IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Clin. Cancer Res. (1078-0432) 2014 imex curation Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer Affinomics - Interactions curated for the Affinomics consortium. I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk 22-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions human-m059j M059J-Human glioblastoma cell line m059j M059J-Human glioblastoma cell line http://www.lgcstandards-atcc.org/products/all/CRL-2366.aspx lacks DNA-dependent protein kinase activity. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk Accepted 2015-JAN-05 by ORCHARD Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Clin. Cancer Res. (1078-0432) 2014 imex curation Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer Affinomics - Interactions curated for the Affinomics consortium. I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk 22-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions human-bon1 BON1 Human pancreatic Carcinoid tumor cell line bon1 BON1 Human pancreatic Carcinoid tumor cell line derived from a lymph node metastasis Secretes chromogranin A (which is cleaved into 13 chains including vasostatin peptides, SP-I peptide, Pancreastatin and others.) confocal microscopy confocal microscopy immunocytochemistry immunocytochemistry Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk Accepted 2015-JAN-05 by ORCHARD Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Clin. Cancer Res. (1078-0432) 2014 imex curation Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer Affinomics - Interactions curated for the Affinomics consortium. I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk 22-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions human-m059j M059J-Human glioblastoma cell line m059j M059J-Human glioblastoma cell line http://www.lgcstandards-atcc.org/products/all/CRL-2366.aspx lacks DNA-dependent protein kinase activity. pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk Accepted 2015-JAN-05 by ORCHARD Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Clin. Cancer Res. (1078-0432) 2014 imex curation Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer Affinomics - Interactions curated for the Affinomics consortium. I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk 22-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions human-bon1 BON1 Human pancreatic Carcinoid tumor cell line bon1 BON1 Human pancreatic Carcinoid tumor cell line derived from a lymph node metastasis Secretes chromogranin A (which is cleaved into 13 chains including vasostatin peptides, SP-I peptide, Pancreastatin and others.) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk Accepted 2015-JAN-05 by ORCHARD Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Clin. Cancer Res. (1078-0432) 2014 imex curation Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer Affinomics - Interactions curated for the Affinomics consortium. I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk 22-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions human-qgp1 Human QGP1; pancreatic islet cell carcinoma/somatostatinoma qgp1 Human QGP1 cell line derived from a pancreatic islet cell carcinoma/somatostatinoma produces (CEA) and Somatostatin pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk Accepted 2015-JAN-05 by ORCHARD Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Clin. Cancer Res. (1078-0432) 2014 imex curation Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer Affinomics - Interactions curated for the Affinomics consortium. I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk 22-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions human-m059k Human glioblastoma M059JK cells m059k Human glioblastoma M059K cells These cells express DNA-dependent protein kinase (DNA-PK) http://www.lgcstandards-atcc.org/products/all/CRL-2365.aspx?geo_country=gb#generalinformation confocal microscopy confocal microscopy immunocytochemistry immunocytochemistry Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk Accepted 2015-JAN-05 by ORCHARD Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Clin. Cancer Res. (1078-0432) 2014 imex curation Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer Affinomics - Interactions curated for the Affinomics consortium. I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk 22-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions human-qgp1 Human QGP1; pancreatic islet cell carcinoma/somatostatinoma qgp1 Human QGP1 cell line derived from a pancreatic islet cell carcinoma/somatostatinoma produces (CEA) and Somatostatin confocal microscopy confocal microscopy immunocytochemistry immunocytochemistry Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk Accepted 2015-JAN-05 by ORCHARD Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Clin. Cancer Res. (1078-0432) 2014 imex curation Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer Affinomics - Interactions curated for the Affinomics consortium. I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk 22-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions human-bon1 BON1 Human pancreatic Carcinoid tumor cell line bon1 BON1 Human pancreatic Carcinoid tumor cell line derived from a lymph node metastasis Secretes chromogranin A (which is cleaved into 13 chains including vasostatin peptides, SP-I peptide, Pancreastatin and others.) pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk Accepted 2015-JAN-05 by ORCHARD Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Clin. Cancer Res. (1078-0432) 2014 imex curation Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer Affinomics - Interactions curated for the Affinomics consortium. I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk 22-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions human-m059j M059J-Human glioblastoma cell line m059j M059J-Human glioblastoma cell line http://www.lgcstandards-atcc.org/products/all/CRL-2366.aspx lacks DNA-dependent protein kinase activity. anti bait coip anti bait coimmunoprecipitation anti bait coip sequence tag sequence tag identification sequence tag Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk Accepted 2015-JAN-05 by ORCHARD Irradiation with X rays - 4 Gy Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Clin. Cancer Res. (1078-0432) 2014 imex curation Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer Affinomics - Interactions curated for the Affinomics consortium. I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk 22-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions human-m059k Human glioblastoma M059JK cells m059k Human glioblastoma M059K cells These cells express DNA-dependent protein kinase (DNA-PK) http://www.lgcstandards-atcc.org/products/all/CRL-2365.aspx?geo_country=gb#generalinformation anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk Accepted 2015-JAN-05 by ORCHARD Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Clin. Cancer Res. (1078-0432) 2014 imex curation Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer Affinomics - Interactions curated for the Affinomics consortium. I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk 22-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions human-a_431 Homo sapiens epidermoid carcinoma a_431 Human epidermoid carcinoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk Accepted 2015-JAN-05 by ORCHARD Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Clin. Cancer Res. (1078-0432) 2014 imex curation Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer Affinomics - Interactions curated for the Affinomics consortium. I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk 22-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions human-a_549 Homo sapiens Caucasian lung carcinoma cell line a_549 Human Caucasian lung carcinoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk Accepted 2015-JAN-05 by ORCHARD Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Clin. Cancer Res. (1078-0432) 2014 imex curation Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer Affinomics - Interactions curated for the Affinomics consortium. I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk 22-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions human-qgp1 Human QGP1; pancreatic islet cell carcinoma/somatostatinoma qgp1 Human QGP1 cell line derived from a pancreatic islet cell carcinoma/somatostatinoma produces (CEA) and Somatostatin anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk Accepted 2015-JAN-05 by ORCHARD Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Clin. Cancer Res. (1078-0432) 2014 imex curation Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer Affinomics - Interactions curated for the Affinomics consortium. I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk 