IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Mol. Cell. Biol. (0270-7306) 2010 imex curation Beguelin W., Diaz Flaque M.C., Proietti C.J., Cayrol F., Rivas M.A., Tkach M., Rosemblit C., Tocci J.M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer Fig. S1 at http://www.ibyme.org.ar/laboratorios/elizalde.htm) and all other "S" figures - when clicking on, give a "404 error" and other errors - so cannot see if there is anything relevant there...(unlikely there is) Interactions involving H3 have not been included due to non-specificity of the antibody used for ch-IP. Elizalde@dna.uba.ar 19-Sept-2012: Contacted by IntAct-Help. Only protein-protein interactions human-t47d human breast cancer tumour cell line-epithelial cells t47d Epithelial cells derived from human breast tumour confocal microscopy confocal microscopy immunostaining immunostaining Beguelin W., Diaz Flaque M.C., Proietti C.J., Cayrol F., Rivas M.A., Tkach M., Rosemblit C., Tocci J.M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer Fig. S1 at http://www.ibyme.org.ar/laboratorios/elizalde.htm) and all other "S" figures - when clicking on, give a "404 error" and other errors - so cannot see if there is anything relevant there...(unlikely there is) Interactions involving H3 have not been included due to non-specificity of the antibody used for ch-IP. Elizalde@dna.uba.ar Accepted 2012-AUG-09 by ORCHARD 19-Sept-2012: Contacted by IntAct-Help. Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Mol. Cell. Biol. (0270-7306) 2010 imex curation Beguelin W., Diaz Flaque M.C., Proietti C.J., Cayrol F., Rivas M.A., Tkach M., Rosemblit C., Tocci J.M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer Fig. S1 at http://www.ibyme.org.ar/laboratorios/elizalde.htm) and all other "S" figures - when clicking on, give a "404 error" and other errors - so cannot see if there is anything relevant there...(unlikely there is) Interactions involving H3 have not been included due to non-specificity of the antibody used for ch-IP. Elizalde@dna.uba.ar 19-Sept-2012: Contacted by IntAct-Help. Only protein-protein interactions human-t47d human breast cancer tumour cell line-epithelial cells t47d Epithelial cells derived from human breast tumour ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Beguelin W., Diaz Flaque M.C., Proietti C.J., Cayrol F., Rivas M.A., Tkach M., Rosemblit C., Tocci J.M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer Fig. S1 at http://www.ibyme.org.ar/laboratorios/elizalde.htm) and all other "S" figures - when clicking on, give a "404 error" and other errors - so cannot see if there is anything relevant there...(unlikely there is) RE-ch-Ip experiment Interactions involving H3 have not been included due to non-specificity of the antibody used for ch-IP. Elizalde@dna.uba.ar Accepted 2012-AUG-09 by ORCHARD 19-Sept-2012: Contacted by IntAct-Help. Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Mol. Cell. Biol. (0270-7306) 2010 imex curation Beguelin W., Diaz Flaque M.C., Proietti C.J., Cayrol F., Rivas M.A., Tkach M., Rosemblit C., Tocci J.M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer Fig. S1 at http://www.ibyme.org.ar/laboratorios/elizalde.htm) and all other "S" figures - when clicking on, give a "404 error" and other errors - so cannot see if there is anything relevant there...(unlikely there is) Interactions involving H3 have not been included due to non-specificity of the antibody used for ch-IP. Elizalde@dna.uba.ar 19-Sept-2012: Contacted by IntAct-Help. Only protein-protein interactions mouse-c4hd Mouse C4HD - ER+and PR+ progestin (MPA) induced mammary adenocarcinoma cell line c4hd C4HD Mouse ER+and PR+ progestin (MPA) induced mammary adenocarcinoma cell line anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Beguelin W., Diaz Flaque M.C., Proietti C.J., Cayrol F., Rivas M.A., Tkach M., Rosemblit C., Tocci J.M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer Fig. S1 at http://www.ibyme.org.ar/laboratorios/elizalde.htm) and all other "S" figures - when clicking on, give a "404 error" and other errors - so cannot see if there is anything relevant there...