IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ puig-2020-1 in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Puig E., Tolchard J., Riera A., Carulla N. Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases. Synthetic monomeric Abeta(1-42) samples were dissolved in DPC (dodecyl phosphocholine) solution. eduardpgc@me.com,antoni.riera@irbbarcelona.org,natalia.carulla@gmail.com ACS chemical neuroscience 2020 Only protein-protein interactions imex curation imex curation Alzheimers - Interactions investigated in the context of Alzheimers disease puig-2020-3 in vitro In vitro ms of complexes mass spectrometry studies of complexes ms of complexes predetermined predetermined participant predetermined Puig E., Tolchard J., Riera A., Carulla N. Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases. Detergent used was lauryldimethylamine N-oxide (LDAO). eduardpgc@me.com,antoni.riera@irbbarcelona.org,natalia.carulla@gmail.com ACS chemical neuroscience 2020 Only protein-protein interactions imex curation imex curation Alzheimers - Interactions investigated in the context of Alzheimers disease puig-2020-2 in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Puig E., Tolchard J., Riera A., Carulla N. Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases. eduardpgc@me.com,antoni.riera@irbbarcelona.org,natalia.carulla@gmail.com ACS chemical neuroscience 2020 Only protein-protein interactions imex curation imex curation Synthetic monomeric Abeta(1−42) samples were dissolved in DPC (dodecyl phosphocholine) solution. Alzheimers - Interactions investigated in the context of Alzheimers disease puig-2020-4 in vitro In vitro solution nmr solution state nmr solution state nmr solution nmr predetermined predetermined participant predetermined Puig E., Tolchard J., Riera A., Carulla N. Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases. The 15 N Abeta(1-42) tetramer was prepared in DPC micelles. eduardpgc@me.com,antoni.riera@irbbarcelona.org,natalia.carulla@gmail.com ACS chemical neuroscience 2020 Only protein-protein interactions imex curation imex curation Alzheimers - Interactions investigated in the context of Alzheimers disease p61278-pro_0000033088 Somatostatin-14 SST Growth hormone release-inhibiting factor protein protein human Homo sapiens Human AGCKNFFWKTFTSC 103 116 p05067-pro_0000000092 Amyloid-beta protein 42 Alzheimer disease amyloid protein Cerebral vascular amyloid peptide APP A4 AD1 ABPP PreA4 Protease nexin-II APPI Amyloid precursor protein Amyloid-beta A4 protein Alzheimer disease amyloid A4 protein homolog Amyloid-beta (A4) precursor protein protein protein human Homo sapiens Human DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA 672 713 app-sst-9 3949667 N/A 3949671 unspecified role unspecified role neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) N/A 3949672 unspecified role unspecified role neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) Stoichiometry: 4.0 direct interaction direct interaction false false false 1A, Supp. figure 2C/D Coincubation of Abeta(1−42) with SST14 under conditions that lead to tetramer formation resulted in an increase of 65% of the area under the peak assigned to tetramers.(Figure 1A). When SST14 was added to preformed tetramers, a 20% increase of the area under the peak assigned to the tetramer (Figure S2D) was seen. app-app-132 3949667 N/A 3949672 unspecified role unspecified role neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) Stoichiometry: 1.0 N/A 3949672 unspecified role unspecified role neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) Stoichiometry: 1.0 N/A 3949672 unspecified role unspecified role neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) Stoichiometry: 1.0 N/A 3949672 unspecified role unspecified role neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) Stoichiometry: 1.0 direct interaction direct interaction false false false Supp figure 2A sst-sst-2 3949667 N/A 3949671 unspecified role unspecified role neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) N/A 3949671 unspecified role unspecified role neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction false false false Supp figure 2B app-sst-8 3949668 N/A 3949672 unspecified role unspecified role neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) Stoichiometry: 1.0 N/A 3949672 unspecified role unspecified role neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) Stoichiometry: 1.0 N/A 3949672 unspecified role unspecified role neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) Stoichiometry: 1.0 N/A 3949672 unspecified role unspecified role neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) Stoichiometry: 1.0 direct interaction direct interaction false false false 2A app-sst-10 3949668 N/A 3949671 unspecified role unspecified role neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) N/A 3949672 unspecified role unspecified role neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) Stoichiometry: 4.0 direct interaction direct interaction false false false 2B, Supp. figure 3, table S2 app-sst-7 3949669 N/A 3949671 unspecified role unspecified role neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) N/A 3949672 unspecified role unspecified role neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) Stoichiometry: 4.0 direct interaction direct interaction false false false 3949669 1B/C app-sst-11 3949670 N/A 3949671 unspecified role unspecified role neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) N/A 3949672 unspecified role unspecified role neutral component neutral component region 15n label 15n label 15N N15 15N N15 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false chemical synthesis Chemical synthesis (Chemical synthesis) Stoichiometry: 4.0 direct interaction direct interaction false false false 3,4, Supp. figure 4.