DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ groll-1997-1 yeast Saccharomyces cerevisiae Baker's yeast x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Groll M., Ditzel L., Löwe J., Stock D., Bochtler M., Bartunik HD., Huber R. Robert Huber Nature 1997 Only protein-protein interactions imex curation imex curation psb7_yeast Proteasome subunit beta type-7 PRE4 YFR050C Macropain subunit PRE4 Proteinase YSCE subunit PRE4 Multicatalytic endopeptidase complex subunit PRE4 Proteasome component PRE4 protein protein yeast Saccharomyces cerevisiae Baker's yeast MNHDPFSWGRPADSTYGAYNTQIANAGASPMVNTQQPIVTGTSVISMKYDNGVIIAADNLGSYGSLLRFNGVERLIPVGDNTVVGISGDISDMQHIERLLKDLVTENAYDNPLADAEEALEPSYIFEYLATVMYQRRSKMNPLWNAIIVAGVQSNGDQFLRYVNLLGVTYSSPTLATGFGAHMANPLLRKVVDRESDIPKTTVQVAEEAIVNAMRVLYYRDARSSRNFSLAIIDKNTGLTFKKNLQVENMKWDFAKDIKGYGTQKI E585BB3B5D0C8E2C psb6_yeast Proteasome subunit beta type-6 PRE7 PRS3 PTS1 YBL0407 YBL041W Proteasome component C5 Multicatalytic endopeptidase complex subunit C5 protein protein yeast Saccharomyces cerevisiae Baker's yeast MATIASEYSSEASNTPIEHQFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKGAVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD 770A4DF1DF0A0F0E psb5_yeast Proteasome subunit beta type-5 PRE2 DOA3 PRG1 YPR103W P8283.10 Macropain subunit PRE2 Proteinase YSCE subunit PRE2 Multicatalytic endopeptidase complex subunit PRE2 Proteasome component PRE2 protein protein yeast Saccharomyces cerevisiae Baker's yeast MQAIADSFSVPNRLVKELQYDNEQNLESDFVTGASQFQRLAPSLTVPPIASPQQFLRAHTDDSRNPDCKIKIAHGTTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG D0EBAC611F7A4F37 psb4_yeast Proteasome subunit beta type-4 PRE1 YER012W Proteasome component C11 Macropain subunit C11 Proteinase YSCE subunit 11 Multicatalytic endopeptidase complex subunit C11 protein protein yeast Saccharomyces cerevisiae Baker's yeast MDIILGIRVQDSVILASSKAVTRGISVLKDSDDKTRQLSPHTLMSFAGEAGDTVQFAEYIQANIQLYSIREDYELSPQAVSSFVRQELAKSIRSRRPYQVNVLIGGYDKKKNKPELYQIDYLGTKVELPYGAHGYSGFYTFSLLDHHYRPDMTTEEGLDLLKLCVQELEKRMPMDFKGVIVKIVDKDGIRQVDDFQAQ ED43D319A5895B40 psb3_yeast Proteasome subunit beta type-3 PUP3 Proteasome component PUP3 YER094C Macropain subunit PUP3 Multicatalytic endopeptidase complex subunit PUP3 protein protein yeast Saccharomyces cerevisiae Baker's yeast MSDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 5AA92D746454BCB7 psb2_yeast Proteasome subunit beta type-2 PUP1 YOR157C Macropain subunit PUP1 Proteinase YSCE subunit PUP1 Multicatalytic endopeptidase complex subunit PUP1 Proteasome component PUP1 protein protein yeast Saccharomyces cerevisiae Baker's yeast MAGLSFDNYQRNNFLAENSHTQPKATSTGTTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICDIQEEQVDITA 13A8F2B75584539A psb1_yeast Proteasome subunit beta type-1 PRE3 YJL001W J1407 Macropain subunit PRE3 Proteinase YSCE subunit PRE3 Multicatalytic endopeptidase complex subunit PRE3 Proteasome component PRE3 protein protein yeast Saccharomyces cerevisiae Baker's yeast MNGIQVDINRLKKGEVSLGTSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL BD1FCE649678D86B psa7_yeast Probable proteasome subunit alpha type-7 PRE10 