IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Analysis of the subunit composition of complex I from bovine heart mitochondria. Analysis of the subunit composition of complex I from bovine heart mitochondria. Mol. Cell Proteomics (1535-9476) 2003 imex curation Carroll J., Fearnley IM., Shannon RJ., Hirst J., Walker JE. Apoptosis - Interactions involving proteins with a function related to apoptosis Complexes isolated from bovine heart and purified by ammonium sulphate precipitation followed by gel filtration. Sub-complexes were further separated on a salt gradient over an ion exchange column. Proteins were separated by 2D gel electrophoresis and identified following MALD-TOF and Q-TOF mass spectometry. jh@mrc-dunn.cam.ac.uk 26-APR-2007: Contacted by JYOTI. Only protein-protein interactions bovin-heart Bos taurus heast heart Heart [Cardiac; Cardiac tissue] chromatography chromatography technology column chromatography chromatography fingerprinting peptide massfingerprinting fingerprinting Carroll J., Fearnley IM., Shannon RJ., Hirst J., Walker JE. Apoptosis - Interactions involving proteins with a function related to apoptosis Complexes isolated from bovine heart and purified by ammonium sulphate precipitation followed by gel filtration. Sub-complexes were further separated on a salt gradient over an ion exchange column. Proteins were separated by 2D gel electrophoresis and identified following MALD-TOF and Q-TOF mass spectometry. jh@mrc-dunn.cam.ac.uk Accepted 2007-MAY-11 by DAVET. 26-APR-2007: Contacted by JYOTI. Mol. Cell Proteomics (1535-9476) 2003 Only protein-protein interactions imex curation nu5m_bovin NADH-ubiquinone oxidoreductase chain 5 MT-ND5 MTND5 NADH5 ND5 NADH dehydrogenase subunit 5 protein protein bovin Bos taurus (Bovine) Bovine MNMFSSLSLVTLLLLTMPIMMMSFNTYKPSNYPLYVKTAISYAFITSMIPTMMFIHSGQELIISNWHWLTIQTLKLSLSFKMDYFSMMFIPVALFVTWSIMEFSMWYMYSDPNINKFFKYLLLFLITMLILVTANNLFQLFIGWEGVGIMSFLLIGWWYGRADANTAALQAILYNRIGDIGFILAMAWFLTNLNTWDLQQIFMLNPSDSNMPLIGLALAATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFYPLTENNKYIQSITLCLGAITTLFTAMCALTQNDIKKIIAFSTSSQLGLMMVTIGINQPYLAFLHICTHAFFKAMLFMCSGSIIHSLNDEQDIRKMGGLFKAMPFTTTALIVGSLALTGMPFLTGFYSKDLIIEAANTSYTNAWALLMTLIATSFTAIYSTRIIFFALLGQPRFPTLVNINENNPLLINSIKRLLIGSLFAGYIISNNIPPTTIPQMTMPYYLKTTALIVTILGFILALEISNMTKNLKYHYPSNAFKFSTLLGYFPTIMHRLAPYMNLSMSQKSASSLLDLIWLEAILPKTISLAQMKASTLVTNQKGLIKLYFLSFLITILISMILFNFHE 3DC4371F0328B068 nduv2_bovin NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 NADH-ubiquinone oxidoreductase 24 kDa subunit NADH dehydrogenase subunit II protein protein bovin Bos taurus (Bovine) Bovine MFLSAALRARAAGLAAHWGKHIRNLHKTAVQNGAGGALFVHRDTPENNPETPFDFTPENYKRIEAIVKNYPEGHKAAAVLPVLDLAQRQNGWLPISAMNKVAEILQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRNSDSILEAIQKKLGIKVGETTPDKLFTLIEVECLGACVNAPMVQINDNYYEDLTPKDIEEIIDELKAGKIPKPGPRSGRFSCEPAGGLTSLTEPPKGPGFGVQAGL 8F7E8259F08EBF65 ndus8_bovin NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 NADH-ubiquinone oxidoreductase 23 kDa subunit Complex I-23kD TYKY subunit protein protein bovin Bos taurus (Bovine) Bovine MRCLTMPMLLRALAQAQAARAGHASVRGLHSSAVAATYKYVNLREPSMDMKSVTDRAAQTLLWTELIRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAVCPAQAITIEAEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNGDKWEAEIAANIQADYLYR 4D5F95E4C918FEF8 