22-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions human-m059k Human glioblastoma M059JK cells m059k Human glioblastoma M059K cells These cells express DNA-dependent protein kinase (DNA-PK) http://www.lgcstandards-atcc.org/products/all/CRL-2365.aspx?geo_country=gb#generalinformation anti bait coip anti bait coimmunoprecipitation anti bait coip sequence tag sequence tag identification sequence tag Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk Accepted 2015-JAN-05 by ORCHARD Irradiation with X rays - 4 Gy Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Clin. Cancer Res. (1078-0432) 2014 imex curation Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer Affinomics - Interactions curated for the Affinomics consortium. I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk 22-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions human-m059j M059J-Human glioblastoma cell line m059j M059J-Human glioblastoma cell line http://www.lgcstandards-atcc.org/products/all/CRL-2366.aspx lacks DNA-dependent protein kinase activity. confocal microscopy confocal microscopy immunocytochemistry immunocytochemistry Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk Accepted 2015-JAN-05 by ORCHARD Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Clin. Cancer Res. (1078-0432) 2014 imex curation Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer Affinomics - Interactions curated for the Affinomics consortium. I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk 22-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions human-m059k Human glioblastoma M059JK cells m059k Human glioblastoma M059K cells These cells express DNA-dependent protein kinase (DNA-PK) http://www.lgcstandards-atcc.org/products/all/CRL-2365.aspx?geo_country=gb#generalinformation pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer I cannot see any difference between Fig 3 and Supp 3A for the cell lines involved - not sure if I have missed something.... d.hochhauser@ucl.ac.uk Accepted 2015-JAN-05 by ORCHARD Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation mcm6_human DNA replication licensing factor MCM6 MCM6 p105MCM protein protein human Homo sapiens Human MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVSFVDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDFYVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNICRNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKHLRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEIQMEVDEGAGGINGHADSPAPVNGINGYNEDINQESAPKASLRLGFSEYCRISNLIVLHLRKVEEEEDESALKRSELVNWYLKEIESEIDSEEELINKKRIIEKVIHRLTHYDHVLIELTQAGLKGSTEGSESYEEDPYLVVNPNYLLED DIP protein Q14566 original sequence version: 145 DIP protein Q14566 original sequence version: 98 DIP protein Q14566 original sequence version: 109 DIP protein Q14566 original sequence version: 150 F94968EB25A3E501 nucl_human Nucleolin NCL Protein C23 protein protein human Homo sapiens Human MVKLAKAGKNQGDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVSPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVATPGKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQDELKEVFEDAAEIRLVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQNQDYRGGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNQNGKSKGYAFIEFASFEDAKEALNSCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFDGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDHKPQGKKTKFE DIP protein P19338 original sequence version: 93 DIP protein P19338 original sequence version: 123 C97F6E34E5CA6727 lmna_human Prelamin-A/C LMNA LMN1 protein protein human Homo sapiens Human METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASASGSGAQVGGPISSGSSASSVTVTRSYRSVGGSGGGSFGDNLVTRSYLLGNSSPRTQSPQNCSIM E0855F7699F0318B xrn2_human 5'-3' exoribonuclease 2 XRN2 DHM1-like protein protein protein human Homo sapiens Human MGVPAFFRWLSRKYPSIIVNCVEEKPKECNGVKIPVDASKPNPNDVEFDNLYLDMNGIIHPCTHPEDKPAPKNEDEMMVAIFEYIDRLFSIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEGMEAAVEKQRVREEILAKGGFLPPEEIKERFDSNCITPGTEFMDNLAKCLRYYIADRLNNDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIMLGLATHEPNFTIIREEFKPNKPKPCGLCNQFGHEVKDCEGLPREKKGKHDELADSLPCAEGEFIFLRLNVLREYLERELTMASLPFTFDVERSIDDWVFMCFFVGNDFLPHLPSLEIRENAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFRRRQKEKRKRMKRDQPAFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSSPSISPNTSFTSDGSPSPLGGIKRKAEDSDSEPEPEDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPFASDFEGIADMPSDFEKGTKPFKPLEQLMGVFPAASGNFLPPSWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEETRRNSLGGDVLFVGKHHPLHDFILELYQTGSTEPVEVPPELCHGIQGKFSLDEEAILPDQIVCSPVPMLRDLTQNTVVSINFKDPQFAEDYIFKAVMLPGARKPAAVLKPSDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVMPRGSGTGIYSNAAPPPVTYQGNLYRPLLRGQAQIPKLMSNMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPRRDDRGGRQGYPREGRKYPLPPPSGRYNWN