<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<entrySet level="2" version="5" minorVersion="4" xsi:schemaLocation="http://psi.hupo.org/mi/mif http://psidev.sourceforge.net/mi/rel25/src/MIF254.xsd" xmlns="http://psi.hupo.org/mi/mif" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
    <entry>
        <source releaseDate="2021-10-18+01:00">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="primary-reference" refTypeAc="MI:0358"/>
            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="4088669">
                <names>
                    <shortLabel>kern-2019-1</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="30775971" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-27097357" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-29274" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="7108">
                        <names>
                            <shortLabel>spofr-sf_9</shortLabel>
                            <fullName>Spodoptera frugiperda insect cells</fullName>
                            <alias typeAc="MI:1041" type="synonym">Fall armyworm</alias>
                        </names>
                        <cellType>
                            <names>
                                <shortLabel>sf_9</shortLabel>
                                <fullName>insect cells</fullName>
                            </names>
                            <xref>
                                <primaryRef db="cabri" dbAc="MI:0246" id="ACC 125" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="mint" dbAc="MI:0471" id="MINT-86941" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-346407" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="IA:0078" refType="identity" refTypeAc="MI:0356"/>
                            </xref>
                            <attributeList>
                                <attribute name="comment" nameAc="MI:0612">Derived from pupal ovarian tissue of the fall armyworm</attribute>
                                <attribute name="comment" nameAc="MI:0612">Cloned from the parent cell line, IPLB-SF-21-AE (SF-21)</attribute>
                                <attribute name="comment" nameAc="MI:0612">derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae</attribute>
                                <attribute name="comment" nameAc="MI:0612">cells are susceptible to Baculovirus infection</attribute>
                            </attributeList>
                        </cellType>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>3d-em</shortLabel>
                        <fullName>3D electron microscopy</fullName>
                        <alias typeAc="MI:1041" type="synonym">3D-EM</alias>
                        <alias typeAc="MI:1041" type="synonym">electron tomog</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0410" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="12160704" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608522" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>experimental particp</shortLabel>
                        <fullName>experimental participant identification</fullName>
                        <alias typeAc="MI:1041" type="synonym">experimental particp</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0661" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-933978" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Kern DM., Oh S., Hite RK., Brohawn SG.</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">brohawn@berkeley.edu</attribute>
                    <attribute name="journal" nameAc="MI:0885">eLife</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2019</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959">imex curation</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="4088670">
                <names>
                    <shortLabel>lrc8a_mouse</shortLabel>
                    <fullName>Volume-regulated anion channel subunit LRRC8A</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Protein ebouriffe</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Leucine-rich repeat-containing protein 8A</alias>
                    <alias typeAc="MI:0301" type="gene name">Lrrc8a</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Lrrc8</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q80WG5" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006820" secondary="anion transport" version="SP_148"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000007476" version="SP_148" refType="gene"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-20718010" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1902476" secondary="chloride transmembrane transport" version="SP_148"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7M19" version="SP_148"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6G9O" version="SP_148"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000092690" version="SP_148" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006970" secondary="response to osmotic stress" version="SP_148"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002329" secondary="pre-B cell differentiation" version="SP_148"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032024" secondary="positive regulation of insulin secretion" version="SP_148"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6G8Z" version="SP_148"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" secondary="integral component of membrane" version="SP_148"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000139454" version="SP_148" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009986" secondary="cell surface" version="SP_148"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001611" version="SP_148"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0015734" secondary="taurine transport" version="SP_148"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003591" version="SP_148"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005225" secondary="volume-sensitive anion channel activity" version="SP_148"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7M17" version="SP_148"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000095078" version="SP_148" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_148"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905103" secondary="integral component of lysosomal membrane" version="SP_148"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0140360" secondary="cyclic-GMP-AMP transmembrane transporter activity" version="SP_148"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR021040" version="SP_148"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5223345" version="SP_148"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6FNW" version="SP_148"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034214" secondary="protein hexamerization" version="SP_148"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0140361" secondary="cyclic-GMP-AMP transmembrane import across plasma membrane" version="SP_148"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007283" secondary="spermatogenesis" version="SP_148"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000099041" version="SP_148" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005887" secondary="integral component of plasma membrane" version="SP_148"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_808393.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045663" secondary="positive regulation of myoblast differentiation" version="SP_148"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NZW" version="SP_148"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000109284" version="SP_148" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006884" secondary="cell volume homeostasis" version="SP_148"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6G9L" version="SP_148"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR032675" version="SP_148"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000113654" version="SP_148" refType="transcript"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A2AQZ0" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0015810" secondary="aspartate transmembrane transport" version="SP_148"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001678" secondary="cellular glucose homeostasis" version="SP_148"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NZZ" version="SP_148"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0098656" secondary="anion transmembrane transport" version="SP_148"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034702" secondary="ion channel complex" version="SP_148"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000139038" version="SP_148" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_148"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="Q80WG5" version="SP_148"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6O00" version="SP_148"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10090">
                    <names>
                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
                </organism>
                <sequence>MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWVTKDSCNDSFRGWAASSPEPTYPNSTVLPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFALIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFSTLPPEVKERLWRADKEQA</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-29274-1" id="4088671">
                <names>
                    <shortLabel>lrrc8a-7</shortLabel>
                </names>
                <xref>
                    <primaryRef db="emdb" dbAc="MI:0936" id="EMD-0563" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-27097364" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-29274-1" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="emdb" dbAc="MI:0936" id="EMD-0564" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="emdb" dbAc="MI:0936" id="EMD-0562" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="wwpdb" dbAc="MI:0805" id="6NZW" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="wwpdb" dbAc="MI:0805" id="6O00" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="wwpdb" dbAc="MI:0805" id="6NZZ" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>4088669</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="4088672">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-27097369" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>4088670</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>predetermined</shortLabel>
                                    <fullName>predetermined participant</fullName>
                                    <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </participantIdentificationMethod>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>structure determination</shortLabel>
                                    <fullName>identification by structure determination</fullName>
                                    <alias typeAc="MI:1041" type="synonym">identification by structure determination</alias>
                                    <alias typeAc="MI:1041" type="synonym">structure determination</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:2287" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="7877166" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-20597534" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>purified</shortLabel>
                                    <fullName>purified</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="7108">
                                <names>
                                    <shortLabel>spofr-sf_9</shortLabel>
                                    <fullName>Spodoptera frugiperda insect cells</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Fall armyworm</alias>
                                </names>
                                <cellType>
                                    <names>
                                        <shortLabel>sf_9</shortLabel>
                                        <fullName>insect cells</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="cabri" dbAc="MI:0246" id="ACC 125" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="mint" dbAc="MI:0471" id="MINT-86941" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-346407" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="IA:0078" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                    <attributeList>
                                        <attribute name="comment" nameAc="MI:0612">Derived from pupal ovarian tissue of the fall armyworm</attribute>
                                        <attribute name="comment" nameAc="MI:0612">Cloned from the parent cell line, IPLB-SF-21-AE (SF-21)</attribute>
                                        <attribute name="comment" nameAc="MI:0612">derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae</attribute>
                                        <attribute name="comment" nameAc="MI:0612">cells are susceptible to Baculovirus infection</attribute>
                                    </attributeList>
                                </cellType>
                            </hostOrganism>
                        </hostOrganismList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 6.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">Table 1</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