nduac_bovin NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 NADH-ubiquinone oxidoreductase subunit B17.2 Complex I-B17.2 protein protein bovin Bos taurus (Bovine) Bovine MELLQVLKRGLQQVSGHGGLRGYLRVLFRANDVRVGTLVGEDKYGNKYYEDNKQFFGRHRWVIYTTEMNGKNTFWDVDGSMVPPEWHRWLHCMTDDPPTVKPPTARKFIWTNHKFNLSGTPQQYVPYSTTRKKIQEWVPPSTPYK 7471348CC3AD53C7 ndub5_bovin NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 NADH-ubiquinone oxidoreductase SGDH subunit Complex I-SGDH protein protein bovin Bos taurus (Bovine) Bovine MAAMSLLHRASVSAVAALSGRRLGTRLGFGGFLTRDFPKTVAPVRHSGDHGKRLFIIKPSGFYDKRFLKLLRFYILLTGIPVAIGITLINVFIGEAELAEIPEGYVPEHWEYFKHPISRWIARTFFDGPEKNYERTMAILQIEAEKAELRLKELEVRRLMRARGDGPWFHYPTIDKELIDHSPKATPDN AE3ADBA0E26DEC8D nduv3_bovin NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 NADH-ubiquinone oxidoreductase 9 kDa subunit Complex I-9kD protein protein bovin Bos taurus (Bovine) Bovine MAASLLLRQGRAGALKTVLLEAGVFRGVAPAVSLSAESGKNEKGLPPNPKKQSPPKKPVSAAPTEPFDNTTYKNLQHHDYSTYTFLDLNLDLSKFRMPQPSSGRESPRH A49719C74AC1AC70 nu3m_bovin NADH-ubiquinone oxidoreductase chain 3 MT-ND3 MTND3 NADH3 ND3 NADH dehydrogenase subunit 3 protein protein bovin Bos taurus (Bovine) Bovine MNLMLALLTNFTLATLLVIIAFWLPQLNVYSEKTSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWASQTANLNTMLTMALFLIILLAVSLAYEWTQKGLEWTE A55C1B856B1C3515 nu2m_bovin NADH-ubiquinone oxidoreductase chain 2 MT-ND2 MTND2 NADH2 ND2 NADH dehydrogenase subunit 2 protein protein bovin Bos taurus (Bovine) Bovine MNPIIFIIILLTIMLGTIIVMISSHWLLVWIGFEMNMLAIIPIMMKNHNPRATEASTKYFLTQSTASMLLMMAVIINLMFSGQWTVMKLFNPMASMLMTMALAMKLGMAPFHFWVPEVTQGIPLSSGLILLTWQKLAPMSVLYQIFPSINLNLILTLSVLSILIGGWGGLNQTQLRKIMAYSSIAHMGWMTAVLPYNPTMTLLNLIIYIIMTSTMFTMFMANSTTTTLSLSHTWNKTPIMTVLILATLLSMGGLPPLSGFMPKWMIIQEMTKNNSIILPTFMAITALLNLYFYMRLTYSTTLTMFPSTNNMKMKWQFPLMKKMTFLPTMVVLSTMMLPLTPMLSVLE 24105538A1374585 ndus7_bovin NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 NADH-ubiquinone oxidoreductase 20 kDa subunit Complex I-20kD PSST subunit protein protein bovin Bos taurus (Bovine) Bovine MAALAALRLLHPILAVRSGVGAALQVRGVHSSMAADSPSSTQPAVSQARAVVPKPAALPSSRGEYVVAKLDDLINWARRSSLWPMTFGLACCAVEMMHMAAPRYDMDRFGVVFRASPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTAEALLYGILQLQKKIKREKRLRIWYRR 514B8A63C59BE641 ndua6_bovin NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 NADH-ubiquinone oxidoreductase B14 subunit Complex I-B14 protein protein bovin Bos taurus (Bovine) Bovine MAASGLRQAAVAASTSVKPIFSRDMNEAKRRVRELYRAWYREVPNTVHLFQLDISVKQGRDKVREMFKKNAHITDPRVVDLLVIKGKMELEETIKVWKQRTHVMRFFHETEAPRPKDFLSKFYVGHDP 4DB92284502488BD ndub3_bovin NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 NADH-ubiquinone oxidoreductase B12 subunit Complex I-B12 protein protein bovin Bos taurus (Bovine) Bovine MAHGHGHEHGPSKMELPDYKQWKIEGTPLETVQEKLAARGLRDPWGRNEAWRYMGGFANNVSFVGALLKGFKWGFAAFVVAIGAEYYLESQKKDKKHH F1251DCAB266FFD7 ndua2_bovin NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 NADH-ubiquinone oxidoreductase B8 subunit Complex I-B8 protein protein bovin Bos taurus (Bovine) Bovine MAAAAAIRGVRGKLGLREIRIHLCQRSPGSQGVRDFIEKRYVELKKANPDLPILIRECSDVQPKLWARYAFGQEKNVSLNNFSADQVTRALENVLSSKA B844420E64652EC2 ndub9_bovin NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 UQOR22 NADH-ubiquinone oxidoreductase B22 subunit Complex I-B22 protein protein bovin Bos taurus (Bovine) Bovine