DIP protein Q9H0D6 original sequence version: 130 DIP protein Q9H0D6 original sequence version: 141 DIP protein Q9H0D6 original sequence version: 140 763B5E0E628F97A8 npm_human Nucleophosmin NPM1 NPM Nucleolar phosphoprotein B23 Numatrin Nucleolar protein NO38 protein protein human Homo sapiens Human MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKSIRDTPAKNAQKSNQNGKDSKPSSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL 620BC7BA2E4A0054 ercc1_human DNA excision repair protein ERCC-1 ERCC1 protein protein human Homo sapiens Human MDPGKDKEGVPQPSGPPARKKFVIPLDEDEVPPGVAKPLFRSTQSLPTVDTSAQAAPQTYAEYAISQPLEGAGATCPTGSEPLAGETPNQALKPGAKSNSIIVSPRQRGNPVLKFVRNVPWEFGDVIPDYVLGQSTCALFLSLRYHNLHPDYIHGRLQSLGKNFALRVLLVQVDVKDPQQALKELAKMCILADCTLILAWSPEEAGRYLETYKAYEQKPADLLMEKLEQDFVSRVTECLTTVKSVNKTDSQTLLTTFGSLEQLIAASREDLALCPGLGPQKARRLFDVLHEPFLKVP DIP protein P07992 original sequence version: 109 DIP protein P07992 original sequence version: 69 DIP protein P07992 original sequence version: 162 6FCE3615732349E5 egfr_human Epidermal growth factor receptor ERBB1 EGFR Receptor tyrosine-protein kinase erbB-1 Proto-oncogene c-ErbB-1 ERBB HER1 protein protein human Homo sapiens Human MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA DIP protein P00533 original sequence version: 213 DIP protein P00533 original sequence version: 214 DIP protein P00533 original sequence version: 119 DIP protein P00533 original sequence version: 207 DIP protein P00533 original sequence version: 132 DIP protein P00533-1 original sequence version: 197 DIP protein P00533 original sequence version: 163 DIP protein P00533-1 original sequence version: 159 DIP protein P00533 original sequence version: 184 DIP protein P00533-1 original sequence version: 174 DIP protein P00533-1 original sequence version: 191 DIP protein P00533 original sequence version: 218 DIP protein P00533 original sequence version: 221 DIP protein P00533-1 original sequence version: 221 DIP protein P00533 original sequence version: 226 DIP protein P00533 original sequence version: 166 DIP protein P00533-1 original sequence version: 166 DIP protein P00533 original sequence version: 194 DIP protein P00533-1 original sequence version: 194 DIP protein P00533-1 original sequence version: 224 DIP protein P00533 original sequence version: 189 DIP protein P00533-1 original sequence version: 207 DIP protein P00533 original sequence version: 177 DIP protein P00533 original sequence version: 168 D8A2A50B4EFB6ED2 fen1_human Flap endonuclease 1 Flap structure-specific endonuclease 1 Maturation factor 1 DNase IV FEN1 RAD2 protein protein human Homo sapiens Human MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEPNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEPKGSTKKKAKTGAAGKFKRGK DIP protein P39748 original sequence version: 106 DIP protein P39748 original sequence version: 112 DIP protein P39748 original sequence version: 160 5154F2F6E57592C5 top1_human DNA topoisomerase 1 DNA topoisomerase I TOP1 protein protein human Homo sapiens Human MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEPEDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKDKDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF DIP protein P11387 original sequence version: 189 6FBED540BCF7BE28 tif1b_human Transcription intermediary factor 1-beta TRIM28 KAP1 RNF96 TIF1B Tripartite motif-containing protein 28 Nuclear corepressor KAP-1 KRAB-associated protein 1 KRAB-interacting protein 1 RING finger protein 96 E3 SUMO-protein ligase TRIM28 RING-type E3 ubiquitin transferase TIF1-beta protein protein human Homo sapiens Human