IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. Cancer Cell (1535-6108) 2011 imex curation Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis Cancer - Interactions investigated in the context of cancer The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. delsal@lncib.it 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions mouse-lymphoma Mus musculus lymphoma Lymphoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. delsal@lncib.it Accepted 2011-AUG-03 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. Cancer Cell (1535-6108) 2011 imex curation Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis Cancer - Interactions investigated in the context of cancer The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. delsal@lncib.it 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions mouse-embryonic_fibroblast Mus musculus embryonic fibroblasts embryonic_fibroblast Embryonic fibroblast Fibroblasts taken from an embryonic as opposed to a foetal or adult source. Foetus is defined as the stage at which tissue diferentiation is initiated. Tissue taken from an embryonic as opposed to a foetal or adult source. Embryo is defined as the development stage prior to organ formation. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. delsal@lncib.it Accepted 2011-AUG-03 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. Cancer Cell (1535-6108) 2011 imex curation Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis Cancer - Interactions investigated in the context of cancer The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. delsal@lncib.it 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. the exact (endogenous) mutations given for the cell lines are to be found at near the end of the supplement - p27, under Cell culture + constructs. (this info given here so you do not have to spend as long as I did looking for them!) The p53 mutation R172H has been entered as R169H, using amino acid numbering in the current UniProt version of (mus) p53. The authors state that the TAp63alpha construct is murine in origin. (and has an identity of ~ 97% with TAp63alpha of human origin) GST-Pin1 is stated to be Human, in Zacchi et al., 2002. delsal@lncib.it Accepted 2011-AUG-03 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. Cancer Cell (1535-6108) 2011 imex curation Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis Cancer - Interactions investigated in the context of cancer The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. delsal@lncib.it 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions human-mda_mb_231 Homo sapiens Caucasian breast adenocarcinoma mda_mb_231 Human Caucasian breast adenocarcinoma anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. delsal@lncib.it Accepted 2011-AUG-03 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. Cancer Cell (1535-6108) 2011 imex curation Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis Cancer - Interactions investigated in the context of cancer The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. delsal@lncib.it 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions human-mda_mb_231 Homo sapiens Caucasian breast adenocarcinoma mda_mb_231 Human Caucasian breast adenocarcinoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. delsal@lncib.it Accepted 2011-AUG-03 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. Cancer Cell (1535-6108) 2011 imex curation Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis Cancer - Interactions investigated in the context of cancer The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. delsal@lncib.it 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions human-h1299 Homo sapiens lung lymph node carcinoma h1299 Human lung lymph node carcinoma p53 null. These cells have also been reported to secrete the peptide hormone neuromedin B (NMB), but not gastrin releasing peptide (GRP). Also known as NCI H1299 or CRL-5803. http://www.lgcpromochem.com/atcc/ ATCC number: CRL-5803. ATCC number of the cell line is CRL-5803. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. delsal@lncib.it Accepted 2011-AUG-03 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. Cancer Cell (1535-6108) 2011 imex curation Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis Cancer - Interactions investigated in the context of cancer The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. delsal@lncib.it 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions human-mda_mb_231 Homo sapiens Caucasian breast adenocarcinoma mda_mb_231 Human Caucasian breast adenocarcinoma anti bait coip anti bait coimmunoprecipitation anti bait coip anti tag western anti tag western blot anti tag western Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. cant see what is wrong with this -Fig 3B? Maybe you did not see this remark I entered at the interaction level -regarding the 4M mutation? - "some of the exact (endogenous) mutations given for the cell lines are to be found at near the end of the supplement - p27, under Cell culture + constructs. (this info given here so you do not have to spend as long as I did looking for them!)" delsal@lncib.it Accepted 2011-AUG-03 