IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Cell (0092-8674) 2010 imex curation Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu 13-Sept-2010: Contacted by JYOTI. jyoti Only protein-protein interactions human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti bait coip anti bait coimmunoprecipitation anti bait coip sequence tag sequence tag identification sequence tag Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu Accepted 2010-JUL-30 by JYOTI. Cell (0092-8674) 2010 jyoti Only protein-protein interactions imex curation Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Cell (0092-8674) 2010 imex curation Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu 13-Sept-2010: Contacted by JYOTI. jyoti Only protein-protein interactions mouse-neuron Mus musculus neuronal cell neuron Neuron [Neuronal cell; Neural cell confocal microscopy confocal microscopy immunostaining immunostaining Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis Mouse E10.5-11.5 commissural neurons UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu Accepted 2010-JUL-30 by JYOTI. 13-Sept-2010: Contacted by JYOTI. Cell (0092-8674) 2010 jyoti Only protein-protein interactions imex curation Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Cell (0092-8674) 2010 imex curation Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu 13-Sept-2010: Contacted by JYOTI. jyoti Only protein-protein interactions in vitro In vitro far western blotting far western blotting Affinity blotting Affinity blotting western blot western blot Immuno blot Immuno blot Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu Accepted 2010-JUL-30 by JYOTI. 13-Sept-2010: Contacted by JYOTI. Cell (0092-8674) 2010 jyoti Only protein-protein interactions imex curation Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Cell (0092-8674) 2010 imex curation Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu 13-Sept-2010: Contacted by JYOTI. jyoti Only protein-protein interactions human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu Accepted 2010-JUL-30 by JYOTI. 13-Sept-2010: Contacted by JYOTI. Cell (0092-8674) 2010 jyoti Only protein-protein interactions imex curation Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Cell (0092-8674) 2010 imex curation Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu 13-Sept-2010: Contacted by JYOTI. jyoti Only protein-protein interactions mouse-spinal-cord Mouse spinal cord spinal-cord spinal cord density sedimentation cosedimentation through density gradient density sedimentation western blot western blot Immuno blot Immuno blot Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis Sucrose velocity gradient UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu Accepted 2010-JUL-30 by JYOTI. 13-Sept-2010: Contacted by JYOTI. Cell (0092-8674) 2010 jyoti Only protein-protein interactions imex curation Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Cell (0092-8674) 2010 imex curation Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu 13-Sept-2010: Contacted by JYOTI. jyoti Only protein-protein interactions human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. confocal microscopy confocal microscopy immunostaining immunostaining Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis Tagged proteins visualised by tag fluorescence UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu Accepted 2010-JUL-30 by JYOTI. 13-Sept-2010: Contacted by JYOTI. Cell (0092-8674) 2010 jyoti Only protein-protein interactions imex curation Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Cell (0092-8674) 2010 imex curation Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu 13-Sept-2010: Contacted by JYOTI. jyoti Only protein-protein interactions human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. density sedimentation cosedimentation through density gradient density sedimentation western blot western blot Immuno blot Immuno blot Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis Sucrose velocity gradient UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu Accepted 2010-JUL-30 by JYOTI. 