IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ PTPIP51: a new interaction partner of the insulin receptor and PKA in adipose tissue. PTPIP51: a new interaction partner of the insulin receptor and PKA in adipose tissue. J Obes (2090-0708) 2013 imex curation Bobrich M.A., Schwabe S.A., Brobeil A., Viard M., Kamm M., Mooren F.C., Krüger K., Tag C., Wimmer M. Diabetes - Interactions investigated in the context of Diabetes Affinomics - Interactions curated for the Affinomics consortium. manuelanton.bobrich@usz.ch Only protein-protein interactions imex curation mouse-adipocytes Mus musculus adipocyte ADIPOCYTE fluorescence imaging fluorescence microscopy fluorescence imaging immunocytochemistry immunocytochemistry Bobrich M.A., Schwabe S.A., Brobeil A., Viard M., Kamm M., Mooren F.C., Krüger K., Tag C., Wimmer M. Diabetes - Interactions investigated in the context of Diabetes Interactions using antibody ab58187 (Abcam) to PKA cannot be included as the specificity of the antibody with regard to the three catalytic subunits of PKA is not known. (Antibody immunogen corresponding to "amino acids 1-121 of Human cAMP Protein Kinase Catalytic subunit" ; the alpha and beta subunits are ~90% homologous at the N-terminal region) manuelanton.bobrich@usz.ch Accepted 2015-MAY-01 by PPORRAS J Obes (2090-0708) 2013 Only protein-protein interactions imex curation imex curation PTPIP51: a new interaction partner of the insulin receptor and PKA in adipose tissue. PTPIP51: a new interaction partner of the insulin receptor and PKA in adipose tissue. J Obes (2090-0708) 2013 imex curation Bobrich M.A., Schwabe S.A., Brobeil A., Viard M., Kamm M., Mooren F.C., Krüger K., Tag C., Wimmer M. Diabetes - Interactions investigated in the context of Diabetes Affinomics - Interactions curated for the Affinomics consortium. manuelanton.bobrich@usz.ch Only protein-protein interactions imex curation mouse-adipocytes Mus musculus adipocyte ADIPOCYTE pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Bobrich M.A., Schwabe S.A., Brobeil A., Viard M., Kamm M., Mooren F.C., Krüger K., Tag C., Wimmer M. Diabetes - Interactions investigated in the context of Diabetes Interactions using antibody ab58187 (Abcam) to PKA cannot be included as the specificity of the antibody with regard to the three catalytic subunits of PKA is not known. (Antibody immunogen corresponding to "amino acids 1-121 of Human cAMP Protein Kinase Catalytic subunit" ; the alpha and beta subunits are ~90% homologous at the N-terminal region) manuelanton.bobrich@usz.ch Accepted 2015-MAY-01 by PPORRAS J Obes (2090-0708) 2013 Only protein-protein interactions imex curation imex curation insr_mouse Insulin receptor Insr protein protein mouse Mus musculus Mouse MGFGRGCETTAVPLLVAVAALLVGTAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDVCPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHFKCRNSRKPGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYCLKGLKLPSRTWSPPFESDDSQKHNQSEYDDSASECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRPSRKRRSLEEVGNVTATTLTLPDFPNVSSTIVPTSQEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPDERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPMGPLYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFYSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGREGGSSLSIKRTYDEHIPYTHMNGGKKNGRVLTLPRSNPS DIP protein P15208 original sequence version: 104 DIP protein P15208 original sequence version: 144 DIP protein P15208 original sequence version: 148 mint This receptor binds insulin and has a tyrosine-protein kinase activity B0FA7DBD2AD4646A rmd3_mouse Regulator of microtubule dynamics protein 3 Rmdn3 Fam82a2 Fam82c Protein FAM82A2 Protein FAM82C protein protein mouse Mus musculus Mouse MSRLGALGGSRAGLGLLLGTAAGLGFLCVLYSQRWKRTQRHGRSHSLPNSLDYAQASERGRQVTQFRAIPGEAGDAAILPSLSQEGQEKVLDRLDFVLTSLMALRREVEELQRSLQGLAGEIVGEVRSHIEENQRVARRRRFPFARERSDSTGSSSVYFTASSGAALTDAESEGGYTTANAESDYERDSDKESGDAEDEVSCETVRMGRKDSLDLDVEAASSPAAAALEEDDSSGREDVQLVLLQADELHQGSKQDKREGFQLLLNNKLAYGSRQDFLWRLARAYSDMSDLTEEESGKKSYALNGKEEAEAALKKGDESAACHLWYAVLCGQLAEHEGISKRIQSGFSFKEHVDKAIELQPEDPRGHFLLGRWCYQVSHLNWLEKKTATALFESPLSATVQDALQSFLKAEELQPGFSKAGRVYISKCYRELGKNSEARKWMKLAQELPDVTNEDSAFQKDLEELEVILG BA82C57843985A1B insr-rmdn3-2 1 3 unspecified role unspecified role neutral component neutral component 4 unspecified role unspecified role neutral component neutral component colocalization colocalization 3 A/B insr-rmdn3-1 2 3 unspecified role unspecified role neutral component neutral component 4 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction 4A, 5 Animals fed a high fat diet showed the highest interaction level.