PRC1 PRS1 O6650 YOR362C Proteasome component C1 Macropain subunit C1 Proteinase YSCE subunit 1 Multicatalytic endopeptidase complex subunit C1 protein protein yeast Saccharomyces cerevisiae Baker's yeast MTSIGTGYDLSNSVFSPDGRNFQVEYAVKAVENGTTSIGIKCNDGVVFAVEKLITSKLLVPQKNVKIQVVDRHIGCVYSGLIPDGRHLVNRGREEAASFKKLYKTPIPIPAFADRLGQYVQAHTLYNSVRPFGVSTIFGGVDKNGAHLYMLEPSGSYWGYKGAATGKGRQSAKAELEKLVDHHPEGLSAREAVKQAAKIIYLAHEDNKEKDFELEISWCSLSETNGLHKFVKGDLLQEAIDFAQKEINGDDDEDEDDSDNVMSSDDENAPVATNANATTDQEGDIHLE 1E51D904CF336747 psa6_yeast Proteasome subunit alpha type-6 PRE5 YMR314W YM9924.06 Proteasome component PRE5 Macropain subunit PRE5 Proteinase YSCE subunit PRE5 Multicatalytic endopeptidase complex subunit PRE5 protein protein yeast Saccharomyces cerevisiae Baker's yeast MFRNNYDGDTVTFSPTGRLFQVEYALEAIKQGSVTVGLRSNTHAVLVALKRNADELSSYQKKIIKCDEHMGLSLAGLAPDARVLSNYLRQQCNYSSLVFNRKLAVERAGHLLCDKAQKNTQSYGGRPYGVGLLIIGYDKSGAHLLEFQPSGNVTELYGTAIGARSQGAKTYLERTLDTFIKIDGNPDELIKAGVEAISQSLRDESLTVDNLSIAIVGKDTPFTIYDGEAVAKYI C43CBCC1C6B9E39E psa5_yeast Proteasome subunit alpha type-5 PUP2 DOA5 YGR253C G9155 Proteasome component PUP2 Macropain subunit PUP2 Proteinase YSCE subunit PUP2 Multicatalytic endopeptidase complex subunit PUP2 protein protein yeast Saccharomyces cerevisiae Baker's yeast MFLTRSEYDRGVSTFSPEGRLFQVEYSLEAIKLGSTAIGIATKEGVVLGVEKRATSPLLESDSIEKIVEIDRHIGCAMSGLTADARSMIEHARTAAVTHNLYYDEDINVESLTQSVCDLALRFGEGASGEERLMSRPFGVALLIAGHDADDGYQLFHAEPSGTFYRYNAKAIGSGSEGAQAELLNEWHSSLTLKEAELLVLKILKQVMEEKLDENNAQLSCITKQDGFKIYDNEKTAELIKELKEKEAAESPEEADVEMS E8EDEB212BF4EC6E psa4_yeast Proteasome subunit alpha type-4 PRE6 YOL038W Proteasome component PRE6 Macropain subunit PRE6 Proteinase YSCE subunit PRE6 Multicatalytic endopeptidase complex subunit PRE6 protein protein yeast Saccharomyces cerevisiae Baker's yeast MSGYDRALSIFSPDGHIFQVEYALEAVKRGTCAVGVKGKNCVVLGCERRSTLKLQDTRITPSKVSKIDSHVVLSFSGLNADSRILIEKARVEAQSHRLTLEDPVTVEYLTRYVAGVQQRYTQSGGVRPFGVSTLIAGFDPRDDEPKLYQTEPSGIYSSWSAQTIGRNSKTVREFLEKNYDRKEPPATVEECVKLTVRSLLEVVQTGAKNIEITVVKPDSDIVALSSEEINQYVTQIEQEKQEQQEQDKKKKSNH 73AEE63B836E618A psa3_yeast Proteasome subunit alpha type-3 PRE9 YGR135W PRS5 Proteasome component Y13 Macropain subunit Y13 Proteinase YSCE subunit 13 Multicatalytic endopeptidase complex subunit Y13 protein protein yeast Saccharomyces cerevisiae Baker's yeast MGSRRYDSRTTIFSPEGRLYQVEYALESISHAGTAIGIMASDGIVLAAERKVTSTLLEQDTSTEKLYKLNDKIAVAVAGLTADAEILINTARIHAQNYLKTYNEDIPVEILVRRLSDIKQGYTQHGGLRPFGVSFIYAGYDDRYGYQLYTSNPSGNYTGWKAISVGANTSAAQTLLQMDYKDDMKVDDAIELALKTLSKTTDSSALTYDRLEFATIRKGANDGEVYQKIFKPQEIKDILVKTGITKKDEDEEADEDMK B43BB05233A01A9E psa2_yeast Proteasome subunit alpha type-2 PRE8 PRS4 YML092C Proteasome component Y7 Macropain subunit Y7 Proteinase YSCE subunit 7 Multicatalytic endopeptidase complex subunit Y7 protein protein yeast Saccharomyces cerevisiae Baker's yeast MTDRYSFSLTTFSPSGKLGQIDYALTAVKQGVTSLGIKATNGVVIATEKKSSSPLAMSETLSKVSLLTPDIGAVYSGMGPDYRVLVDKSRKVAHTSYKRIYGEYPPTKLLVSEVAKIMQEATQSGGVRPFGVSLLIAGHDEFNGFSLYQVDPSGSYFPWKATAIGKGSVAAKTFLEKRWNDELELEDAIHIALLTLKESVEGEFNGDTIELAIIGDENPDLLGYTGIPTDKGPRFRKLTSQEINDRLEAL 12D7DFB1AA10E9FE psa1_yeast Proteasome subunit