13-Sept-2010: Contacted by JYOTI. Cell (0092-8674) 2010 jyoti Only protein-protein interactions imex curation Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Cell (0092-8674) 2010 imex curation Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu 13-Sept-2010: Contacted by JYOTI. jyoti Only protein-protein interactions mouse-spinal-cord Mouse spinal cord spinal-cord spinal cord anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu Accepted 2010-JUL-30 by JYOTI. 13-Sept-2010: Contacted by JYOTI. Cell (0092-8674) 2010 jyoti Only protein-protein interactions imex curation Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Cell (0092-8674) 2010 imex curation Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu 13-Sept-2010: Contacted by JYOTI. jyoti Only protein-protein interactions chick-neuron Chick neuron neuron Neuron [Neuronal cell; Neural cell confocal microscopy confocal microscopy immunostaining immunostaining Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis Tagged proteins visualised by tag fluorescence UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu Accepted 2010-JUL-30 by JYOTI. 13-Sept-2010: Contacted by JYOTI. Cell (0092-8674) 2010 jyoti Only protein-protein interactions imex curation ezri_human Ezrin EZR VIL2 p81 Cytovillin Villin-2 protein protein human Homo sapiens Human MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL DIP protein P15311 original sequence version: 170 DIP protein P15311 original sequence version: 142 F1B592CF49A7CC46 fak1_human Focal adhesion kinase 1 PTK2 FAK FAK1 pp125FAK Protein-tyrosine kinase 2 Focal adhesion kinase-related nonkinase Protein phosphatase 1 regulatory subunit 71 p125FAK protein protein human Homo sapiens Human MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH D8A4C15138AB0243 dcc_rat Netrin receptor DCC Dcc Tumor suppressor protein DCC protein protein rat Rattus norvegicus (Rat) Rat MENSLGCVWVPKLAFVLFGASLLSAHLQVTGFQIKPFTSLHFVSEPSDAVTMRGGNVLLNCSAESDRGVPVIKWKKDGLILALGMDDRKQQLPNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVMVAGPLRFLSQTESITAFMGDTVLLKCEVIGDPMPTIHWQKNQQDLNPIPGDSRVVVLPSGALQISRLQPGDSGVYRCSARNPASTRTGNEAEVRILSDPGLHRQLYFLQRPSNVIAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGTYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECAVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQSSAQLIVPKPAIPSSSILPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLHAVSASPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYTLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSGPDVSTPMLPPVGVQAVALTHEAVRVSWADNSVPKNQKTSDVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLSLDTMYYFRIQARNAKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVITVVTVGVLTVLVVVIVAVICTRRSSAQQRKKRATHSASKRKGSQKDLRPPDLWIHHEEMEMKNIEKPAGTDPAGRGSPIQSCQDLTPVSHSQSESQMGSKSASHSGQDTEEAGSSMSTLERSLAARRATRTKLMIPMEAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRTVSEGPTAQQQPMLPPAQPEHPSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDPASVYEQDDLSEQMASLEGLMKQLNAITGSAF DIP protein Q63155 original sequence version: 91 DIP protein Q63155 original sequence version: 76 084F625954481988 rs24_human 40S ribosomal protein S24 RPS24 Small ribosomal subunit protein eS24 protein protein human Homo sapiens Human MNDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTPDVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKTSRKQRKERKNRMKKVRGTAKANVGAGKKPKE CE9065C0764D60A6 eif3e_human Eukaryotic translation initiation factor 3 subunit E EIF3E INT6 EIF3S6 Eukaryotic translation initiation factor 3 subunit 6 eIF-3 p48 Viral integration site protein INT-6 homolog protein protein human Homo sapiens Human MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDLLSDTNMVDFAMDVYKNLYSDDIPHALREKRTTVVAQLKQLQAETEPIVKMFEDPETTRQMQSTRDGRMLFDYLADKHGFRQEYLDTLYRYAKFQYECGNYSGAAEYLYFFRVLVPATDRNALSSLWGKLASEILMQNWDAAMEDLTRLKETIDNNSVSSPLQSLQQRTWLIHWSLFVFFNHPKGRDNIIDLFLYQPQYLNAIQTMCPHILRYLTTAVITNKDVRKRRQVLKDLVKVIQQESYTYKDPITEFVECLYVNFDFDGAQKKLRECESVLVNDFFLVACLEDFIENARLFIFETFCRIHQCISINMLADKLNMTPEEAERWIVNLIRNARLDAKIDSKLGHVVMGNNAVSPYQQVIEKTKSLSFRSQMLAMNIEKKLNQNSRSEAPNWATQDSGFY DIP protein P60228 original sequence version: 120 DIP protein