UniProt UniProt http://www.uniprot.org NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. Genes Dev. (0890-9369) 2005 mimix curation Hublitz P., Kunowska N., Mayer U.P., Muller J.M., Heyne K., Yin N., Fritzsche C., Poli C., Miguet L., Schupp I.W., van Grunsven L.A., Potiers N., van Dorsselaer A., Metzger E., Roemer K., Schule R. Apoptosis - Interactions involving proteins with a function related to apoptosis I added results concerning figure 3A and 3B, may be to delete (see data-processing comments). The retained NIR activity prevents acetylation of all core histones by the p300 histone acetyltransferase Experiments from figure 3A: omitted because participants detection by coomasie staining is not specific. Experiment from figure 3B: peptide used is not specific to a known species (because protein sequences are identical between several species). Origin of p300 is human according to PMID: 7523245 Experiments from figure 3C: omitted because H3, H2B, H2A and H4 participants are used as a mixture and cannot be mapped to a UniProt AC number. Source of KAT2B inferred from sequence length of construct produced by contributing author. roland.schuele@uniklinik-freiburg.de in vitro In vitro pull down pull down autoradiography autoradiography Hublitz P., Kunowska N., Mayer U.P., Muller J.M., Heyne K., Yin N., Fritzsche C., Poli C., Miguet L., Schupp I.W., van Grunsven L.A., Potiers N., van Dorsselaer A., Metzger E., Roemer K., Schule R. Apoptosis - Interactions involving proteins with a function related to apoptosis I added results concerning figure 3A and 3B, may be to delete (see data-processing comments). The retained NIR activity prevents acetylation of all core histones by the p300 histone acetyltransferase Experiments from figure 3A: omitted because participants detection by coomasie staining is not specific. Experiment from figure 3B: peptide used is not specific to a known species (because protein sequences are identical between several species). Origin of p300 is human according to PMID: 7523245 Experiments from figure 3C: omitted because H3, H2B, H2A and H4 participants are used as a mixture and cannot be mapped to a UniProt AC number. Source of KAT2B inferred from sequence length of construct produced by contributing author. roland.schuele@uniklinik-freiburg.de Accepted 2011-DEC-08 by ORCHARD Genes Dev. (0890-9369) 2005 mimix curation NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. Genes Dev. (0890-9369) 2005 mimix curation Hublitz P., Kunowska N., Mayer U.P., Muller J.M., Heyne K., Yin N., Fritzsche C., Poli C., Miguet L., Schupp I.W., van Grunsven L.A., Potiers N., van Dorsselaer A., Metzger E., Roemer K., Schule R. Apoptosis - Interactions involving proteins with a function related to apoptosis I added results concerning figure 3A and 3B, may be to delete (see data-processing comments). The retained NIR activity prevents acetylation of all core histones by the p300 histone acetyltransferase Experiments from figure 3A: omitted because participants detection by coomasie staining is not specific. Experiment from figure 3B: peptide used is not specific to a known species (because protein sequences are identical between several species). Origin of p300 is human according to PMID: 7523245 Experiments from figure 3C: omitted because H3, H2B, H2A and H4 participants are used as a mixture and cannot be mapped to a UniProt AC number. Source of KAT2B inferred from sequence length of construct produced by contributing author. roland.schuele@uniklinik-freiburg.de human-hct116 Human colon carcinoma HCT116 cells hct116 Human colon carcinoma line HCT116 anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Hublitz P., Kunowska N., Mayer U.P., Muller J.M., Heyne K., Yin N., Fritzsche C., Poli C., Miguet L., Schupp I.W., van Grunsven L.A., Potiers N., van Dorsselaer A., Metzger E., Roemer K., Schule R. Apoptosis - Interactions involving proteins with a function related to apoptosis I added results concerning figure 3A and 3B, may be to delete (see data-processing comments). The retained NIR activity prevents acetylation of all core histones by the p300 histone acetyltransferase Experiments from figure 3A: omitted because participants detection by coomasie staining is not specific. Experiment from figure 3B: peptide used is not specific to a known species (because protein sequences are identical between several species). Origin of p300 is human according to PMID: 7523245 Experiments from figure 3C: omitted because H3, H2B, H2A and H4 participants are used as a mixture and cannot be mapped to a UniProt AC number. Source of KAT2B inferred from sequence length of construct produced by contributing author. roland.schuele@uniklinik-freiburg.de Accepted 2011-DEC-08 by ORCHARD Genes Dev. (0890-9369) 2005 mimix curation NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. Genes Dev. (0890-9369) 2005 mimix curation Hublitz P., Kunowska N., Mayer U.P., Muller J.M., Heyne K., Yin N., Fritzsche C., Poli C., Miguet L., Schupp I.W., van Grunsven L.A., Potiers N., van Dorsselaer A., Metzger E., Roemer K., Schule R. Apoptosis - Interactions involving proteins with a function related to apoptosis I added results concerning figure 3A and 3B, may be to delete (see data-processing comments). The retained NIR activity prevents acetylation of all core histones by the p300 histone acetyltransferase Experiments from figure 3A: omitted because participants detection by coomasie staining is not specific. Experiment from figure 3B: peptide used is not specific to a known species (because protein sequences are identical between several species). Origin of p300 is human according to PMID: 7523245 Experiments from figure 3C: omitted because H3, H2B, H2A and H4 participants are used as a mixture and cannot be mapped to a UniProt AC number. Source of KAT2B inferred from sequence length of construct produced by contributing author. roland.schuele@uniklinik-freiburg.de human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. tap tandem affinity purification TAP TAP tap sequence tag sequence tag identification sequence tag Hublitz P., Kunowska N., Mayer U.P., Muller J.M., Heyne K., Yin N., Fritzsche C., Poli C., Miguet L., Schupp I.W., van Grunsven L.A., Potiers N., van Dorsselaer A., Metzger E., Roemer K., Schule R. Apoptosis - Interactions involving proteins with a function related to apoptosis I added results concerning figure 3A and 3B, may be to delete (see data-processing comments). The retained NIR activity prevents acetylation of all core histones by the p300 histone acetyltransferase Experiments from figure 3A: omitted because participants detection by coomasie staining is not specific. Experiment from figure 3B: peptide used is not specific to a known species (because protein sequences are identical between several species). Origin of p300 is human according to PMID: 7523245 Experiments from figure 3C: omitted because H3, H2B, H2A and H4 participants are used as a mixture and cannot be mapped to a UniProt AC number. Source of KAT2B inferred from sequence length of construct produced by contributing author. roland.schuele@uniklinik-freiburg.de Accepted 2011-DEC-08 by ORCHARD Genes Dev. (0890-9369) 2005 mimix curation NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. Genes Dev. (0890-9369) 2005 mimix curation Hublitz P., Kunowska N., Mayer U.P., Muller J.M., Heyne K., Yin N., Fritzsche C., Poli C., Miguet L., Schupp I.W., van Grunsven L.A., Potiers N., van Dorsselaer A., Metzger E., Roemer K., Schule R. Apoptosis - Interactions involving proteins with a function related to apoptosis I added results concerning figure 3A and 3B, may be to delete (see data-processing comments). The retained NIR activity prevents acetylation of all core histones by the p300 histone acetyltransferase Experiments from figure 3A: omitted because participants detection by coomasie staining is not specific. Experiment from figure 3B: peptide used is not specific to a known species (because protein sequences are identical between several species). Origin of p300 is human according to PMID: 7523245 Experiments from figure 3C: omitted because H3, H2B, H2A and H4 participants are used as a mixture and cannot be mapped to a UniProt AC number. Source of KAT2B inferred from sequence length of construct produced by contributing author. roland.schuele@uniklinik-freiburg.de mesau-bhk Mesocricetus auratus baby kidney cell line BHK bhk Golden (Syrian) Hamster baby kidney cell line BHK Established from the kidneys of five unsexed, one-day-old hamsters in 1961. anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Hublitz P., Kunowska N., Mayer U.P., Muller