(unlikely there is) Interactions involving H3 have not been included due to non-specificity of the antibody used for ch-IP. Elizalde@dna.uba.ar Accepted 2012-AUG-09 by ORCHARD 19-Sept-2012: Contacted by IntAct-Help. Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Mol. Cell. Biol. (0270-7306) 2010 imex curation Beguelin W., Diaz Flaque M.C., Proietti C.J., Cayrol F., Rivas M.A., Tkach M., Rosemblit C., Tocci J.M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer Fig. S1 at http://www.ibyme.org.ar/laboratorios/elizalde.htm) and all other "S" figures - when clicking on, give a "404 error" and other errors - so cannot see if there is anything relevant there...(unlikely there is) Interactions involving H3 have not been included due to non-specificity of the antibody used for ch-IP. Elizalde@dna.uba.ar 19-Sept-2012: Contacted by IntAct-Help. Only protein-protein interactions mouse-c4hd Mouse C4HD - ER+and PR+ progestin (MPA) induced mammary adenocarcinoma cell line c4hd C4HD Mouse ER+and PR+ progestin (MPA) induced mammary adenocarcinoma cell line ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Beguelin W., Diaz Flaque M.C., Proietti C.J., Cayrol F., Rivas M.A., Tkach M., Rosemblit C., Tocci J.M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer Fig. S1 at http://www.ibyme.org.ar/laboratorios/elizalde.htm) and all other "S" figures - when clicking on, give a "404 error" and other errors - so cannot see if there is anything relevant there...(unlikely there is) Interactions involving H3 have not been included due to non-specificity of the antibody used for ch-IP. Elizalde@dna.uba.ar Accepted 2012-AUG-09 by ORCHARD 19-Sept-2012: Contacted by IntAct-Help. Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Mol. Cell. Biol. (0270-7306) 2010 imex curation Beguelin W., Diaz Flaque M.C., Proietti C.J., Cayrol F., Rivas M.A., Tkach M., Rosemblit C., Tocci J.M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer Fig. S1 at http://www.ibyme.org.ar/laboratorios/elizalde.htm) and all other "S" figures - when clicking on, give a "404 error" and other errors - so cannot see if there is anything relevant there...(unlikely there is) Interactions involving H3 have not been included due to non-specificity of the antibody used for ch-IP. Elizalde@dna.uba.ar 19-Sept-2012: Contacted by IntAct-Help. Only protein-protein interactions human-t47d-y Human T47D-Y (T47DY) -PR negative variant of T47D cell line t47d-y T47D-Y (T47DY) -PR negative variant of T47D cell line ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Beguelin W., Diaz Flaque M.C., Proietti C.J., Cayrol F., Rivas M.A., Tkach M., Rosemblit C., Tocci J.M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer Fig. S1 at http://www.ibyme.org.ar/laboratorios/elizalde.htm) and all other "S" figures - when clicking on, give a "404 error" and other errors - so cannot see if there is anything relevant there...(unlikely there is) T47D-Y cells (PR-null T47D cells) were transfected with mutant PR - C587A Interactions involving H3 have not been included due to non-specificity of the antibody used for ch-IP. Elizalde@dna.uba.ar Accepted 2012-AUG-09 by ORCHARD 19-Sept-2012: Contacted by IntAct-Help. Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Mol. Cell. Biol. (0270-7306) 2010 imex curation Beguelin W., Diaz Flaque M.C., Proietti C.J., Cayrol F., Rivas M.A., Tkach M., Rosemblit C., Tocci J.M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer Fig. S1 at http://www.ibyme.org.ar/laboratorios/elizalde.htm) and all other "S" figures - when clicking on, give a "404 error" and other errors - so cannot see if there is anything relevant there...(unlikely there is) Interactions involving H3 have not been included due to non-specificity of the antibody used for ch-IP. Elizalde@dna.uba.ar 19-Sept-2012: Contacted by IntAct-Help. Only protein-protein interactions mouse-c4hd Mouse C4HD - ER+and PR+ progestin (MPA) induced mammary adenocarcinoma cell line c4hd C4HD Mouse ER+and PR+ progestin (MPA) induced mammary adenocarcinoma cell line confocal microscopy confocal microscopy immunostaining immunostaining Beguelin W., Diaz Flaque M.C., Proietti C.J., Cayrol F., Rivas M.A., Tkach M., Rosemblit C., Tocci J.M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer Fig. S1 at http://www.ibyme.org.ar/laboratorios/elizalde.htm) and all other "S" figures - when clicking on, give a "404 error" and other errors - so cannot see if there is anything relevant there...(unlikely there is) Interactions involving H3 have not been included due to non-specificity of the antibody used for ch-IP. Elizalde@dna.uba.ar Accepted 2012-AUG-09 by ORCHARD 19-Sept-2012: Contacted by IntAct-Help. Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Mol. Cell. Biol. (0270-7306) 2010 imex curation Beguelin W., Diaz Flaque M.C., Proietti C.J., Cayrol F., Rivas M.A., Tkach M., Rosemblit C., Tocci J.M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer Fig. S1 at http://www.ibyme.org.ar/laboratorios/elizalde.htm) and all other "S" figures - when clicking on, give a "404 error" and other errors - so cannot see if there is anything relevant there...(unlikely there is) Interactions involving H3 have not been included due to non-specificity of the antibody used for ch-IP. Elizalde@dna.uba.ar 19-Sept-2012: Contacted by IntAct-Help. Only protein-protein interactions human-t47d human breast cancer tumour cell line-epithelial cells t47d Epithelial cells derived from human breast tumour ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Beguelin W., Diaz Flaque M.C., Proietti C.J., Cayrol F., Rivas M.A., Tkach M., Rosemblit C., Tocci J.M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer Interactions involving H3 have not been added as the identity of the histone molecule is not known. Fig. S1 at http://www.ibyme.org.ar/laboratorios/elizalde.htm) and all other "S" figures - when clicking on, give a "404 error" and other errors - so cannot see if there is anything relevant there...(unlikely there is) Interactions involving H3 have not been included due to non-specificity of the antibody used for ch-IP. Elizalde@dna.uba.ar Accepted 2012-AUG-09 by ORCHARD 19-Sept-2012: Contacted by IntAct-Help. Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Mol. Cell. Biol. (0270-7306) 2010 imex curation Beguelin W., Diaz Flaque M.C., Proietti C.J., Cayrol F., Rivas M.A., Tkach M., Rosemblit C., Tocci J.M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer Fig. S1 at http://www.ibyme.org.ar/laboratorios/elizalde.htm) and all other "S" figures - when clicking on, give a "404 error" and other errors - so cannot see if there is anything relevant there...(unlikely there is) Interactions involving H3 have not been included due to non-specificity of the antibody used for ch-IP. Elizalde@dna.uba.ar 19-Sept-2012: Contacted by IntAct-Help. Only protein-protein interactions mouse-c4hd Mouse C4HD - ER+and PR+ progestin (MPA) induced mammary adenocarcinoma cell line c4hd C4HD Mouse ER+and PR+ progestin (MPA) induced mammary adenocarcinoma cell line ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Beguelin W., Diaz Flaque M.C., Proietti C.J., Cayrol F., Rivas M.A., Tkach M., Rosemblit C., Tocci J.M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer Fig. S1 at http://www.ibyme.org.ar/laboratorios/elizalde.htm) and all other "S" figures - when clicking on, give a "404 error" and other errors - so cannot see if there is anything relevant there...