P60228 original sequence version: 60 DIP protein P60228 original sequence version: 76 DIP protein P60228 original sequence version: 111 A5368651DD0DDD0C dcc_human Netrin receptor DCC DCC Tumor suppressor protein DCC Colorectal cancer suppressor IGDCC1 Immunoglobulin superfamily DCC subclass member 1 protein protein human Homo sapiens Human MENSLRCVWVPKLAFVLFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGKRKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSKSTSHSGQDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRSQSVSEGPTTQQPPMLPPSQPEHSSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSANVYEQDDLSEQMASLEGLMKQLNAITGSAF DIP protein P43146 original sequence version: 148 DIP protein P43146 original sequence version: 109 BC17EA0E93DE8768 rs6_human 40S ribosomal protein S6 RPS6 Phosphoprotein NP33 Small ribosomal subunit protein eS6 OK/SW-cl.2 protein protein human Homo sapiens Human MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK DIP protein P62753 original sequence version: 72 DIP protein P62753 original sequence version: 68 DIP protein P62753 original sequence version: 123 A61E435884E636AE if2g_human Eukaryotic translation initiation factor 2 subunit 3 Eukaryotic translation initiation factor 2 subunit gamma X EIF2S3 EIF2G protein protein human Homo sapiens Human MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIKPTVDDD 7A292A6AAF6DF983 ei2ba_human Translation initiation factor eIF-2B subunit alpha eIF-2B GDP-GTP exchange factor subunit alpha EIF2B1 EIF2BA protein protein human Homo sapiens Human MDDKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLASLEYSDYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKVAQTGQDLKEEHPWVDYTAPSLITLLFTDLGVLTPSAVSDELIKLYL 91A915FF1B80B780 rs10_human 40S ribosomal protein S10 RPS10 Small ribosomal subunit protein eS10 protein protein human Homo sapiens Human MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETGRPRPKGLEGERPARLTRGEADRDTYRRSAVPPGADKKAEAGAGSATEFQFRGGFGRGRGQPPQ 64106DFCD97AABA3 dcc_mouse Netrin receptor DCC Dcc Tumor suppressor protein DCC protein protein mouse Mus musculus Mouse MENSLGCVWVPKLAFVLFGASLLSAHLQVTGFQIKPFTSLHFVSEPSDAVTMRGGNVLLNCSAESDRGVPVIKWKKDGLILALGMDDRKQQLPNGSLLIQNILHSRHHKPDEGLYQCEASLADSGSIISRTAKVTVAGPLRFLSQTESITAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLNPLPGDSRVVVLPSGALQISRLQPGDSGVYRCSARNPASIRTGNEAEVRILSDPGLHRQLYFLQRPSNVIAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGTYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECAVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQSSAQLIVPKPAIPSSSILPSAPRDVLPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLHAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYTLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNISLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSGPDVSTPMLPPVGVQAVALTHEAVRVSWADNSVPKNQKTSDVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLSLDTMYYFRIQARNVKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVITVVTVGVLTVLVVVIVAVICTRRSSAQQRKKRATHSVSKRKGSQKDLRPPDLWIHHEEMEMKNIEKPTGTDPAGRDSPIQSCQDLTPVSHSQSETQMGSKSASHSGQDTEDAGSSMSTLERSLAARRATRAKLMIPMEAQSSNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRTQSVSEGPTTQQQPMLPPAQPEHPSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDPASVYEQDDLSEQMASLEGLMKQLNAITGSAF F905BE27C991EA42 if2b_human Eukaryotic translation initiation factor 2 subunit 2 Eukaryotic translation initiation factor 2 subunit beta EIF2S2 EIF2B protein protein human Homo sapiens Human MSGDEMIFDPTMSKKKKKKKKPFMLDEEGDTQTEETQPSETKEVEPEPTEDKDLEADEEDTRKKDASDDLDDLNFFNQKKKKKKTKKIFDIDEAEEGVKDLKIESDVQEPTEPEDDLDIMLGNKKKKKKNVKFPDEDEILEKDEALEDEDNKKDDGISFSNQTGPAWAGSERDYTYEELLNRVFNIMREKNPDMVAGEKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAKAN 3E9FD4B48AA61A51 dcc_chick_protein Netrin receptor DCC protein protein chick Gallus gallus (Chicken) Chicken An amino acid sequence which is not represented in UniProt Similar to P43146 - does not appear to be in Ensembl ei2bd_human Translation initiation factor eIF-2B subunit delta EIF2B4 EIF2BD eIF-2B GDP-GTP exchange factor subunit delta protein protein human Homo sapiens Human MAAVAVAVREDSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQVGPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQYSRQNSLTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYTTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELRAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSDQ 5F38CF10CAD5A45E if5a2_human Eukaryotic translation initiation factor 5A-2 Eukaryotic initiation factor 5A isoform 2 EIF5A2 protein protein human Homo sapiens Human MADEIDFTTGDAGASSTYPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDYQLICIQDGYLSLLTETGEVREDLKLPEGELGKEIEGKYNAGEDVQVSVMCAMSEEYAVAIKPCK 632BFE7F6DB073BD rl38_human 60S ribosomal protein L38 RPL38 Large ribosomal subunit protein eL38 protein protein human Homo sapiens Human MPRKIEEIKDFLLTARRKDAKSVKIKKNKDNVKFKVRCSRYLYTLVITDKEKAEKLKQSLPPGLAVKELK FDD9A107BC98DBBA if2a_human Eukaryotic translation initiation factor 2 subunit 1 EIF2S1 EIF2A Eukaryotic translation initiation factor 2 subunit alpha protein protein human Homo sapiens Human MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQMERLERENAEVDGDDDAEEMEAKAED DIP protein P05198 original sequence version: 149 FF3E75E3816E6B1E rl10a_human 60S ribosomal protein L10a RPL10A NEDD6 CSA-19 Neural precursor cell expressed developmentally down-regulated protein 6 Large ribosomal subunit protein uL1 protein protein human Homo sapiens Human MSSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPRPKFSVCVLGDQQHCDEAKAVDIPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMKKVLCLAVAVGHVKMTDDELVYNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY 38F1A31119A751D3 ei2bb_human Translation initiation factor eIF-2B subunit beta eIF-2B GDP-GTP exchange factor subunit beta S20I15 S20III15 EIF2B2 EIF2BB protein protein human Homo sapiens Human MPGSAAKGSELSERIESFVETLKRGGGPRSSEEMARETLGLLRQIITDHRWSNAGELMELIRREGRRMTAAQPSETTVGNMVRRVLKIIREEYGRLHGRSDESDQQESLHKLLTSGGLNEDFSFHYAQLQSNIIEAINELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKEAARKRKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGALRAVTGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDHVL C29FE477143F545A if4e3_human Eukaryotic translation initiation factor 4E type 3 EIF4E3 protein protein human Homo sapiens Human MALPPAAAPPAGAREPPGSRAAAAAAAPEPPLGLQQLSALQPEPGGVPLHSSWTFWLDRSLPGATAAECASNLKKIYTVQTVQIFWSVYNNIPPVTSLPLRCSYHLMRGERRPLWEEESNAKGGVWKMKVPKDSTSTVWKELLLATIGEQFTDCAAADDEVIGVSVSVRDREDVVQVWNVNASLVGEATVLEKIYELLPHITFKAVFYKPHEEHHAFEGGRGKH C724BF3A6438D728 rs6_mouse 40S ribosomal protein S6 Rps6 Phosphoprotein NP33 protein protein mouse Mus musculus Mouse MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK DIP protein P62754 original sequence version: 64 A61E435884E636AE rl23_human 60S ribosomal protein L23 RPL23 60S ribosomal protein L17 Large ribosomal subunit protein uL14 protein protein human Homo sapiens Human MSKRGRGGSSGAKFRISLGLPVGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGDMVMATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVNNKGEMKGSAITGPVAKECADLWPRIASNAGSIA DIP protein P62829 original sequence version: 116 807E14139B2EB0B5 rs13_human 40S ribosomal protein S13 RPS13 Small ribosomal subunit protein uS15 protein protein human Homo sapiens Human MGRMHAPGKGLSQSALPYRRSVPTWLKLTSDDVKEQIYKLAKKGLTPSQIGVILRDSHGVAQVRFVTGNKILRILKSKGLAPDLPEDLYHLIKKAVAVRKHLERNRKDKDAKFRLILIESRIHRLARYYKTKRVLPPNWKYESSTASALVA 23F94D38F87B8D53 rl28_human 60S ribosomal protein L28 RPL28 Large ribosomal subunit protein eL28 protein protein human Homo sapiens Human MSAHLQWMVVRNCSSFLIKRNKQTYSTEPNNLKARNSFRYNGLIHRKTVGVEPAADGKGVVVVIKRRSGQRKPATSYVRTTINKNARATLSSIRHMIRKNKYRPDLRMAAIRRASAILRSQKPVMVKRKRTRPTKSS 44DCDE45473D7C7B eif2a_mouse Eukaryotic translation initiation factor 2A Eif2a D3Ertd194e protein protein mouse Mus musculus Mouse MAPSTPLLTVRGSEGLYMVNGPPHFTESTVLPRESGRNCKVYTFSKDGTLFAWSNGEKVNIINVANKGLLHSFDLPKAVCLEFSPNNTVLATWQPYTTSKDGTAGTPNLQLYDMKTGACLKSFIQKKMQNWCPSWSDDEIICARNVNNEVHFFENNNFNTIANKLHLQKVNDFNLSPGTQPYKVAVYVPGSKGAPSFVRLYQYPNFAGPQAALANKSFFKADKVTMLWNKKATAVLVIASTEVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATVFNLKCDPVFDFGTGPRNAAFYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSLLHKYDVPSNGELWQVSWQPFLDGIFPAKTIKYQAVPSEVPSEEPKVATAYRPPALRNKPVTNSKLHEEEPPQNMKPHPGSDKPLSKTALKNQRKHEAKKAAKQEARSDAAPTPVPQSAPRNTVTQSASGDPEVDKKIKNLKKKLKAIEQLKEQAAAGKQLEKNQLEKIQKETALLQELEDLELGV