UniProt UniProt http://www.uniprot.org SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity. SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity. J. Cell. Physiol. (0021-9541) 2007 imex curation Dai J.M., Wang Z.Y., Sun D.C., Lin R.X., Wang S.Q. Apoptosis - Interactions involving proteins with a function related to apoptosis Origin of HA-tagged p73 according pmid 10321734 sgwang@nic.bmi.ac.cn 14-Mar-2012: Contacted by JYOTI. Only protein-protein interactions human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Dai J.M., Wang Z.Y., Sun D.C., Lin R.X., Wang S.Q. Apoptosis - Interactions involving proteins with a function related to apoptosis Origin of HA-tagged p73 according pmid 10321734 sgwang@nic.bmi.ac.cn Accepted 2011-NOV-18 by JYOTI 14-Mar-2012: Contacted by JYOTI. J. Cell. Physiol. (0021-9541) 2007 Only protein-protein interactions imex curation SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity. SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity. J. Cell. Physiol. (0021-9541) 2007 imex curation Dai J.M., Wang Z.Y., Sun D.C., Lin R.X., Wang S.Q. Apoptosis - Interactions involving proteins with a function related to apoptosis Origin of HA-tagged p73 according pmid 10321734 sgwang@nic.bmi.ac.cn 14-Mar-2012: Contacted by JYOTI. Only protein-protein interactions in vitro In vitro deacetylase assay deacetylase assay predetermined predetermined participant predetermined Dai J.M., Wang Z.Y., Sun D.C., Lin R.X., Wang S.Q. Apoptosis - Interactions involving proteins with a function related to apoptosis Origin of HA-tagged p73 according pmid 10321734 sgwang@nic.bmi.ac.cn Accepted 2011-NOV-18 by JYOTI 14-Mar-2012: Contacted by JYOTI. J. Cell. Physiol. (0021-9541) 2007 Only protein-protein interactions imex curation SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity. SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity. J. Cell. Physiol. (0021-9541) 2007 imex curation Dai J.M., Wang Z.Y., Sun D.C., Lin R.X., Wang S.Q. Apoptosis - Interactions involving proteins with a function related to apoptosis Origin of HA-tagged p73 according pmid 10321734 sgwang@nic.bmi.ac.cn 14-Mar-2012: Contacted by JYOTI. Only protein-protein interactions human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Dai J.M., Wang Z.Y., Sun D.C., Lin R.X., Wang S.Q. Apoptosis - Interactions involving proteins with a function related to apoptosis Origin of HA-tagged p73 according pmid 10321734 sgwang@nic.bmi.ac.cn Accepted 2011-NOV-18 by JYOTI J. Cell. Physiol. (0021-9541) 2007 Only protein-protein interactions imex curation p73_human Tumor protein p73 TP73 P73 p53-like transcription factor p53-related protein protein protein human Homo sapiens Human MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPNLGPVGPGMLNNHGHAVPANGEMSSSHSAQSMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQPIKEEFTEAEIH DIP protein O15350 original sequence version: 170 DIP protein O15350-1 original sequence version: 100 DIP protein O15350 original sequence version: 123 DIP protein O15350 original sequence version: 149 DIP protein O15350-1 original sequence version: 165 DIP protein O15350 original sequence version: 92 DIP protein O15350-1 original sequence version: 122 DIP protein O15350-1 original sequence version: 135 DIP protein O15350-1 original sequence version: 174 A467493C5D93EEE0 sir1_human NAD-dependent protein deacetylase sirtuin-1 NAD-dependent protein deacylase sirtuin-1 SIRT1 SIR2L1 SIR2-like protein 1 Regulatory protein SIR2 homolog 1 protein protein human Homo sapiens Human MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSSPERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDLKNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTDGDDQEAINEAISVKQEVTDMNYPSNKS DIP protein Q96EB6 original sequence version: 140 DIP protein Q96EB6 original sequence version: 71 DIP protein Q96EB6 original sequence version: 125 DIP protein Q96EB6 original sequence version: 115 DIP protein Q96EB6 original sequence version: 63 DIP protein Q96EB6-1 original sequence version: 102 DIP protein Q96EB6 original sequence version: 102 DIP protein Q96EB6 original sequence version: 98 DIP protein Q96EB6 original sequence version: 144 DIP protein Q96EB6 original sequence version: 120 DIP protein Q96EB6-1 original sequence version: 120 DIP protein Q96EB6 original sequence version: 113 DIP protein Q96EB6-1 original sequence version: 117 2D3BEA6D73DA229F sirt1-tp73 3 5 unspecified role unspecified role bait bait region myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 4 unspecified role unspecified role prey prey physical association physical association 3a sirt1-tp73-1 1 5 unspecified role unspecified role bait bait 4 unspecified role unspecified role prey prey physical association physical association 3b tp73-sirt1 1 5 unspecified role unspecified role prey prey 4 unspecified role unspecified role bait bait physical association physical association 3b sirt1-tp73-2 2 5 enzyme enzyme neutral component neutral component region myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. 4 enzyme target enzyme target substrate substrate neutral component neutral component region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. direct interaction direct interaction 4b