MAFLSSGAYLTHQQKVLRLYKRALRHLESWCIHRDKYRYFACLLRARFDEHKNEKDMVKATQLLREAEEEFWHGQHPQPYIFPESPGGTSYERYECYKVPEWCLDDWHPSEKAMYPDYFAKREQWKKLRRESWEREVKQLQEETPVGGPRTEALPPARKQGDLPPLWWHIVTRPRERPM 6D7BFA4AAAAD7C97 ndus5_bovin NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 NADH-ubiquinone oxidoreductase 15 kDa subunit Complex I-15 kDa protein protein bovin Bos taurus (Bovine) Bovine MPFFDVQKRLGVDLDRWMTIQSAEQPHKIPSRCHAFEKEWIECAHGIGSIRAEKECKIEFEDFRECLLRQKTMKRLHAIRRQREKLIKEGKYTPPPHHSGQEEPRS 75BE02EF2C1A9144 acpm_bovin Acyl carrier protein, mitochondrial NDUFAB1 NADH-ubiquinone oxidoreductase 9.6 kDa subunit CI-SDAP protein protein bovin Bos taurus (Bovine) Bovine MAVRVLCACVRRLPTAFAPLPRLPTLAAARPLSTTLFAAETRTRPGAPLPALVLAQVPGRVTQLCRQYSDAPPLTLEGIKDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKKDVYE 340A12BFF005463F ndub8_bovin NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 NADH-ubiquinone oxidoreductase ASHI subunit Complex I-ASHI protein protein bovin Bos taurus (Bovine) Bovine MAAARAGVLGVRWLQKAARNVVPLGARTASHITKDMLPGPYPKTPEERAAAAKKYNMRVEDYEPYPDDGTGYGDYPKLPDRSQQERDPWYDWDHPDLRLNWGEPMHWDLDMYIRNRVDTSPTPVNWNLMCKHLFGFVAFMLFMFWVGETYPAYQPVGPKQYPYNNLYLERGGDPNKEPEPVVHYEI 523A3596D2F73E5C nduab_bovin NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 NADH-ubiquinone oxidoreductase subunit B14.7 Complex I-B14.7 protein protein bovin Bos taurus (Bovine) Bovine MAKTVLRQYWDIPEGTECHRKTYATTSIGGAAGLVVSAYSVALKTPTSFLEGVARTGRYTFTAAAIGAIFGLTSCISAQVREKPDDPLNYLIGGCAGGLILGARTRSYGIGAAACAYMGLTAALVKMGQLEGWQVFAEPKV 700A92AA15E431E4 nu4m_bovin NADH-ubiquinone oxidoreductase chain 4 MT-ND4 MTND4 NADH4 ND4 NADH dehydrogenase subunit 4 protein protein bovin Bos taurus (Bovine) Bovine MLKYIIPTIMLMPLTWLSKNNMIWVNSTAHSLLISFTSLLLMNQFGDNSLNFSLLFFSDSLSTPLLILTMWLLPLMLMASQHHLSKENLTRKKLFITMLISLQLFLIMTFTAMELILFYILFEATLVPTLIIITRWGNQTERLNAGLYFLFYTLAGSLPLLVALIYIQNTVGSLNFLMLQYWVQPVHNSWSNVFMWLACMMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLGGYGMLRITLILNPMTDFMAYPFIMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSYMGATALMIAHGLTSSMLFCLANSNYERIHSRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVVMSTFSWSNITIILMGVNMVITALYSLYMLIMTQRGKYTYHINNISPSFTRENALMSLHILPLLLLTLNPKIILGPLY EE7061AA41977CB4 ndus4_bovin NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 NADH-ubiquinone oxidoreductase 18 kDa subunit Complex I-18 kDa Complex I-AQDQ protein protein bovin Bos taurus (Bovine) Bovine MAAVSMSVALRQALWGRRVATVAAVSVSKVSTRSLSTSTWRLAQDQTRDTQLITVDEKLDITTITGVPEEHIKTRKARIFVPARNNMQSGVNNTKKWKMEFDTRERWENPLMGWASTADPLSNLVLTFSTKEDAVAFAEKNGWSYDVEERKVPKPKSKSYGANFSWNKRTRVSTK C77BE67FE6E5A407 ndus1_bovin NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 Complex I-75kD protein protein bovin Bos taurus (Bovine) Bovine MLRIPVRKALVGLSKSSKGCVRTTATAASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQIPRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKTKKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMMFGSDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQRLTEPMVRNEKGLLTHTTWEDALSRVAGMLQSFQGNDVAAIAGGLVDAEALIALKDLLNRVDSDTLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYRYDHLGDSPKILQDIASGSHPFSQVLQEAKKPMVILGSSALQRNDGAAILAAVSNIAQKIRTSSGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIQKNPPKMLFLLGADGGCITRQDLPKDCFIVYQGHHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLPYDTLDQVRNRLEEVSPNLVRYDDVEGANYFQQASELSKLVNQQLLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAHAVEEPSIC BEAD8AB5D76FC22D ndua9_bovin NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 NADH-ubiquinone oxidoreductase 39 kDa subunit Complex I-39kD protein protein bovin Bos taurus (Bovine) Bovine MAAAVHPRVVRVLPMSRSSVPALAASVFHSPPQRQLHHAVIPHGKGGRSSVSGIVATVFGATGFLGRYVVNHLGRMGSQVIVPHRCEPYDTMHLRPMGDLGQIIFMDWNGRDKDSIRRAVEHSSVVINLVGREWETQNFDFEDVFVKIPQAIAQVSKEAGVEKFIHISHLNADIKSSSKYLRSKAVGEKEVRETFPEATIIKPAEIFGREDRFLNYFANIRWFGGVPLISLGKKTVKQPVYIVDVTKGIINAIKDPDARGKTFAFVGPSRYLLFDLVQYVFAVAHRPFLPYPLPHFAYRWIGRLFEISPFEPWTTRDKVERIHTTDKILPHLPGLEDLGVEATPLELKAIEVLRRHRTYRWLSSEIEDVQPAKTIPTSGP B453FA19D48D03CD ndub7_bovin NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 NADH-ubiquinone oxidoreductase B18 subunit Complex I-B18 protein protein bovin Bos taurus (Bovine) Bovine MGAHLARRYLGDASVEPDPLRMPTFPPDYGFPERKEREMVATQQEMNDAQLVLQQRDYCAHYLIRFLKCKRDSFPNFLACKHERHDWDYCEHLDYVKRMKEFERERRLLQRKKRREQREADMAKGLGPGEVAPEVAL F75B1365E32DC573 nduaa_bovin NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 NADH-ubiquinone oxidoreductase 42 kDa subunit Complex I-42kD protein protein bovin Bos taurus (Bovine) Bovine MALRLLRLVPPRVGGIHTSVQFKLQYGPLAYILGEKATKKMTEKSKLITVDGNICSGKSKLAKEIAEKLGLKHFPEAGIHYVDSTTGDGKPLPVQFSGNCSLEKFYDDPKSNDGNSYRLQAWLYASRLLQYADALEHLLSTGQGVVLERSIYSDFVFLEAMYRQGFIRKQCVDHYNQVKKVTICEYLPPHVVVYVDVPVPEVQSRIQKKGNPHEMKITSAYLQDIENAYKGTFLPEMSEKCEVLQYSAWEAQDAEKVVEDIEYLKYDKGPWLDQNDRNLHKLRMLVQDKLEVLNYTSIPVFLPEVTVGAHQSDQVFQEFTELPGRKYRAGYNEDVGDKWIWLK F1AA5A93B438BA42 ndua1_bovin NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 NADH-ubiquinone oxidoreductase MWFE subunit Complex I-MWFE protein protein bovin Bos taurus (Bovine) Bovine MWFEVLPGIAVMGVCLFIPGMATARIHRFSNGGKEKRVAHYPYQWYLMERDRRVSGVNRSYVSKGLENID DC64CF71EA573324 ndub2_bovin NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 NADH-ubiquinone oxidoreductase AGGG subunit Complex I-AGGG protein protein bovin Bos taurus (Bovine) Bovine MAGMSALKRLAPFAHVGGHLFRGRCARAAGARGVRRAGGGAHIEPRYRQFPQLTRSQVIQAEFFSATMWFWILWRFWHDSDAVLGHFPYPDPSQWTDEELGIPPDDED 0F0AD8B6A38120C7 nduba_bovin NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 NADH-ubiquinone oxidoreductase PDSW subunit Complex I-PDSW protein protein bovin Bos taurus (Bovine) Bovine MPDSWDKDVYPEPPRRTPAPSPQTSLPNPITYLTKAFDLLVDRPVTLVREFIERQHAKNKYYYYHREFRRVPDITECQEKDVLCMFEAEMQWRRDYKVDQEIVNIIQERLKACQQREGESHRQNCAKELEQFTQVVKAYQDRYHDLGAHYSARKCLAKQKQRMLAERKAAKEAAAA F4409C8D49AE0AB4 ndua7_bovin NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 CI-B14-5A NADH-ubiquinone oxidoreductase subunit B14.5a Complex I-B14.5a protein protein bovin Bos taurus (Bovine) Bovine MASATRFIQWLRNWASGRDLQAKLQLRYQEISKRTQPPPKLPVGPSHKLSNNYYCTRDGRREAMPPSIVMSSQKVLVAGKPAESSAVAASEKKAVSPAPPIKRWELSQDEPYL 49A79CD9F3B46118 nduc1_bovin NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 NADH-ubiquinone oxidoreductase KFYI subunit Complex I-KFYI protein protein bovin Bos taurus (Bovine) Bovine MAPSALLRPFWKLLAPARFPSVSSSRSKFYIQEPPHGSPNWLKVGLTLGTSVFLWIYLIKQHNEDVLEYKRRNGLE 326286716C4394F9 ndus3_bovin NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 NADH-ubiquinone oxidoreductase 30 kDa subunit Complex I-30kD protein protein bovin Bos taurus (Bovine) Bovine