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. Cancer Cell (1535-6108) 2011 imex curation Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis Cancer - Interactions investigated in the context of cancer The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. delsal@lncib.it 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions human-mda_mb_231 Homo sapiens Caucasian breast adenocarcinoma mda_mb_231 Human Caucasian breast adenocarcinoma ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. Formaldehyde was used for crosslinking. delsal@lncib.it Accepted 2011-AUG-03 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation pin1_mouse Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Pin1 Peptidyl-prolyl cis-trans isomerase Pin1 protein protein mouse Mus musculus Mouse MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGGSTVGGSSKNGQGEPAKVRCSHLLVKHSQSRRPSSWRQEKITRSKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGPFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE DIP protein Q9QUR7 original sequence version: 81 188E95F009176B1F o88898-1 Tumor protein 63 TA*-alpha TA*p63alpha Tp63 P63 P73l Tp73l Trp63 Transformation-related protein 63 Tumor protein p73-like protein protein mouse Mus musculus Mouse MNFETSRCATLQYCPDPYIQRFIETPAHFSWKESYYRSAMSQSTQTSEFLSPEVFQHIWDFLEQPICSVQPIELNFVDEPSENGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSAKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSMQSQSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTMPEGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDSRRNKQQRIKEEGE Produced by alternative promoter usage. 8DFF0284F247C68A pin1_human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Rotamase Pin1 Peptidyl-prolyl cis-trans isomerase Pin1 PIN1 protein protein human Homo sapiens Human MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE DIP protein Q13526 original sequence version: 65 DIP protein Q13526 original sequence version: 64 DIP protein Q13526 original sequence version: 163 DIP protein Q13526 original sequence version: 156 DIP protein Q13526 original sequence version: 117 35391AF40B7D1E13 e41lb_human_gene Human EPB41L4B gene gene gene human Homo sapiens Human ccne2_human_gene Human CCNE2 gene gene gene human Homo sapiens Human p53_mouse Cellular tumor antigen p53 Tp53 P53 Trp53 Tumor suppressor p53 protein protein mouse Mus musculus Mouse MTAMEESQSDISLELPLSQETFSGLWKLLPPEDILPSPHCMDDLLLPQDVEEFFEGPSEALRVSGAPAAQDPVTETPGPVAPAPATPWPLSSFVPSQKTYQGNYGFHLGFLQSGTAKSVMCTYSPPLNKLFCQLAKTCPVQLWVSATPPAGSRVRAMAIYKKSQHMTEVVRRCPHHERCSDGDGLAPPQHLIRVEGNLYPEYLEDRQTFRHSVVVPYEPPEAGSEYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKEVLCPELPPGSAKRALPTCTSASPPQKKKPLDGEYFTLKIRGRKRFEMFRELNEALELKDAHATEESGDSRAHSSYLKTKKGQSTSRHKKTMVKKVGPDSD DIP protein P02340 original sequence version: 117 DIP protein P02340 original sequence version: 165 DIP protein P02340 original sequence version: 187 DIP protein P02340 original sequence version: 201 DIP protein P02340 original sequence version: 111 DIP protein P02340 original sequence version: 141 DIP protein P02340 original sequence version: 180 DIP protein P02340 original sequence version: 163 DIP protein P02340 original sequence version: 152 ED5A607378D921D7 smad2_human Mothers against decapentaplegic homolog 2 SMAD2 MADH2 MADR2 Mad-related protein 2 SMAD family member 2 JV18-1 protein protein human Homo sapiens Human MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS DIP protein Q15796 original sequence version: 174 DIP protein Q15796 original sequence version: 100 DIP protein Q15796-1 original sequence version: 141 95406DB5FC0AA4C9 cnd2_human_gene Human NCAPH gene gene gene human Homo sapiens Human cpsf6_human_gene Human CPSF6 gene gene gene human Homo sapiens Human p53_human Cellular tumor antigen p53 TP53 P53 Tumor suppressor p53 Phosphoprotein p53 Antigen NY-CO-13 protein protein human Homo sapiens Human MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD DIP protein P04637 original sequence version: 121 DIP protein P04637 original sequence version: 115 DIP protein P04637-1 original sequence version: 224 DIP protein P04637 original sequence version: 117 DIP protein P04637-1 original sequence version: 226 DIP protein P04637 original sequence version: 226 DIP protein P04637 original sequence version: 212 DIP protein P04637 original sequence version: 220 DIP protein P04637-1 original sequence version: 220 DIP protein P04637-1 original sequence version: 145 DIP protein P04637 original sequence version: 146 DIP protein P04637 original sequence version: 145 DIP protein P04637 original sequence version: 166 DIP protein P04637-1 original sequence version: 166 DIP protein P04637 original sequence version: 169 DIP protein P04637 original sequence version: 177 DIP protein P04637 original sequence version: 175 DIP protein P04637-1 original sequence version: 175 DIP protein P04637-1 original sequence version: 172 DIP protein P04637-1 original sequence version: 169 DIP protein P04637 original sequence version: 170 DIP protein P04637 original sequence version: 172 DIP protein P04637-1 original sequence version: 194 DIP protein P04637 original sequence version: 196 DIP protein P04637 original sequence version: 185 DIP