS5 CSN5 JAB1 protein protein human Homo sapiens Human MAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINIS DIP protein Q92905 original sequence version: 161 DIP protein Q92905 original sequence version: 87 DIP protein Q92905 original sequence version: 132 DIP protein Q92905 original sequence version: 149 DIP protein Q92905 original sequence version: 136 DIP protein Q92905 original sequence version: 101 B5742F4AAD03A1CF bmi1_human Polycomb complex protein BMI-1 BMI1 PCGF4 RNF51 Polycomb group RING finger protein 4 RING finger protein 51 protein protein human Homo sapiens Human MHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIVRYLETSKYCPICDVQVHKTRPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFYAAHPSADAANGSNEDRGEVADEDKRIITDDEIISLSIEFFDQNRLDRKVNKDKEKSKEEVNDKRYLRCPAAMTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYTWRRNGPLPLKYRVRPTCKRMKISHQRDGLTNAGELESDSGSDKANSPAGGIPSTSSCLPSPSTPVQSPHPQFPHISSTMNGTSNSPSGNHQSSFANRPRKSSVNGSSATSSG DIP protein P35226 original sequence version: 105 DIP protein P35226 original sequence version: 136 DIP protein P35226 original sequence version: 110 DIP protein P35226 original sequence version: 129 030A7D396BADA543 rbx1_human E3 ubiquitin-protein ligase RBX1 RBX1 RNF75 ROC1 Regulator of cullins 1 RING finger protein 75 Protein ZYP RING-box protein 1 E3 ubiquitin-protein transferase RBX1 protein protein human Homo sapiens Human MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH DIP protein P62877 original sequence version: 120 DIP protein P62877 original sequence version: 115 DIP protein P62877 original sequence version: 78 DIP protein P62877 original sequence version: 113 DIP protein P62877 original sequence version: 75 DIP protein P62877 original sequence version: 86 DIP protein P62877 original sequence version: 136 DIP protein P62877 original sequence version: 126 DIP protein P62877 original sequence version: 90 DIP protein P62877 original sequence version: 114 30FC5ADF66096C0E rbbp7_human Histone-binding protein RBBP7 RBBP7 RBAP46 Retinoblastoma-binding protein 7 Retinoblastoma-binding protein p46 Histone acetyltransferase type B subunit 2 Nucleosome-remodeling factor subunit RBAP46 protein protein human Homo sapiens Human MASKEMFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDYALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSELEGQGS DIP protein Q16576 original sequence version: 75 DIP protein Q16576 original sequence version: 136 DIP protein Q16576 original sequence version: 97 DIP protein Q16576 original sequence version: 102 DIP protein Q16576 original sequence version: 145 DIP protein Q16576 original sequence version: 116 DIP protein Q16576 original sequence version: 96 1A4B4CD1A8E96815 co4a1_human_gene CO4A1_HUMAN_GENE gene gene human Homo sapiens Human mll3_human_gene MLL3_HUMAN_GENE gene gene human Homo sapiens Human tgfb1_human_gene TGFB1_HUMAN_GENE gene gene human Homo sapiens Human csn4_human COP9 signalosome complex subunit 4 COPS4 CSN4 JAB1-containing signalosome subunit 4 protein protein human Homo sapiens Human MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEIYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ DIP protein Q9BT78 original sequence version: 72 DIP protein Q9BT78-1 original sequence version: 115 DIP protein Q9BT78 original sequence version: 132 DIP protein Q9BT78 original sequence version: 110 4EFF9079058EB609 foxo3_human_gene FOXO3_HUMAN_GENE gene gene human Homo sapiens Human suz12_human Polycomb protein SUZ12 CHET9 JJAZ1 KIAA0160 SUZ12 Suppressor of zeste 12 protein homolog Joined to JAZF1 protein Chromatin precipitated E2F target 9 protein protein protein human Homo sapiens Human MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL DIP protein Q15022 original sequence version: 92 DIP protein Q15022 original sequence version: 88 DIP protein Q15022 original sequence version: 91 DIP protein Q15022 original sequence version: 106 A8830EBC3FD38D56 mcm8_human_gene MCM8_HUMAN_GENE gene gene human Homo sapiens Human ibp3_human_gene IBP3_HUMAN_GENE gene gene human Homo sapiens Human axin2_human_gene gene gene human Homo sapiens Human fancm_human Fanconi anemia group M protein FANCM KIAA1596 ATP-dependent RNA helicase FANCM Fanconi anemia-associated polypeptide of 250 kDa Protein Hef ortholog protein protein human Homo sapiens Human MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVAAYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEIWCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFRILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAIQKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGEFAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMFARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVMIFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTLVSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQSQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKSSIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKPAQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELEVESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIVKQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRTSDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENLLFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSLCDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDVNTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANSFKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLYGRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEELLSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNSTFDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPEDQKNSEVDSPLHAVKKRRFPINRSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRPHLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLNQDRLKSDI ezh2_human Histone-lysine N-methyltransferase EZH2 KMT6 Enhancer of zeste homolog 2 ENX-1 Lysine N-methyltransferase 6 EZH2 protein protein human Homo sapiens Human MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP DIP protein Q15910 original sequence version: 97 DIP protein Q15910 original sequence version: 94 DIP protein Q15910 original sequence version: 92 DIP protein Q15910 original sequence version: 96 DIP protein Q15910 original sequence version: 122 DIP protein Q15910 original sequence version: 100 1B5029EB9D509BE5 jard2_human Protein Jumonji JARID2 JMJ Jumonji/ARID domain-containing protein 2 protein protein human Homo sapiens Human MSKERPKRNIIQKKYDDSDGIPWSEERVVRKVLYLSLKEFKNSQKRQHAEGIAGSLKTVNGLLGNDQSKGLGPASEQSENEKDDASQVSSTSNDVSSSDFEEGPSRKRPRLQAQRKFAQSQPNSPSTTPVKIVEPLLPPPATQISDLSKRKPKTEDFLTFLCLRGSPALPNSMVYFGSSQDEEEVEEEDDETEDVKTATNNASSSCQSTPRKGKTHKHVHNGHVFNGSSRSTREKEPVQKHKSKEATPAKEKHSDHRADSRREQASANHPAAAPSTGSSAKGLAATHHHPPLHRSAQDLRKQVSKVNGVTRMSSLGAGVTSAKKMREVRPSPSKTVKYTATVTKGAVTYTKAKRELVKDTKPNHHKPSSAVNHTISGKTESSNAKTRKQVLSLGGASKSTGPAVNGLKVSGRLNPKSCTKEVGGRQLREGLQLREGLRNSKRRLEEAHQAEKPQSPPKKMKGAAGPAEGPGKKAPAERGLLNGHVKKEVPERSLERNRPKRATAGKSTPGRQAHGKADSASCENRSTSQPESVHKPQDSGKAEKGGGKAGWAAMDEIPVLRPSAKEFHDPLIYIESVRAQVEKFGMCRVIPPPDWRPECKLNDEMRFVTQIQHIHKLGRRWGPNVQRLACIKKHLKSQGITMDELPLIGGCELDLACFFRLINEMGGMQQVTDLKKWNKLADMLRIPRTAQDRLAKLQEAYCQYLLSYDSLSPEEHRRLEKEVLMEKEILEKRKGPLEGHTENDHHKFHPLPRFEPKNGLIHGVAPRNGFRSKLKEVGQAQLKTGRRRLFAQEKEVVKEEEEDKGVLNDFHKCIYKGRSVSLTTFYRTARNIMSMCFSKEPAPAEIEQEYWRLVEEKDCHVAVHCGKVDTNTHGSGFPVGKSEPFSRHGWNLTVLPNNTGSILRHLGAVPGVTIPWLNIGMVFSTSCWSRDQNHLPYIDYLHTGADCIWYCIPAEEENKLEDVVHTLLQANGTPGLQMLESNVMISPEVLCKEGIKVHRTVQQSGQFVVCFPGSFVSKVCCGYSVSETVHFATTQWTSMGFETAKEMKRRHIAKPFSMEKLLYQIAQAEAKKENGPTLSTISALLDELRDTELRQRRQLFEAGLHSSARYGSHDGSSTVADGKKKPRKWLQLETSERRCQICQHLCYLSMVVQENENVVFCLECALRHVEKQKSCRGLKLMYRYDEEQIISLVNQICGKVSGKNGSIENCLSKPTPKRGPRKRATVDVPPSRLSASSSSKSASSSS DIP protein Q92833 original sequence version: 81 E4929984259110DB fancb_human_gene FANCB_HUMAN_GENE gene gene human Homo sapiens Human grwd1_human Glutamate-rich WD repeat-containing protein 1 GRWD1 GRWD WDR28 KIAA1942 protein protein human Homo sapiens Human MAARKGRRRTCETGEPMEAESGDTSSEGPAQVYLPGRGPPLREGEELVMDEEAYVLYHRAQTGAPCLSFDIVRDHLGDNRTELPLTLYLCAGTQAESAQSNRLMMLRMHNLHGTKPPPSEGSDEEEEEEDEEDEEERKPQLELAMVPHYGGINRVRVSWLGEEPVAGVWSEKGQVEVFALRRLLQVVEEPQALAAFLRDEQAQMKPIFSFAGHMGEGFALDWSPRVTGRLLTGDCQKNIHLWTPTDGGSWHVDQRPFVGHTRSVEDLQWSPTENTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWSRREPFLLSGGDDGALKIWDLRQFKSGSPVATFKQHVAPVTSVEWHPQDSGVFAASGADHQITQWDLAVERDPEAGDVEADPGLADLPQQLLFVHQGETELKELHWHPQCPGLLVSTALSGFTIFRTISV 748CA005313FF8A8 nkd2_human_gene NKD2_HUMAN_GENE gene gene human Homo sapiens Human cul4b_human Cullin-4B CUL4B KIAA0695 protein protein human Homo sapiens Human MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLRFEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA DIP protein Q13620 original sequence version: 135 DIP protein Q13620 original sequence version: 98 DIP protein Q13620 original sequence version: 110 DIP protein Q13620 original sequence version: 145 DIP protein Q13620 original sequence version: 119 3E58C5868FDF0700 cul4b-cops3 10 47 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 22 unspecified role unspecified role prey prey 41 unspecified