IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ imam-2006-5 in vitro In vitro protein kinase assay protein kinase assay predetermined predetermined participant predetermined Imam SZ., Indig FE., Cheng WH., Saxena SP., Stevnsner T., Kufe D., Bohr VA., Imam SZ., Indig FE., Cheng WH., Saxena SP., Stevnsner T., Kufe D., Bohr VA. From ref 34, CSB is from human origin (retrieved by blasting sequence provided against UniProtKB) and is HA-tagged at the N-terminal and His-tagged at the C-terminal. From ref 39, c-Abl K-R mutant corresponds to K294R mutant. S-tegged-CSB is from human origin (retrieved by blasting sequence provided in Fig.2E against UniProtKB). According to IMEx curation rules, protein kinase assays performed in vivo or performed using partially purified proteins (Fig.3D) were not annotated. vbohr@nih.gov Nucleic acids research 2006 Only protein-protein interactions imex curation imex curation imam-2006-1 in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Imam SZ., Indig FE., Cheng WH., Saxena SP., Stevnsner T., Kufe D., Bohr VA., Imam SZ., Indig FE., Cheng WH., Saxena SP., Stevnsner T., Kufe D., Bohr VA. From ref 34, CSB is from human origin (retrieved by blasting sequence provided against UniProtKB) and is HA-tagged at the N-terminal and His-tagged at the C-terminal. From ref 39, c-Abl K-R mutant corresponds to K294R mutant. S-tegged-CSB is from human origin (retrieved by blasting sequence provided in Fig.2E against UniProtKB). According to IMEx curation rules, protein kinase assays performed in vivo or performed using partially purified proteins (Fig.3D) were not annotated. vbohr@nih.gov Nucleic acids research 2006 Only protein-protein interactions imex curation imex curation imam-2006-2 in vitro In vitro pull down pull down anti tag western anti tag western blot anti tag western Imam SZ., Indig FE., Cheng WH., Saxena SP., Stevnsner T., Kufe D., Bohr VA., Imam SZ., Indig FE., Cheng WH., Saxena SP., Stevnsner T., Kufe D., Bohr VA. From ref 34, CSB is from human origin (retrieved by blasting sequence provided against UniProtKB) and is HA-tagged at the N-terminal and His-tagged at the C-terminal. From ref 39, c-Abl K-R mutant corresponds to K294R mutant. S-tegged-CSB is from human origin (retrieved by blasting sequence provided in Fig.2E against UniProtKB). According to IMEx curation rules, protein kinase assays performed in vivo or performed using partially purified proteins (Fig.3D) were not annotated. vbohr@nih.gov Nucleic acids research 2006 Only protein-protein interactions imex curation imex curation imam-2006-3 in vitro In vitro protein kinase assay protein kinase assay ms participant Identification by mass spectrometry ms participant Imam SZ., Indig FE., Cheng WH., Saxena SP., Stevnsner T., Kufe D., Bohr VA., Imam SZ., Indig FE., Cheng WH., Saxena SP., Stevnsner T., Kufe D., Bohr VA. From ref 34, CSB is from human origin (retrieved by blasting sequence provided against UniProtKB) and is HA-tagged at the N-terminal and His-tagged at the C-terminal. From ref 39, c-Abl K-R mutant corresponds to K294R mutant. S-tegged-CSB is from human origin (retrieved by blasting sequence provided in Fig.2E against UniProtKB). According to IMEx curation rules, protein kinase assays performed in vivo or performed using partially purified proteins (Fig.3D) were not annotated. vbohr@nih.gov Nucleic acids research 2006 Only protein-protein interactions imex curation imex curation imam-2006-4 human-gm_739 human-gm_739 CS1AN gm-739 gm00739 GM-739 CS1AN Human Cockayne syndrome immortalized fibroblasts anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Imam SZ., Indig FE., Cheng WH., Saxena SP., Stevnsner T., Kufe D., Bohr VA., Imam SZ., Indig FE., Cheng WH., Saxena SP., Stevnsner T., Kufe D., Bohr VA. From ref 34, CSB is from human origin (retrieved by blasting sequence provided against UniProtKB) and is HA-tagged at the N-terminal and His-tagged at the C-terminal. From ref 39, c-Abl K-R mutant corresponds to K294R mutant. S-tegged-CSB is from human origin (retrieved by blasting sequence