UniProt UniProt http://www.uniprot.org pannen-2016-1 ecolx Escherichia coli gallex lex-a dimerization assay gallex predetermined predetermined participant predetermined Pannen D., Fabisch M., Gausling L., Schnetz K. One partner is fused to LexA(1–87)WT and the other partner is fused to a 408 mutant DNA-binding domain (LexA(1–87)408), in the case of homodimes, both proteins have the LexA(1–87)WT tag. Homo/heterodimers then bind to the hybrid operator and repress PsulA lacZ expression schnetz@uni-koeln.de The Journal of biological chemistry 2016 Only protein-protein interactions imex curation imex curation bglj_ecoli Transcriptional activator protein BglJ yjjR bglJ b4366 JW5955 protein protein ecoli Escherichia coli (strain K12) MEHSRIKKRNVALIEKCVMSSIGIESLFRKFAGNPYKLHTYTSQESFQDAMSRISFAAVIFSFSAMRSERREGLSCLTELAIKFPRTRRLVIADDDIEARLIGSLSPSPLDGVLSKASTLEIFHQELFLSLNGVRQATDRLNNQWYINQSRTLSPTEREILRFMSRGYSMTQIAEQLKRNIKTIRAHKFNVMSKLGVSSDAGLLEAADILLCMRHCETSNVLHPY rcsb_ecoli Transcriptional regulatory protein RcsB rcsB Capsular synthesis regulator component B JW2205 b2217 protein protein ecoli Escherichia coli (strain K12) MNNMNVIIADDHPIVLFGIRKSLEQIEWVNVVGEFEDSTALINNLPKLDAHVLITDLSMPGDKYGDGITLIKYIKRHFPSLSIIVLTMNNNPAILSAVLDLDIEGIVLKQGAPTDLPKALAALQKGKKFTPESVSRLLEKISAGGYGDKRLSPKESEVLRLFAEGFLVTEIAKKLNRSIKTISSQKKSAMMKLGVENDIALLNYLSSVTLSPADKD This sequence has been withdrawn from Uniprot. A78D1BD3004E0680 rcsa_ecoli Transcriptional regulatory protein RcsA rcsA Colanic acid capsular biosynthesis activation protein A JW1935 b1951 protein protein ecoli Escherichia coli (strain K12) MSTIIMDLCSYTRLGLTGYLLSRGVKKREINDIETVDDLAIACDSQRPSVVFINEDCFIHDASNSQRIKLIINQHPNTLFIVFMAIANVHFDEYLLVRKNLLISSKSIKPESLDDILGDILKKETTITSFLNMPTLSLSRTESSMLRMWMAGQGTIQISDQMNIKAKTVSSHKGNIKRKIKTHNKQVIYHVVRLTDNVTNGIFVNMR This sequence has been withdrawn from Uniprot. 6DAA22097807AF62 ecpr_ecoli HTH-type transcriptional regulator EcpR ecpR matA ykgK JW5031 b0294 protein protein ecoli Escherichia coli (strain K12) MTWQSDYSRDYEVKNHMECQNRSDKYIWSPHDAYFYKGLSELIVDIDRLIYLSLEKIRKDFVFINLSTDSLSEFINRDNEWLSAVKGKQVVLIAARKSEALANYWYYNSNIRGVVYAGLSRDIRKELVYVINGRFLRKDIKKDKITDREMEIIRMTAQGMQPKSIARIENCSVKTVYTHRRNAEAKLYSKIYKLVQ dctr_ecoli HTH-type transcriptional regulator DctR yhiF dctR b3507 JW3475 protein protein ecoli Escherichia coli (strain K12) MFLIITRDTMFFTAMKNILSKGNVVHIQNEEEIDVMLHQNAFVIIDTLMNNVFHSNFLTQIERLKPVHVIIFSPFNIKRCLGKVPVTFVPRTITIIDFVALINGSYCSVPEAAVSLSRKQHQVLSCIANQMTTEDILEKLKISLKTFYCHKHNIMMILNLKRINELVRHQHIDYLV fimz_ecoli Fimbriae Z protein ybcA fimZ b0535 JW5073 protein protein ecoli Escherichia coli (strain K12) MKPTSVIIMDTHPIIRMSIEVLLQKNSELQIVLKTDDYRITIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQIQSTVKVLFLSSKSECFYAGRAIQAGANGFVSKCNDQNDIFHAVQMILSGYTFFPSETLNYIKSNKCSTNSSTVTVLSNREVTILRYLVSGLSNKEIADKLLLSNKTVSAHKSNIYGKLGLHSIVELIDYAKLYELI narl_ecoli Nitrate/nitrite response regulator protein NarL narL frdR b1221 JW1212 protein protein ecoli Escherichia coli (strain K12) MSNQEPATILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVFSVSNHEEDVVTALKRGADGYLLKDMEPEDLLKALHQAAAGEMVLSEALTPVLAASLRANRATTERDVNQLTPRERDILKLIAQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEAAVWVHQERIF narp_ecoli Nitrate/nitrite response regulator protein NarP narP b2193 JW2181 protein protein ecoli Escherichia coli (strain K12) MPEATPFQVMIVDDHPLMRRGVRQLLELDPGSEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREMFGAEEDPFSVLTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILFLQQRGAQ uhpa_ecoli Transcriptional regulatory protein UhpA uhpA b3669 JW3644 protein protein ecoli Escherichia coli (strain K12) MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSVHDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKLGVSNDVELARRMFDGW uvry_ecoli Response regulator UvrY yecB uvrY b1914 JW1899 protein protein ecoli Escherichia coli (strain K12) MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRTNAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLMITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ This sequence has been withdrawn from Uniprot. 