D485C05ACE5D0908 rs23_human 40S ribosomal protein S23 RPS23 Small ribosomal subunit protein uS12 protein protein human Homo sapiens Human MGKCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPRS 8417A48B8CF0A8E5 rl5_human 60S ribosomal protein L5 RPL5 Large ribosomal subunit protein uL18 MSTP030 protein protein human Homo sapiens Human MGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMYKKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES DIP protein P46777 original sequence version: 147 DIP protein P46777 original sequence version: 109 07CA9FBA842BD2A3 net1_human Netrin-1 NTN1 NTN1L Epididymis tissue protein Li 131P protein protein human Homo sapiens Human MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRSCHLCNASDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQCRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARDSYFYAVSDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPVAPPTTAASSVEEPEDCDSYCKASKGKLKINMKKYCKKDYAVQIHILKADKAGDWWKFTVNIISVYKQGTSRIRRGDQSLWIRSRDIACKCPKIKPLKKYLLLGNAEDSPDQSGIVADKSSLVIQWRDTWARRLRKFQQREKKGKCKKA DIP protein O95631 original sequence version: 69 DIP protein O95631 original sequence version: 86 9827C09D0D783B27 mk01_human Mitogen-activated protein kinase 1 MAPK1 ERK2 PRKM1 Extracellular signal-regulated kinase 2 Mitogen-activated protein kinase 2 MAP kinase isoform p42 ERT1 PRKM2 protein protein human Homo sapiens Human MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS DIP protein P28482 original sequence version: 173 DIP protein P28482 original sequence version: 103 DIP protein P28482 original sequence version: 101 DIP protein P28482 original sequence version: 131 DIP protein P28482 original sequence version: 156 DIP protein P28482 original sequence version: 166 DIP protein P28482 original sequence version: 144 E85D0B2A5D2D724E eif3e_mouse Eukaryotic translation initiation factor 3 subunit E Eif3e Eif3s6 Int6 Eukaryotic translation initiation factor 3 subunit 6 eIF-3 p48 Mammary tumor-associated protein INT-6 Viral integration site protein INT-6 MMTV integration site 6 protein protein mouse Mus musculus Mouse MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDLLSDTNMVDFAMDVYKNLYSDDIPHALREKRTTVVAQLKQLQAETEPIVKMFEDPETTRQMQSTRDGRMLFDYLADKHGFRQEYLDTLYRYAKFQYECGNYSGAAEYLYFFRVLVPATDRNALSSLWGKLASEILMQNWDAAMEDLTRLKETIDNNSVSSPLQSLQQRTWLIHWSLFVFFNHPKGRDNIIDLFLYQPQYLNAIQTMCPHILRYLTTAVITNKDVRKRRQVLKDLVKVIQQESYTYKDPITEFVECLYVNFDFDGAQKKLRECESVLVNDFFLVACLEDFIENARLFIFETFCRIHQCISINMLADKLNMTPEEAERWIVNLIRNARLDAKIDSKLGHVVMGNNAVSPYQQVIEKTKSLSFRSQMLAMNIEKKLNQNSRSEAPNWATQDSGFY DIP protein P60229 original sequence version: 83 A5368651DD0DDD0C rl13_human 60S ribosomal protein L13 RPL13 BBC1 Breast basic conserved protein 1 Large ribosomal subunit protein eL13 OK/SW-cl.46 protein protein human Homo sapiens Human MAPSRNGMVLKPHFHKDWQRRVATWFNQPARKIRRRKARQAKARRIAPRPASGPIRPIVRCPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPRRRNKSTESLQANVQRLKEYRSKLILFPRKPSAPKKGDSSAEELKLATQLTGPVMPVRNVYKKEKARVITEEEKNFKAFASLRMARANARLFGIRAKRAKEAAEQDVEKKK DB9FC57768E6BEDE rl5_mouse 60S ribosomal protein L5 Rpl5 protein protein mouse Mus musculus Mouse MGFVKVVKNKAYFKRYQVRFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVNGGEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNNVTPDMMEEMYKKAHAAIRENPVYEKKPKREVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES 30D74B9E66E17C65 dcc-rpl13-1 1 14 unspecified role unspecified role prey prey 32 unspecified role unspecified role prey prey 37 unspecified role unspecified role prey prey 10 unspecified role unspecified role prey prey 11 unspecified role unspecified role prey prey 29 unspecified role unspecified role prey prey 21 unspecified role unspecified role prey prey 38 unspecified role unspecified role prey prey 24 unspecified role unspecified role prey prey 13 unspecified role unspecified role prey prey 25 unspecified role unspecified role prey prey 33 unspecified role unspecified role prey prey 18 