provided in Fig.2E against UniProtKB). According to IMEx curation rules, protein kinase assays performed in vivo or performed using partially purified proteins (Fig.3D) were not annotated. vbohr@nih.gov Nucleic acids research 2006 Only protein-protein interactions imex curation imex curation imam-2006-6 human-gm_739 human-gm_739 CS1AN gm-739 gm00739 GM-739 CS1AN Human Cockayne syndrome immortalized fibroblasts confocal microscopy confocal microscopy anti tag immunost anti tag immunostaining anti tag immunost Imam SZ., Indig FE., Cheng WH., Saxena SP., Stevnsner T., Kufe D., Bohr VA., Imam SZ., Indig FE., Cheng WH., Saxena SP., Stevnsner T., Kufe D., Bohr VA. From ref 34, CSB is from human origin (retrieved by blasting sequence provided against UniProtKB) and is HA-tagged at the N-terminal and His-tagged at the C-terminal. From ref 39, c-Abl K-R mutant corresponds to K294R mutant. S-tegged-CSB is from human origin (retrieved by blasting sequence provided in Fig.2E against UniProtKB). According to IMEx curation rules, protein kinase assays performed in vivo or performed using partially purified proteins (Fig.3D) were not annotated. vbohr@nih.gov Nucleic acids research 2006 Only protein-protein interactions imex curation imex curation abl1_human Tyrosine-protein kinase ABL1 Abelson tyrosine-protein kinase 1 ABL1 ABL JTK7 Abelson murine leukemia viral oncogene homolog 1 Proto-oncogene c-Abl p150 protein protein human Homo sapiens Human MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR ercc6_human DNA excision repair protein ERCC-6 ERCC6 CSB ATP-dependent helicase ERCC6 Cockayne syndrome protein CSB protein protein human Homo sapiens Human MPNEGIPHSSQTQEQDCLQSQPVSNNEEMAIKQESGGDGEVEEYLSFRSVGDGLSTSAVGCASAAPRRGPALLHIDRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVDNAIHEASRASQLVDVEKEYRSVLDDLTSCTTSLRQINKIIEQLSPQAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHLQAILGGAEVKIELDHASLEEDAEPGPSSLGSMLMPVQETAWEELIRTGQMTPFGTQIPQKQEKKPRKIMLNEASGFEKYLADQAKLSFERKKQGCNKRAARKAPAPVTPPAPVQNKNKPNKKARVLSKKEERLKKHIKKLQKRALQFQGKVGLPKARRPWESDMRPEAEGDSEGEESEYFPTEEEEEEEDDEVEGAEADLSGDGTDYELKPLPKGGKRQKKVPVQEIDDDFFPSSGEEAEAASVGEGGGGGRKVGRYRDDGDEDYYKQRLRRWNKLRLQDKEKRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHTWWPPFRVAILHETGSYTHKKEKLIRDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLPDKNEQVLFCRLTDEQHKVYQNFVDSKEVYRILNGEMQIFSGLIALRKICNHPDLFSGGPKNLKGLPDDELEEDQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLDILEVFLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVVIYDPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQRRFFKSNDLYELFTLTSPDASQSTETSAIFAGTGSDVQTPKCHLKRRIQPAFGADHDVPKRKKFPASNISVNDATSSEEKSEAKGAEVNAVTSNRSDPLKDDPHMSSNVTSNDRLGEETNAVSGPEELSVISGNGECSNSSGTGKTSMPSGDESIDEKLGLSYKRERPSQAQTEAFWENKQMENNFYKHKSKTKHHSVAEEETLEKHLRPKQKPKNSKHCRDAKFEGTRIPHLVKKRRYQKQDSENKSEAKEQSNDDYVLEKLFKKSVGVHSVMKHDAIMDGASPDYVLVEAEANRVAQDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGKKSRFGKKRNSNFSVQHPSSTSPTEKCQDGIMKKEGKDNVPEHFSGRAEDADSSSGPLASSSLLAKMRARNHLILPERLESESGHLQEASALLPTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQSCVFRELLRNLCTFHRTSGGEGIWKLKPEYC abl1_mouse Tyrosine-protein kinase ABL1 Abl1 Abl Abelson murine leukemia viral oncogene homolog 1 Proto-oncogene c-Abl p150 Abelson tyrosine-protein kinase 1 protein protein mouse Mus musculus Mouse MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKRGTRGGAGSMLQAPELPTKTRTCRRAAEQKDAPDTPELLHTKGLGESDALDSEPAVSPLLPRKERGPPDGSLNEDERLLPRDRKTNLFSALIKKKKKMAPTPPKRSSSFREMDGQPDRRGASEDDSRELCNGPPALTSDAAEPTKSPKASNGAGVPNGAFREPGNSGFRSPHMWKKSSTLTGSRLAAAEEESGMSSSKRFLRSCSASCMPHGARDTEWRSVTLPRDLPSAGKQFDSSTFGGHKSEKPALPRKRTSESRSEQVAKSTAMPPPRLVKKNEEAAEEGFKDTESSPGSSPPSLTPKLLRRQVTASPSSGLSHKEEATKGSASGMGTPATAEPAPPSNKVGLSKASSEEMRVRRHKHSSESPGRDKGRLAKLKPAPPPPPACTGKAGKPAQSPSQEAGEAGGPTKTKCTSLAMDAVNTDPTKAGPPGEGLRKPVPPSVPKPQSTAKPPGTPTSPVSTPSTAPAPSPLAGDQQPSSAAFIPLISTRVSLRKTRQPPERIASGTITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLESNLRELQICPATASSGPAATQDFSKLLSSVKEISDIVRR abl-csb-2 3540190 N/A 3540196 enzyme enzyme neutral component neutral component purified purified region