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  <entry>
    <source releaseDate="2022-02-04">
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        <shortLabel>IntAct</shortLabel>
        <fullName>European Bioinformatics Institute</fullName>
        <alias type="synonym" typeAc="MI:1041">IntAct</alias>
        <alias type="synonym" typeAc="MI:1041">intact</alias>
      </names>
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      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
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        <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
        <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
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        <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>PSA forms complexes with alpha-1-antichymotrypsin in prostate.</fullName>
        </names>
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          <xref>
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          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">PSA forms complexes with alpha-1-antichymotrypsin in prostate.</attribute>
            <attribute name="journal" nameAc="MI:0885">Prostate (0270-4137)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2013</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Zhu L., Jäämaa S., Af Hällström T.M., Laiho M., Sankila A., Nordling S., Stenman U.H., Koistinen H.</attribute>
            <attribute name="dataset" nameAc="MI:0875">Cancer - Interactions investigated in the context of cancer</attribute>
            <attribute name="dataset" nameAc="MI:0875">Affinomics - Interactions curated for the Affinomics consortium.</attribute>
            <attribute name="contact-email" nameAc="MI:0634">hannu.k.koistinen@helsinki.fi</attribute>
            <attribute name="author-announcement">09-Sep-2013: Contacted by IntAct-Help.</attribute>
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            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
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        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="9606">
            <names>
              <shortLabel>human-prostate_carcinoma</shortLabel>
              <fullName>Homo sapiens prostate carcinoma</fullName>
            </names>
            <tissue>
              <names>
                <shortLabel>prostate_carcinoma</shortLabel>
                <fullName>Prostate carcinoma (cancer)</fullName>
              </names>
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          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>pla</shortLabel>
            <fullName>proximity ligation assay</fullName>
            <alias type="go synonym" typeAc="MI:0303">pELISA</alias>
            <alias type="synonym" typeAc="MI:1041">pELISA</alias>
            <alias type="synonym" typeAc="MI:1041">PLA</alias>
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        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>antibody detection</shortLabel>
            <fullName>identification by antibody</fullName>
            <alias type="synonym" typeAc="MI:1041">antibody detection</alias>
          </names>
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          <attribute name="contact-email" nameAc="MI:0634">hannu.k.koistinen@helsinki.fi</attribute>
          <attribute name="accepted">Accepted 2013-AUG-23 by MGT</attribute>
          <attribute name="author-announcement">09-Sep-2013: Contacted by IntAct-Help.</attribute>
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          <attribute name="publication year" nameAc="MI:0886">2013</attribute>
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          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
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      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>klk3_human</shortLabel>
          <fullName>Prostate-specific antigen</fullName>
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          <alias type="gene name synonym" typeAc="MI:0302">APS</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Kallikrein-3</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Semenogelase</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Gamma-seminoprotein</alias>
          <alias type="gene name synonym" typeAc="MI:0302">P-30 antigen</alias>
        </names>
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        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MWVPVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRNKSVILLGRHSLFHPEDTGQVFQVSHSFPHPLYDMSLLKNRFLRPGDDSSHDLMLLRLSEPAELTDAVKVMDLPTQEPALGTTCYASGWGSIEPEEFLTPKKLQCVDLHVISNDVCAQVHPQKVTKFMLCAGRWTGGKSTCSGDSGGPLVCNGVLQGITSWGSEPCALPERPSLYTKVVHYRKWIKDTIVANP</sequence>
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          <attribute name="crc64">AE9E732AF872141A</attribute>
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      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>aact_human</shortLabel>
          <fullName>Alpha-1-antichymotrypsin</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">Cell growth-inhibiting gene 24/25 protein</alias>
          <alias type="gene name" typeAc="MI:0301">SERPINA3</alias>
          <alias type="gene name synonym" typeAc="MI:0302">AACT</alias>
          <alias type="orf name" typeAc="MI:0306">GIG24</alias>
          <alias type="orf name" typeAc="MI:0306">GIG25</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Serpin A3</alias>
        </names>
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            <shortLabel>protein</shortLabel>
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            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MERMLPLLALGLLAAGFCPAVLCHPNSPLDEENLTQENQDRGTHVDLGLASANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAAAKKLINDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKWEMPFDPQDTHQSRFYLSKKKWVMVPMMSLHHLTIPYFRDEELSCTVVELKYTGNASALFILPDQDKMEEVEAMLLPETLKRWRDSLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSGITGARNLAVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTIVRFNRPFLMIIVPTDTQNIFFMSKVTNPKQA</sequence>
        <attributeList>
          <attribute name="crc64">B002F946C86A8951</attribute>
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      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-21141-1">
        <names>
          <shortLabel>klk3-serpina3</shortLabel>
        </names>
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        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="6">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>proximity</shortLabel>
            <fullName>proximity</fullName>
            <alias type="synonym" typeAc="MI:1041">close-contact colocalization</alias>
            <alias type="synonym" typeAc="MI:1041">neighbourhood interaction</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:2364" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-26564119" refType="identity" refTypeAc="MI:0356"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">4</attribute>
          <attribute name="comment" nameAc="MI:0612">This interaction is negative or dubious at best in normal prostate tissue.</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>