(unlikely there is) RE-ChIp experiment Interactions involving H3 have not been included due to non-specificity of the antibody used for ch-IP. Elizalde@dna.uba.ar Accepted 2012-AUG-09 by ORCHARD 19-Sept-2012: Contacted by IntAct-Help. Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation stat3_human Signal transducer and activator of transcription 3 Acute-phase response factor STAT3 APRF protein protein human Homo sapiens Human MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM 6C00632211C8012D DIP protein P40763 original sequence version: 157 DIP protein P40763-1 original sequence version: 147 DIP protein P40763-1 original sequence version: 135 DIP protein P40763-1 original sequence version: 157 DIP protein P40763 original sequence version: 165 DIP protein P40763 original sequence version: 182 DIP protein P40763 original sequence version: 135 6C00632211C8012D ep300_human Histone acetyltransferase p300 Histone butyryltransferase p300 Histone crotonyltransferase p300 Protein propionyltransferase p300 EP300 P300 E1A-associated protein p300 Protein 2-hydroxyisobutyryltransferase p300 Protein lactyltransferas p300 protein protein human Homo sapiens Human MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDINQLQTSLGMVQDAASKHKQLSELLRSGSSPNLNMGVGGPGQVMASQAQQSSPGLGLINSMVKSPMTQAGLTSPNMGMGTSGPNQGPTQSTGMMNSPVNQPAMGMNTGMNAGMNPGMLAAGNGQGIMPNQVMNGSIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPLKMGMMNNPNPYGSPYTQNPGQQIGASGLGLQIQTKTVLSNNLSPFAMDKKAVPGGGMPNMGQQPAPQVQQPGLVTPVAQGMGSGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKNAGDKRNQQPILTGAPVGLGNPSSLGVGQQSAPNLSTVSQIDPSSIERAYAALGLPYQVNQMPTQPQVQAKNQQNQQPGQSPQGMRPMSNMSASPMGVNGGVGVQTPSLLSDSMLHSAINSQNPMMSENASVPSLGPMPTAAQPSTTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKRRTRLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPNQMMPRITPQSGLNQFGQMSMAQPPIVPRQTPPLQHHGQLAQPGALNPPMGYGPRMQQPSNQGQFLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPSLPAAPSADQPQQQPRSQQSTAASVPTPTAPLLPPQPATPLSQPAVSIEGQVSNPPSTSSTEVNSQAIAEKQPSQEVKMEAKMEVDQPEPADTQPEDISESKVEDCKMESTETEERSTELKTEIKEEEDQPSTSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAKKKNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHHVETRWHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENKCPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVGQQQGLPSPTPATPTTPTGQQPTTPQTPQPTSQPQPTPPNSMPPYLPRTQAAGPVSQGKAAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPPMTPMAPMGMNPPPMTRGPSGHLEPGMGPTGMQQQPPWSQGGLPQPQQLQSGMPRPAMMSVAQHGQPLNMAPQPGLGQVGISPLKPGTVSQQALQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANSNPQPIPGQPGMPQGQPGLQPPTMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQPQQQLQPPMGGMSPQAQQMNMNHNTMPSQFRDILRRQQMMQQQQQQGAGPGIGPGMANHNQFQQPQGVGYPPQQQQRMQHHMQQMQQGNMGQIGQLPQALGAEAGASLQAYQQRLLQQQMGSPVQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHSSPSPRMQPQPSPHHVSPQTSSPHPGLVAAQANPMEQGHFASPDQNSMLSQLASNPGMANLHGASATDLGLSTDNSDLNSNLSQSTLDIH DIP protein Q09472 original sequence version: 193 DIP protein Q09472 original sequence version: 186 DIP protein Q09472 original sequence version: 107 DIP protein Q09472 original sequence version: 112 DIP protein Q09472 original sequence version: 181 DIP protein Q09472 original sequence version: 183 DIP protein Q09472 original sequence version: 136 DIP protein Q09472 original sequence version: 146 DIP protein Q09472 original sequence version: 165 DIP protein Q09472 original sequence version: 192 DIP protein Q09472 