sufficient to bind sufficient binding region sufficient to bind range range range range false phosphorylated Tyr optyr O4'-phospho-L-tyrosine (2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid 2-azanyl-3-(4-phosphonooxyphenyl)propanoic acid MOD_RES Phosphotyrosine O4-phosphotyrosine tyrosine phosphate 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-phosphate O4'-phospho-L-tyrosine O4'-phosphorylated L-tyrosine OPTyr Phospho Phospho Tyrosinyl Phosphorylation phosphorylationy undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 3540197 enzyme target enzyme target substrate substrate neutral component neutral component purified purified s tag s tag s tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false phosphorylated Tyr optyr O4'-phospho-L-tyrosine (2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid 2-azanyl-3-(4-phosphonooxyphenyl)propanoic acid MOD_RES Phosphotyrosine O4-phosphotyrosine tyrosine phosphate 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-phosphate O4'-phospho-L-tyrosine O4'-phosphorylated L-tyrosine OPTyr Phospho Phospho Tyrosinyl Phosphorylation phosphorylationy undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human-gm_739 human-gm_739 CS1AN gm-739 gm00739 GM-739 CS1AN Human Cockayne syndrome immortalized fibroblasts phosphorylation phosphorylation reaction phosphorylation false false false Fig. 3A CHEBI:45783 - imatinib abl1-ercc6-4 3540190 N/A 3540196 enzyme enzyme neutral component neutral component purified purified phosphorylated Tyr optyr O4'-phospho-L-tyrosine (2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid 2-azanyl-3-(4-phosphonooxyphenyl)propanoic acid MOD_RES Phosphotyrosine O4-phosphotyrosine tyrosine phosphate 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-phosphate O4'-phospho-L-tyrosine O4'-phosphorylated L-tyrosine OPTyr Phospho Phospho Tyrosinyl Phosphorylation phosphorylationy undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false P00519:p.Lys294Arg mutation disrupting rate mutation disrupting interaction rate mutation disrupting rate certain certain sequence position certain certain certain sequence position certain false gst tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 3540197 enzyme target enzyme target substrate substrate neutral component neutral component purified purified s tag s tag s tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false phosphorylated Tyr optyr O4'-phospho-L-tyrosine (2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid 2-azanyl-3-(4-phosphonooxyphenyl)propanoic acid MOD_RES Phosphotyrosine O4-phosphotyrosine tyrosine phosphate 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-phosphate O4'-phospho-L-tyrosine O4'-phosphorylated L-tyrosine OPTyr Phospho Phospho Tyrosinyl Phosphorylation phosphorylationy undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human-gm_739 human-gm_739 CS1AN gm-739 gm00739 GM-739 CS1AN Human Cockayne syndrome immortalized fibroblasts phosphorylation phosphorylation reaction phosphorylation false false false Fig. 3C abl1-ercc6-5 3540190 N/A 3540197 enzyme target enzyme target substrate substrate neutral component neutral component purified purified s tag s tag s tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false phosphorylated Tyr optyr O4'-phospho-L-tyrosine (2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid 2-azanyl-3-(4-phosphonooxyphenyl)propanoic acid MOD_RES Phosphotyrosine O4-phosphotyrosine tyrosine phosphate 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-phosphate O4'-phospho-L-tyrosine O4'-phosphorylated L-tyrosine OPTyr Phospho Phospho Tyrosinyl Phosphorylation phosphorylationy undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human-gm_739 human-gm_739 CS1AN gm-739 gm00739 GM-739 CS1AN Human Cockayne syndrome immortalized fibroblasts N/A 3540198 enzyme enzyme neutral component neutral component purified purified phosphorylated Tyr optyr O4'-phospho-L-tyrosine (2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid 2-azanyl-3-(4-phosphonooxyphenyl)propanoic acid MOD_RES