protein P04637-1 original sequence version: 191 DIP protein P04637 original sequence version: 191 DIP protein P04637 original sequence version: 180 DIP protein P04637-1 original sequence version: 197 DIP protein P04637 original sequence version: 183 DIP protein P04637-1 original sequence version: 183 DIP protein P04637-1 original sequence version: 185 DIP protein P04637 original sequence version: 199 DIP protein P04637 original sequence version: 201 DIP protein P04637 original sequence version: 189 DIP protein P04637 original sequence version: 235 DIP protein P04637 original sequence version: 230 DIP protein P04637 original sequence version: 234 DIP protein P04637-1 original sequence version: 234 DIP protein P04637-1 original sequence version: 235 DIP protein P04637 original sequence version: 239 DIP protein P04637-1 original sequence version: 212 DIP protein P04637-1 original sequence version: 213 DIP protein P04637 original sequence version: 213 DIP protein P04637 original sequence version: 206 DIP protein P04637-1 original sequence version: 188 DIP protein P04637-1 original sequence version: 228 DIP protein P04637 original sequence version: 208 DIP protein P04637 original sequence version: 240 DIP protein P04637-1 original sequence version: 240 DIP protein P04637 original sequence version: 204 DIP protein P04637-1 original sequence version: 204 DIP protein P04637-1 original sequence version: 209 DIP protein P04637-1 original sequence version: 203 DIP protein P04637 original sequence version: 221 DIP protein P04637-1 original sequence version: 152 DIP protein P04637 original sequence version: 217 DIP protein P04637-1 original sequence version: 140 DIP protein P04637 original sequence version: 215 DIP protein P04637 original sequence version: 214 DIP protein P04637-1 original sequence version: 182 DIP protein P04637 original sequence version: 182 DIP protein P04637 original sequence version: 188 DIP protein P04637 original sequence version: 192 DIP protein P04637-1 original sequence version: 192 DIP protein P04637 original sequence version: 218 DIP protein P04637-1 original sequence version: 218 AD5C149FD8106131 q9h3d4-1 Tumor protein 63 TP63 KET P63 P73H P73L TP73L Chronic ulcerative stomatitis protein Keratinocyte transcription factor KET Transformation-related protein 63 Tumor protein p73-like p40 p51 TA*-alpha TAp63alpha P51B protein protein human Homo sapiens Human MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHEFSSPSHLLRTPSSASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE Produced by alternative promoter usage. F66ECD45E87D9799 fa64a_human_gene Human FAM64A gene gene gene human Homo sapiens Human cenpa_human_gene Human CENPA gene gene gene human Homo sapiens Human p63_human Tumor protein 63 TP63 KET P63 P73H P73L TP73L Transformation-related protein 63 Tumor protein p73-like p51 p40 Keratinocyte transcription factor KET Chronic ulcerative stomatitis protein protein protein human Homo sapiens Human MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHEFSSPSHLLRTPSSASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE DIP protein Q9H3D4 original sequence version: 99 DIP protein Q9H3D4 original sequence version: 100 DIP protein Q9H3D4 original sequence version: 119 DIP protein Q9H3D4-1 original sequence version: 146 DIP protein Q9H3D4 original sequence version: 146 DIP protein Q9H3D4 original sequence version: 142 DIP protein Q9H3D4 original sequence version: 68 F66ECD45E87D9799 dep1a_human_gene DEP domain-containing protein 1A gene gene gene human Homo sapiens Human wdr67_human_gene Human WDR67 gene gene gene human Homo sapiens Human bub1_human_gene Human BUB1 gene gene gene human Homo sapiens Human mis18a_human_gene Human MIS18A gene gene gene human Homo sapiens Human pin1-tp53 3 11 unspecified role unspecified role bait bait region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 14 unspecified role unspecified role prey prey P02340:p.Arg172His mutation mutation certain certain sequence position certain certain certain sequence position certain R H Wed May 02 19:33:27 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg169his' Tue Oct 30 13:57:04 GMT 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg169His' Tue Jun 30 20:02:06 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg172His' mouse-embryonic_fibroblast Mus musculus embryonic fibroblasts embryonic_fibroblast Embryonic fibroblast Fibroblasts taken from an embryonic as opposed to a foetal or adult source. Foetus is defined as the stage at which tissue diferentiation is initiated. Tissue taken from an embryonic as opposed to a foetal or adult source. Embryo is defined as the development stage prior to organ formation. physical association physical association 1E (RHS) H-RasV12 tp63-tp53 5 22 unspecified role unspecified role bait bait 18 unspecified role unspecified role prey prey P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain R K Wed May 02 18:54:47 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg280lys' Tue Jun 30 17:18:53 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg280Lys' physical association physical association 3A PIN1 tp63-tp53-1 7 18 unspecified role unspecified role prey prey P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain R K Wed May 02 15:42:11 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg280lys' Tue Jun 30 18:01:00 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg280Lys' P04637:p.