MAASAAAASAAAASAASGSPGPGEGSAGGEKRSTAPSAAASASASAAASSPAGGGAEALELLEHCGVCRERLRPEREPRLLPCLHSACSACLGPAAPAAANSSGDGGAAGDGTVVDCPVCKQQCFSKDIVENYFMRDSGSKAATDAQDANQCCTSCEDNAPATSYCVECSEPLCETCVEAHQRVKYTKDHTVRSTGPAKSRDGERTVYCNVHKHEPLVLFCESCDTLTCRDCQLNAHKDHQYQFLEDAVRNQRKLLASLVKRLGDKHATLQKSTKEVRSSIRQVSDVQKRVQVDVKMAILQIMKELNKRGRVLVNDAQKVTEGQQERLERQHWTMTKIQKHQEHILRFASWALESDNNTALLLSKKLIYFQLHRALKMIVDPVEPHGEMKFQWDLNAWTKSAEAFGKIVAERPGTNSTGPAPMAPPRAPGPLSKQGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVKRSRSGEGEVSGLMRKVPRVSLERLDLDLTADSQPPVFKVFPGSTTEDYNLIVIERGAAAAATGQPGTAPAGTPGAPPLAGMAIVKEEETEAAIGAPPTATEGPETKPVLMALAEGPGAEGPRLASPSGSTSSGLEVVAPEGTSAPGGGPGTLDDSATICRVCQKPGDLVMCNQCEFCFHLDCHLPALQDVPGEEWSCSLCHVLPDLKEEDGSLSLDGADSTGVVAKLSPANQRKCERVLLALFCHEPCRPLHQLATDSTFSLDQPGGTLDLTLIRARLQEKLSPPYSSPQEFAQDVGRMFKQFNKLTEDKADVQSIIGLQRFFETRMNEAFGDTKFSAVLVEPPPMSLPGAGLSSQELSGGPGDGP DIP protein Q13263 original sequence version: 156 DIP protein Q13263 original sequence version: 154 DIP protein Q13263-1 original sequence version: 143 DIP protein Q13263 original sequence version: 198 DIP protein Q13263 original sequence version: 155 2027BABB7C94FE20 mcm3_human DNA replication licensing factor MCM3 MCM3 DNA polymerase alpha holoenzyme-associated protein P1 RLF subunit beta p102 P1-MCM3 protein protein human Homo sapiens Human MAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGYTSGTFRTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMPQVHTPKTADSQETKESQKVELSESRLKAFKVALLDVFREAHAQSIGMNRLTESINRDSEEPFSSVEIQAALSKMQDDNQVMVSEGIIFLI DIP protein P25205 original sequence version: 135 DIP protein P25205 original sequence version: 179 C967C068B7090558 xpf_human DNA repair endonuclease XPF ERCC4 ERCC11 XPF DNA excision repair protein ERCC-4 DNA repair protein complementing XP-F cells Xeroderma pigmentosum group F-complementing protein protein protein human Homo sapiens Human MESGQPARRIAMAPLLEYERQLVLELLDTDGLVVCARGLGADRLLYHFLQLHCHPACLVLVLNTQPAEEEYFINQLKIEGVEHLPRRVTNEITSNSRYEVYTQGGVIFATSRILVVDFLTDRIPSDLITGILVYRAHRIIESCQEAFILRLFRQKNKRGFIKAFTDNAVAFDTGFCHVERVMRNLFVRKLYLWPRFHVAVNSFLEQHKPEVVEIHVSMTPTMLAIQTAILDILNACLKELKCHNPSLEVEDLSLENAIGKPFDKTIRHYLDPLWHQLGAKTKSLVQDLKILRTLLQYLSQYDCVTFLNLLESLRATEKAFGQNSGWLFLDSSTSMFINARARVYHLPDAKMSKKEKISEKMEIKEGEETKKELVLESNPKWEALTEVLKEIEAENKESEALGGPGQVLICASDDRTCSQLRDYITLGAEAFLLRLYRKTFEKDSKAEEVWMKFRKEDSSKRIRKSHKRPKDPQNKERASTKERTLKKKKRKLTLTQMVGKPEELEEEGDVEEGYRREISSSPESCPEEIKHEEFDVNLSSDAAFGILKEPLTIIHPLLGCSDPYALTRVLHEVEPRYVVLYDAELTFVRQLEIYRASRPGKPLRVYFLIYGGSTEEQRYLTALRKEKEAFEKLIREKASMVVPEEREGRDETNLDLVRGTASADVSTDTRKAGGQEQNGTQQSIVVDMREFRSELPSLIHRRGIDIEPVTLEVGDYILTPEMCVERKSISDLIGSLNNGRLYSQCISMSRYYKRPVLLIEFDPSKPFSLTSRGALFQEISSNDISSKLTLLTLHFPRLRILWCPSPHATAELFEELKQSKPQPDAATALAITADSETLPESEKYNPGPQDFLLKMPGVNAKNCRSLMHHVKNIAELAALSQDELTSILGNAANAKQLYDFIHTSFAEVVSKGKGKK DIP protein Q92889 original sequence version: 109 DIP protein Q92889 original sequence version: 127 DIP protein Q92889 original sequence version: 166 C58CDE900378CCA8 apex1_human DNA-(apurinic or apyrimidinic site) endonuclease Apurinic-apyrimidinic endonuclease 1 APEX nuclease APE1 APEX1 APE APEX APX HAP1 REF1 REF-1 Redox factor-1 protein protein human Homo sapiens Human MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL DIP protein P27695 original sequence version: 139 DIP protein P27695 original sequence version: 152 DIP protein P27695 original sequence version: 187 B88579C01BAF80C6 parp1_human Poly [ADP-ribose] polymerase 1 PARP1 ADPRT PPOL NAD(+) ADP-ribosyltransferase 1 Poly[ADP-ribose] synthase 1 ADP-ribosyltransferase diphtheria toxin-like 1 DNA ADP-ribosyltransferase PARP1 Protein poly-ADP-ribosyltransferase PARP1 protein protein human Homo sapiens Human MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW DIP protein P09874 original sequence version: 189 DIP protein P09874 original sequence version: 183 DIP protein P09874 original sequence version: 166 DIP protein P09874 original sequence version: 117 DIP protein P09874 original sequence version: 143 DIP protein P09874 original sequence version: 136 DIP protein P09874 original sequence version: 137 DIP protein P09874 original sequence version: 147 DIP protein P09874 original sequence version: 193 DIP protein P09874 original sequence version: 202 DIP protein P09874 original sequence version: 171 DIP protein P09874 original sequence version: 153 DIP protein P09874 original sequence version: 175 6A5FC01EB91C046B fus_human RNA-binding protein FUS FUS TLS Oncogene FUS Oncogene TLS Translocated in liposarcoma protein POMp75 75 kDa DNA-pairing protein protein protein human Homo sapiens Human MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGEHRQDRRERPY DIP protein P35637 original sequence version: 165 DIP protein P35637 original sequence version: 156 DIP protein P35637-1 original sequence version: 156 DIP protein P35637-1 original sequence version: 92 DIP