role unspecified role prey prey 42 unspecified role unspecified role prey prey 27 unspecified role unspecified role prey prey 45 unspecified role unspecified role prey prey 13 unspecified role unspecified role prey prey 28 unspecified role unspecified role prey prey 25 unspecified role unspecified role prey prey 35 unspecified role unspecified role prey prey 26 unspecified role unspecified role prey prey association association Table S1, Fig1A. cul4b-ddb1-4 1 37 unspecified role unspecified role prey prey 22 unspecified role unspecified role prey prey 42 unspecified role unspecified role prey prey 25 unspecified role unspecified role prey prey 47 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 13 unspecified role unspecified role prey prey 30 unspecified role unspecified role prey prey association association Fig 1B,2E. cul4b-ddb1-5 9 37 unspecified role unspecified role prey prey 47 unspecified role unspecified role bait bait 25 unspecified role unspecified role prey prey 42 unspecified role unspecified role prey prey association association Fig 1C top-1, 1F. Depletion of either DDB1 or RbAp46/48 could disrupt the interaction between CUL4B and the PRC2 subunits. ezh2-rnf2 9 29 unspecified role unspecified role prey prey 23 unspecified role unspecified role prey prey 22 unspecified role unspecified role prey prey 42 unspecified role unspecified role bait bait 30 unspecified role unspecified role prey prey 47 unspecified role unspecified role prey prey association association Fig 1C middle-1 cul4b-ddb1-9 9 23 unspecified role unspecified role bait bait 42 unspecified role unspecified role prey prey 25 unspecified role unspecified role prey prey association association Fig 1C bottom-1 rnf2-eed 9 25 unspecified role unspecified role prey prey 42 unspecified role unspecified role prey prey 29 unspecified role unspecified role bait bait association association Fig 1C bottom-2 cul4b-ddb1-10 9 42 unspecified role unspecified role prey prey 25 unspecified role unspecified role prey prey 37 unspecified role unspecified role prey prey 22 unspecified role unspecified role bait bait association association Fig 1C top-2 ezh2-suz12-3 9 23 unspecified role unspecified role prey prey 22 unspecified role unspecified role prey prey 30 unspecified role unspecified role prey prey 47 unspecified role unspecified role prey prey 29 unspecified role unspecified role prey prey 37 unspecified role unspecified role bait bait association association Fig 1C middle-2 ezh2-suz12-4 8 37 unspecified role unspecified role bait bait 47 unspecified role unspecified role prey prey 22 unspecified role unspecified role prey prey 29 unspecified role unspecified role prey prey 30 unspecified role unspecified role prey prey 23 unspecified role unspecified role prey prey association association Fig 1C middle-2 cul4b-ddb1-11 8 22 unspecified role unspecified role bait bait 25 unspecified role unspecified role prey prey 37 unspecified role unspecified role prey prey 42 unspecified role unspecified role prey prey association association Fig 1C top-2 cul4b-ddb1-11 8 25 unspecified role unspecified role prey prey 37 unspecified role unspecified role prey prey 47 unspecified role unspecified role bait bait 42 unspecified role unspecified role prey prey association association Fig 1C top-1 rnf2-eed-1 8 25 unspecified role unspecified role prey prey 42 unspecified role unspecified role prey prey 29 unspecified role unspecified role bait bait association association Fig 1C bottom-2 ezh2-rnf2-1 8 30 unspecified role unspecified role prey prey 29 unspecified role unspecified role prey prey 22 unspecified role unspecified role prey prey 47 unspecified role unspecified role prey prey 42 unspecified role unspecified role bait bait 23 unspecified role unspecified role prey prey association association Fig 1C middle-1 cul4b-ddb1-11 8 42 unspecified role unspecified role prey prey 23 unspecified role unspecified role bait bait 25 unspecified role unspecified role prey prey association association Fig 1C bottom-1 cul4b-ddb1-12 2 25 unspecified role unspecified role prey prey 42 unspecified role unspecified role prey prey 23 unspecified role unspecified role bait bait association association Fig 1C bottom-1 rnf2-eed-2 2 25 unspecified role unspecified role prey prey 42 unspecified role unspecified role prey prey 29 unspecified role unspecified role bait bait association association Fig 1C bottom-2 cul4b-ddb1-12 2 37 unspecified role unspecified role prey prey 22 unspecified