IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ chen-2017-7 mouse-mn9d Mus musculus MN9D neuronal cells mn9d Murine immortalized dopamine-containing neuronal mesencephalic hybrid mirna interference luciferase assay miRNA interference luciferase reporter assay miRNA interference luciferase assay tag fluorescence tag visualisation by fluorescence tag fluorescence Chen Q., Huang X., Li R. rjliwh@yeah.net American journal of translational research 2017 Only protein-protein interactions imex curation imex curation chen-2017-8 mouse-mn9d Mus musculus MN9D neuronal cells mn9d Murine immortalized dopamine-containing neuronal mesencephalic hybrid mirna interference luciferase assay miRNA interference luciferase reporter assay miRNA interference luciferase assay qrt-pcr quantitative reverse transcription pcr QRT-PCR Chen Q., Huang X., Li R. the target RNA is not luciferase tagged so the expression is not measured with luciferase assay but with qrtpcr rjliwh@yeah.net American journal of translational research 2017 Only protein-protein interactions imex curation imex curation mrna_lrrk2 mrna messenger rna mRNA mrna human Homo sapiens Human GCGCTGGCTGCGGGCGGTGAGCTGAGCTCGCCCCCGGGGAGCTGTGGCCGGCGCCCCTGCCGGTTCCCTGAGCAGCGGACGTTCATGCTGGGAGGGCGGCGGGTTGGAAGCAGGTGCCACCATGGCTAGTGGCAGCTGTCAGGGGTGCGAAGAGGACGAGGAAACTCTGAAGAAGTTGATAGTCAGGCTGAACAATGTCCAGGAAGGAAAACAGATAGAAACGCTGGTCCAAATCCTGGAGGATCTGCTGGTGTTCACGTACTCCGAGCACGCCTCCAAGTTATTTCAAGGCAAAAATATCCATGTGCCTCTGTTGATCGTCTTGGACTCCTATATGAGAGTCGCGAGTGTGCAGCAGGTGGGTTGGTCACTTCTGTGCAAATTAATAGAAGTCTGTCCAGGTACAATGCAAAGCTTAATGGGACCCCAGGATGTTGGAAATGATTGGGAAGTCCTTGGTGTTCACCAATTGATTCTTAAAATGCTAACAGTTCATAATGCCAGTGTAAACTTGTCAGTGATTGGACTGAAGACCTTAGATCTCCTCCTAACTTCAGGTAAAATCACCTTGCTGATATTGGATGAAGAAAGTGATATTTTCATGTTAATTTTTGATGCCATGCACTCATTTCCAGCCAATGATGAAGTCCAGAAACTTGGATGCAAAGCTTTACATGTGCTGTTTGAGAGAGTCTCAGAGGAGCAACTGACTGAATTTGTTGAGAACAAAGATTATATGATATTGTTAAGTGCGTTAACAAATTTTAAAGATGAAGAGGAAATTGTGCTTCATGTGCTGCATTGTTTACATTCCCTAGCGATTCCTTGCAATAATGTGGAAGTCCTCATGAGTGGCAATGTCAGGTGTTATAATATTGTGGTGGAAGCTATGAAAGCATTCCCTATGAGTGAAAGAATTCAAGAAGTGAGTTGCTGTTTGCTCCATAGGCTTACATTAGGTAATTTTTTCAATATCCTGGTATTAAACGAAGTCCATGAGTTTGTGGTGAAAGCTGTGCAGCAGTACCCAGAGAATGCAGCATTGCAGATCTCAGCGCTCAGCTGTTTGGCCCTCCTCACTGAGACTATTTTCTTAAATCAAGATTTAGAGGAAAAGAATGAGAATCAAGAGAATGATGATGAGGGGGAAGAAGATAAATTGTTTTGGCTGGAAGCCTGTTACAAAGCATTAACGTGGCATAGAAAGAACAAGCACGTGCAGGAGGCCGCATGCTGGGCACTAAATAATCTCCTTATGTACCAAAACAGTTTACATGAGAAGATTGGAGATGAAGATGGCCATTTCCCAGCTCATAGGGAAGTGATGCTCTCCATGCTGATGCATTCTTCATCAAAGGAAGTTTTCCAGGCATCTGCGAATGCATTGTCAACTCTCTTAGAACAAAATGTTAATTTCAGAAAAATACTGTTATCAAAAGGAATACACCTGAATGTTTTGGAGTTAATGCAGAAGCATATACATTCTCCTGAAGTGGCTGAAAGTGGCTGTAAAATGCTAAATCATCTTTTTGAAGGAAGCAACACTTCCCTGGATATAATGGCAGCAGTGGTCCCCAAAATACTAACAGTTATGAAACGTCATGAGACATCATTACCAGTGCAGCTGGAGGCGCTTCGAGCTATTTTACATTTTATAGTGCCTGGCATGCCAGAAGAATCCAGGGAGGATACAGAATTTCATCATAAGCTAAATATGGTTAAAAAACAGTGTTTCAAGAATGATATTCACAAACTGGTCCTAGCAGCTTTGAACAGGTTCATTGGAAATCCTGGGATTCAGAAATGTGGATTAAAAGTAATTTCTTCTATTGTACATTTTCCTGATGCATTAGAGATGTTATCCCTGGAAGGTGCTATGGATTCAGTGCTTCACACACTGCAGATGTATCCAGATGACCAAGAAATTCAGTGTCTGGGTTTAAGTCTTATAGGATACTTGATTACAAAGAAGAATGTGTTCATAGGAACTGGACATCTGCTGGCAAAAATTCTGGTTTCCAGCTTATACCGATTTAAGGATGTTGCTGAAATACAGACTAAAGGATTTCAGACAATCTTAGCAATCCTCAAATTGTCAGCATCTTTTTCTAAGCTGCTGGTGCATCATTCATTTGACTTAGTAATATTCCATCAAATGTCTTCCAATATCATGGAACAAAAGGATCAACAGTTTCTAAACCTCTGTTGCAAGTGTTTTGCAAAAGTAGCTATGGATGATTACTTAAAAAATGTGATGCTAGAGAGAGCGTGTGATCAGAATAACAGCATCATGGTTGAATGCTTGCTTCTATTGGGAGCAGATGCCAATCAAGCAAAGGAGGGATCTTCTTTAATTTGTCAGGTATGTGAGAAAGAGAGCAGTCCCAAATTGGTGGAACTCTTACTGAATAGTGGATCTCGTGAACAAGATGTACGAAAAGCGTTGACGATAAGCATTGGGAAAGGTGACAGCCAGATCATCAGCTTGCTCTTAAGGAGGCTGGCCCTGGATGTGGCCAACAATAGCATTTGCCTTGGAGGATTTTGTATAGGAAAAGTTGAACCTTCTTGGCTTGGTCCTTTATTTCCAGATAAGACTTCTAATTTAAGGAAACAAACAAATATAGCATCTACACTAGCAAGAATGGTGATCAGATATCAGATGAAAAGTGCTGTGGAAGAAGGAACAGCCTCAGGCAGCGATGGAAATTTTTCTGAAGATGTGCTGTCTAAATTTGATGAATGGACCTTTATTCCTGACTCTTCTATGGACAGTGTGTTTGCTCAAAGTGATGACCTGGATAGTGAAGGAAGTGAAGGCTCATTTCTTGTGAAAAAGAAATCTAATTCAATTAGTGTAGGAGAATTTTACCGAGATGCCGTATTACAGCGTTGCTCACCAAATTTGCAAAGACATTCCAATTCCTTGGGGCCCATTTTTGATCATGAAGATTTACTGAAGCGAAAAAGAAAAATATTATCTTCAGATGATTCACTCAGGTCATCAAAACTTCAATCCCATATGAGGCATTCAGACAGCATTTCTTCTCTGGCTTCTGAGAGAGAATATATTACATCACTAGACCTTTCAGCAAATGAACTAAGAGATATTGATGCCCTAAGCCAGAAATGCTGTATAAGTGTTCATTTGGAGCATCTTGAAAAGCTGGAGCTTCACCAGAATGCACTCACGAGCTTTCCACAACAGCTATGTGAAACTCTGAAGAGTTTGACACATTTGGACTTGCACAGTAATAAATTTACATCATTTCCTTCTTATTTGTTGAAAATGAGTTGTATTGCTAATCTTGATGTCTCTCGAAATGACATTGGACCCTCAGTGGTTTTAGATCCTACAGTGAAATGTCCAACTCTGAAACAGTTTAACCTGTCATATAACCAGCTGTCTTTTGTACCTGAGAACCTCACTGATGTGGTAGAGAAACTGGAGCAGCTCATTTTAGAAGGAAATAAAATATCAGGGATATGCTCCCCCTTGAGACTGAAGGAACTGAAGATTTTAAACCTTAGTAAGAACCACATTTCATCCCTATCAGAGAACTTTCTTGAGGCTTGTCCTAAAGTGGAGAGTTTCAGTGCCAGAATGAATTTTCTTGCTGCTATGCCTTTCTTGCCTCCTTCTATGACAATCCTAAAATTATCTCAGAACAAATTTTCCTGTATTCCAGAAGCAATTTTAAATCTTCCACACTTGCGGTCTTTAGATATGAGCAGCAATGATATTCAGTACCTACCAGGTCCCGCACACTGGAAATCTTTGAACTTAAGGGAACTCTTATTTAGCCATAATCAGATCAGCATCTTGGACTTGAGTGAAAAAGCATATTTATGGTCTAGAGTAGAGAAACTGCATCTTTCTCACAATAAACTGAAAGAGATTCCTCCTGAGATTGGCTGTCTTGAAAATCTGACATCTCTGGATGTCAGTTACAACTTGGAACTAAGATCCTTTCCCAATGAAATGGGGAAATTAAGCAAAATATGGGATCTTCCTTTGGATGAACTGCATCTTAACTTTGATTTTAAACATATAGGATGTAAAGCCAAAGACATCATAAGGTTTCTTCAACAGCGATTAAAAAAGGCTGTGCCTTATAACCGAATGAAACTTATGATTGTGGGAAATACTGGGAGTGGTAAAACCACCTTATTGCAGCAATTAATGAAAACCAAGAAATCAGATCTTGGAATGCAAAGTGCCACAGTTGGCATAGATGTGAAAGACTGGCCTATCCAAATAAGAGACAAAAGAAAGAGAGATCTCGTCCTAAATGTGTGGGATTTTGCAGGTCGTGAGGAATTCTATAGTACTCATCCCCATTTTATGACGCAGCGAGCATTGTACCTTGCTGTCTATGACCTCAGCAAGGGACAGGCTGAAGTTGATGCCATGAAGCCTTGGCTCTTCAATATAAAGGCTCGCGCTTCTTCTTCCCCTGTGATTCTCGTTGGCACACATTTGGATGTTTCTGATGAGAAGCAACGCAAAGCCTGCATGAGTAAAATCACCAAGGAACTCCTGAATAAGCGAGGGTTCCCTGCCATACGAGATTACCACTTTGTGAATGCCACCGAGGAATCTGATGCTTTGGCAAAACTTCGGAAAACCATCATAAACGAGAGCCTTAATTTCAAGATCCGAGATCAGCTTGTTGTTGGACAGCTGATTCCAGACTGCTATGTAGAACTTGAAAAAATCATTTTATCGGAGCGTAAAAATGTGCCAATTGAATTTCCCGTAATTGACCGGAAACGATTATTACAACTAGTGAGAGAAAATCAGCTGCAGTTAGATGAAAATGAGCTTCCTCACGCAGTTCACTTTCTAAATGAATCAGGAGTCCTTCTTCATTTTCAAGACCCAGCACTGCAGTTAAGTGACTTGTACTTTGTGGAACCCAAGTGGCTTTGTAAAATCATGGCACAGATTTTGACAGTGAAAGTGGAAGGTTGTCCAAAACACCCTAAGGGCATTATTTCGCGTAGAGATGTGGAAAAATTTCTTTCAAAAAAAAGGAAATTTCCAAAGAACTACATGTCACAGTATTTTAAGCTCCTAGAAAAATTCCAGATTGCTTTGCCAATAGGAGAAGAATATTTGCTGGTTCCAAGCAGTTTGTCTGACCACAGGCCTGTGATAGAGCTTCCCCATTGTGAGAACTCTGAAATTATCATCCGACTATATGAAATGCCTTATTTTCCAATGGGATTTTGGTCAAGATTAATCAATCGATTACTTGAGATTTCACCTTACATGCTTTCAGGGAGAGAACGAGCACTTCGCCCAAACAGAATGTATTGGCGACAAGGCATTTACTTAAATTGGTCTCCTGAAGCTTATTGTCTGGTAGGATCTGAAGTCTTAGACAATCATCCAGAGAGTTTCTTAAAAATTACAGTTCCTTCTTGTAGAAAAGGCTGTATTCTTTTGGGCCAAGTTGTGGACCACATTGATTCTCTCATGGAAGAATGGTTTCCTGGGTTGCTGGAGATTGATATTTGTGGTGAAGGAGAAACTCTGTTGAAGAAATGGGCATTATATAGTTTTAATGATGGTGAAGAACATCAAAAAATCTTACTTGATGACTTGATGAAGAAAGCAGAGGAAGGAGATCTCTTAGTAAATCCAGATCAACCAAGGCTCACCATTCCAATATCTCAGATTGCCCCTGACTTGATTTTGGCTGACCTGCCTAGAAATATTATGTTGAATAATGATGAGTTGGAATTTGAACAAGCTCCAGAGTTTCTCCTAGGTGATGGCAGTTTTGGATCAGTTTACCGAGCAGCCTATGAAGGAGAAGAAGTGGCTGTGAAGATTTTTAATAAACATACATCACTCAGGCTGTTAAGACAAGAGCTTGTGGTGCTTTGCCACCTCCACCACCCCAGTTTGATATCTTTGCTGGCAGCTGGGATTCGTCCCCGGATGTTGGTGATGGAGTTAGCCTCCAAGGGTTCCTTGGATCGCCTGCTTCAGCAGGACAAAGCCAGCCTCACTAGAACCCTACAGCACAGGATTGCACTCCACGTAGCTGATGGTTTGAGATACCTCCACTCAGCCATGATTATATACCGAGACCTGAAACCCCACAATGTGCTGCTTTTCACACTGTATCCCAATGCTGCCATCATTGCAAAGATTGCTGACTACGGCATTGCTCAGTACTGCTGTAGAATGGGGATAAAAACATCAGAGGGCACACCAGGGTTTCGTGCACCTGAAGTTGCCAGAGGAAATGTCATTTATAACCAACAGGCTGATGTTTATTCATTTGGTTTACTACTCTATGACATTTTGACAACTGGAGGTAGAATAGTAGAGGGTTTGAAGTTTCCAAATGAGTTTGATGAATTAGAAATACAAGGAAAATTACCTGATCCAGTTAAAGAATATGGTTGTGCCCCATGGCCTATGGTTGAGAAATTAATTAAACAGTGTTTGAAAGAAAATCCTCAAGAAAGGCCTACTTCTGCCCAGGTCTTTGACATTTTGAATTCAGCTGAATTAGTCTGTCTGACGAGACGCATTTTATTACCTAAAAACGTAATTGTTGAATGCATGGTTGCTACACATCACAACAGCAGGAATGCAAGCATTTGGCTGGGCTGTGGGCACACCGACAGAGGACAGCTCTCATTTCTTGACTTAAATACTGAAGGATACACTTCTGAGGAAGTTGCTGATAGTAGAATATTGTGCTTAGCCTTGGTGCATCTTCCTGTTGAAAAGGAAAGCTGGATTGTGTCTGGGACACAGTCTGGTACTCTCCTGGTCATCAATACCGAAGATGGGAAAAAGAGACATACCCTAGAAAAGATGACTGATTCTGTCACTTGTTTGTATTGCAATTCCTTTTCCAAGCAAAGCAAACAAAAAAATTTTCTTTTGGTTGGAACCGCTGATGGCAAGTTAGCAATTTTTGAAGATAAGACTGTTAAGCTTAAAGGAGCTGCTCCTTTGAAGATACTAAATATAGGAAATGTCAGTACTCCATTGATGTGTTTGAGTGAATCCACAAATTCAACGGAAAGAAATGTAATGTGGGGAGGATGTGGCACAAAGATTTTCTCCTTTTCTAATGATTTCACCATTCAGAAACTCATTGAGACAAGAACAAGCCAACTGTTTTCTTATGCAGCTTTCAGTGATTCCAACATCATAACAGTGGTGGTAGACACTGCTCTCTATATTGCTAAGCAAAATAGCCCTGTTGTGGAAGTGTGGGATAAGAAAACTGAAAAACTCTGTGGACTAATAGACTGCGTGCACTTTTTAAGGGAGGTAATGGTAAAAGAAAACAAGGAATCAAAACACAAAATGTCTTATTCTGGGAGAGTGAAAACCCTCTGCCTTCAGAAGAACACTGCTCTTTGGATAGGAACTGGAGGAGGCCATATTTTACTCCTGGATCTTTCAACTCGTCGACTTATACGTGTAATTTACAACTTTTGTAATTCGGTCAGAGTCATGATGACAGCACAGCTAGGAAGCCTTAAAAATGTCATGCTGGTATTGGGCTACAACCGGAAAAATACTGAAGGTACACAAAAGCAGAAAGAGATACAATCTTGCTTGACCGTTTGGGACATCAATCTTCCACATGAAGTGCAAAATTTAGAAAAACACATTGAAGTGAGAAAAGAATTAGCTGAAAAAATGAGACGAACATCTGTTGAGTAAGAGAGAAATAGGAATTGTCTTTGGATAGGAAAATTATTCTCTCCTCTTGTAAATATTTATTTTAAAAATGTTCACATGGAAAGGGTACTCACATTTTTTGAAATAGCTCGTGTGTATGAAGGAATGTTATTATTTTTAATTTAAATATATGTAAAAATACTTACCAGTAAATGTGTATTTTAAAGAACTATTTAAAACACAATGTTATATTTCTTATAAATACCAGTTACTTTCGTTCATTAATTAATGAAAATAAATCTGTGAAGTACCTAATTTAAGTACTCATACTAAAATTTATAAGGCCGATAATTTTTTGTTTTCTTGTCTGTAATGGAGGTAAACTTTATTTTAAATTCTGTGCTTAAGACAGGACTATTGCTTGTCGATTTTTCTAGAAATCTGCACGGTATAATGAAAATATTAAGACAGTTTCCCATGTAATGTATTCCTTCTTAGATTGCATCGAAATGCACTATCATATATGCTTGTAAATATTCAAATGAATTTGCACTAATAAAGTCCTTTGTTGGTATGTGAATTCTCTTTGTTGCTGTTGCAAACAGTGCATCTTACACAACTTCACTCAATTCAAAAGAAAACTCCATTAAAAGTACTAATGAAAAAACATGACATACTGTCAAAGTCCTCATATCTAGGAAAGACACAGAAACTCTCTTTGTCACAGAAACTCTCTGTGTCTTTCCTAGACATAATAGAGTTGTTTTTCAACTCTATGTTTGAATGTGGATACCCTGAATTTTGTATAATTAGTGTAAATACAGTGTTCAGTCCTTCAAGTGATATTTTTATTTTTTTATTCATACCACTAGCTACTTGTTTTCTAATCTGCTTCATTCTAATGCTTATATTCATCTTTTCCCTAAATTTGTGATGCTGCAGATCCTACATCATTCAGATAGAAACCTTTTTTTTTTTCAGAATTATAGAATTCCACAGCTCCTACCAAGACCATGAGGATAAATATCTAACACTTTTCAGTTGCTGAAGGAGAAAGGAGCTTTAGTTATGATGGATAAAAATATCTGCCACCCTAGGCTTCCAAATTATACTTAAATTGTTTACATAGCTTACCACAATAGGAGTATCAGGGCCAAATACCTATGTAATAATTTGAGGTCATTTCTGCTTTAGGAAAAGTACTTTCGGTAAATTCTTTGGCCCTGACCAGTATTCATTATTTCAGATAATTCCCTGTGATAGGACAACTAGTACATTTAATATTCTCAGAACTTATGGCATTTTACTATGTGAAAACTTTAAATTTATTTATATTAAGGGTAATCAAATTCTTAAAGATGAAAGATTTTCTGTATTTTAAAGGAAGCTATGCTTTAACTTGTTATGTAATTAACAAAAAAATCATATATAATAGAGCTCTTTGTTCCAGTGTTATCTCTTTCATTGTTACTTTGTATTTGCAATTTTTTTTACCAAAGACAAATTAAAAAAATGAATACCATATTTAAATGGAATAATAAAGGTTTTTTAAAAACTTTAAAAAAAAAAAAAAAAA hsa-mir-205 5p micro RNA 205 mirna micro rna micro RNA micro-RNA micro-rna mirna miRNA human Homo sapiens Human UCCUUCAUUCCACCGGAGUCUG lncrn_malat1 mouse lncrna long non-coding ribonucleic acid lncRNA long non coding RNA long non coding ribonucleic acid long non-coding RNA lncrna mouse Mus musculus Mouse AGGCATTCAGGCAGCGAGAGCAGAGCAGCGTAGAGCAGCACAGCTGAGCTCGTGAGGCAGGAGACTCAGCCCGAGGAAATCGCAGATAAGTTTTTAATTAAAAAGATTGAGCAGTAAAAAGAATTAGAACTCTAAACTTAAGCTAATAGAGTAGCTTATCGAAATATTACTTAGTCTTAATAATCTAAGAAGATCTTAAGAGATAACATGAAGGCTTATTTAAACAGTTTGAAAAAGGAAATGAGGAGAAAAGTATTTGTACTGTATAATGGAGGCTGACCAGAGCAGTTTAGGAGATTGTAAAGGGAGGTTTTGTGAAGTTCTAAAAGGTTCTAGTTTGAAGGTCGGCCTTGTAGATTAAAACGAAGGTTACCTAAATAGAATCTAAGTGGCATTTAAAACAGTAAAGTTGTAGAGAATAGTTTGAAAATGAGGTGTAGTTTTAAAAGATTGAGAAAAGTAGGTTAAGTTGACGGCCGTTATAAAAATCCTTCGACTGGCGCATGTACGTTTGAAGGCATGAGTTGGAAACAGGGAAGATGGAAGTGTTAGGCTAGCCGGGCGATGGTGGCGCACGCCTTTAATCCTAGCACTTGGGAGGCAGAGGCAGGCGGATTTCTGAGTTCGAGGCCAGCCTGGTCTACAGAGTGAGTTCCAGGACAGCCAGGGCTACACAGAGAAACCCTGTCTTGAAAAAACAAAAAGGTTAGGCTAGTATTTGGAGAAAGAAGATTAGAAAATGGAAGTGAAAGACGAAGAAGACATACAGGAAGGTGAAGAAAAAGCTGTTAGAGAAGATAGGAAAATAGAAGACAAAGCATCTTTAGAAGACAGAAAAGGTACTTAAAGGCACAGGTAGTAGGAAGCCGAAGAATAGAAGATAGAAAGAAGCAAGATAGAAAAACAAAATGGAAGTTAAGACAACTTTGGATGCCAGCATTCAAGATAGGCAAAGAAGATAAGATTGAGGCCAAAAGGTTGGATAAGATATAAAGTCAGAAGGAAATTATCTTTAAAGCCATAAGTTCAAATTTCTGATGGAGCGAGCAGTTTAGAAGAGTCTTTAGACAGCCACATACAAGATTGAAGCTAGCAATCAAAGCTACTAGGACTGAAGTAAAAAGTTAAGGCAGAATGCCTTTGAAGAGTTAGAAGAATATTAAAAGCCTTAACTTGTAGCTTAATTTTGCTTGATGACAAAAGGACTTTTGATAACAGTTTCAAGATTGTCAGCATTTTGCATTGGACTTGAGCTGAGGTGCTTTTAAAATCCTAACGACTAGCATTGGCAGCTGACCCAGGTCTACACAGAAGTGCATTCAGTGAACTAGGAAGACAGGAGCGGCAGACAGGAGTCCCGAAGCCAGTTTGGTGAAGCTAGGAAGGACTGAGGAGCCAGCAGCAGCAGTGCATGGTGAAGATAGCCCAGGAAAGAGTGCGGTTCGGTGGAGGAAGCTAGGAAGAAGGAGCCATACGGATGTGGTGGTGAAGCTGGGAAAGGGTTCCAGGATGGTGGAGCGAGAGCGAGTTGGTGATGAAGCTAGCTGGCGGCTTGGCTTGTCAACTGCGCGGAGGAGGCGAGCAGGCATTGTGGAGAGGATAGATAGCGGCTCCTAGACCAGCATGCCAGTGTGCAAGAAAGGCTGCAGGGAGAGCATGCGGTGCGGTAACATTCCTTGAGGTCGGCAACATGGTGGTGGTTTTCTGTAACTTGGATGGTAACTTGTTTACTTTGTCTTAATAGTTATGGGGGAGTTGTAGGCTTCTGTGTAAAGAGATATATCTGGGGCTGTATGTAGGCCTTTGCGGGTGTTGTAGGTTTTTCTTTTTCAGGGTTATGTCCTCTTGCATCTTGTCAGAAGCTTTTGAGGGCTGACTGCCAAGGCCCAGAAAGAAGAATGGTAGATGGCAAGTTGTCTTTAACCGCTCAGAGGGGAATGAATGGTAGAGCCAGCACAACCTCCCAGTTTTGTAAGACGTTGTAGTTTGAACAGATGACCTACCACAAGCCTCACTCCTGTGTAGGGGAGGTAATTGGGCAAAGTGCTTTTGGGGGAATGGGGGCAAAATATATTTTGAGTTCTTTTCCCCTTAGGTCTGTCTAGAATCCTAAAGGCAGATGACTCAAGGGAACCAGAAAAAAGGAAATCCACTCTCAGGATAAGCAGAGCTCGCCAGGTTTACAGTTTGTAGGAAGTAGAGGATGGATGCTAGCTTTCACACTGAGTGTGGAGGAGCTGGCCATGGCGGAATTGCTGGTAGTTTACTCTTTCCCCCTCCCTTAATGAGATTTGTAAAATCCTAAACACTTTTACTTGAAATATTTGGGAGTGGTCTTAACAGGGAGGAGTGGGTGGGGGAAACGTTTTTTTTCTAAGATTTTCCACAGATGCTATAGTTGTGTTGACACACTGGGTTAGAGAAGGCGTGTACTGCTATGCTGTTGGCACGACACCTTCAGGGACTGGAGCTGCCTTTTGTCCTTGGAAGAGTTTTCCCAGTTGCCGCTGAAGTCAGCACAGTGCGGCTTTGGTTCACAGTCACCTCAGGAGAACCTCAGGAGCTTGGCTAGGCCAGAGGTTGAAGTTAAGTTTTACAGCACCGTGATTTAAAATATTTCATTAAAGGGGAGGGGTAAAACTTAGTTGGCTGTGGCCTTGTGTTTGGGTGGGTGGGGGTGTTAGGTAATTGTTTAGTTTATGATTTCAGATAATCATACCAGAGAACTTAAATATTTGGAAAAACAGGAAATCTCAGCTTTCAAGTTGGCAAGTAACTCCCAATCCAGTTTTTGCTTCTTTTTTCCTTTTTCTTTTTTTGAGGCGGGCAGCTAAGGAAGGTTGGTTCCTCTGCCGGTCCCTCGAAAGCGTAGGGCTTGGGGGTTGGTCTGGTCCACTGGGATGATGTGATGCTACAGTGGGGACTCTTCTGAAGCTGTTGGATGAATATAGATTGTAGTGTGTGGTTCTCTTTTGAAATTTTTTTCAGGTGACTTAATGTATCTTAATAACTACTATAGGAACAAAGGAAGTGGCTTTAATGACCCTGAAGGAATTTCTTCTGGTGATAGCTTTTATATTATCAAGTAAGAGATACTATCTCAGTTTTGTATAAGCAAGTCTTTTTCCTAGTGTAGGAGAAATGATTTTCCTTGTGACTAAACAAGATGTAAAGGTATGCTTTTTTTCTTCTTGTGCATTGTATACTTGTGTTTATTTGTAACTTATAATTTAAGAATTATGATAATTCAGCCTGAATGTCTTTTAGAGGGTGGGCTTTTGTTGATGAGGGAGGGGAAACCTTTTTTTTTCTGTAGACCTTTTTCAGATAACACCATCTGAGTCATAACCAGCCTGGCAGTGTGATGACGTAGATGCAGAGGGAGCAGCTCCTTGGTGAATGAGTGATAAGTAAAGGCAGAAAAAATAATGTCATGTCTCCATGGGGAATGAGCATGAGCCAGAGATTGTTCCTACTGATGAAAAGCTGCATATGCAAAAATTTAAGCAAATGAAAGCAACCAGTATAAAGTTATGGCAATACCTTTAAAAGTTATGGCTTATCTACCAAGCTTTATCCACAAAAGTAAAGAATTGATGAAAAACAGTGAAGATCAAATGTTCATCTCAAAACTGCTTTTACAAAAGCAGAATAGAAATGAAGTGAAAATGCTGCATTAAGCCTGGAGTAAAAAGAAGCTGAGCTTGTTGAGATGAGTGGGATCGAGCGGCTGCGAGGCGGTGCAGTGTGCCAATGTTTCGTTTGCCTCAGACAGGTTTCTCTTCATAAGCAGAAGAGTTGCTTCATTCCATCTCGGAGCAGGAAACAGCAGACTGCTGTTGACAGATAAGTGTAACTTGGATCTGCAGTATTGCATGTTAGGGATAGATAAGTGCCTTTTTTCTCTTTTTCCAAAAAGACCTGTAGAGCTGTTGAATGTTTGCAGCTGGCCCCTCTTAGGCAGTTCAGAATTTTGAGTAGTTTTCCCATCCAGCCTCTTAAAAATTCCTAAGCCTTGCACCGATGGGCTTTCATGATGGGATAGCTAATAGGCTTTTGCATCGTAAACTTCAACACAAAAGCCTACATGATTAATGCCTACTTTAATTACATTGCTTACAAGATTAAGGAATCTTTATCTTGAAGACCCCATGAAAGGGATCATTATGTGCTGAAAATTAGATGTTCATATTGCTAAAATTTAAATGTGCTCCAATGTACTTGTGCTTAAAATCATTAAATTATACAAATTAATAAAATACTTCACTAGAGAATGTATGTATTTAGAAGGCTGTCTCCTTATTTAAATAAAGTCTTGTTTGTTGTCTGTAGTTAGTGTGGGCAATTTTGGGGGGATGTTCTTCTCTAATCTTTTCAGAAACTTGACTTCGAACACTTAAGTGGACCAGATCAGGATTTGAGCCAGAAGACCGAAATTAACTTTAAGGCAGGAAAGACAAATTTTATTCTCCATGCAGTGATGAGCATTTAATAATTGCAGGCCTGGCATAGAGGCCGTCTAACTAAGGACTAAGTACCTTAGGCAGGTGGGAGATGATGGTCAGAGTAAAAGGTAACTACATATTTTGTTTCCAGAAAGTCAGGGGTCTAATTTGACCATGGCTAAACATCTAGGGTAAGACACTTTTCCCCCACATTTCCAAATATGCATGTTGAGTTTAAATGCTTACGATCATCTCATCCACTTTAGCCTTTTGTCACCTCACTTGAGCCACGAGTGGGGTCAGGCATGTGGGTTTAAAGAGTTTTCCTTTGCAGAGCCTCATTTCATCCTTCATGGAGCTGCTCAGGACTTTGCATATAAGCGCTTGCCTCTGTCTTCTGTTCTGCTAGTGAGTGTGTGATGTGAGACCTTGCAGTGAGTTTGTTTTTCCTGGAATGTGGAGGGAGGGGGGGATGGGGCTTACTTGTTCTAGCTTTTTTTTTACAGACCACACAGAATGCAGGTGTCTTGACTTCAGGTCATGTCTGTTCTTTGGCAAGTAATATGTGCAGTACTGTTCCAATCTGCTGCTATTAGAATGCATTGTGACGCGACTGGAGTATGATTAAAGAAAGTTGTGTTTCCCCAAGTGTTTGGAGTAGTGGTTGTTGGAGGAAAAGCCATGAGTAACAGGCTGAGTGTTGAGGAAATGGCTCTCTGCAGCTTTAAGTAACCCGTGTTTGTGATTGGAGCCGAGTCCCTTTGCTGTGCTGCCTTAGGTAAATGTTTTTGTTCATTTCTGGTGAGGGGGGTTGGGAGCACTGAAGCCTTTAGTCTCTTCCAGATTCAACTTAAAATCTGACAAGAAATAAATCAGACAAGCAACATTCTTGAAGAAATTTTAACTGGCAAGTGGAAATGTTTTGAACAGTTCCGTGGTCTTTAGTGCATTATCTTTGTGTAGGTGTTCTCTCTCCCCTCCCTTGGTCTTAATTCTTACATGCAGGAACATTGACAACAGCAGACATCTATCTATTCAAGGGGCCAGAGAATCCAGACCCAGTAAGGAAAAATAGCCCATTTACTTTAAATCGATAAGTGAAGCAGACATGCCATTTTCAGTGTGGGGATTGGGAAGCCCTAGTTCTTTCAGATGTACTTCAGACTGTAGAAGGAGCTTCCAGTTGAATTGAAATTCACCAGTGGACAAAATGAGGACAACAGGTGAACGAGCCTTTTCTTGTTTAAGATTAGCTACTGGTAATCTAGTGTTGAATCCTCTCCAGCTTCATGCTGGAGCAGCTAGCATGTGATGTAATGTTGGCCTTGGGGTGGAGGGGTGAGGTGGGCGCTAAGCCTTTTTTTAAGATTTTTCAGGTACCCCTCACTAAAGGCACTGAAGGCTTAATGTAGGACAGCGGAGCCTTCCTGTGTGGCAAGAATCAAGCAAGCAGTATTGTATCGAGACCAAAGTGGTATCATGGTCGGTTTTGATTAGCAGTGGGGACTACCCTACCGTAACACCTTGTTGGAATTGAAGCATCCAAAGAAAATACTTGAGAGGCCCTGGGCTTGTTTTAACATCTGGAAAAAAGGCTGTTTTTATAGCAGCGGTTACCAGCCCAAACCTCAAGTTGTGCTTGCAGGGGAGGGAAAAGGGGGAAAGCGGGCAACCAGTTTCCCCAGCTTTTCCAGAATCCTGTTACAAGGTCTCCCCACAAGTGATTTCTCTGCCACATCGCCACCATGGGCCTTTGGCCTAATCACAGACCCTTCACCCCTCACCTTGATGCAGCCAGTAGCTGGATCCTTGAGGTCACGTTGCATATCGGTTTCAAGGTAACCATGGTGCCAAGGTCCTGTGGGTTGCACCAGAAAAGGCCATCAATTTTCCCCTTGCCTGTAATTTAACATTAAAACCATAGCTAAGATGTTTTATACATAGCACCTATGCAGAGTAAACAAACCAGTATGGGTATAGTATGTTTGATACCAGTGCTGGGTGGGAATGTAGGAAGTCGGATGAAAAGCAAGCCTTTGTAGGAAGTTGTTGGGGTGGGATTGCAAAAATTCTCTGCTAAGACTTTTTCAGGTGGACATAACAGACTTGGCCAAGCTAGCATCTTAGTGGAAGCAGATTCGTCAGTAGGGTTGTAAAGGTTTTTCTTTTCCTGAGAAAACAACCTTTTGTTTTCTCAGGTTTTGCTTTTTGGCCTTTCCCTAGCTTTAAAAAAAAAAAAGCAAAAGACGCTGGTGGCTGGCACTCCTGGTTTCCAGGACGGGGTTCAAGTCCCTGCGGTGTCTTTGCTTGACTCTTATATCATGAGGCCATTACATTTTTCTTGGAGGGTTCTAAAGGCTCTGGGTATGGTAGCTGATATCACTGGAACACTCCCCAGCCTCAGTGTTGAACTCTTGATAATTAACTGCATTGTCTTTCAGGTTATGCCCAATTCGTCTTATTACCTCTGAGTCGACACACCTCCTACTATTTATTGAATACTTTGATTTTATGAAATAAAAACTAAATATCTCTCA hsa_mir_205 5p-mrna_lrrk2-1 3435703 N/A 3435705 regulator target regulator target regulator target modulator target neutral component neutral component over-expressed over expressed level over-expressed living cell living cell engineered engineered tag luciferase tag luciferase tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false r.7821_7828delinscgagtccg mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false N/A 3435706 predetermined predetermined participant predetermined regulator regulator modulator regulator neutral component neutral component over-expressed over expressed level over-expressed living cell living cell engineered engineered physical association physical association false false false Fig 3A,B hsa_mir_205 5p-lncrn_malat1 human-1 3435704 N/A 3435707 regulator regulator modulator regulator neutral component neutral component over-expressed over expressed level over-expressed living cell living cell engineered engineered r.[g1531_1540delinscaacgcagta; a3657_g3665delinsgcatccatg] mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false g1531_1540delinscaacgcagta mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain false a3657_g3665delinsgcatccatg mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain false N/A 3435706 predetermined predetermined participant predetermined regulator target regulator target regulator target modulator target neutral component neutral component over-expressed over expressed level over-expressed living cell living cell engineered engineered physical association physical association false false false Fig 2A, B