J.M., Heyne K., Yin N., Fritzsche C., Poli C., Miguet L., Schupp I.W., van Grunsven L.A., Potiers N., van Dorsselaer A., Metzger E., Roemer K., Schule R. Apoptosis - Interactions involving proteins with a function related to apoptosis I added results concerning figure 3A and 3B, may be to delete (see data-processing comments). The retained NIR activity prevents acetylation of all core histones by the p300 histone acetyltransferase Experiments from figure 3A: omitted because participants detection by coomasie staining is not specific. Experiment from figure 3B: peptide used is not specific to a known species (because protein sequences are identical between several species). Origin of p300 is human according to PMID: 7523245 Experiments from figure 3C: omitted because H3, H2B, H2A and H4 participants are used as a mixture and cannot be mapped to a UniProt AC number. Source of KAT2B inferred from sequence length of construct produced by contributing author. roland.schuele@uniklinik-freiburg.de Accepted 2011-DEC-08 by ORCHARD Genes Dev. (0890-9369) 2005 mimix curation NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. Genes Dev. (0890-9369) 2005 mimix curation Hublitz P., Kunowska N., Mayer U.P., Muller J.M., Heyne K., Yin N., Fritzsche C., Poli C., Miguet L., Schupp I.W., van Grunsven L.A., Potiers N., van Dorsselaer A., Metzger E., Roemer K., Schule R. Apoptosis - Interactions involving proteins with a function related to apoptosis I added results concerning figure 3A and 3B, may be to delete (see data-processing comments). The retained NIR activity prevents acetylation of all core histones by the p300 histone acetyltransferase Experiments from figure 3A: omitted because participants detection by coomasie staining is not specific. Experiment from figure 3B: peptide used is not specific to a known species (because protein sequences are identical between several species). Origin of p300 is human according to PMID: 7523245 Experiments from figure 3C: omitted because H3, H2B, H2A and H4 participants are used as a mixture and cannot be mapped to a UniProt AC number. Source of KAT2B inferred from sequence length of construct produced by contributing author. roland.schuele@uniklinik-freiburg.de human-hct116 Human colon carcinoma HCT116 cells hct116 Human colon carcinoma line HCT116 anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Hublitz P., Kunowska N., Mayer U.P., Muller J.M., Heyne K., Yin N., Fritzsche C., Poli C., Miguet L., Schupp I.W., van Grunsven L.A., Potiers N., van Dorsselaer A., Metzger E., Roemer K., Schule R. Apoptosis - Interactions involving proteins with a function related to apoptosis I added results concerning figure 3A and 3B, may be to delete (see data-processing comments). The retained NIR activity prevents acetylation of all core histones by the p300 histone acetyltransferase Experiments from figure 3A: omitted because participants detection by coomasie staining is not specific. Experiment from figure 3B: peptide used is not specific to a known species (because protein sequences are identical between several species). Origin of p300 is human according to PMID: 7523245 Experiments from figure 3C: omitted because H3, H2B, H2A and H4 participants are used as a mixture and cannot be mapped to a UniProt AC number. Source of KAT2B inferred from sequence length of construct produced by contributing author. roland.schuele@uniklinik-freiburg.de Accepted 2011-DEC-08 by ORCHARD Genes Dev. (0890-9369) 2005 mimix curation NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. Genes Dev. (0890-9369) 2005 mimix curation Hublitz P., Kunowska N., Mayer U.P., Muller J.M., Heyne K., Yin N., Fritzsche C., Poli C., Miguet L., Schupp I.W., van Grunsven L.A., Potiers N., van Dorsselaer A., Metzger E., Roemer K., Schule R. Apoptosis - Interactions involving proteins with a function related to apoptosis I added results concerning figure 3A and 3B, may be to delete (see data-processing comments). The retained NIR activity prevents acetylation of all core histones by the p300 histone acetyltransferase Experiments from figure 3A: omitted because participants detection by coomasie staining is not specific. Experiment from figure 3B: peptide used is not specific to a known species (because protein sequences are identical between several species). Origin