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    <entry>
        <source releaseDate="2020-12-23Z">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="primary-reference" refTypeAc="MI:0358"/>
            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3588058">
                <names>
                    <shortLabel>iyer-2006-1</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="16616187" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-25777199" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-28495" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="-1">
                        <names>
                            <shortLabel>in vitro</shortLabel>
                            <fullName>In vitro</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>x-ray diffraction</shortLabel>
                        <fullName>x-ray crystallography</fullName>
                        <alias typeAc="MI:0303" type="go synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">x-ray diffraction</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0114" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1272" refType="identity" refTypeAc="MI:0356"/>
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                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Iyer S., Scotney PD., Nash AD., Ravi Acharya K.</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">k.r.acharya@bath.ac.uk</attribute>
                    <attribute name="journal" nameAc="MI:0885">Journal of molecular biology</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2006</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3588059">
                <names>
                    <shortLabel>vegfb_human</shortLabel>
                    <fullName>Vascular endothelial growth factor B</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">VRF</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">VEGF-related factor</alias>
                    <alias typeAc="MI:0301" type="gene name">VEGFB</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P49765" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043183" secondary="vascular endothelial growth factor receptor 1 binding" version="SP_177"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR023581" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" secondary="membrane" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001934" secondary="positive regulation of protein phosphorylation" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042056" secondary="chemoattractant activity" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050731" secondary="positive regulation of peptidyl-tyrosine phosphorylation" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005172" secondary="vascular endothelial growth factor receptor binding" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002040" secondary="sprouting angiogenesis" version="SP_177"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000311127" version="SP_177" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_003368.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035470" secondary="positive regulation of vascular wound healing" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005615" secondary="extracellular space" version="SP_177"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000173511" version="SP_177" refType="gene"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000309422" version="SP_177" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001666" secondary="response to hypoxia" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060976" secondary="coronary vasculature development" version="SP_177"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2799898" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042493" secondary="response to drug" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043524" secondary="negative regulation of neuron apoptotic process" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070374" secondary="positive regulation of ERK1 and ERK2 cascade" version="SP_177"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-6045N"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-114608" version="SP_177"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0038084" secondary="vascular endothelial growth factor signaling pathway" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050930" secondary="induction of positive chemotaxis" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051897" secondary="positive regulation of protein kinase B signaling" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010629" secondary="negative regulation of gene expression" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043066" secondary="negative regulation of apoptotic process" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008083" secondary="growth factor activity" version="SP_177"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2VWE" version="SP_177"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000072" version="SP_177"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001230662.1"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-195399" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031093" secondary="platelet alpha granule lumen" version="SP_177"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2C7W" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060048" secondary="cardiac muscle contraction" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051781" secondary="positive regulation of cell division" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008201" secondary="heparin binding" version="SP_177"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q16528" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060754" secondary="positive regulation of mast cell chemotaxis" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030949" secondary="positive regulation of vascular endothelial growth factor receptor signaling pathway" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001938" secondary="positive regulation of endothelial cell proliferation" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048010" secondary="vascular endothelial growth factor receptor signaling pathway" version="SP_177"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2XAC" version="SP_177"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-194313" version="SP_177"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6TKK" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005576" secondary="extracellular region" version="SP_177"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR029034" version="SP_177"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006493" secondary="protein O-linked glycosylation" version="SP_177"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MSPLLRRLLLAALLQLAPAQAPVSQPDAPGHQRKVVSWIDVYTRATCQPREVVVPLTVELMGTVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQLGEMSLEEHSQCECRPKKKDSAVKPDRAATPHHRPQPRSVPGWDSAPGAPSPADITHPTPAPGPSAHAAPSTTSALTPGPAAAAADAAASSVAKGGA</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-28495-1" id="3588060">
                <names>
                    <shortLabel>vegfb-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="wwpdb" dbAc="MI:0805" id="2C7W" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-25777206" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-28495-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>3588058</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3588061">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-25777208" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3588059</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>purified</shortLabel>
                                    <fullName>purified</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <featureList>
                            <feature id="3588062">
                                <names>
                                    <shortLabel>binding region</shortLabel>
                                    <fullName>binding region</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-25777210" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>binding region</shortLabel>
                                        <fullName>binding-associated region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">binding region</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0117" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456493" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
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                                            </xref>
                                        </startStatus>
                                        <begin position="10"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="108"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="83333">
                                <names>
                                    <shortLabel>ecoli</shortLabel>
                                    <fullName>Escherichia coli (strain K12)</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 2.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">Fig 1, Table 1</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