[Ser33Ala;Ser46Ala;Thr81Ala;Ser315Ala] mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain S A certain certain sequence position certain certain certain sequence position certain S A certain certain sequence position certain certain certain sequence position certain T A certain certain sequence position certain certain certain sequence position certain S A Wed May 02 16:54:01 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser33ala,ser46ala,thr81ala,ser315ala' Tue Jun 30 19:31:49 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ser33Ala;Ser46Ala;Thr81Ala;Ser315Ala]' region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 22 unspecified role unspecified role bait bait physical association physical association 3B some of the exact (endogenous) mutations given for the cell lines are to be found at near the end of the supplement - p27, under Cell culture + constructs. (this info given here so you do not have to spend as long as I did looking for them!) tp53-bub1 8 18 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain R K Wed May 02 14:35:46 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg280lys' Tue Jun 30 17:55:57 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg280Lys' 25 unspecified role unspecified role prey prey association association 4D, S4G Mutant p53 is specifically recruited on the promoters of all the Pin1/mutant p53 signature genes, whereas on Pin1 depletion its recruitment was reduced by about 2-fold. tp53-mis18a 8 26 unspecified role unspecified role prey prey 18 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain R K Wed May 02 17:09:38 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg280lys' Tue Jun 30 16:18:37 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg280Lys' association association 4D, S4G Mutant p53 is specifically recruited on the promoters of all the Pin1/mutant p53 signature genes, whereas on Pin1 depletion its recruitment was reduced by about 2-fold. tp53-ccne2 8 13 unspecified role unspecified role prey prey 18 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain R K Wed May 02 16:58:07 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg280lys' Tue Jun 30 20:00:13 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg280Lys' association association 4D, S4G Mutant p53 is specifically recruited on the promoters of all the Pin1/mutant p53 signature genes, whereas on Pin1 depletion its recruitment was reduced by about 2-fold. tp53-cenpa 8 18 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain R K Wed May 02 18:50:16 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg280lys' Tue Jun 30 17:40:12 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg280Lys' 21 unspecified role unspecified role prey prey association association 4D, S4G Mutant p53 is specifically recruited on the promoters of all the Pin1/mutant p53 signature genes, whereas on Pin1 depletion its recruitment was reduced by about 2-fold. tp53-cpsf6 8 18 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain R K Wed May 02 19:15:06 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg280lys' Tue Jun 30 15:41:20 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg280Lys' 17 unspecified role unspecified role prey prey association association 4D, S4G Mutant p53 is specifically recruited on the promoters of all the Pin1/mutant p53 signature genes, whereas on Pin1 depletion its recruitment was reduced by about 2-fold. tp53-dep1a 8 23 unspecified role unspecified role prey prey 18 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain R K Wed May 02 14:31:45 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg280lys' Tue Jun 30 16:19:16 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg280Lys' association association 4D, S4G Mutant p53 is specifically recruited on the promoters of all the Pin1/mutant p53 signature genes, whereas on Pin1 depletion its recruitment was reduced by about 2-fold. tp53-e41lb 8 12 unspecified role unspecified role prey prey 18 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain R K Wed May 02 16:51:14 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg280lys' Tue Jun 30 18:53:17 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg280Lys' association association 4D, S4G Mutant p53 is specifically recruited on the promoters of all the Pin1/mutant p53 signature genes, whereas on Pin1 depletion its recruitment was reduced by about 2-fold. tp53-fa64a 8 18 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain R K Wed May 02 19:55:02 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg280lys' Tue Jun 30 17:50:16 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg280Lys' 20 unspecified role unspecified role prey prey association association 4D, S4G Mutant p53 is specifically recruited on the promoters of all the Pin1/mutant p53 signature genes, whereas on Pin1 depletion its recruitment was reduced by about 2-fold. tp53-cnd2 8 16 unspecified role unspecified role prey prey 