role unspecified role bait bait 42 unspecified role unspecified role prey prey 25 unspecified role unspecified role prey prey association association Fig 1C top-2 ezh2-suz12-5 2 23 unspecified role unspecified role prey prey 29 unspecified role unspecified role prey prey 47 unspecified role unspecified role prey prey 30 unspecified role unspecified role prey prey 37 unspecified role unspecified role bait bait 22 unspecified role unspecified role prey prey association association Fig 1C middle-2 cul4b-ddb1-12 2 42 unspecified role unspecified role prey prey 37 unspecified role unspecified role prey prey 25 unspecified role unspecified role prey prey 47 unspecified role unspecified role bait bait association association Fig 1C top-1 ezh2-rnf2-2 2 30 unspecified role unspecified role prey prey 22 unspecified role unspecified role prey prey 42 unspecified role unspecified role bait bait 29 unspecified role unspecified role prey prey 47 unspecified role unspecified role prey prey 23 unspecified role unspecified role prey prey association association Fig 1C middle-1 cul4b-ddb1-13 4 47 unspecified role unspecified role neutral component neutral component 42 unspecified role unspecified role neutral component neutral component 25 unspecified role unspecified role neutral component neutral component 30 unspecified role unspecified role neutral component neutral component 37 unspecified role unspecified role neutral component neutral component 22 unspecified role unspecified role neutral component neutral component physical association physical association Fig 1D-1 ddb1-cul4b-1 7 47 unspecified role unspecified role prey prey in vitro In vitro 22 unspecified role unspecified role bait bait region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecoli Escherichia coli (strain K12) physical association physical association Fig 1E ddb1-rbbp7 7 22 unspecified role unspecified role bait bait region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecoli Escherichia coli (strain K12) 13 unspecified role unspecified role prey prey in vitro In vitro physical association physical association Fig 1E ddb1-rbbp4 7 22 unspecified role unspecified role bait bait region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecoli Escherichia coli (strain K12) 31 unspecified role unspecified role prey prey in vitro In vitro physical association physical association Fig 1E ddb1-gal4 6 19 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 22 unspecified role unspecified role bait bait 47 unspecified role unspecified role ancillary ancillary did_domain required to bind necessary binding region required to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain association association 2D-1 The artificial recruitment of CUL4B resulted in the recruitment of DDB1 and EXH2. ddb1-gal4-1 6 47 unspecified role unspecified role ancillary ancillary did_domain required to bind necessary binding region required to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain cullin_domain required to bind necessary binding region required to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain 42 unspecified role unspecified role bait bait 19 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 2D-2 The artificial recruitment of CUL4B resulted in the recruitment of DDB1 and EXH2. cul4b-ddb1-14 6 19 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 47 unspecified role unspecified role bait bait association association 2D-3 cul4b-ddb1-17 1 47 unspecified role unspecified role bait bait did_domain required to bind necessary binding region required to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 25 unspecified role unspecified role prey prey 42 unspecified role unspecified role prey prey 37 unspecified role unspecified role prey prey 13 unspecified role unspecified role prey prey 22 unspecified role unspecified role prey prey association association Fig 2E. The DID domain is responsible for the formation of the CRL4B-PRC2 machinery, while the Cullin domain is responsible for the binding of the ring finger protein ROC1 (along with E1/E2/E3). cul4b-ddb1-18 1 47 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined cullin_domain required to bind necessary binding region required to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain 30 unspecified role unspecified role prey prey association association Fig 2Eii. The DID domain is responsible for the formation of the CRL4B-PRC2 machinery, while the Cullin domain is responsible for the binding of the