of p300 is human according to PMID: 7523245 Experiments from figure 3C: omitted because H3, H2B, H2A and H4 participants are used as a mixture and cannot be mapped to a UniProt AC number. Source of KAT2B inferred from sequence length of construct produced by contributing author. roland.schuele@uniklinik-freiburg.de human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Hublitz P., Kunowska N., Mayer U.P., Muller J.M., Heyne K., Yin N., Fritzsche C., Poli C., Miguet L., Schupp I.W., van Grunsven L.A., Potiers N., van Dorsselaer A., Metzger E., Roemer K., Schule R. Apoptosis - Interactions involving proteins with a function related to apoptosis I added results concerning figure 3A and 3B, may be to delete (see data-processing comments). The retained NIR activity prevents acetylation of all core histones by the p300 histone acetyltransferase Experiments from figure 3A: omitted because participants detection by coomasie staining is not specific. Experiment from figure 3B: peptide used is not specific to a known species (because protein sequences are identical between several species). Origin of p300 is human according to PMID: 7523245 Experiments from figure 3C: omitted because H3, H2B, H2A and H4 participants are used as a mixture and cannot be mapped to a UniProt AC number. Source of KAT2B inferred from sequence length of construct produced by contributing author. roland.schuele@uniklinik-freiburg.de Accepted 2011-DEC-08 by ORCHARD Genes Dev. (0890-9369) 2005 mimix curation NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. Genes Dev. (0890-9369) 2005 mimix curation Hublitz P., Kunowska N., Mayer U.P., Muller J.M., Heyne K., Yin N., Fritzsche C., Poli C., Miguet L., Schupp I.W., van Grunsven L.A., Potiers N., van Dorsselaer A., Metzger E., Roemer K., Schule R. Apoptosis - Interactions involving proteins with a function related to apoptosis I added results concerning figure 3A and 3B, may be to delete (see data-processing comments). The retained NIR activity prevents acetylation of all core histones by the p300 histone acetyltransferase Experiments from figure 3A: omitted because participants detection by coomasie staining is not specific. Experiment from figure 3B: peptide used is not specific to a known species (because protein sequences are identical between several species). Origin of p300 is human according to PMID: 7523245 Experiments from figure 3C: omitted because H3, H2B, H2A and H4 participants are used as a mixture and cannot be mapped to a UniProt AC number. Source of KAT2B inferred from sequence length of construct produced by contributing author. roland.schuele@uniklinik-freiburg.de mesau-bhk Mesocricetus auratus baby kidney cell line BHK bhk Golden (Syrian) Hamster baby kidney cell line BHK Established from the kidneys of five unsexed, one-day-old hamsters in 1961. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Hublitz P., Kunowska N., Mayer U.P., Muller J.M., Heyne K., Yin N., Fritzsche C., Poli C., Miguet L., Schupp I.W., van Grunsven L.A., Potiers N., van Dorsselaer A., Metzger E., Roemer K., Schule R. Apoptosis - Interactions involving proteins with a function related to apoptosis I added results concerning figure 3A and 3B, may be to delete (see data-processing comments). The retained NIR activity prevents acetylation of all core histones by the p300 histone acetyltransferase Experiments from figure 3A: omitted because participants detection by coomasie staining is not specific. Experiment from figure 3B: peptide used is not specific to a known species (because protein sequences are identical between several species). Origin of p300 is human according to PMID: 7523245 Experiments from figure 3C: omitted because H3, H2B, H2A and H4 participants are used as a mixture and cannot be mapped to a UniProt AC number. Source of KAT2B inferred from sequence length of construct produced by contributing author. roland.schuele@uniklinik-freiburg.de Accepted 2011-DEC-08 by ORCHARD Genes Dev. (0890-9369) 2005 mimix curation NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. Genes Dev. (0890-9369) 2005 mimix curation Hublitz P., Kunowska N., Mayer U.P., Muller J.M., Heyne K., Yin N., Fritzsche C., Poli C., Miguet L., Schupp I.W., van Grunsven L.A., Potiers N., van Dorsselaer A., Metzger E., Roemer K., Schule R. Apoptosis - Interactions