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey 31 unspecified role unspecified role prey prey 17 unspecified role unspecified role prey prey 40 unspecified role unspecified role prey prey 15 unspecified role unspecified role bait bait 36 unspecified role unspecified role prey prey 27 unspecified role unspecified role prey prey 23 unspecified role unspecified role prey prey 28 unspecified role unspecified role prey prey association association Fig. 2A dcc-rpl13-2 4 36 unspecified role unspecified role prey prey 40 unspecified role unspecified role prey prey 15 unspecified role unspecified role bait bait 14 unspecified role unspecified role prey prey 33 unspecified role unspecified role prey prey 28 unspecified role unspecified role prey prey 23 unspecified role unspecified role prey prey 17 unspecified role unspecified role prey prey 27 unspecified role unspecified role prey prey 21 unspecified role unspecified role prey prey association association Fig. 2B dcc-rps6-1 2 30 unspecified role unspecified role neutral component neutral component 20 unspecified role unspecified role neutral component neutral component colocalization colocalization Figs. 1A-D, Supp. Figs 1A-C dcc-rpl5-1 7 16 unspecified role unspecified role neutral component neutral component 15 unspecified role unspecified role neutral component neutral component 36 unspecified role unspecified role neutral component neutral component 26 unspecified role unspecified role neutral component neutral component association association Fig. 3A eIF4E was also observed but could not be assigned to a single gene product. rpl5-rs6-1 7 26 unspecified role unspecified role neutral component neutral component 36 unspecified role unspecified role neutral component neutral component 16 unspecified role unspecified role neutral component neutral component 15 unspecified role unspecified role neutral component neutral component association association Fig. 3A eIF4E was also observed but could not be assigned to a single gene product. dcc-rpl28-1 5 15 unspecified role unspecified role neutral component neutral component 33 unspecified role unspecified role neutral component neutral component association association Fig. 3B dcc-rpl13-3 8 34 unspecified role unspecified role prey prey 41 unspecified role unspecified role prey prey 39 unspecified role unspecified role prey prey 20 unspecified role unspecified role bait bait association association Fig. 3B eIF4E was also observed but could ot be ascribed to a single gene product. dcc-rpl5-2 7 15 unspecified role unspecified role neutral component neutral component 35 unspecified role unspecified role neutral component neutral component 36 unspecified role unspecified role neutral component neutral component physical association physical association Supp. Fig. 3A DCC was in 40S, 60S and 80S fractions but was not seen prominently in the polysome fraction. S23 was in 40S, 80S and polysomal fractions; L5 was in 60S, 80S and polysomal fractions. In the presence of 25 mM EDTA to dissociate monosomes and polysomes, the 80S and polysome fractions were absent, while the 40S and 60S fractions were increased. Accordingly, L5, S23, and DCC bands were shifted to the 40S and 60S fractions, and were no longer seen in the 80S fraction. rs23-rpl5-1 7 35 unspecified role unspecified role neutral component neutral component 36 unspecified role unspecified role neutral component neutral component physical association physical association Supp. Fig. 3A DCC was in 40S, 60S and 80S fractions but was not seen prominently in the polysome fraction. S23 was in 40S, 80S and polysomal fractions; L5 was in 60S, 80S and polysomal fractions. In the presence of 25 mM EDTA to dissociate monosomes and polysomes, the 80S and polysome fractions were absent, while the 40S and 60S fractions were increased. Accordingly, L5, S23, and DCC bands were shifted to the 40S and 60S fractions, and were no longer seen in the 80S fraction. dcc-rs23-1 7 15 unspecified role unspecified role neutral component neutral component 35 unspecified role unspecified role neutral component neutral component