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        <source releaseDate="2021-07-12+01:00">
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                <shortLabel>MINT</shortLabel>
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                <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
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                <names>
                    <shortLabel>mallick-2014-1</shortLabel>
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                    <hostOrganism ncbiTaxId="10116">
                        <names>
                            <shortLabel>rat-brain</shortLabel>
                            <fullName>Rattus norvegicus brain</fullName>
                        </names>
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                                <shortLabel>brain</shortLabel>
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                    <names>
                        <shortLabel>anti bait coip</shortLabel>
                        <fullName>anti bait coimmunoprecipitation</fullName>
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                    <names>
                        <shortLabel>western blot</shortLabel>
                        <fullName>western blot</fullName>
                        <alias typeAc="MI:0303" type="go synonym">Immuno blot</alias>
                        <alias typeAc="MI:1041" type="synonym">Immuno blot</alias>
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                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Mallick S., D'Mello SR.</attribute>
                    <attribute name="dataset" nameAc="MI:0875">Brain Disease - Neurological Diseases &amp; Disorders</attribute>
                    <attribute name="data-processing" nameAc="MI:0633">interactions from fig. 2a and b could not be captured as origin species of FLAG-SIRT1 was not provided.</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">sdmello@smu.edu,dmello@neugneron.com</attribute>
                    <attribute name="journal" nameAc="MI:0885">The Journal of biological chemistry</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2014</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959">imex curation</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
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                    <shortLabel>sir1_rat</shortLabel>
                    <fullName>NAD-dependent protein deacetylase sirtuin-1</fullName>
                    <alias typeAc="MI:0301" type="gene name">Sirt1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">NAD-dependent protein deacylase sirtuin-1</alias>
                </names>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032922" secondary="circadian regulation of gene expression" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0014858" secondary="positive regulation of skeletal muscle cell proliferation" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009267" secondary="cellular response to starvation" version="SP_47"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-26982029" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000773" secondary="negative regulation of cellular senescence" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004407" secondary="histone deacetylase activity" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042311" secondary="vasodilation" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000731" secondary="DNA synthesis involved in DNA repair" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046969" secondary="NAD-dependent histone deacetylase activity (H3-K9 specific)" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032071" secondary="regulation of endodeoxyribonuclease activity" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0018394" secondary="peptidyl-lysine acetylation" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019213" secondary="deacetylase activity" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043422" secondary="protein kinase B binding" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070403" secondary="NAD+ binding" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1904644" secondary="cellular response to curcumin" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006642" secondary="triglyceride mobilization" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070301" secondary="cellular response to hydrogen peroxide" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001525" secondary="angiogenesis" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030308" secondary="negative regulation of cell growth" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071456" secondary="cellular response to hypoxia" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045722" secondary="positive regulation of gluconeogenesis" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071236" secondary="cellular response to antibiotic" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010883" secondary="regulation of lipid storage" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046628" secondary="positive regulation of insulin receptor signaling pathway" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006476" secondary="protein deacetylation" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042595" secondary="behavioral response to starvation" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000791" secondary="euchromatin" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002039" secondary="p53 binding" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030426" secondary="growth cone" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010460" secondary="positive regulation of heart rate" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032007" secondary="negative regulation of TOR signaling" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1900113" secondary="negative regulation of histone H3-K9 trimethylation" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032088" secondary="negative regulation of NF-kappaB transcription factor activity" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008284" secondary="positive regulation of cell population proliferation" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000720" secondary="pyrimidine dimer repair by nucleotide-excision repair" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005730" secondary="nucleolus" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034391" secondary="regulation of smooth muscle cell apoptotic process" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033210" secondary="leptin-mediated signaling pathway" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1900181" secondary="negative regulation of protein localization to nucleus" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000481" secondary="positive regulation of cAMP-dependent protein kinase activity" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1902237" secondary="positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1904179" secondary="positive regulation of adipose tissue development" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010629" secondary="negative regulation of gene expression" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060548" secondary="negative regulation of cell death" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045766" secondary="positive regulation of angiogenesis" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031507" secondary="heterochromatin assembly" version="SP_47"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035358" secondary="regulation of peroxisome proliferator activated receptor signaling pathway" version="SP_47"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10116">
                    <names>
                        <shortLabel>rat</shortLabel>
                        <fullName>Rattus norvegicus (Rat)</fullName>
                        <alias typeAc="MI:1041" type="synonym">Rat</alias>
                    </names>
                </organism>
                <sequence>MIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELVHLSELPPTPLHISEDSSSPERTVPQDSSVIATLVDQTIKNKVDDLEVSEPKSCVEEKSQEVQTYRNVESINVENPDFKAVGSSTGDKNERTSVAETVRKCWPNRLAKEQISKRLDGNQYLFVPPNRYIFHGAEVYSDSEDDALSSSSCGSNSDSGTCQSPSLEEPLEDESEIEEFYNGLEDDADRPECAGGSGADGGDQEAVNEAIAMKQELTDVNCTPDKSEHY</sequence>
            </interactor>
            <interactor id="4058932">
                <names>
                    <shortLabel>d3zql4_rat</shortLabel>
                    <alias typeAc="MI:0301" type="gene name">Zfp346</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="D3ZQL4" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="TrEMBL_72"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043065" secondary="positive regulation of apoptotic process" version="TrEMBL_72"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" secondary="nucleoplasm" version="TrEMBL_72"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003604" version="TrEMBL_72"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035198" secondary="miRNA binding" version="TrEMBL_72"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013087" version="TrEMBL_72"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036236" version="TrEMBL_72"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003725" secondary="double-stranded RNA binding" version="TrEMBL_72"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-21996050" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005730" secondary="nucleolus" version="TrEMBL_72"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_006253690.1"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOG00000016867" version="TrEMBL_72" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008270" secondary="zinc ion binding" version="TrEMBL_72"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOP00000022646" version="TrEMBL_72" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019899" secondary="enzyme binding" version="TrEMBL_72"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOT00000022646" version="TrEMBL_72" refType="transcript"/>
                    <secondaryRef db="rgd" dbAc="MI:0483" id="1308068"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10116">
                    <names>
                        <shortLabel>rat</shortLabel>
                        <fullName>Rattus norvegicus (Rat)</fullName>
                        <alias typeAc="MI:1041" type="synonym">Rat</alias>
                    </names>
                </organism>
                <sequence>MRSSSTARLAEKMECPVPDFTEAADPGGAGPYKSSEEPEGREPDGVRFDRERARRLWEAVSGAQPAGREEVEHMIQKNQCLFTSTQCKVCCAMLISESQKLAHYQSKKHANKVKRYLAIHGMETLKGDVKRLDSDQKSSRSKDKNHCCPVCNMTFSSPVVAQSHYLGKTHARNLKLKQQPAKGAALQQHRETLDPDKFCSLCHSAFNDPAMAQQHYTGKRHRKQETKLKLMAHYGRLAGPTASDSPAGKGYPCKTCKIVLNSIEQYQAHVSGFKHKNQSPKTLVTLGSQMPVQTQPTPKDSSTVED</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-28996-1" id="4058933">
                <names>
                    <shortLabel>jaz-sirt1-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-26981903" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-28996-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>4058930</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="4058934">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-26982032" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>4058931</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>physiological level</shortLabel>
                                    <fullName>physiological level</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous level</alias>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous level</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                    </participant>
                    <participant id="4058935">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-26981906" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>4058932</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>physiological level</shortLabel>
                                    <fullName>physiological level</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous level</alias>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous level</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">Fig. 2C</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