involving proteins with a function related to apoptosis I added results concerning figure 3A and 3B, may be to delete (see data-processing comments). The retained NIR activity prevents acetylation of all core histones by the p300 histone acetyltransferase Experiments from figure 3A: omitted because participants detection by coomasie staining is not specific. Experiment from figure 3B: peptide used is not specific to a known species (because protein sequences are identical between several species). Origin of p300 is human according to PMID: 7523245 Experiments from figure 3C: omitted because H3, H2B, H2A and H4 participants are used as a mixture and cannot be mapped to a UniProt AC number. Source of KAT2B inferred from sequence length of construct produced by contributing author. roland.schuele@uniklinik-freiburg.de in vitro In vitro acetylase assay acetylase assay autoradiography autoradiography Hublitz P., Kunowska N., Mayer U.P., Muller J.M., Heyne K., Yin N., Fritzsche C., Poli C., Miguet L., Schupp I.W., van Grunsven L.A., Potiers N., van Dorsselaer A., Metzger E., Roemer K., Schule R. Apoptosis - Interactions involving proteins with a function related to apoptosis I added results concerning figure 3A and 3B, may be to delete (see data-processing comments). The retained NIR activity prevents acetylation of all core histones by the p300 histone acetyltransferase Experiments from figure 3A: omitted because participants detection by coomasie staining is not specific. Experiment from figure 3B: peptide used is not specific to a known species (because protein sequences are identical between several species). Origin of p300 is human according to PMID: 7523245 Experiments from figure 3C: omitted because H3, H2B, H2A and H4 participants are used as a mixture and cannot be mapped to a UniProt AC number. Source of KAT2B inferred from sequence length of construct produced by contributing author. roland.schuele@uniklinik-freiburg.de Accepted 2011-DEC-08 by ORCHARD Genes Dev. (0890-9369) 2005 mimix curation h32_human Histone H3.2 H3C13 H3C14 H3C15 H3-clustered histone 13 H3-clustered histone 14 H3-clustered histone 15 H3F2 H3FM HIST2H3A HIST2H3C HIST2H3D Histone H3/m Histone H3/o protein protein human Homo sapiens Human MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA DIP protein Q71DI3 original sequence version: 82 DIP protein Q71DI3 original sequence version: 133 DIP protein Q71DI3 original sequence version: 140 DIP protein Q71DI3 original sequence version: 107 6FD8508EA50A0EEC p53_human Cellular tumor antigen p53 TP53 P53 Tumor suppressor p53 Phosphoprotein p53 Antigen NY-CO-13 protein protein human Homo sapiens Human MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD DIP protein P04637 original sequence version: 121 DIP protein P04637 original sequence version: 115 DIP protein P04637-1 original sequence version: 224 DIP protein P04637 original sequence version: 117 DIP protein P04637-1 original sequence version: 226 DIP protein P04637 original sequence version: 226 DIP protein P04637 original sequence version: 212 DIP protein P04637 original sequence version: 220 DIP protein P04637-1 original sequence version: 220 DIP protein P04637-1 original sequence version: 145 DIP protein P04637 original sequence version: 146 DIP protein P04637 original sequence version: 145 DIP protein P04637 original sequence version: 166 DIP protein P04637-1 original sequence version: 166 DIP protein P04637 original sequence version: 169 DIP protein P04637 original sequence version: 177 DIP protein P04637 original sequence version: 175 DIP protein P04637-1 original sequence version: 175 DIP protein P04637-1 original sequence version: 172 DIP protein P04637-1 original sequence version: 169 DIP protein P04637 original sequence version: 170 DIP protein P04637 original sequence version: 172 DIP protein P04637-1 original sequence version: 194 DIP protein P04637 original sequence version: 196 DIP protein P04637 original sequence version: 185 DIP protein P04637-1 original sequence version: 191 DIP protein P04637 original sequence version: 191 DIP protein P04637 original sequence version: 180 DIP protein P04637-1 original sequence version: 197 DIP protein P04637 original sequence version: 183 DIP protein P04637-1 original sequence version: 183 DIP protein P04637-1 original