UniProt UniProt http://www.uniprot.org zhang-2018-21 yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Zhang L., Köhler S., Rillo-Bohn R., Dernburg AF. afdernburg@lbl.gov eLife 2018 Only protein-protein interactions imex curation imex curation zhp2_caeel Zip homologous protein 2 zhp-2 D1081.9 protein protein caeel Caenorhabditis elegans MDWIQCNHCGIKPNQTKLYLTACGHVFCQNCTKAAFNSQCYLCKKPLKVDEINKNLRPDLMELFKDPRQLASDLVNELKQVVAFQAKQREIYVKCKNAEAKKDTERFAEARSKHVEKTQEIEKRKKAFLEDNVKLKNAKEEKNQLMARLKELREQPSQNLSVNKRRSNTRTEPPFSKISRTGPPSVMRKASHEFSLNLRDQSTSKILTSTPLSNIDYSRRDHRNRLFGAGLEHPSPILRQ zhp1_caeel Zip homologous protein 1 zhp-1 F55A12.10 protein protein caeel Caenorhabditis elegans MEFIVCNGCGCSPSKRQFFITACSHVFCETCRTTPTADFCHLCKIPTKTLKMDASLPKNVKKMFGDVGVMSTDIHKRLARVIGFQKIQKSIQLKMENKKSVMRKEQTKKVEKKTEEMHCQLSKLTSFEENNRKKLEDIERENEKLRNLISALELKVASSRDIDDDEFFMQGTPTSSNPSVAGSDVDNDELLDYDLLGLRNRSDSSSSNCSSQSNRGGSLF zhp3_caeel Zip homologous protein 3 zhp-3 Zip3-homologous protein K02B12.8 protein protein caeel Caenorhabditis elegans MDFVHCNKCFNRKPPDGFFISSCFHIFCTKCAKADLAVCLICKKNVRLVRLDGNISSGIKIYFADPIKMVADSLAKIQKKIDFQQSTRDHLVKYLTKEKEKKRQMEVYFRTKGQEFDSQRKKLAEATAWIQMAEKKLQASEEERVKAEREIEECQAKLKSMTNLMSADTLGMNSQTPFPFSLAESQETAPSLVESSANSTFNMVSPLVSSPASSPNSINYNSFFENGSRTRPESLNEEAMFNTMLQSSGQSANANTSESSAFSVAFNNIFTPSRNNMGDSSMINKTTANQTIMDKTSMSLENWRQNRANSFGVHDISKRDSSLPTGGGSAIRVHHFKQNSRITPIAQNRRSAAGFDRQQIQEMRRISSQPGYLAQRKPINGRSFIGPAD zhp4_caeel Zip homologous protein 4 zhp-4 Y39B6A.16 protein protein caeel Caenorhabditis elegans MEAVHCFRCYKFPSKQIEFYLTNCMHMFCIECERLCHPPEEEPLKCIQCSKTPIRIVKMGPELPMTIKSMFTPISEEINQYTRDLTRVLTFQHRQRASLSTFLERKVAAFDRLRDAYSEEKTKKEHYKKQLEEAYHLLKSKEHEISKLKKQLAEQAPPPQTPPRSNSLKVASSRSLETPSMMRVFSDSMYETPVQIQRRFTKAQAKAEAEAEAPAKSPGSKAQTTKCTSNYQSHPPASFETPIHHPPKTSMGFTTPANPPHMFPYLKKHEAQREKHKEHRNSQ rb_human Retinoblastoma-associated protein pRb pp110 p105-Rb RB1 p110-RB1 protein protein human Homo sapiens Human MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGICIFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSSISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFMNSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKSNLDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGNLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEMTSTRTRMQKQKMNDSMDTSNKEEK e2f1_human Transcription factor E2F1 Retinoblastoma-associated protein 1 Retinoblastoma-binding protein 3 PBR3 E2F1 RBBP3 pRB-binding protein E2F-1 protein protein human Homo sapiens Human MALAGAPAGGPCAPALEALLGAGALRLLDSSQIVIISAAQDASAPPAPTGPAAPAAGPCDPDLLLFATPQAPRPTPSAPRPALGRPPVKRRLDLETDHQYLAESSGPARGRGRHPGKGVKSPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLIAKKSKNHIQWLGSHTTVGVGGRLEGLTQDLRQLQESEQQLDHLMNICTTQLRLLSEDTDSQRLAYVTCQDLRSIADPAEQMVMVIKAPPETQLQAVDSSENFQISLKSKQGPIDVFLCPEETVGGISPGKTPSQEVTSEEENRATDSATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLSRMGSLRAPVDEDRLSPLVAADSLLEHVREDFSGLLPEEFISLSPPHEALDYHFGLEEGEGIRDLFDCDFGDLTPLDF fos_rat Proto-oncogene c-Fos Fos Cellular oncogene fos protein protein rat Rattus norvegicus (Rat) Rat MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNTQDFCADLSVSSANFIPTVTAISTSPDLQWLVQPTLVSSVAPSQTRAPHPYGLPTPSTGAYARAGVVKTMSGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPNDLGFPEEMSVTSLDLTGGLPEATTPESEEAFTLPLLNDPEPKPSLEPVKNISNMELKAEPFDDFLFPASSRPSGSETARSVPDVDLSGSFYAADWEPLHSSSLGMGPMVTELEPLCTPVVTCTPSCTTYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL mint Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation jun_mouse Transcription factor AP-1 Activator protein 1 Proto-oncogene c-Jun V-jun avian sarcoma virus 17 oncogene homolog AH119 Jun protein protein mouse Mus musculus Mouse MTAKMETTFYDDALNASFLQSESGAYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVSGAGMVAPAVASVAGAGGGGGYSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPSQPQQQQQPPQPPHHLPQQIPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF tfdp_drome Transcription factor Dp Dp CG4654 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MAHSTGGTVKTDEVNFFFRNEHGQISKMLKPAQNKSEMEGGKPVAVVYATGSSARNSGSASGIGNVGRMGAFSQMGSQGQFIRLQDNGLSIPKTEAGTTYTTVSAQKTSGAGSGHYDLPLKGDRYVKFTPNPIKMKSKLHAIQSNSLHSMSASSSSVQRKRKPDKAGKGLRHFSMKVCEKVEEKGKTTYNEVADDLVSEEMKNNAYDNNCDQKNIRRRVYDALNVLMAINVISKDKKEIRWIGLPANSTETFLALEEENCQRRERIKQKNEMLREMIMQHVAFKGLVERNKRNESQGVVPSPNASIQLPFIIVNTHKSTKINCSVTNDKSEYIFKFDKTFEMHDDIEVLKRMGFLLGLDKGECTPENIERVKSWVPPNLAKYVEAYGTGKTGENMYESDDEDNEFNGYLESANESQGFAQHSAQHTTDGEFKLEMDDDELDDDID e2f1_drome Transcription factor E2f1 E2f1 E2f dE2F CG6376 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MSKFFVNVAPINNSNSSSSHTTTSSNTQRHQQHQQHYGGSGTTGHTMVARRLNYDLHGGTTSINNNNNIVIKNESVDLDYDHVLSSSDSNSNGGVAAHLRDHVYISLDKGHNTGAVATAAAAATAGHTQQQLQQQHHHQNQQQRKATGKSNDITNYYKVKRRPHAVSDEIHPKKQAKQSAHHQTVYQKHTASSAPQQLRHSHHQLRHDADAELDEDVVERVAKPASHHPFSLSTPQQQLAASVASSSSSGDRNRADTSLGILTKKFVDLLQESPDGVVDLNEASNRLHVQKRRIYDITNVLEGINILEKKSKNNIQWRCGQSMVSQERSRHIEADSLRLEQQENELNKAIDLMRENLAEISQEVENSGGMAYVTQNDLLNVDLFKDQIVIVIKAPPEAKLVLPNTKLPREIYVKAENSGEINVFLCHDTSPENSPIAPGAGYVGAPGAGCVRTATSTRLHPLTNQRLNDPLFNNIDAMSTKGLFQTPYRSARNLSKSIEEAAKQSQPEYNNICDIAMGQHHNLNQQQQQQQQQLLQQPEEDDVDVELNQLVPTLTNPVVRTHQFQQHQQPSIQELFSSLTESSPPTPTKRRREAAAAAIAAGSSTTATTTLNSHNNRNHSNHSNHSNHSSSNNSKSQPPTIGYGSSQRRSDVPMYNCAMEGATTTSATADTTAATSRSAAASSLQMQFAAVAESNNGSSSGGGGGGGGYGSIAGAGANADPHQPYSHDRNSLPPGVADCDANSNSSSVTLQGLDALFNDIGSDYFSNDIAFVSINPPDDNDYPYALNANEGIDRLFDFGSDAYGP zhp_1-zhp_2-1 3714030 N/A 3714031 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A 3714032 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig 2I, Supp Fig.2E zhp_2-zhp_1-1 3714030 N/A 3714031 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed N/A 3714032 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association false false false Fig 2I, Supp Fig.2E zhp_3-zhp_4-1 3714030 N/A 3714033 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed N/A 3714034 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association false false false Fig 2I, Supp Fig.2E zhp_4-zhp_3-1 3714030 N/A 3714033 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A 3714034 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig 2I, Supp Fig.2E e2f1-rb1-5 3714030 N/A 3714035 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A 3714036 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false Fig.2I Weak interaction fos-jun-6 3714030 N/A 3714037 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A 3714038 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false Fig.2I fos-jun-7 3714030 N/A 3714039 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A 3714040 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false Fig.2I