708E52D8BFA97716 csgd_ecoli CsgBAC operon transcriptional regulatory protein csgD b1040 JW1023 protein protein ecoli Escherichia coli (strain K12) MFNEVHSIHGHTLLLITKSSLQATALLQHLKQSLAITGKLHNIQRSLDDISSGSIILLDMMEADKKLIHYWQDTLSRKNNNIKILLLNTPEDYPYRDIENWPHINGVFYSMEDQERVVNGLQGVLRGECYFTQKLASYLITHSGNYRYNSTESALLTHREKEILNKLRIGASNNEIARSLFISENTVKTHLYNLFKKIAVKNRTQAVSWANDNLRR sdia_ecoli Regulatory protein SdiA sdiA b1916 JW1901 protein protein ecoli Escherichia coli (strain K12) MQDKDFFSWRRTMLLRFQRMETAEEVYHEIELQAQQLEYDYYSLCVRHPVPFTRPKVAFYTNYPEAWVSYYQAKNFLAIDPVLNPENFSQGHLMWNDDLFSEAQPLWEAARAHGLRRGVTQYLMLPNRALGFLSFSRCSAREIPILSDELQLKMQLLVRESLMALMRLNDEIVMTPEMNFSKREKEILRWTAEGKTSAEIAMILSISENTVNFHQKNMQKKINAPNKTQVACYAAATGLI yhjb_ecoli Putative HTH-type transcriptional regulator YhjB yhjB b3520 JW3488 protein protein ecoli Escherichia coli (strain K12) MQIVMFDRQSIFIHGMKISLQQRIPGVSIQGASQADELWQKLESYPEALVMLDGDQDGEFCYWLLQKTVVQFPEVKVLITATDCNKRWLQEVIHFNVLAIVPRDSTVETFALAVNSAAMGMMFLPGDWRTTPEKDIKDLKSLSARQREILTMLAAGESNKEIGRALNISTGTVKAHLESLYRRLEVKNRTQAAMMLNISS malt_ecoli HTH-type transcriptional regulator MalT malT malA b3418 JW3381 ATP-dependent transcriptional activator MalT protein protein ecoli Escherichia coli (strain K12) MLIPSKLSRPVRLDHTVVRERLLAKLSGANNFRLALITSPAGYGKTTLISQWAAGKNDIGWYSLDEGDNQQERFASYLIAAVQQATNGHCAICETMAQKRQYASLTSLFAQLFIELAEWHSPLYLVIDDYHLITNPVIHESMRFFIRHQPENLTLVVLSRNLPQLGIANLRVRDQLLEIGSQQLAFTHQEAKQFFDCRLSSPIEAAESSRICDDVSGWATALQLIALSARQNTHSAHKSARRLAGINASHLSDYLVDEVLDNVDLATRHFLLKSAILRSMNDALITRVTGEENGQMRLEEIERQGLFLQRMDDTGEWFCYHPLFGNFLRQRCQWELAAELPEIHRAAAESWMAQGFPSEAIHHALAAGDALMLRDILLNHAWSLFNHSELSLLEESLKALPWDSLLENPQLVLLQAWLMQSQHRYGEVNTLLARAEHEIKDIREDTMHAEFNALRAQVAINDGNPDEAERLAKLALEELPPGWFYSRIVATSVLGEVLHCKGELTRSLALMQQTEQMARQHDVWHYALWSLIQQSEILFAQGFLQTAWETQEKAFQLINEQHLEQLPMHEFLVRIRAQLLWAWARLDEAEASARSGIEVLSSYQPQQQLQCLAMLIQCSLARGDLDNARSQLNRLENLLGNGKYHSDWISNANKVRVIYWQMTGDKAAAANWLRHTAKPEFANNHFLQGQWRNIARAQILLGEFEPAEIVLEELNENARSLRLMSDLNRNLLLLNQLYWQAGRKSDAQRVLLDALKLANRTGFISHFVIEGEAMAQQLRQLIQLNTLPELEQHRAQRILREINQHHRHKFAHFDENFVERLLNHPEVPELIRTSPLTQREWQVLGLIYSGYSNEQIAGELEVAATTIKTHIRNLYQKLGVAHRQDAVQHAQQLLKMMGYGV bglj-rcsb-1 3710658 N/A 3710659 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 3710660 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)408 tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false Fig. 1 rcsa-rcsb-1 3710658 N/A 3710661 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 3710660 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)408 tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false Fig. 1 ecpr-rcsb-1 3710658 N/A 3710662 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 3710660 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)408 tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false Fig. 1 dctr-rcsb-1 3710658 N/A 3710663 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 3710660 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)408 tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false Fig. 1 bglj-rcsb-2 3710658 N/A 3710659 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)408 tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 3710660 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false Fig. 1 rcsb-rcsb-2 3710658 N/A 3710660 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 3710660 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false Fig. 1 fimz-fimz-1 3710658 N/A 3710664 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 3710664 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false Table 4 narl-narl-1 3710658 N/A 3710665 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 3710665 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false Table 4 narp-narp-1 3710658 N/A 3710666 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 3710666 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false Table 4 uhpa-uhpa-1 3710658 N/A 3710667 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 3710667 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false Table 4 uvry-uvry-1 3710658 N/A 3710668 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 3710668 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false Table 4 csgd-csgd-2 3710658 N/A 3710669 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 3710669 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false Table 4 sdia-sdia-1 3710658 N/A 3710670 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 3710670 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false Table 4 yhjb-yhjb-1 3710658 N/A 3710671 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 3710671 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false Table 4 malt-malt-3 3710658 N/A 3710672 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 3710672 unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed LexA(1–87)WT tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false Table 4