original sequence version: 200 DIP protein Q09472 original sequence version: 206 DIP protein Q09472 original sequence version: 194 DIP protein Q09472 original sequence version: 171 DIP protein Q09472 original sequence version: 142 DIP protein Q09472 original sequence version: 180 8E869E1F174A6FEB erbb2_human Receptor tyrosine-protein kinase erbB-2 p185erbB2 MLN19 Proto-oncogene c-ErbB-2 Tyrosine kinase-type cell surface receptor HER2 Proto-oncogene Neu ERBB2 HER2 NEU NGL Metastatic lymph node gene 19 protein protein protein human Homo sapiens Human MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV DIP protein P04626 original sequence version: 198 DIP protein P04626 original sequence version: 122 DIP protein P04626 original sequence version: 206 DIP protein P04626 original sequence version: 195 DIP protein P04626 original sequence version: 150 DIP protein P04626 original sequence version: 179 DIP protein P04626 original sequence version: 146 DIP protein P04626 original sequence version: 147 39E9DFDA04DCF962 ccnd1_human_gene Human Cyclin D1 gene gene gene human Homo sapiens Human erbb2_mouse Receptor tyrosine-protein kinase erbB-2 Erbb2 Kiaa3023 Neu Proto-oncogene Neu Proto-oncogene c-ErbB-2 p185erbB2 protein protein mouse Mus musculus Mouse MELAAWCRWGFLLALLSPGAAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPANASLSFLQDIQEVQGYMLIAHNRVKHVPLQRLRIVRGTQLFEDKYALAVLDNRDPLDNVTTAAPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVLWKDVLRKNNQLAPVDMDTNRSRACPPCAPTCKDNHCWGESPEDCQILTGTICTSGCARCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALITYNTDTFESMLNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPCAGVCYGLGMEHLRGARAITSDNIQEFAGCKKIFGSLAFLPESFDGNPSSGVAPLKPEHLQVFETLEEITGYLYISAWPESFQDLSVFQNLRVIRGRILHDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNTHLCFVNTVPWDQLFRNPHQALLHSGNRPEEACGLEGLVCNSLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVWKGLPREYVRGKHCLPCHPECQPQNSSETCYGSEADQCEACAHYKDSSSCVARCPSGVKPDLSYMPIWKYPDEEGICQPCPINCTHSCVDLDERGCPAEQRASPVTFIIATVVGVLLFLIIVVVIGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAVPNQAQMRILKETELRKLKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSPMDSTFYRSLLEDDDMGELVDAEEYLVPQQGFFSPDPALGTGSTAHRRHRSSSARSGGGELTLGLEPSEEEPPRSPLAPSEGAGSDVFDGDLAVGVTKGLQSLSPHDLSPLQRYSEDPTLPLPPETDGYVAPLACSPQPEYVNQPEVRPQSPLTPEGPPPPIRPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLAPRAGTASQPHPSPAFSPAFDNLYYWDQNSSEQGPPPSTFEGTPTAENPEYLGLDVPV DIP protein P70424 original sequence version: 159 6040978428B93A28 prgr_human Progesterone receptor PGR NR3C3 Nuclear receptor subfamily 3 group C member 3 protein protein human Homo sapiens Human MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLFPRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLAPSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK DIP protein P06401 original sequence version: 196 DIP protein P06401-1 original sequence version: 186 DIP protein P06401-1 original sequence version: 192 80452E54FF3A0454 stat3_mouse Signal transducer and activator of transcription 3 Acute-phase response factor Stat3 Aprf protein protein mouse Mus musculus Mouse MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM DIP protein P42227 original sequence version: 169 DIP protein P42227 original sequence version: 162 DIP protein P42227 original sequence version: 164 DIP protein P42227 original sequence version: 141 6C00626711C8012D cbp_human CREB-binding protein CREBBP CBP Histone lysine acetyltransferase CREBBP Protein-lysine acetyltransferase CREBBP protein protein human Homo sapiens Human MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSSELSLVGDTTGDTLEKFVEGL DIP protein Q92793 original sequence version: 134 DIP protein Q92793-1 original sequence version: 171 DIP protein Q92793 original sequence version: 