Molecular Connections Molecular Connections Pvt. Ltd. 2/2, Kariappa Road, Basavanagudi, Bangalore -560 004 www.molecularconnections.com Soluble Frizzled-7 inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin. Soluble Frizzled-7 inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin. Mol. Cancer (null) 2011 imex curation Wei W., Chua MS., Grepper S., So SK. Cancer - Interactions investigated in the context of cancer Species detail of the interacting protein (sFZD7) obtained from author mchua@stanford.edu jyoti Only protein-protein interactions Curation by: Molecular Connections Pvt. Ltd human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma pull down pull down western blot western blot Immuno blot Immuno blot Wei W., Chua MS., Grepper S., So SK. Cancer - Interactions investigated in the context of cancer Species detail of the interacting protein (sFZD7) obtained from author mchua@stanford.edu Accepted 2011-MAR-25 by JYOTI Mol. Cancer (null) 2011 jyoti Only protein-protein interactions imex curation Curation by: Molecular Connections Pvt. Ltd fzd7_human Frizzled-7 FzE3 FZD7 protein protein human Homo sapiens Human MRDPGAAAPLSSLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV 801934246B426DF5 wnt3_human Proto-oncogene Wnt-3 WNT3 INT4 Proto-oncogene Int-4 homolog protein protein human Homo sapiens Human MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 85D15F2C7884A64F fzd7-wnt3 1 3 unspecified role unspecified role prey prey 2 unspecified role unspecified role bait bait region his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association fig. 1b