protein P35637-1 original sequence version: 146 88C8E263B7905549 baba2_human BRISC and BRCA1-A complex member 2 BABAM2 BRCA1-A complex subunit BRE BRCA1/BRCA2-containing complex subunit 45 BRCC45 BRE Brain and reproductive organ-expressed protein protein protein human Homo sapiens Human MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDAEFLPDPSALQNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVDFSNIPTYLLKDVNEDPGEDVALLSVSFEDTEATQVYPKLYLSPRIEHALGGSSALHIPAFPGGGCLIDYVPQVCHLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGFTKLTLLLMWKDFCFLVHIDLPLFFPRDQPTLTFQSVYHFTNSGQLYSQAQKNYPYSPRWDGNEMAKRAKAYFKTFVPQFQEAAFANGKL D830226E2B8F2C4B mcm4_human DNA replication licensing factor MCM4 MCM4 CDC21 CDC21 homolog P1-CDC21 protein protein human Homo sapiens Human MSSPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGEDSTSTGELQPMPTSPGVDLQSPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGSAQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVAACKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGRIAEPSVCGRCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMFEEALRALADDDFLTVTGKTVRLL DIP protein P33991 original sequence version: 121 DIP protein P33991 original sequence version: 165 DIP protein P33991 original sequence version: 168 96D9CA2A7D88D015 ilf2_human Interleukin enhancer-binding factor 2 PRO3063 NF45 ILF2 Nuclear factor of activated T-cells 45 kDa protein protein human Homo sapiens Human MRGDRGRGRGGRFGSRGGPGGGFRPFVPHIPFDFYLCEMAFPRVKPAPDETSFSEALLKRNQDLAPNSAEQASILSLVTKINNVIDNLIVAPGTFEVQIEEVRQVGSYKKGTMTTGHNVADLVVILKILPTLEAVAALGNKVVESLRAQDPSEVLTMLTNETGFEISSSDATVKILITTVPPNLRKLDPELHLDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQILAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTAQTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEKPPEKKEGEEEEENTEEPPQGEEEESMETQE 75BAD022DCD4EE01 dhx9_human ATP-dependent RNA helicase A DHX9 DDX9 NDH2 DExH-box helicase 9 RNA helicase A LKP Nuclear DNA helicase II DEAH box protein 9 Leukophysin protein protein human Homo sapiens Human MGDVKNFLYAWCGKRKMTPSYEIRAVGNKNRQKFMCEVQVEGYNYTGMGNSTNKKDAQSNAARDFVNYLVRINEIKSEEVPAFGVASPPPLTDTPDTTANAEGDLPTTMGGPLPPHLALKAENNSEVGASGYGVPGPTWDRGANLKDYYSRKEEQEVQATLESEEVDLNAGLHGNWTLENAKARLNQYFQKEKIQGEYKYTQVGPDHNRSFIAEMTIYIKQLGRRIFAREHGSNKKLAAQSCALSLVRQLYHLGVVEAYSGLTKKKEGETVEPYKVNLSQDLEHQLQNIIQELNLEILPPPEDPSVPVALNIGKLAQFEPSQRQNQVGVVPWSPPQSNWNPWTSSNIDEGPLAFATPEQISMDLKNELMYQLEQDHDLQAILQERELLPVKKFESEILEAISQNSVVIIRGATGCGKTTQVPQFILDDFIQNDRAAECNIVVTQPRRISAVSVAERVAFERGEEPGKSCGYSVRFESILPRPHASIMFCTVGVLLRKLEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPEVRIVLMSATIDTSMFCEYFFNCPIIEVYGRTYPVQEYFLEDCIQMTHFVPPPKDKKKKDKDDDGGEDDDANCNLICGDEYGPETRLSMSQLNEKETPFELIEALLKYIETLNVPGAVLVFLPGWNLIYTMQKHLEMNPHFGSHRYQILPLHSQIPREEQRKVFDPVPVGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFERLETHMTPEMFRTPLHEIALSIKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAICTIAAATCFPEPFINEGKRLGYIHRNFAGNRFSDHVALLSVFQAWDDARMGGEEAEIRFCEHKRLNMATLRMTWEAKVQLKEILINSGFPEDCLLTQVFTNTGPDNNLDVVISLLAFGVYPNVCYHKEKRKILTTEGRNALIHKSSVNCPFSSQDMKYPSPFFVFGEKIRTRAISAKGMTLVTPLQLLLFASKKVQSDGQIVLVDDWIKLQISHEAAACITGLRAAMEALVVEVTKQPAIISQLDPVNERMLNMIRQISRPSAAGINLMIGSTRYGDGPRPPKMARYDNGSGYRRGGSSYSGGGYGGGYSSGGYGSGGYGGSANSFRAGYGAGVGGGYRGVSRGGFRGNSGGDYRGPSGGYRGSGGFQRGGGRGAYGTGYFGQGRGGGGY DIP protein Q08211 original sequence version: 114 DIP protein Q08211 original sequence version: 177 A607DA8F4C4B217A ercc2_human General transcription and DNA repair factor IIH helicase subunit XPD ERCC2 XPD XPDC Basic transcription factor 2 80 kDa subunit CXPD DNA excision repair protein ERCC-2 DNA repair protein complementing XP-D cells TFIIH basal transcription factor complex 80 kDa subunit Xeroderma pigmentosum group D-complementing protein protein protein human Homo sapiens Human MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQQL DIP protein P18074 original sequence version: 90 DIP protein P18074 original sequence version: 132 DIP protein P18074 original sequence version: 198 746C0888CDF2E331 ilf3_human Interleukin enhancer-binding factor 3 ILF3 MPHOSPH4 NF90 Nuclear factor of activated T-cells 90 kDa Double-stranded RNA-binding protein 76 Translational control protein 80 Nuclear factor associated with dsRNA M-phase phosphoprotein 4 DRBF protein protein human Homo sapiens Human MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQAESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKLVSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAEQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLALDANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRGFGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSYYQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKGYNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR DIP protein Q12906 original sequence version: 87 DIP protein Q12906 original sequence version: 149 20903ABD0331F370 egfr-apex1 14 20 unspecified role unspecified role prey prey 31 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey 29 unspecified role unspecified role prey prey 18 unspecified role unspecified role prey prey 33 unspecified role unspecified role prey prey 30 unspecified role unspecified role prey prey 21 unspecified role unspecified role prey prey 26 unspecified role unspecified role prey prey 36 unspecified role unspecified role prey prey 23 unspecified role unspecified role bait bait association association Supp Table 1 No egfr-apex1-2 14 27 unspecified role unspecified role prey prey 22 unspecified role unspecified role prey prey 34 unspecified role unspecified role prey prey 28 unspecified role unspecified role prey prey 37 unspecified role unspecified role prey prey 26 unspecified role unspecified role prey prey 21 unspecified role unspecified role prey prey 23 unspecified role unspecified role bait bait 33 unspecified role unspecified role prey prey 29 unspecified role unspecified role prey prey 18 unspecified role unspecified role prey prey 24 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey 20 unspecified role unspecified role prey prey 31 unspecified role unspecified role prey prey 17 unspecified role unspecified role prey prey association association Supp Table 1 Yes egfr-apex1-5 9 30 unspecified role unspecified role prey prey 32 unspecified role unspecified role prey prey 25 unspecified role unspecified role prey prey 35 unspecified role unspecified role prey prey 29 unspecified role unspecified role prey prey 17 unspecified role unspecified role prey prey 37 unspecified role unspecified role prey prey 24 unspecified role unspecified role prey prey 34 unspecified role unspecified role prey prey 20 unspecified role unspecified role prey prey 21 unspecified role unspecified role prey prey 33 unspecified role unspecified role prey prey 18 unspecified role unspecified role prey prey 27 unspecified role unspecified role prey prey 28 unspecified role unspecified role prey prey 26 unspecified role unspecified role prey prey 31 unspecified role unspecified role prey prey 22 unspecified role unspecified role prey prey 23 unspecified role unspecified role bait bait 19 unspecified role unspecified role prey prey association association Supp Table 1 No egfr-apex1-7 9 28 unspecified role unspecified role prey prey 18 unspecified role unspecified role prey prey 26 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey 23 unspecified role unspecified role bait bait 22 unspecified role unspecified role prey prey 37 unspecified role unspecified role prey prey 33 unspecified role unspecified role prey prey 34 unspecified role unspecified role prey prey 25 unspecified role unspecified role prey prey 20 unspecified role unspecified role prey prey 31 unspecified role unspecified role prey prey 21 unspecified role unspecified role prey prey 30 unspecified role unspecified role prey prey 29 unspecified role unspecified role prey prey association association Supp Table 1 Yes egfr-ercc1 10 22 unspecified role unspecified role prey prey 23 unspecified role unspecified role bait bait physical association physical association 2 A/B Irradiation:- 4Gy XRays for 1 minute there is a time-dependent association of EGFR and ERCC1, peaking at 20 minutes following 4 Gy IR. ercc1-egfr-1 10 22 unspecified role unspecified role bait bait 23 unspecified role unspecified role prey prey 28 unspecified role unspecified role prey prey association association 2C Irradiation:- 4Gy XRays for 1 minute The complex did not include EGFR when irradiation was absent. ercc1-egfr-2 10 22 unspecified role unspecified role bait bait 28 unspecified role unspecified role prey prey physical association physical association 2C-2 this interaction was seen in the presence or absence of irradiation ercc1-egfr-3 1 22 unspecified role unspecified role bait bait 28 unspecified role unspecified role prey prey physical association