MAAAVAAAARGCWQRLVGSAAPARVAGRPSVLLLPVRRESSAADTRPTVRPRNDVAHKQLSAFGEYVAEILPKYVQQVQVSCFNELEICIHPDGVIPVLTFLRDHSNAQFKSLADLTAVDIPTRQNRFEIVYNLLSLRFNSRIRVKTYTDELTPIESSVPVYKAANWYEREIWDMFGVFFANHPDLRRILTDYGFEGHPFRKDFPLSGYVELRYDDEVKRVVAEPVELAQEFRKFDLNSPWEAFPAYRQPPESLKLEAGDTKPEAK 43494B3359D2FEB1 ndub6_bovin NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 NADH-ubiquinone oxidoreductase B17 subunit Complex I-B17 protein protein bovin Bos taurus (Bovine) Bovine MSGYTPEEKLRLQQLRELRRRWLKDQELSPREPVLPPQRVSPVERFWNKFLQDGALWKNVIYKTYRHSIFAFTHVLIPVWIIHYYLKYHVTTKPYTIVEKKPRIFPGDTILETGEVIPPMKEFPDQHH 2F702A1ABC5C39F7 ndua8_bovin NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 NADH-ubiquinone oxidoreductase 19 kDa subunit Complex I-19kD Complex I-PGIV protein protein bovin Bos taurus (Bovine) Bovine MPGIVELPSLEDLKVQEVKVSSSVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNQCALEFFRQIKRHCAEPFTEYWTCIDYSGLQLFRRCRKQQAQFDECVLDKLGWVRPDLGDLSKVTKVKTDRPLPENPYHSRARPEPNPEVEGDLKPARHGSRLFFWTM C5EEB86E73BF22AB ndua3_bovin NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 NADH-ubiquinone oxidoreductase B9 subunit Complex I-B9 protein protein bovin Bos taurus (Bovine) Bovine MAERVAAFLKNVWAKEPVLVASFAIAGLAVILPTLSPYTKYSLMINRATPYNYPVPLRDDGNMPDVPSHPQDPQGPSLEWLKRL C2E60366AF5ADDBF nduad_bovin NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 GRIM19 NADH-ubiquinone oxidoreductase B16.6 subunit Complex I-B16.6 Gene associated with retinoic-interferon-induced mortality 19 protein Cell death regulatory protein GRIM-19 protein protein bovin Bos taurus (Bovine) Bovine MAASKVKQDMPPVGGYGPIDYKRNLPRRGLSGYSMFAVGIGALLFGYWSMMKWNRERRRLQIEDFEARIALMPLLQAEKDRRVLQMLRENLEEEATVMKDVPGWKVGESVFHTTRWVTPMMGELYGLRASEEVLSATYGFIWYT 9AA885FFA4748347 ndub4_bovin NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 NADH-ubiquinone oxidoreductase B15 subunit Complex I-B15 protein protein bovin Bos taurus (Bovine) Bovine MSFPKYEASRLSSLPTTLDPAEYDISSETRKAQAERLAIRSRLKREYQLQYYDPSRRGVIEDPALVRWTYARSANIYPNFRPNTKTSLLGALFGIGPLVFWYYVFKTDRDRKEKLIQEGKLDRTFNISY F5DA3419E80D9125 nu1m_bovin NADH-ubiquinone oxidoreductase chain 1 MT-ND1 MTND1 NADH1 ND1 NADH dehydrogenase subunit 1 protein protein bovin Bos taurus (Bovine) Bovine MFMINILMLIIPILLAVAFLTLVERKVLGYMQLRKGPNVVGPYGLLQPIADAIKLFIKEPLRPATSSASMFILAPIMALGLALTMWIPLPMPYPLINMNLGVLFMLAMSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSVLLMSGSFTLSTLITTQEQMWLILPAWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFALFFMAEYANIIMMNIFTAILFLGTSHNPHMPELYTINFTIKSLLLTMSFLWIRASYPRFRYDQLMHLLWKNFLPLTLALCMWHVSLPILTSGIPPQT 638727DBA839B1C3 ndub1_bovin NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 NADH-ubiquinone oxidoreductase MNLL subunit Complex I-MNLL protein protein bovin Bos taurus (Bovine) Bovine MNLLQVVRDHWVHVLVPMGFVFGYYLDRKNDEKLTAFRNKSLLYKRELKPNEEVTWK 56D0A3C8CB046973 ndus2_bovin NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 NADH-ubiquinone oxidoreductase 49 kDa subunit Complex I-49kD protein protein bovin Bos taurus (Bovine) Bovine MAALRALCRLRGAAAQVLRPGAGVRLPIQPSRGARQWQPDVEWAEQYGGAVMYPTKETAHWKPPPWNDVDPPKDTLVSNLTLNFGPQHPAAHGVLRLVMELSGEMVRKCDPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMCNEQAYSLAVEKLLNIQPPPRAQWIRVLFGEITRLLNHIMAVTTHALDIGAMTPFFWMFEEREKMFEFYERVSGARMHAAYVRPGGVHQDLPLGLMDDIYEFSKNFSLRIDELEEMLTNNRIWRNRTVDIGIVTAEDALNYGFSGVMLRGSGIQWDLRKTQPYDVYDQVEFDVPIGSRGDCYDRYLCRVEEMRQSIRIISQCLNKMPPGEIKVDDAKVSPPKRAEMKTSMESLIHHFKLYTEGYQVPPGATYTAIEAPKGEFGVYLVSDGSSRPYRCKIKAPGFAHLAGLDKMSKGHMLADVVAIIGTQDIVFGEVDR 