ring finger protein ROC1 (along with E1/E2/E3). cul4b-pten 3 20 unspecified role unspecified role prey prey 47 unspecified role unspecified role bait bait association association 4B-1,4D/E,5D, 5F Knockdown of the expression of CUL4B or DDB1 led to a significant reduction of the binding of EZH2 and SUZ12 to the promoters of p16 and PTEN. Depletion of EZH2 or SUZ12 expression resulted in only a marginal decrease in the association of CUL4B and DDB1 with these promoters. cul4b-pten-1 3 47 unspecified role unspecified role bait bait 14 unspecified role unspecified role prey prey association association 4B-2 cul4b-socs1 3 47 unspecified role unspecified role bait bait 40 unspecified role unspecified role prey prey association association 4B-3 cul4b-axin2 3 47 unspecified role unspecified role bait bait 40 unspecified role unspecified role prey prey association association 4B-4 cul4b-axin2-1 3 36 unspecified role unspecified role prey prey 47 unspecified role unspecified role bait bait association association 4B-5 cul4b-foxo3 3 24 unspecified role unspecified role prey prey 47 unspecified role unspecified role bait bait association association 4B-6 cul4b-siah1 3 47 unspecified role unspecified role bait bait 21 unspecified role unspecified role prey prey association association 4D/E cul4b-e2f1 3 47 unspecified role unspecified role bait bait 16 unspecified role unspecified role prey prey association association 4B-8 cul4b-runx1 3 44 unspecified role unspecified role prey prey 47 unspecified role unspecified role bait bait association association 4B-9 cul4b-fancb 3 47 unspecified role unspecified role bait bait 38 unspecified role unspecified role prey prey association association 4B-10 cul4b-mcm8 3 47 unspecified role unspecified role bait bait 46 unspecified role unspecified role prey prey association association 4B-11 cul4b-nkd2 3 32 unspecified role unspecified role prey prey 47 unspecified role unspecified role bait bait association association 4B-12 cul4b-co4a1 3 47 unspecified role unspecified role bait bait 39 unspecified role unspecified role prey prey association association 4B-13 cul4b-cdkn2a 3 47 unspecified role unspecified role bait bait 33 unspecified role unspecified role prey prey association association 4B-15 cul4b-mll3 3 47 unspecified role unspecified role bait bait 15 unspecified role unspecified role prey prey association association 4B-16 cul4b-cabl2 3 17 unspecified role unspecified role prey prey 47 unspecified role unspecified role bait bait association association 4B-17 cul4b-rnh1 3 47 unspecified role unspecified role bait bait 34 unspecified role unspecified role prey prey association association 4B-18 cul4b-siah1-1 3 42 unspecified role unspecified role bait bait 21 unspecified role unspecified role prey prey association association 4B-7 cul4b-cdkn2a-1 3 33 unspecified role unspecified role prey prey 42 unspecified role unspecified role bait bait association association 4B-15 cul4b-mcm8-1 3 46 unspecified role unspecified role prey prey 42 unspecified role unspecified role bait bait association association 4B-11 cul4b-cabl2-1 3 42 unspecified role unspecified role bait bait 17 unspecified role unspecified role prey prey association association 4B-17 cul4b-fancb-1 3 42 unspecified role unspecified role bait bait 38 unspecified role unspecified role prey prey association association 4B-10 cul4b-foxo3-1 3 24 unspecified role unspecified role prey prey 42 unspecified role unspecified role bait bait association association 4B-6 cul4b-rnh1-1 3 42 unspecified role unspecified role bait bait 34 unspecified role unspecified role prey prey association association 4B-18 cul4b-runx1-1 3 42 unspecified role unspecified role bait bait 44 unspecified role unspecified role prey prey association association 4B-9 cul4b-nkd2-1 3 42 unspecified role unspecified role bait bait 32 unspecified role unspecified role prey prey association association 4B-12 cul4b-socs1-1 3 42 unspecified role unspecified role bait bait 40 unspecified role unspecified role prey prey association association 4B-3 cul4b-co4a1-1 3 42 unspecified role unspecified role bait bait 39 unspecified role unspecified role prey prey association association 4B-13 cul4b-e2f1-1 3 42 unspecified role unspecified role bait bait 16 unspecified role unspecified role prey prey association association 4B-8 cul4b-axin2-2 3 36 unspecified role unspecified role prey prey 42 unspecified role unspecified role bait bait association association 4B-5 cul4b-axin2-2 3 40 