Phosphotyrosine O4-phosphotyrosine tyrosine phosphate 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-phosphate O4'-phospho-L-tyrosine O4'-phosphorylated L-tyrosine OPTyr Phospho Phospho Tyrosinyl Phosphorylation phosphorylationy undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false phosphorylation phosphorylation reaction phosphorylation false false false Fig. 3B CHEBI:45783 - imatinib abl1-ercc6-1 3540191 N/A 3540196 unspecified role unspecified role bait bait purified purified gst tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm N/A 3540197 unspecified role unspecified role prey prey cell lysate cell lysate physiological level physiological level endogenous level endogenous endogenous endogenous level human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 physical association physical association false false false Fig. 1B abl1-ercc6-2 3540191 N/A 3540196 unspecified role unspecified role prey prey purified purified N/A 3540197 unspecified role unspecified role bait bait partially purified partially purified region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false s tag s tag s tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human-gm_739 human-gm_739 CS1AN gm-739 gm00739 GM-739 CS1AN Human Cockayne syndrome immortalized fibroblasts physical association physical association false false false Fig. 2D This interaction was not detected by a canonical pull down but using the following procedure: S-protein pull-down products of whole cell extracts obtained from CS1AN cells transfected with S-protein tagged fragments of CSB, incubated with human c-Abl protein, separated by SDS-PAGE and immunoblotted, either with anti-Abl or anti-S-protein. csb-abl-1 3540192 N/A 3540196 unspecified role unspecified role bait bait purified purified gst tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false region sufficient to bind sufficient binding region sufficient to bind range range range range false spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm N/A 3540197 unspecified role unspecified role prey prey purified purified his tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false ha tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm direct interaction direct interaction false false false Fig. 1A, Fig. 2A abl1-ercc6-6 3540193 N/A 3540196 enzyme enzyme neutral component neutral component purified purified region sufficient to bind sufficient binding region sufficient to bind range range range range false N/A 3540197 enzyme target enzyme target substrate substrate neutral component neutral component purified purified s tag s tag s tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false phosphorylated Tyr optyr O4'-phospho-L-tyrosine (2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid 2-azanyl-3-(4-phosphonooxyphenyl)propanoic acid MOD_RES Phosphotyrosine O4-phosphotyrosine tyrosine phosphate 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-phosphate O4'-phospho-L-tyrosine O4'-phosphorylated L-tyrosine OPTyr Phospho Phospho Tyrosinyl Phosphorylation phosphorylationy modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain false human-gm_739 human-gm_739 CS1AN gm-739 gm00739 GM-739 CS1AN Human Cockayne syndrome immortalized fibroblasts phosphorylation phosphorylation reaction phosphorylation false false false Fig. 4 abl-csb-1 3540194 N/A 3540196 unspecified role unspecified role bait bait living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 3540197 unspecified role unspecified role prey prey purified purified physical association physical association false false false Fig. 1C abl1-ercc6-7 3540195 N/A 3540196 immunostaining immunostaining unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 3540197 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed cfp tag cfp tag cyan fluorescent protein tag CFP cyan fluorescent protein cyan fluorescent protein CFP cfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false colocalization colocalization false false false Fig. 5, Table 1 CHEBI:45783 - imatinib CHEBI:16240 - hydrogen peroxide