physical association physical association Supp. Fig. 3A DCC was in 40S, 60S and 80S fractions but was not seen prominently in the polysome fraction. S23 was in 40S, 80S and polysomal fractions; L5 was in 60S, 80S and polysomal fractions. In the presence of 25 mM EDTA to dissociate monosomes and polysomes, the 80S and polysome fractions were absent, while the 40S and 60S fractions were increased. Accordingly, L5, S23, and DCC bands were shifted to the 40S and 60S fractions, and were no longer seen in the 80S fraction. dcc-rpl5-3 7 36 unspecified role unspecified role neutral component neutral component 15 unspecified role unspecified role neutral component neutral component physical association physical association Supp. Fig. 3A DCC was in 40S, 60S and 80S fractions but was not seen prominently in the polysome fraction. S23 was in 40S, 80S and polysomal fractions; L5 was in 60S, 80S and polysomal fractions. In the presence of 25 mM EDTA to dissociate monosomes and polysomes, the 80S and polysome fractions were absent, while the 40S and 60S fractions were increased. Accordingly, L5, S23, and DCC bands were shifted to the 40S and 60S fractions, and were no longer seen in the 80S fraction. dcc-rpl5-4 4 36 unspecified role unspecified role prey prey 15 unspecified role unspecified role bait bait physical association physical association Fig. 4B, Supp. 5A Expression of Netrin-1 ERK, eIF4e and S4x (small ribosomal subunit) were also observed in this interaction. dcc-rpl5-5 7 12 unspecified role unspecified role neutral component neutral component cytoplasmic region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis range range range range 35 unspecified role unspecified role neutral component neutral component 36 unspecified role unspecified role neutral component neutral component physical association physical association Fig. 4D Exact coordinates of the Dcc cytoplasmic domain were not given in the text so have been inferred from the UniProt KB entry. rpl5-dcc-1 3 36 unspecified role unspecified role bait bait region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 12 unspecified role unspecified role prey prey cytoplasmic region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis range range range range ecoli Escherichia coli (strain K12) direct interaction direct interaction Far-western dot blot quantitation of direct binding of purified recombinant DCC cytoplasmic domain to purified recombinant L5. Fig. 5C Exact coordinates of the Dcc cytoplasmic domain were not given in the text so have been inferred from the UniProt KB entry. rpl5-dcc-2 6 12 unspecified role unspecified role neutral component neutral component cytoplasmic region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis range range range range p1 region required to bind necessary binding region required to bind range range certain certain sequence position certain 36 unspecified role unspecified role neutral component neutral component region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined colocalization colocalization Immunofluorescence of DCC (red) and GFP-L5 (green) cotransfected into 293 cells, showing colocalization in neurite-like extensions, notably at the tips (arrowheads). Fig. 5H Exact coordinates of the Dcc cytoplasmic domain were not given in the text so have been inferred from the UniProt KB entry. dcc-rpl5-6 4 12 unspecified role unspecified role bait bait 36 unspecified role unspecified role prey prey physical association physical association Supp. 5A ERK, eIF4e and S4x (small ribosomal subunit) were also observed in this interaction. The P1 domain of the cytoplasm was required for the interaction with eIF4e and S4x (small ribosomal subunit) but not with ERK. rpl5-dcc-3 9 22 unspecified role unspecified role neutral component neutral component 36 unspecified role unspecified role neutral component neutral component region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined colocalization colocalization Similarly, GFP-L5 expressed in commissural neurons colocalized with DCC at filopodial tips in axon growth cones (Figure S5B). Supp. Fig. 5B