unspecified role unspecified role prey prey 42 unspecified role unspecified role bait bait association association 4B-4 cul4b-mll3-1 3 42 unspecified role unspecified role bait bait 15 unspecified role unspecified role prey prey association association 4B-16 cul4b-pten-2 3 14 unspecified role unspecified role prey prey 42 unspecified role unspecified role bait bait association association 4B-2 cul4b-siah1-2 3 24 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 47 unspecified role unspecified role bait bait association association 4D/E EZH2 depletion had little effect on the recruitment of CUL4B to target promoters;however, in CUL4B-depleted cells, the recruitment of EZH2 was greatly reduced. ezh2-axin2 3 40 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 42 unspecified role unspecified role bait bait association association 4D/E EZH2 depletion had little effect on the recruitment of CUL4B to target promoters;however, in CUL4B-depleted cells, the recruitment of EZH2 was greatly reduced. cul4b-cdkn2a-2 3 12 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 47 unspecified role unspecified role bait bait association association 4B/D/E, 5D, 5F. Knockdown of the expression of CUL4B or DDB1 led to a significant reduction of the binding of EZH2 and SUZ12 to the promoters of p16 and PTEN. Depletion of EZH2 or SUZ12 expression resulted in only a marginal decrease in the association of CUL4B and DDB1 with these promoters. ezh2-ibp3 3 42 unspecified role unspecified role bait bait 39 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 4D/E EZH2 depletion had little effect on the recruitment of CUL4B to target promoters;however, in CUL4B-depleted cells, the recruitment of EZH2 was greatly reduced. ezh2-pten 3 42 unspecified role unspecified role bait bait 20 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 4B/D/E, 5D/F. Knockdown of the expression of CUL4B or DDB1 led to a significant reduction of the binding of EZH2 and SUZ12 to the promoters of p16 and PTEN. Depletion of EZH2 or SUZ12 expression resulted in only a marginal decrease in the association of CUL4B and DDB1 with these promoters. ezh2-mcm8 3 42 unspecified role unspecified role bait bait 38 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 4D/E EZH2 depletion had little effect on the recruitment of CUL4B to target promoters;however, in CUL4B-depleted cells, the recruitment of EZH2 was greatly reduced. cul4b-fancb-2 3 44 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 47 unspecified role unspecified role bait bait association association 4D/E EZH2 depletion had little effect on the recruitment of CUL4B to target promoters;however, in CUL4B-depleted cells, the recruitment of EZH2 was greatly reduced. ezh2-fancb 3 42 unspecified role unspecified role bait bait 44 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 4D/E EZH2 depletion had little effect on the recruitment of CUL4B to target promoters;however, in CUL4B-depleted cells, the recruitment of EZH2 was greatly reduced. ezh2-foxo3 3 36 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 42 unspecified role unspecified role bait bait association association 4D/E EZH2 depletion had little effect on the recruitment of CUL4B to target promoters;however, in CUL4B-depleted cells, the recruitment of EZH2 was greatly reduced. ezh2-e2f1 3 42 unspecified role unspecified role bait bait 21 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 4D/E EZH2 depletion had little effect on the recruitment of CUL4B to target promoters;however, in CUL4B-depleted cells, the recruitment of EZH2 was greatly reduced. cul4b-axin2-3 3 40 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 47 unspecified role unspecified role bait bait association association 4D/E EZH2 depletion had little effect on the recruitment of CUL4B to target promoters;however, in CUL4B-depleted cells, the recruitment of EZH2 was greatly reduced. cul4b-ibp3-2 3 39 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 47 unspecified role unspecified role bait bait association association 4D/E EZH2 depletion had little effect on the recruitment of CUL4B to target promoters;however, in CUL4B-depleted cells, the recruitment of EZH2 was greatly reduced. ezh2-co4a1 3 32 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 42 unspecified role unspecified role bait bait association association 4D/E EZH2 depletion had little effect on the recruitment of CUL4B to target promoters;however, in CUL4B-depleted cells, the recruitment of EZH2 was greatly