I2D I2D Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects. Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects. Oncogene (0950-9232) 2010 imex curation Marshall GM., Gherardi S., Xu N., Neiron Z., Trahair T., Scarlett CJ., Chang DK., Liu PY., Jankowski K., Iraci N., Haber M., Norris MD., Keating J., Sekyere E., Jonquieres G., Stossi F., Katzenellenbogen BS., Biankin AV., Perini G., Liu T. Cancer - Interactions investigated in the context of cancer Dual crosslinking ChIP and quantitative PCR were applied in Be(2)-C cells. tliu@ccia.unsw.edu.au 06-April-2011: Contacted by JYOTI. orchard Only protein-protein interactions Curated by: I2D - Interologous Interaction Database human-sk_n_be(2) Human caucasian neuroblastoma cell line sk_n_be(2) Human neuroblastoma cell line ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Marshall GM., Gherardi S., Xu N., Neiron Z., Trahair T., Scarlett CJ., Chang DK., Liu PY., Jankowski K., Iraci N., Haber M., Norris MD., Keating J., Sekyere E., Jonquieres G., Stossi F., Katzenellenbogen BS., Biankin AV., Perini G., Liu T. Cancer - Interactions investigated in the context of cancer Dual crosslinking ChIP and quantitative PCR were applied in Be(2)-C cells. tliu@ccia.unsw.edu.au tliu@ccia.unsw.edu.au Accepted 2010-Not a month!-7 by ORCHARD. 06-April-2011: Contacted by JYOTI. Oncogene (0950-9232) 2010 orchard Only protein-protein interactions imex curation Curated by: I2D - Interologous Interaction Database Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects. Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects. Oncogene (0950-9232) 2010 imex curation Marshall GM., Gherardi S., Xu N., Neiron Z., Trahair T., Scarlett CJ., Chang DK., Liu PY., Jankowski K., Iraci N., Haber M., Norris MD., Keating J., Sekyere E., Jonquieres G., Stossi F., Katzenellenbogen BS., Biankin AV., Perini G., Liu T. Cancer - Interactions investigated in the context of cancer Dual crosslinking ChIP and quantitative PCR were applied in Be(2)-C cells. tliu@ccia.unsw.edu.au 06-April-2011: Contacted by JYOTI. orchard Only protein-protein interactions Curated by: I2D - Interologous Interaction Database human-sk_n_be(2) Human caucasian neuroblastoma cell line sk_n_be(2) Human neuroblastoma cell line anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Marshall GM., Gherardi S., Xu N., Neiron Z., Trahair T., Scarlett CJ., Chang DK., Liu PY., Jankowski K., Iraci N., Haber M., Norris MD., Keating J., Sekyere E., Jonquieres G., Stossi F., Katzenellenbogen BS., Biankin AV., Perini G., Liu T. Cancer - Interactions investigated in the context of cancer Dual crosslinking ChIP and quantitative PCR were applied in Be(2)-C cells. tliu@ccia.unsw.edu.au tliu@ccia.unsw.edu.au Accepted 2010-Not a month!-7 by ORCHARD. 06-April-2011: Contacted by JYOTI. Oncogene (0950-9232) 2010 orchard Only protein-protein interactions imex curation Curated by: I2D - Interologous Interaction Database sp1_human Transcription factor Sp1 SP1 TSFP1 protein protein human Homo sapiens Human MSDQDHSMDEMTAVVKIEKGVGGNNGGNGNGGGAFSQARSSSTGSSSSTGGGGQESQPSPLALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATPTSKEQSGSSTNGSNGSESSKNRTVSGGQYVVAAAPNLQNQQVLTGLPGVMPNIQYQVIPQFQTVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIITNRGSGGNIIAAMPNLLQQAVPLQGLANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAVTISSSGSQESGSQPVTSGTTISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTTSGSSGTNSQGQTPQRVSGLQGSDALNIQQNQTSGGSLQAGQQKEGEQNQQTQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQLQAVPNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTSGIQVHPIQGLPLAIANAPGDHGAQLGLHGAGGDGIHDDTAGGEEGENSPDAQPQAGRRTRREACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCTWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVALSVGTLPLDSGAGSEGSGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVADLQSINISGNGF DIP protein P08047 original sequence version: 185 DIP protein P08047 original sequence version: 187 DIP protein P08047 original sequence version: 181 DIP protein P08047 original sequence version: 162 DIP protein P08047 original sequence version: 161 43893DBF6518B9EA ccng2_human_gene gene gene human Homo sapiens Human hdac2_human Histone deacetylase 2 HDAC2 protein protein human Homo sapiens Human MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP DIP protein Q92769 original sequence version: 161 DIP protein Q92769 original sequence version: 154 DIP protein Q92769 original sequence version: 117 DIP protein Q92769 original sequence version: 113 DIP protein Q92769 original sequence version: 139 DIP protein Q92769 original sequence version: 163 DIP protein Q92769 original sequence version: 179 DIP protein Q92769 original sequence version: 153 DIP protein Q92769 original sequence version: 112 775419CCCDAE07FA mycn_human N-myc proto-oncogene protein MYCN NMYC BHLHE37 Class E basic helix-loop-helix protein 37 protein protein human Homo sapiens Human MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLGGLGGLTPNPVILQDCMWSGFSAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGAASPAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTITVRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC DIP protein P04198 original sequence version: 157 560E885602E30DAD sp1-ccng2 1 3 unspecified role unspecified role bait bait 4 unspecified role unspecified role prey prey association association Fig. 5b n-myc-ccng2 1 6 unspecified role unspecified role bait bait 4 unspecified role unspecified role prey prey association association Fig. 5b hdac2-ccng2 1 5 unspecified role unspecified role bait bait 4 unspecified role unspecified role prey prey association association Fig. 5b n-myc-sp1-hdac2 2 6 unspecified role unspecified role bait bait 3 unspecified role unspecified role prey prey 5 unspecified role unspecified role prey prey physical association physical association Fig. 5d hdac2-n-myc-sp1 2 6 unspecified role unspecified role prey prey 5 unspecified role unspecified role bait bait 3 unspecified role unspecified role prey prey physical association physical association Fig. 5d