DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ ramanjulu-2018-1 ecoli Escherichia coli (strain K12) x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction experimental particp experimental participant identification experimental particp Ramanjulu JM., Pesiridis GS., Yang J., Concha N., Singhaus R., Zhang SY., Tran JL., Moore P., Lehmann S., Eberl HC., Muelbaier M., Schneck JL., Clemens J., Adam M., Mehlmann J., Romano J., Morales A., Kang J., Leister L., Graybill TL., Charnley AK., Ye G., Nevins N., Behnia K., Wolf AI., Kasparcova V., Nurse K., Wang L., Li Y., Klein M., Hopson CB., Guss J., Bantscheff M., Bergamini G., Reilly MA., Lian Y., Duffy KJ., Adams J., Foley KP., Gough PJ., Marquis RW., Smothers J., Hoos A., Bertin J. joshi.m.ramanjulu@gsk.com Nature 2018 imex curation Only protein-protein interactions imex curation sting_human Stimulator of interferon genes protein STING1 ERIS Endoplasmic reticulum interferon stimulator MITA Mediator of IRF3 activation TMEM173 Transmembrane protein 173 protein protein human Homo sapiens Human MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS sting-1 3524977 N/A 3524978 predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false ecoli Escherichia coli (strain K12) Stoichiometry: 2.0 direct interaction direct interaction false false false Fig 1, Extended Data Table 2