reduced. cul4b-co4a1-2 3 32 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 47 unspecified role unspecified role bait bait association association 4D/E EZH2 depletion had little effect on the recruitment of CUL4B to target promoters;however, in CUL4B-depleted cells, the recruitment of EZH2 was greatly reduced. cul4b-foxo3-2 3 36 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 47 unspecified role unspecified role bait bait association association 4D/E EZH2 depletion had little effect on the recruitment of CUL4B to target promoters;however, in CUL4B-depleted cells, the recruitment of EZH2 was greatly reduced. cul4b-e2f1-2 3 47 unspecified role unspecified role bait bait 21 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 4D/E EZH2 depletion had little effect on the recruitment of CUL4B to target promoters;however, in CUL4B-depleted cells, the recruitment of EZH2 was greatly reduced. ezh2-siah1 3 24 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 42 unspecified role unspecified role bait bait association association 4D/E EZH2 depletion had little effect on the recruitment of CUL4B to target promoters;however, in CUL4B-depleted cells, the recruitment of EZH2 was greatly reduced. cul4b-mcm8-2 3 47 unspecified role unspecified role bait bait 38 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 4D/E EZH2 depletion had little effect on the recruitment of CUL4B to target promoters;however, in CUL4B-depleted cells, the recruitment of EZH2 was greatly reduced. ezh2-cdkn2a 3 42 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 4B/D/E, 5D, 5F Knockdown of the expression of CUL4B or DDB1 led to a significant reduction of the binding of EZH2 and SUZ12 to the promoters of p16 and PTEN. Depletion of EZH2 or SUZ12 expression resulted in only a marginal decrease in the association of CUL4B and DDB1 with these promoters. ezh2-pten-1 11 20 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 22 unspecified role unspecified role bait bait association association 5C ezh2-pten-2 11 20 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 42 unspecified role unspecified role bait bait association association 5C cul4b-pten-4 11 47 unspecified role unspecified role bait bait 20 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 5 C ezh2-cdkn2a-1 11 12 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 42 unspecified role unspecified role bait bait association association 5C cul4b-cdkn2a-3 11 47 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 5C cul4b-pten-5 11 20 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 37 unspecified role unspecified role bait bait association association 5 C cul4b-cdkn2a-4 11 22 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 5C ddb1-cdkn2a 11 37 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 5C suz12-pten 3 37 unspecified role unspecified role bait bait 20 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 5D, 5F. Knockdown of the expression of CUL4B or DDB1 led to a significant reduction of the binding of EZH2 and SUZ12 to the promoters of p16 and PTEN. Depletion of EZH2 or SUZ12 expression resulted in only a marginal decrease in the association of CUL4B and DDB1 with these promoters. ddb1-pten 3 22 unspecified role unspecified role bait bait 20 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 5D, 5F. Knockdown of the expression of CUL4B or DDB1 led to a significant reduction of the binding of EZH2 and SUZ12 to the promoters of p16 and PTEN. Depletion of EZH2 or SUZ12 expression resulted in only a marginal decrease in the association of CUL4B and DDB1 with these promoters. suz12-cdkn2a 3 12 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 37 unspecified role unspecified role bait bait association association 5D, 5F Knockdown of the expression of CUL4B or DDB1 led to a significant reduction of the binding of EZH2 and SUZ12 to the promoters of p16 and PTEN. Depletion of EZH2 or SUZ12 expression resulted in only a marginal decrease in the association of CUL4B and DDB1 with these promoters. ddb1-cdkn2a-1 3 22 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 5F. Knockdown of the expression of CUL4B or DDB1 led to a significant reduction of the binding of EZH2 and SUZ12 to the promoters of p16 and PTEN. Depletion of EZH2 or SUZ12 expression resulted in only a marginal decrease in the association of CUL4B and DDB1 with these promoters. ddb1-cul4b-2 5 47 unspecified role unspecified role prey prey 22 unspecified role unspecified role bait bait 20 