physical association 2C-2 this interaction was seen in the presence or absence of irradiation egfr-ercc1-1 1 22 unspecified role unspecified role prey prey 23 unspecified role unspecified role bait bait physical association physical association 2 A/B Irradiation:- 4Gy XRays for 1 minute there is a time-dependent association of EGFR and ERCC1, peaking at 20 minutes following 4 Gy IR. ercc1-egfr-3 1 28 unspecified role unspecified role prey prey 23 unspecified role unspecified role prey prey 22 unspecified role unspecified role bait bait association association 2C Irradiation:- 4Gy XRays for 1 minute The complex did not include EGFR when irradiation was absent. ercc1-egfr-4 4 28 unspecified role unspecified role prey prey 22 unspecified role unspecified role bait bait 23 unspecified role unspecified role prey prey association association 2C Irradiation:- 4Gy XRays for 1 minute The complex did not include EGFR when irradiation was absent. egfr-ercc1-2 4 23 unspecified role unspecified role bait bait 22 unspecified role unspecified role prey prey physical association physical association 2 B Irradiation:- 4Gy XRays for 1 minute there is a time-dependent association of EGFR and ERCC1, peaking at 20 minutes following 4 Gy IR. ercc1-egfr-4 4 28 unspecified role unspecified role prey prey 22 unspecified role unspecified role bait bait physical association physical association 2C-2 this interaction was seen in the presence or absence of irradiation egfr-ercc1-3 13 23 unspecified role unspecified role bait bait 22 unspecified role unspecified role prey prey physical association physical association 2 B Irradiation:- 4Gy XRays for 1 minute there is a time-dependent association of EGFR and ERCC1, peaking at 20 minutes following 4 Gy IR. ercc1-egfr-5 13 28 unspecified role unspecified role prey prey 22 unspecified role unspecified role bait bait physical association physical association 2C-2 this interaction was seen in the presence or absence of irradiation ercc1-egfr-5 13 23 unspecified role unspecified role prey prey 28 unspecified role unspecified role prey prey 22 unspecified role unspecified role bait bait association association 2C Irradiation:- 4Gy XRays for 1 minute The complex did not include EGFR when irradiation was absent. egfr-ercc1-4 15 22 unspecified role unspecified role neutral component neutral component 23 unspecified role unspecified role neutral component neutral component colocalization colocalization 3A egfr-ercc1-5 6 23 unspecified role unspecified role neutral component neutral component 22 unspecified role unspecified role neutral component neutral component colocalization colocalization 3A egfr-ercc1-6 2 23 unspecified role unspecified role neutral component neutral component 22 unspecified role unspecified role neutral component neutral component colocalization colocalization 3A egfr-ercc1-7 7 23 unspecified role unspecified role neutral component neutral component 22 unspecified role unspecified role neutral component neutral component colocalization colocalization 3A egfr-ercc1-8 3 22 unspecified role unspecified role neutral component neutral component 23 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction 3B, Supp 3 Irradiation; X Rays 4Gy, I minute Gefitinib; selective inhibitor of the EGFR tyrosine kinase domain. egfr-ercc1-9 16 22 unspecified role unspecified role neutral component neutral component 23 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction 3B, Supp 3 Irradiation; X Rays 4Gy, I minute Gefitinib; selective inhibitor of the EGFR tyrosine kinase domain. egfr-ercc1-10 5 23 unspecified role unspecified role neutral component neutral component 22 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction 3B Irradiation; X Rays 4Gy, I minute egfr-ercc1-11 8 22 unspecified role unspecified role neutral component neutral component 23 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction 3B, Supp 3B Irradiation; X Rays 4Gy, I minute Gefitinib; selective inhibitor of the EGFR tyrosine kinase domain. egfr-ercc1-12 12 23 unspecified role unspecified role bait bait 22 unspecified role unspecified role prey prey physical association physical association Supp 2 Irradiation:- 4Gy XRays for 1 minute egfr-ercc1-13 11 23 unspecified role unspecified role bait bait 22 unspecified role unspecified role prey prey physical association physical association Supp 2 Irradiation:- 4Gy XRays for 1 minute