7EE8B22C289EA76F ndus6_bovin NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 NADH-ubiquinone oxidoreductase 13 kDa-A subunit Complex I-13kD-A protein protein bovin Bos taurus (Bovine) Bovine MAAVLTFLRFLGRGGAVTRGLPGGARCFGVRTSPTGEKVTHTGQVYDDGDYRKVRFVGRQKEVNENFAIDLIAEQPVSQVGSRVISCDGGGGALGHPRVYINLDKETKTGTCGYCGLQFRQQHH B2537AEF5F901F22 ndua5_bovin NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 NADH-ubiquinone oxidoreductase 13 kDa-B subunit Complex I-13kD-B Complex I subunit B13 protein protein bovin Bos taurus (Bovine) Bovine MAGLLKKTTGLVGLAVCETPHERLKILYTKILDVLGHIPKNAAYRKYTEQITNEKLSMVKAEPDVKKLEERLQGGQIEEVILQAENELSLARKMIQWKPWEPLVEEPPASQWKWPI 8AD6550D2ECD7B0D nduc2_bovin NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 NADH-ubiquinone oxidoreductase subunit B14.5b Complex I-B14.5b protein protein bovin Bos taurus (Bovine) Bovine MMTGRQGRATFQFLPDEARSLPPPKLTDPRLAFVGFLGYCSGLIDNAIRRRPVLLAGLHRQLLYITSFVFVGYYLLKRQDYMYAVRDHDMFSYIKSHPEDFPEKDKKTYGEVFEEFHPVR AF35707C2C3F2B89 ndubb_bovin NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial NDUFB11 NADH-ubiquinone oxidoreductase ESSS subunit Complex I-ESSS protein protein bovin Bos taurus (Bovine) Bovine MAARMLGLCGRRLLAVAATRGLPAARVRWESSSSRAVIAPSTLAGKRPSEPTLRWQEDPEPEDENLYEKNPDSHGYDKDPAVDIWNMRVVFFFGFSIVLVLGSTFVAYLPDYRMQEWARREAERLVKYREAHGLPIMESNCFDPSKIQLPEDED 5D0B30342901D748 nduv1_bovin NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 UQOR1 NADH-ubiquinone oxidoreductase 51 kDa subunit Complex I-51kD NADH dehydrogenase flavoprotein 1 protein protein bovin Bos taurus (Bovine) Bovine MLAARRLLGGSLPARVSVRFSGDTTAPKKTSFGSLKDEDRIFTNLYGRHDWRLKGAQSRGDWYKTKEILLKGPDWILGEVKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEGEPGTCKDREIIRHDPHKLVEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYEAGLIGKNACGSGYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPTTVANVETVAVSPTICRRGGAWFASFGRERNSGTKLFNISGHVNNPCTVEEEMSVPLKELIEKHAGGVTGGWDNLLAVIPGGSSTPLIPKSVCETVLMDFDALIQAQTGLGTAAVIVMDRSTDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVRGDARPAEIDSLWEISKQIEGHTICALGDGAAWPVQGLIRHFRPELEERMQQFAQQHQARQAAF 8ACEC256E026B317 ndufs1-ndufv1-1 1 24 unspecified role unspecified role neutral component neutral component 5 unspecified role unspecified role neutral component neutral component 33 unspecified role unspecified role neutral component neutral component 12 unspecified role unspecified role neutral component neutral component 9 unspecified role unspecified role neutral component neutral component 19 unspecified role unspecified role neutral component neutral component 23 unspecified role unspecified role neutral component neutral component 18 unspecified role unspecified role neutral component neutral component 28 unspecified role unspecified role neutral component neutral component 41 unspecified role unspecified role neutral component neutral component 35 unspecified role unspecified role neutral component neutral component 13 unspecified role unspecified role neutral component neutral component 31 unspecified role unspecified role neutral component neutral component 40 unspecified role unspecified role neutral component neutral component 34 unspecified role unspecified role neutral component neutral component 36 unspecified