sequence version: 185 DIP protein P04637 original sequence version: 199 DIP protein P04637 original sequence version: 201 DIP protein P04637 original sequence version: 189 DIP protein P04637 original sequence version: 235 DIP protein P04637 original sequence version: 230 DIP protein P04637 original sequence version: 234 DIP protein P04637-1 original sequence version: 234 DIP protein P04637-1 original sequence version: 235 DIP protein P04637 original sequence version: 239 DIP protein P04637-1 original sequence version: 212 DIP protein P04637-1 original sequence version: 213 DIP protein P04637 original sequence version: 213 DIP protein P04637 original sequence version: 206 DIP protein P04637-1 original sequence version: 188 DIP protein P04637-1 original sequence version: 228 DIP protein P04637 original sequence version: 208 DIP protein P04637 original sequence version: 240 DIP protein P04637-1 original sequence version: 240 DIP protein P04637 original sequence version: 204 DIP protein P04637-1 original sequence version: 204 DIP protein P04637-1 original sequence version: 209 DIP protein P04637-1 original sequence version: 203 DIP protein P04637 original sequence version: 221 DIP protein P04637-1 original sequence version: 152 DIP protein P04637 original sequence version: 217 DIP protein P04637-1 original sequence version: 140 DIP protein P04637 original sequence version: 215 DIP protein P04637 original sequence version: 214 DIP protein P04637-1 original sequence version: 182 DIP protein P04637 original sequence version: 182 DIP protein P04637 original sequence version: 188 DIP protein P04637 original sequence version: 192 DIP protein P04637-1 original sequence version: 192 DIP protein P04637 original sequence version: 218 DIP protein P04637-1 original sequence version: 218 AD5C149FD8106131 h4_drome Histone H4 H4 His4r H4r CG3379 His4:CG31611 CG31611 His4 His4:CG33869 His4:CG33871 His4:CG33873 His4:CG33875 His4:CG33877 His4:CG33879 His4:CG33881 His4:CG33883 His4:CG33885 His4:CG33887 His4:CG33889 His4:CG33891 His4:CG33893 His4:CG33895 His4:CG33897 His4:CG33899 His4:CG33901 His4:CG33903 His4:CG33905 His4:CG33907 His4:CG33909 CG33869 CG33871 CG33873 CG33875 CG33877 CG33879 CG33881 CG33883 CG33885 CG33887 CG33889 CG33891 CG33893 CG33895 CG33897 CG33899 CG33901 CG33903 CG33905 CG33907 CG33909 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MTGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG DIP protein P84040 original sequence version: 97 DIP protein P84040 original sequence version: 36 DIP protein P84040 original sequence version: 50 DF3EB26393BD208C h3_drome Histone H3 His3 His3:CG31613 His3:CG33857 His3:CG33860 His3:CG33863 His3:CG33866 CG31613 CG33803 CG33806 CG33809 CG33812 CG33815 CG33818 CG33821 CG33824 CG33827 CG33830 CG33833 CG33836 CG33839 CG33842 CG33845 CG33848 CG33851 CG33854 CG33857 CG33860 CG33863 CG33866 His3:CG33803 His3:CG33806 His3:CG33809 His3:CG33812 His3:CG33815 His3:CG33818 His3:CG33821 His3:CG33824 His3:CG33827 His3:CG33830 His3:CG33833 His3:CG33836 His3:CG33839 His3:CG33842 His3:CG33845 His3:CG33848 His3:CG33851 His3:CG33854 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA DIP protein P02299 original sequence version: 100 6FD8508EA50A0EEC noc2l_human Nucleolar complex protein 2 homolog NOC2-like protein NOC2L NIR Novel INHAT repressor protein protein human Homo sapiens Human MAAAGSRKRRLAELTVDEFLASGFDSESESESENSPQAETREAREAARSPDKPGGSPSASRRKGRASEHKDQLSRLKDRDPEFYKFLQENDQSLLNFSDSDSSEEEEGPFHSLPDVLEEASEEEDGAEEGEDGDRVPRGLKGKKNSVPVTVAMVERWKQAAKQRLTPKLFHEVVQAFRAAVATTRGDQESAEANKFQVTDSAAFNALVTFCIRDLIGCLQKLLFGKVAKDSSRMLQPSSSPLWGKLRVDIKAYLGSAIQLVSCLSETTVLAAVLRHISVLVPCFLTFPKQCRMLLKRMVIVWSTGEESLRVLAFLVLSRVCRHKKDTFLGPVLKQMYITYVRNCKFTSPGALPFISFMQWTLTELLALEPGVAYQHAFLYIRQLAIHLRNAMTTRKKETYQSVYNWQYVHCLFLWCRVLSTAGPSEALQPLVYPLAQVIIGCIKLIPTARFYPLRMHCIRALTLLSGSSGAFIPVLPFILEMFQQVDFNRKPGRMSSKPINFSVILKLSNVNLQEKAYRDGLVEQLYDLTLEYLHSQAHCIGFPELVLPVVLQLKSFLRECKVANYCRQVQQLLGKVQENSAYICSRRQRVSFGVSEQQAVEAWEKLTREEGTPLTLYYSHWRKLRDREIQLEISGKERLEDLNFPEIKRRKMADRKDEDRKQFKDLFDLNSSEEDDTEGFSERGILRPLSTRHGVEDDEEDEEEGEEDSSNSEDGDPDAEAGLAPGELQQLAQGPEDELEDLQLSEDD B178FE65E711CFDB kat2b_human Histone acetyltransferase KAT2B P300/CBP-associated factor PCAF Lysine acetyltransferase 2B Histone acetyltransferase PCAF KAT2B Spermidine acetyltransferase KAT2B protein protein human