171 DIP protein Q92793 original sequence version: 185 DIP protein Q92793 original sequence version: 106 DIP protein Q92793 original sequence version: 104 DIP protein Q92793 original sequence version: 112 DIP protein Q92793 original sequence version: 135 DIP protein Q92793 original sequence version: 139 DIP protein Q92793 original sequence version: 157 DIP protein Q92793 original sequence version: 177 DIP protein Q92793 original sequence version: 168 DIP protein Q92793-1 original sequence version: 174 DIP protein Q92793 original sequence version: 146 DIP protein Q92793 original sequence version: 161 DIP protein Q92793 original sequence version: 172 3BEA9B8558BA1A5E mouse_ccnd1_gene Ccnd1/G1/S-specific cyclin-D1 Mouse Gene gene gene mouse Mus musculus Mouse h4_human Histone H4 H4-16 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4 HIST2H4A HIST2H4B HIST4H4 protein protein human Homo sapiens Human MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG DIP protein P62805 original sequence version: 68 DIP protein P62805 original sequence version: 111 DIP protein P62805 original sequence version: 94 DIP protein P62805 original sequence version: 97 DIP protein P62805 original sequence version: 116 DIP protein P62805 original sequence version: 105 DIP protein P62805 original sequence version: 120 DIP protein P62805 original sequence version: 144 DIP protein P62805 original sequence version: 150 DIP protein P62805 original sequence version: 154 DIP protein P62805 original sequence version: 156 DIP protein P62805 original sequence version: 112 DIP protein P62805 original sequence version: 121 DIP protein P62805 original sequence version: 123 DIP protein P62805 original sequence version: 126 DIP protein P62805 original sequence version: 132 DIP protein P62805 original sequence version: 136 DIP protein P62805 original sequence version: 119 A9E5DFD3F8B97598 prgr_mouse Progesterone receptor Pgr Nr3c3 Pr Nuclear receptor subfamily 3 group C member 3 protein protein mouse Mus musculus Mouse MTELQAKDPQVLHTSGASPSPPHIGSPLLARLDSGPFQGSQHSDVSSVVSPIPISLDGLLFPRSCRGPELPDGKTGDQQSLSDVEGAFSGVEATHREGGRNSRAPEKDSRLLDSVLDSLLTPSGTEQSHASPPACEAITSWCLFGPELPEDPRSVPATKGLLSPLMSRPEIKAGDSSGTGAGQKVLPKGLSPPRQLLLPTSGSAHWPGAGVKPSPQPAAGEVEEDSGLETEGSAAPLLKSKPRALEGTGSGGGVAANAASAAPGGVTLVPKEDSRFSAPRVSLEQDSPIAPGRSPLATTVVDFIHVPILPLNHALLAARTRQLLEGDSYDGGATAQGPFAPPRGSPSAPSPPVPCGDFPDCTYPLEGDPKEDVFPLYGDFQTPGLKIKEEEEGADAAVRSPRPYLSAGASSSTFPDFPLAPAPQRAPSSRPGEAAVAGGPSSAAVSPASSSGSALECILYKAEGAPPTQGSFAPLPCKPPAAGSCLLPRDSLPAAPATAAAPAIYQPLGLNGLPQLGYQAAVLKDSLPQVYPPYLNYLRPDSEASQSPQYGFDSLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVMRTLDGVALPQSVGLPNESQALGQRITFSPNQEIQLVPPLINLLMSIEPDVVYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKELSFYSLCLTMWQIPQEFVKLQVTHEEFLCMKVLLLLNTIPLEGLRSQSQFEEMRSSYIRELIKAIGLRQKGVVPSSQRFYQLTKLLDSLHDLVKQLHLYCLNTFIQSRTLAVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK E26DDDE9529996A7 erbb2-stat3 6 15 unspecified role unspecified role neutral component neutral component 13 unspecified role unspecified role neutral component neutral component colocalization colocalization Fig 2A MPA -Medroxyprogesterone acetate - a synthetic variant of human progesterone. MPA treatment of C4HD and T47D cells resulted in a strong nuclear colocalization of ErbB-2 and Stat3. In the absence of MPA stimulation, the vast majority of ErbB-2 was localized in the cytoplasmic membrane. RU486-Mifepristone, a progesterone receptor antagonist. AG825-Tyrphostin, a selective inhibitor of ERBB2 autophosphorylation. erbb2-stat3-1 1 9 unspecified role unspecified role neutral component neutral component 11 unspecified role unspecified role neutral component neutral component colocalization colocalization Fig 2A MPA -Medroxyprogesterone acetate - a