IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Crystal structure of the apoptosis-inducing human granzyme A dimer. Crystal structure of the apoptosis-inducing human granzyme A dimer. Nat. Struct. Biol. (1072-8368) 2003 Hink-Schauer C., Estebanez-Perpina E., Kurschus FC., Bode W., Jenne DE. Apoptosis - Interactions involving proteins with a function related to apoptosis in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Hink-Schauer C., Estebanez-Perpina E., Kurschus FC., Bode W., Jenne DE. Apoptosis - Interactions involving proteins with a function related to apoptosis Nat. Struct. Biol. (1072-8368) 2003 graa_human Granzyme A Granzyme-1 Cytotoxic T-lymphocyte proteinase 1 Hanukkah factor CTL tryptase Fragmentin-1 GZMA CTLA3 HFSP protein protein human Homo sapiens Human MRNSYRFLASSLSVVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCNLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLMEKAKINKYVTILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCNDRNHYNFNPVIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKHLNWIIMTIKGAV FD773628BA6F301B gzma-gzma-1 1 2 unspecified role unspecified role neutral component neutral component cys 105 binding region binding-associated region binding region x-ray diffraction x-ray crystallography X-ray x-ray diffraction X-ray certain certain sequence position certain certain certain sequence position certain granzyme a binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain cys 179 binding region binding-associated region binding region x-ray diffraction x-ray crystallography X-ray x-ray diffraction X-ray certain certain sequence position certain certain certain sequence position certain cys 197 binding region binding-associated region binding region x-ray diffraction x-ray crystallography X-ray x-ray diffraction X-ray certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) 2 unspecified role unspecified role neutral component neutral component cys 105 binding region binding-associated region binding region x-ray diffraction x-ray crystallography X-ray x-ray diffraction X-ray certain certain sequence position certain certain certain sequence position certain granzyme a binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain cys 197 binding region binding-associated region binding region x-ray diffraction x-ray crystallography X-ray x-ray diffraction X-ray certain certain sequence position certain certain certain sequence position certain cys 179 binding region binding-associated region binding region x-ray diffraction x-ray crystallography X-ray x-ray diffraction X-ray certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) 10 5 7 8 12 13 covalent binding covalent binding A disulfide bond between the two cys93 links the two dimers. An intramolecular disulfide bond links Cys179 and Cys197 in each monomer. 2.50 working 21.8%, free 28.4%