alpha type-1 SCL1 PRC2 PRS2 YGL011C Proteasome component C7-alpha Macropain subunit C7-alpha Proteinase YSCE subunit 7 Multicatalytic endopeptidase complex C7 Proteasome component Y8 SCL1 suppressor protein protein protein yeast Saccharomyces cerevisiae Baker's yeast MSGAAAASAAGYDRHITIFSPEGRLYQVEYAFKATNQTNINSLAVRGKDCTVVISQKKVPDKLLDPTTVSYIFCISRTIGMVVNGPIPDARNAALRAKAEAAEFRYKYGYDMPCDVLAKRMANLSQIYTQRAYMRPLGVILTFVSVDEELGPSIYKTDPAGYYVGYKATATGPKQQEITTNLENHFKKSKIDHINEESWEKVVEFAITHMIDALGTEFSKNDLEVGVATKDKFFTLSAENIEERLVAIAEQD 5B938C862BC8D7EB pre1-pre10-6 3716651 N/A 3716652 unspecified role unspecified role neutral component neutral component purified purified sufficient to bind sufficient to bind sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Stoichiometry: 2.0 N/A 3716653 unspecified role unspecified role neutral component neutral component purified purified sufficient to bind sufficient to bind sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Stoichiometry: 2.0 N/A 3716654 unspecified role unspecified role neutral component neutral component purified purified sufficient to bind sufficient to bind sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Stoichiometry: 2.0 N/A 3716655 unspecified role unspecified role neutral component neutral component purified purified Stoichiometry: 2.0 N/A 3716656 unspecified role unspecified role neutral component neutral component purified purified Stoichiometry: 2.0 N/A 3716657 unspecified role unspecified role neutral component neutral component purified purified sufficient to bind sufficient to bind sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Stoichiometry: 2.0 N/A 3716658 unspecified role unspecified role neutral component neutral component purified purified Stoichiometry: 2.0 N/A 3716659 unspecified role unspecified role neutral component neutral component purified purified sufficient to bind sufficient to bind sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Stoichiometry: 2.0 N/A 3716660 unspecified role unspecified role neutral component neutral component purified purified Stoichiometry: 2.0 N/A 3716661 unspecified role unspecified role neutral component neutral component purified purified sufficient to bind sufficient to bind sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Stoichiometry: 2.0 N/A 3716662 unspecified role unspecified role neutral component neutral component purified purified sufficient to bind sufficient to bind sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Stoichiometry: 2.0 N/A 3716663 unspecified role unspecified role neutral component neutral component purified purified sufficient to bind sufficient to bind sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Stoichiometry: 2.0 N/A 3716664 unspecified role unspecified role neutral component neutral component purified purified Stoichiometry: 2.0 N/A 3716665 unspecified role unspecified role neutral component neutral component purified purified sufficient to bind sufficient to bind sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Stoichiometry: 2.0 physical association physical association false false false Fig 1, 2, Table 1, 2