synthetic variant of human progesterone. MPA treatment of C4HD and T47D cells resulted in a strong nuclear colocalization of ErbB-2 and Stat3. In the absence of MPA stimulation, the vast majority of ErbB-2 was localized in the cytoplasmic membrane. RU486-Mifepristone, a progesterone receptor antagonist. AG825-Tyrphostin, a selective inhibitor of ERBB2 autophosphorylation. erbb2-stat3-3 3 15 unspecified role unspecified role prey prey 13 unspecified role unspecified role bait bait physical association physical association Fig 2B MPA -Medroxyprogesterone acetate - a synthetic variant of human progesterone. stat3-erbb2-2 3 15 unspecified role unspecified role bait bait 13 unspecified role unspecified role prey prey physical association physical association Fig 2B MPA -Medroxyprogesterone acetate - a synthetic variant of human progesterone. stat3-cdkn1a-2 4 17 unspecified role unspecified role prey prey promoter_region containing_x2_gamma interferon-activated sequences binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 15 unspecified role unspecified role bait bait association association Fig 5A-2, 7E. MPA -Medroxyprogesterone acetate - a synthetic variant of human progesterone. The transfection of hErbB-2ΔNLS (Human ERBB2-NLS deletion mutant) in mouse C4HD cells resulted in no erbb2 binding at the cyclin D1 promoter , yet MPA-induced Stat3 binding at this site remained unaffected. stat3-ccnd1 7 9 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey promoter_region containing_x1_gamma interferon-activated sequence binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Fig 5A-1, 5C-bottom, 5C-middle. MPA -Medroxyprogesterone acetate - a synthetic variant of human progesterone. In the absence of ErbB-2 recruitment (by use of a ERBB2 NLS deletion mutant), PR was not loaded at the GAS site at the cyclin D1 promoter. MPA-induced Stat3 binding at this site remained unaffected. erbb2-cdkn1a 4 17 unspecified role unspecified role prey prey promoter_region containing_x2_gamma interferon-activated sequences binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 13 unspecified role unspecified role bait bait association association Fig 5a-1, 7E. MPA -Medroxyprogesterone acetate - a synthetic variant of human progesterone. The transfection of hErbB-2ΔNLS (Human ERBB2-NLS deletion mutant) in mouse C4HD cells resulted in no erbb2 binding at the cyclin D1 promoter , yet MPA-induced Stat3 binding at this site remained unaffected. pgr-cdkn1a-1 4 19 unspecified role unspecified role bait bait 17 unspecified role unspecified role prey prey promoter_region containing_x2_gamma interferon-activated sequences binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Fig 5A-3 MPA -Medroxyprogesterone acetate - a synthetic variant of human progesterone. erbb2-ccnd1 7 12 unspecified role unspecified role prey prey promoter_region containing_x1_gamma interferon-activated sequence binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 11 unspecified role unspecified role bait bait association association Fig 5A-2, 5C-bottom. MPA -Medroxyprogesterone acetate - a synthetic variant of human progesterone. pgr-ccnd1 7 14 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey promoter_region containing_x1_gamma interferon-activated sequence binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Fig 5A-3, 5C-bottom. MPA -Medroxyprogesterone acetate - a synthetic variant of human progesterone. erbb2-cdkn1a-1 8 17 unspecified role unspecified role prey prey promoter_region containing_x2_gamma interferon-activated sequences binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 15 unspecified role unspecified role prey prey 13 unspecified role unspecified role bait bait association association Fig 5B-1 MPA -Medroxyprogesterone