UniProt UniProt http://www.uniprot.org machado_pineda-2017-2 human-colo_320 Human colon adenocarcinoma colo_320 Human colorectal adenocarcinoma Colo320 anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Machado-Pineda Y., Cardeñes B., Reyes R., López-Martín S., Toribio V., Sánchez-Organero P., Suarez H., Grötzinger J., Lorenzen I., Yáñez-Mó M., Cabañas C. ccabanas@cbm.csic.es Frontiers in Immunology 2017 imex curation Only protein-protein interactions imex curation machado_pineda-2017-1 human-colo_320 Human colon adenocarcinoma colo_320 Human colorectal adenocarcinoma Colo320 pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Machado-Pineda Y., Cardeñes B., Reyes R., López-Martín S., Toribio V., Sánchez-Organero P., Suarez H., Grötzinger J., Lorenzen I., Yáñez-Mó M., Cabañas C. ccabanas@cbm.csic.es Frontiers in Immunology 2017 imex curation Only protein-protein interactions imex curation machado_pineda-2017-3 human-colo_320 Human colon adenocarcinoma colo_320 Human colorectal adenocarcinoma Colo320 confocal microscopy confocal microscopy immunocytochemistry immunocytochemistry Machado-Pineda Y., Cardeñes B., Reyes R., López-Martín S., Toribio V., Sánchez-Organero P., Suarez H., Grötzinger J., Lorenzen I., Yáñez-Mó M., Cabañas C. ccabanas@cbm.csic.es Frontiers in Immunology 2017 imex curation Only protein-protein interactions imex curation ada17_human Disintegrin and metalloproteinase domain-containing protein 17 ADAM17 CSVP TACE TNF-alpha-converting enzyme TNF-alpha convertase Snake venom-like protease protein protein human Homo sapiens Human MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC itb1_human Integrin beta-1 Fibronectin receptor subunit beta VLA-4 subunit beta ITGB1 FNRB MDF2 MSK12 Glycoprotein IIa protein protein human Homo sapiens Human MNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCEASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCTQECSYFNITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVENPECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK cd9_human CD9 antigen CD9 MIC3 TSPAN29 5H9 antigen Cell growth-inhibiting gene 2 protein Leukocyte antigen MIC3 Motility-related protein Tetraspanin-29 p24 GIG2 protein protein human Homo sapiens Human MPVKGGTKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQETNNNNSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAIWGYSHKDEVIKEVQEFYKDTYNKLKTKDEPQRETLKAIHYALNCCGLAGGVEQFISDICPKKDVLETFTVKSCPDAIKEVFDNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRNREMV itav_human Integrin alpha-V ITGAV VNRA Vitronectin receptor subunit alpha MSK8 Vitronectin receptor VTNR protein protein human Homo sapiens Human MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSET itgb1-adam17-1 3531236 N/A 3531239 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level human-colo_320 Human colon adenocarcinoma colo_320 Human colorectal adenocarcinoma Colo320 N/A 3531240 unspecified role unspecified role bait bait physiological level physiological level endogenous level endogenous endogenous endogenous level human-colo_320 Human colon adenocarcinoma colo_320 Human colorectal adenocarcinoma Colo320 physical association physical association false false false CD9 (P21926) Fig. 7a cd9-adam17-1 3531236 N/A 3531241 unspecified role unspecified role bait bait physiological level physiological level endogenous level endogenous endogenous endogenous level human-colo_320 Human colon adenocarcinoma colo_320 Human colorectal adenocarcinoma Colo320 N/A 3531239 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level human-colo_320 Human colon adenocarcinoma colo_320 Human colorectal adenocarcinoma Colo320 N/A 3531240 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level human-colo_320 Human colon adenocarcinoma colo_320 Human colorectal adenocarcinoma Colo320 association association false false false CD9 (P21926) Fig. 7b adam17-itgav-1 3531237 N/A 3531239 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 3531242 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level proximity proximity close-contact colocalization neighbourhood interaction false false false CD9 (P21926) Fig. 6 adam17-itgav-2 3531238 N/A 3531239 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 3531242 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level colocalization colocalization false false false CD9 (P21926) Fig. 5C