18 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain R K Wed May 02 15:58:54 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg280lys' Tue Jun 30 18:56:34 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg280Lys' association association 4D, S4G Mutant p53 is specifically recruited on the promoters of all the Pin1/mutant p53 signature genes, whereas on Pin1 depletion its recruitment was reduced by about 2-fold. tp53-wdr67 8 24 unspecified role unspecified role prey prey 18 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain R K Wed May 02 20:30:22 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg280lys' Tue Jun 30 17:44:32 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg280Lys' association association 4D, S4G Mutant p53 is specifically recruited on the promoters of all the Pin1/mutant p53 signature genes, whereas on Pin1 depletion its recruitment was reduced by about 2-fold. pin1-tp53-1 8 11 unspecified role unspecified role bait bait 13 unspecified role unspecified role prey prey association association 4E, S4H Pin1 is also present on these promoters, but only in a mutant p53 dependent manner. pin1-tp53-2 8 26 unspecified role unspecified role prey prey 11 unspecified role unspecified role bait bait association association 4E, S4H Pin1 is also present on these promoters, but only in a mutant p53 dependent manner. pin1-tp53-3 8 20 unspecified role unspecified role prey prey 11 unspecified role unspecified role bait bait association association 4E, S4H Pin1 is also present on these promoters, but only in a mutant p53 dependent manner. pin1-cpsf6 8 11 unspecified role unspecified role bait bait 17 unspecified role unspecified role prey prey association association 4E, S4H Pin1 is also present on these promoters, but only in a mutant p53 dependent manner. pin1-bub1 8 11 unspecified role unspecified role bait bait 25 unspecified role unspecified role prey prey association association 4E, S4H Pin1 is also present on these promoters, but only in a mutant p53 dependent manner. pin1-tp53-4 8 11 unspecified role unspecified role bait bait 24 unspecified role unspecified role prey prey association association 4E, S4H Pin1 is also present on these promoters, but only in a mutant p53 dependent manner. pin1-tp53-5 8 11 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey association association 4E, S4H Pin1 is also present on these promoters, but only in a mutant p53 dependent manner. pin1-tp53-6 8 11 unspecified role unspecified role bait bait 21 unspecified role unspecified role prey prey association association 4E, S4H Pin1 is also present on these promoters, but only in a mutant p53 dependent manner. pin1-tp53-7 8 11 unspecified role unspecified role bait bait 16 unspecified role unspecified role prey prey association association 4E, S4H Pin1 is also present on these promoters, but only in a mutant p53 dependent manner. pin1-tp53-8 8 11 unspecified role unspecified role bait bait 23 unspecified role unspecified role prey prey association association 4E, S4H Pin1 is also present on these promoters, but only in a mutant p53 dependent manner. tp53-pin1 1 9 unspecified role unspecified role prey prey 14 unspecified role unspecified role bait bait P02340:p.Arg172His mutation mutation certain certain sequence position certain certain certain sequence position certain R H Wed May 02 15:32:56 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg169his' Tue Oct 30 13:59:44 GMT 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg169His' Tue Jun 30 19:20:30 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg172His' physical association physical association S1C H-RasV12 tp53-pin1-1 2 9 unspecified role unspecified role prey prey 14 unspecified role unspecified role bait bait P02340:p.Arg172His mutation mutation certain certain sequence position certain certain certain sequence position certain R H Wed May 02 16:03:35 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg169his' Tue Oct 30 11:32:28 GMT 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg169His' Tue Jun 30 19:49:53 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg172His' physical association physical association S1E H-RasV12 pin1-tp53-9 2 14 unspecified role unspecified role prey prey P02340:p.Arg172His mutation mutation certain certain sequence position certain certain certain sequence position certain R H Wed May 02 14:38:40 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg169his' Tue Oct 30 13:59:31 GMT 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg169His' Tue Jun 30 16:26:17 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg172His' 9 unspecified role unspecified role bait bait physical association physical association S1E H-RasV12 pin1-tp53-11 3 18 unspecified role unspecified role prey prey P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain R K Wed May 02 18:16:04 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg280lys' Tue Jun 30 17:50:53 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg280Lys' human-mda_mb_231 Homo sapiens Caucasian breast adenocarcinoma mda_mb_231 Human Caucasian breast adenocarcinoma 11 unspecified role unspecified role bait bait