acetate - a synthetic variant of human progesterone. pgr-cdkn1a-2 8 19 unspecified role unspecified role bait bait 17 unspecified role unspecified role prey prey promoter_region containing_x2_gamma interferon-activated sequences binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 15 unspecified role unspecified role prey prey association association Fig 5B-2 MPA -Medroxyprogesterone acetate - a synthetic variant of human progesterone. erbb2-cdkn1a-2 2 9 unspecified role unspecified role prey prey 14 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey promoter_region containing_x1_gamma interferon-activated sequence binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Fig 5B-2 MPA -Medroxyprogesterone acetate - a synthetic variant of human progesterone. erbb2-cdkn1a-3 2 12 unspecified role unspecified role prey prey promoter_region containing_x1_gamma interferon-activated sequence binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 11 unspecified role unspecified role bait bait 9 unspecified role unspecified role prey prey association association Fig 5B-1 MPA -Medroxyprogesterone acetate - a synthetic variant of human progesterone. erbb2-cdkn1a-4 2 12 unspecified role unspecified role prey prey promoter_region containing_x1_gamma interferon-activated sequence binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 14 unspecified role unspecified role prey prey 11 unspecified role unspecified role bait bait association association Fig 5B-3 MPA -Medroxyprogesterone acetate - a synthetic variant of human progesterone. pgr-cdkn1a-3 2 11 unspecified role unspecified role prey prey 12 unspecified role unspecified role prey prey promoter_region containing_x1_gamma interferon-activated sequence binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 14 unspecified role unspecified role bait bait association association Fig 5B-4 MPA -Medroxyprogesterone acetate - a synthetic variant of human progesterone. stat3-cdkn1a-3 5 9 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey association association Fig 5C- top MPA while a clear Stat3 recruitment was observed upon the stimulation of T47D-Y-C587A-PR cells by MPA, C587A-PR (lacking a functional DNA binding domain) did not bind to this promoter, nor did ErbB-2. crebbp-ccnd1 7 16 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey promoter_region containing_x1_gamma interferon-activated sequence binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Fig 5D-top and bottom-1. MPA -Medroxyprogesterone acetate - a synthetic variant of human progesterone. In the absence of ErbB-2 recruitment (by use of a ERBB2 NLS deletion mutant), CBP, H4 and p300 were not loaded at the GAS site at the cyclin D1 promoter. ep300-ccnd1 7 10 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey promoter_region containing_x1_gamma interferon-activated sequence binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Fig 5D-top and bottom.-2 MPA -Medroxyprogesterone acetate - a synthetic variant of human progesterone. In the absence of ErbB-2 recruitment (by use of a ERBB2 NLS deletion mutant), CBP, H4 and p300 were not loaded at the GAS site at the cyclin D1 promoter. hist1h4a-ccnd1 7 18 unspecified role unspecified role bait bait region naclys N-acetylated L-lysine NAcLys undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 12 unspecified role unspecified role prey prey promoter_region containing_x1_gamma interferon-activated sequence binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Fig 5D-top and bottom-3. MPA -Medroxyprogesterone acetate - a synthetic variant of human progesterone. In the absence of ErbB-2 recruitment (by use of a ERBB2 NLS deletion mutant), CBP, H4 and p300 were not loaded at the GAS site at the cyclin D1 promoter.