role unspecified role neutral component neutral component 8 unspecified role unspecified role neutral component neutral component 11 unspecified role unspecified role neutral component neutral component 2 unspecified role unspecified role neutral component neutral component 16 unspecified role unspecified role neutral component neutral component 6 unspecified role unspecified role neutral component neutral component 7 unspecified role unspecified role neutral component neutral component 37 unspecified role unspecified role neutral component neutral component 25 unspecified role unspecified role neutral component neutral component 3 unspecified role unspecified role neutral component neutral component 10 unspecified role unspecified role neutral component neutral component 22 unspecified role unspecified role neutral component neutral component 14 unspecified role unspecified role neutral component neutral component 29 unspecified role unspecified role neutral component neutral component 38 unspecified role unspecified role neutral component neutral component 39 unspecified role unspecified role neutral component neutral component 17 unspecified role unspecified role neutral component neutral component 42 unspecified role unspecified role neutral component neutral component 26 unspecified role unspecified role neutral component neutral component 32 unspecified role unspecified role neutral component neutral component 4 unspecified role unspecified role neutral component neutral component 15 unspecified role unspecified role neutral component neutral component 20 unspecified role unspecified role neutral component neutral component 30 unspecified role unspecified role neutral component neutral component 27 unspecified role unspecified role neutral component neutral component 43 unspecified role unspecified role neutral component neutral component 21 unspecified role unspecified role neutral component neutral component physical association physical association Mass measurements by ESI-MS and post-translational modifications of nuclear encoded subunits of bovine complex I Table 1, Table 2, Sup Table S1-4 ndub5-ndub2-1 1 41 unspecified role unspecified role neutral component neutral component 37 unspecified role unspecified role neutral component neutral component 12 unspecified role unspecified role neutral component neutral component 42 unspecified role unspecified role neutral component neutral component 19 unspecified role unspecified role neutral component neutral component 2 unspecified role unspecified role neutral component neutral component 31 unspecified role unspecified role neutral component neutral component 14 unspecified role unspecified role neutral component neutral component 17 unspecified role unspecified role neutral component neutral component 23 unspecified role unspecified role neutral component neutral component 27 unspecified role unspecified role neutral component neutral component 35 unspecified role unspecified role neutral component neutral component 16 unspecified role unspecified role neutral component neutral component 26 unspecified role unspecified role neutral component neutral component 6 unspecified role unspecified role neutral component neutral component physical association physical association Table S1-2: Identification by Mass Spectrometry of Subunits Present in Subcomplex Ib Table 2, Sup Table S1-2 ndufs1-nduad-1 1 30 unspecified role unspecified role neutral component neutral component 18 unspecified role unspecified role neutral component neutral component 32 unspecified role unspecified role neutral component neutral component 13 unspecified role unspecified role neutral component neutral component 38 unspecified role unspecified role neutral component neutral component 11 unspecified role unspecified role neutral component neutral component 15 unspecified role unspecified role neutral component neutral component 5 unspecified role unspecified role neutral component neutral component 4 unspecified role unspecified role neutral component neutral component 35 unspecified role unspecified role neutral component neutral component 21 unspecified role unspecified role neutral component neutral component 40 unspecified role unspecified role neutral component neutral component 7 unspecified role unspecified role neutral component neutral component 28 unspecified role unspecified role neutral component neutral component 25 unspecified role unspecified role neutral component neutral component 24 unspecified role unspecified role neutral component neutral component 20 unspecified role unspecified role neutral component neutral component 10 unspecified role unspecified role neutral component neutral component 22 unspecified role unspecified role neutral component neutral component 3 unspecified role unspecified role neutral component neutral component 33 unspecified role unspecified role neutral component neutral component 39 unspecified role unspecified role neutral component neutral component 34 unspecified role unspecified role neutral component neutral component 16 unspecified role unspecified role neutral component neutral component 43 unspecified role unspecified role neutral component neutral component physical association physical association Subunit compositions of subcomplexes of bovine complex I Table 2 ndufs1-nduad-2 1 3 unspecified role unspecified role neutral component neutral component 21 unspecified role unspecified role neutral component neutral component 28 unspecified role unspecified role neutral component neutral component 7 unspecified role unspecified role neutral component neutral component 43 unspecified role unspecified role neutral component neutral component 39 unspecified role unspecified role neutral component neutral component 4 unspecified role unspecified role neutral component neutral component 30 unspecified role unspecified role neutral component neutral component 13 unspecified role unspecified role neutral component neutral component 38 unspecified role unspecified role neutral component neutral component 40 unspecified role unspecified role neutral component neutral component 10 unspecified role unspecified role neutral component neutral component 5 unspecified role unspecified role neutral component neutral component 18 unspecified role unspecified role neutral component neutral component 34 unspecified role unspecified role neutral component neutral component 20 unspecified role unspecified role neutral component neutral component physical association physical association Subunit compositions of subcomplexes of bovine complex I Table 2