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 5C ezh2-cdkn2a-3 5 47 unspecified role unspecified role prey prey 42 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 5C suz12-cdkn2a-1 5 47 unspecified role unspecified role prey prey 12 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 37 unspecified role unspecified role bait bait association association 5C cul4b-cdkn2a-6 5 12 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 47 unspecified role unspecified role bait bait 22 unspecified role unspecified role prey prey association association 5C ezh2-cul4b 5 47 unspecified role unspecified role prey prey 20 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 42 unspecified role unspecified role bait bait association association 5C ddb1-cul4b-3 5 42 unspecified role unspecified role prey prey 20 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 22 unspecified role unspecified role bait bait association association 5C ddb1-ezh2 5 37 unspecified role unspecified role prey prey 22 unspecified role unspecified role bait bait 20 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 5C cul4b-ddb1-19 5 47 unspecified role unspecified role bait bait 20 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 22 unspecified role unspecified role prey prey association association 5C cul4b-ddb1-20 5 20 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 37 unspecified role unspecified role prey prey 47 unspecified role unspecified role bait bait association association 5C cul4b-pten-7 5 20 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 42 unspecified role unspecified role prey prey 47 unspecified role unspecified role bait bait association association 5C ezh2-cul4b-1 5 42 unspecified role unspecified role bait bait 20 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 22 unspecified role unspecified role prey prey association association 5C ezh2-ddb1 5 20 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 37 unspecified role unspecified role prey prey 42 unspecified role unspecified role bait bait association association 5C suz12-ezh2-2 5 20 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 37 unspecified role unspecified role bait bait 42 unspecified role unspecified role prey prey association association 5C suz12-ezh2-3 5 37 unspecified role unspecified role bait bait 22 unspecified role unspecified role prey prey 20 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 5C suz12-ddb1 5 37 unspecified role unspecified role bait bait 20 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 47 unspecified role unspecified role prey prey association association 5C ezh2-cdkn2a-4 5 42 unspecified role unspecified role bait bait 22 unspecified role unspecified role prey prey 12 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 5C ezh2-cdkn2a-5 5 12 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 42 unspecified role unspecified role bait bait 37 unspecified role unspecified role prey prey association association 5C ddb1-cd2a2 5 12 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 37 unspecified role unspecified role prey prey 22 unspecified role unspecified role bait bait association association 5C suz12-cdkn2a-3 5 42 unspecified role unspecified role prey prey 37 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 5C cul4b-cdkn2a-7 5 47 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 42 unspecified role unspecified role prey prey association association 5C cul4b-cdkn2a-8 5 37 unspecified role unspecified role prey prey 47 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 5C ddb1-cul4b-4 5 47 unspecified role unspecified role prey prey 12 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 22 unspecified role unspecified role bait bait association association 5C ddb1-cd2a2-1 5 12 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 22 unspecified role unspecified role bait bait 42 unspecified role unspecified role prey prey association association 5C suz12-cd2a2 5 37 unspecified role unspecified role bait bait 22 unspecified role unspecified role prey prey 12 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 5C ddb1-jarid2 9 43 unspecified role unspecified role prey prey 18 unspecified role unspecified role prey prey 22 unspecified role unspecified role bait bait association association S1 ddb1-jarid2-1 9 18 unspecified role unspecified role prey prey 47 unspecified role unspecified role bait bait 43 unspecified role unspecified role prey prey association association S1-2