Homo sapiens Human MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEEDADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAKERQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPRYETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQNSPIWDQDFLSASSRTSQLGIQTVINPPPVAGTISYNSTSSSLEQPNAGSSSPACKASSGLEANPGEKRKMTDSHVLEEAKKPRVMGDIPMELINEVMSTITDPAAMLGPETNFLSAHSARDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHDILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFSVIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSKEPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK DIP protein Q92831 original sequence version: 159 DIP protein Q92831 original sequence version: 153 DIP protein Q92831 original sequence version: 84 72F516E8BC00CC0C h33_human Histone H3.3 H3-3A H3-3B H3.3A H3.3B H3F3 H3F3A H3F3B PP781 protein protein human Homo sapiens Human MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA DIP protein P84243 original sequence version: 72 DIP protein P84243 original sequence version: 73 DIP protein P84243 original sequence version: 97 DIP protein P84243 original sequence version: 125 DIP protein P84243 original sequence version: 110 DIP protein P84243 original sequence version: 96 5158ED279E6F9E1C h31_human Histone H3.1 H3FA H3FL H3FD H3FI H3FH H3FK H3FF H3FJ H3FB Histone H3/a Histone H3/b Histone H3/c Histone H3/d Histone H3/f Histone H3/h Histone H3/i Histone H3/j Histone H3/k Histone H3/l H3C1 HIST1H3A H3C2 HIST1H3B H3C3 H3FC HIST1H3C H3C4 HIST1H3D H3C6 HIST1H3E H3C7 HIST1H3F H3C8 HIST1H3G H3C10 HIST1H3H H3C11 HIST1H3I H3C12 HIST1H3J protein protein human Homo sapiens Human MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA DIP protein P68431 original sequence version: 78 DIP protein P68431 original sequence version: 79 DIP protein P68431 original sequence version: 76 DIP protein P68431 original sequence version: 92 DIP protein P68431 original sequence version: 87 DIP protein P68431 original sequence version: 101 DIP protein P68431 original sequence version: 130 DIP protein P68431 original sequence version: 115 9B89008EA50A0EF6 hist1h3a-noc2l 1 13 unspecified role unspecified role prey prey 16 unspecified role unspecified role bait bait physical association physical association 3B his4r-kat2b 8 14 enzyme enzyme neutral component neutral component 11 enzyme target enzyme target substrate substrate neutral component neutral component physical association physical association supplementary fig.5 (lower panel) noc2l-tp53-1 3 13 unspecified role unspecified role bait bait 10 unspecified role unspecified role prey prey association association Supplementary fig 9 tp53-noc2l 1 10 unspecified role unspecified role bait bait 13 unspecified role unspecified role prey prey direct interaction direct interaction 5B tp53-noc2l-1 4 10 unspecified role unspecified role bait bait 13 unspecified role unspecified role prey prey physical association physical association Supplementary Fig 11B noc2l-tp53-2 4 13 unspecified role unspecified role bait bait 10 unspecified role unspecified role prey prey physical association physical association 5C noc2l-tp53-4 6 10 unspecified role unspecified role prey prey 13 unspecified role unspecified role bait bait physical association physical association 5D (Upper panel) noc2l-tp53-5 2 13 unspecified role unspecified role bait bait 10 unspecified role unspecified role prey prey physical association physical association 5D (lower panel) noc2l-tp53-6 5 13 unspecified role unspecified role bait bait 10 unspecified role unspecified role prey prey physical association physical association Supplementary Fig. 11A his3-his4r 8 14 enzyme enzyme neutral component neutral component 12 enzyme target enzyme target substrate substrate neutral component neutral component physical association physical association supplementary fig.5 (lower panel) tp53-noc2l-2 7 13 unspecified role unspecified role prey prey 10 unspecified role unspecified role bait bait physical association physical association Supplementary Fig 11B hist2h3a-noc2l 1 13 unspecified role unspecified role prey prey 9 unspecified role unspecified role bait bait physical association physical association 3B h3f3a-noc2l 1 13 unspecified role unspecified role prey prey 15 unspecified role unspecified role bait bait physical association physical association 3B