region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association S2B doxorubicin pin1-tp53-12 3 11 unspecified role unspecified role bait bait region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 18 unspecified role unspecified role prey prey P04637:p.Arg175His mutation mutation certain certain sequence position certain certain certain sequence position certain R H Wed May 02 20:26:21 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg175his' Tue Jun 30 18:55:55 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg175His' human-skbr3 Homo sapiens SKBR3 skbr3 SKBR3 Species: human; Tissue: breast; Tumor: adenocarcinoma; Derived from: metastatic site: pleural effusion physical association physical association S2B doxorubicin pin1-tp53-13 5 11 unspecified role unspecified role bait bait 18 unspecified role unspecified role prey prey P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain R K Wed May 02 18:18:45 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg280lys' Tue Jun 30 17:47:29 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg280Lys' physical association physical association S2C lambda phosphatase tp53-pin1-2 5 11 unspecified role unspecified role prey prey 18 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain R K Wed May 02 20:21:17 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg280lys' Tue Jun 30 18:43:47 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg280Lys' physical association physical association S2C lambda phosphatase tp53-pin1-3 6 18 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain R K Wed May 02 18:26:50 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg280lys' Tue Jun 30 18:09:19 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg280Lys' 11 unspecified role unspecified role prey prey physical association physical association S2E H-RasV12 tp53-pin1-4 4 11 unspecified role unspecified role prey prey 18 unspecified role unspecified role bait bait P04637:p.[Ser33Ala;Ser46Ala;Thr81Ala;Ser315Ala] mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain S A certain certain sequence position certain certain certain sequence position certain T A certain certain sequence position certain certain certain sequence position certain S A certain certain sequence position certain certain certain sequence position certain S A Fri Jul 22 11:00:22 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'ser46ala,thr81ala,ser33ala,ser315ala' Wed May 02 20:09:26 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser33ala,ser46ala,thr81ala,ser315ala' Tue Jun 30 20:16:36 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ser33Ala;Ser46Ala;Thr81Ala;Ser315Ala]' P04637:p.[Ser33Ala;Thr81Ala;Ser315Ala] mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain S A certain certain sequence position certain certain certain sequence position certain S A certain certain sequence position certain certain certain sequence position certain T A Fri Jul 22 11:15:25 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'ser315ala,ser33ala,thr81ala' Wed May 02 19:19:38 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser33ala,thr81ala,ser315ala' Tue Jun 30 18:14:18 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ser33Ala;Thr81Ala;Ser315Ala]' P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain R K Wed May 02 18:08:10 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg280lys' Tue Jun 30 19:14:01 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg280Lys' region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined P04637:p.[Ser33Ala;Ser46Ala;Thr81Ala] mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain T A certain certain sequence position certain certain certain sequence position certain S A certain certain sequence position certain certain certain sequence position certain S A Fri Jul 22 11:10:31 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'thr81ala,ser33ala,ser46ala' Wed May 02 20:00:47 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser33ala,ser46ala,thr81ala' Tue Jun 30 18:11:11 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ser33Ala;Ser46Ala;Thr81Ala]' physical association physical association S2O doxorubicin tp63-smad2 5 15 unspecified role unspecified role prey prey 22 unspecified role unspecified role bait bait physical association physical association S3A shRNA PIN1 tap63-pin1 5 19 unspecified role unspecified role bait bait 11 unspecified role unspecified role prey prey physical association physical association S3D lambda phosphatase pin1-tp63-2 3 10 unspecified role unspecified role prey prey human-h1299 Homo sapiens lung lymph node carcinoma h1299 Human lung lymph node carcinoma p53 null. These cells have also been reported to secrete the peptide hormone neuromedin B (NMB), but not gastrin releasing peptide (GRP). Also known as NCI H1299 or CRL-5803. http://www.lgcpromochem.com/atcc/ ATCC number: CRL-5803. ATCC number of the cell line is CRL-5803. 11 unspecified role unspecified role bait bait region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ww_domain sufficient to bind sufficient binding region sufficient to bind range range range range physical association physical association S3D (lower panel) lambda phophatase