IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ zhu-2018-1 human-panc1 Homo sapiens pancreatic carcinoma cell line PANC-1 panc1 Human pancreatic carcinoma cell line PANC-1 Established from a pancreatic carcinoma of ductal origin from a 56-year-old Caucasian male. Cells possess the type B phenotype for G6PD. mirna interference luciferase assay miRNA interference luciferase reporter assay miRNA interference luciferase assay tag luciferase tag visualisation by luciferase assay tag luciferase Zhu W., Wang Y., Zhang D., Yu X., Leng X. renminzhuweihua@sina.com Biochemical and biophysical research communications 2018 imex curation Only protein-protein interactions imex curation zhu-2018-2 human-panc1 Homo sapiens pancreatic carcinoma cell line PANC-1 panc1 Human pancreatic carcinoma cell line PANC-1 Established from a pancreatic carcinoma of ductal origin from a 56-year-old Caucasian male. Cells possess the type B phenotype for G6PD. ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Zhu W., Wang Y., Zhang D., Yu X., Leng X. renminzhuweihua@sina.com Biochemical and biophysical research communications 2018 imex curation Only protein-protein interactions imex curation mrna_sox18 transcription factor sox18 mrna mrna messenger rna mRNA mrna human Homo sapiens Human CCGCCATCCGCCCTCCCGGCCTGGCCTGCCCTTGCGCCCGGCTCCCCAGTGCCCGCCGCCCGCCCGCCGCGCTCCCGCGCTCCGTTCCGCCCAGGCCGCGCCCAGCTGGAATGCAGAGATCGCCGCCCGGCTACGGCGCACAGGACGACCCGCCCGCCCGCCGCGACTGTGCATGGGCCCCGGGACACGGGGCCGCCGCTGACACGCGCGGCCTCGCCGCCGGCCCCGCCGCCCTCGCCGCGCCCGCCGCGCCCGCCTCGCCGCCCAGCCCGCAGCGCAGTCCCCCGCGCAGCCCCGAGCCGGGGCGCTATGGCCTCAGCCCGGCCGGCCGCGGGGAACGCCAGGCGGCAGACGAGTCGCGCATCCGGCGGCCCATGAACGCCTTCATGGTGTGGGCAAAGGACGAGCGCAAGCGGCTGGCTCAGCAGAACCCGGACCTGCACAACGCGGTGCTCAGCAAGATGCTGGGCAAAGCGTGGAAGGAGCTGAACGCGGCGGAGAAGCGGCCCTTCGTGGAGGAAGCCGAACGGCTGCGCGTGCAGCACTTGCGCGACCACCCCAACTACAAGTACCGGCCGCGCCGCAAGAAGCAGGCGCGCAAGGCCCGGCGGCTGGAGCCCGGCCTCCTGCTCCCGGGATTAGCGCCCCCGCAGCCACCGCCCGAGCCTTTCCCCGCGGCGTCTGGCTCGGCTCGCGCCTTCCGCGAGCTGCCCCCGCTGGGCGCCGAGTTCGACGGCCTGGGGCTGCCCACGCCCGAGCGCTCGCCTCTGGACGGCCTGGAGCCCGGCGAGGCTGCCTTCTTCCCACCGCCCGCGGCGCCCGAGGACTGCGCGCTGCGGCCCTTCCGCGCGCCCTACGCGCCCACCGAGTTGTCGCGGGACCCCGGCGGTTGCTACGGGGCTCCCCTGGCGGAGGCGCTCAGGACCGCGCCCCCCGCGGCGCCGCTCGCTGGCCTGTACTACGGCACCCTGGGCACGCCCGGCCCGTACCCCGGCCCGCTGTCGCCGCCGCCCGAGGCCCCGCCGCTGGAGAGCGCCGAGCCGCTGGGGCCCGCCGCCGATCTGTGGGCCGACGTGGACCTCACCGAGTTCGACCAGTACCTCAACTGCAGCCGGACTCGGCCCGACGCCCCCGGGCTCCCGTACCACGTGGCACTGGCCAAACTGGGCCCGCGCGCCATGTCCTGCCCAGAGGAGAGCAGCCTGATCTCCGCGCTGTCGGACGCCAGCAGCGCGGTCTATTACAGCGCGTGCATCTCCGGCTAGGCCGCCGGCGCCGCCCGGGTCCCTGCAGCGCTTCCTCCCGCAGCCCCCGCGACCGATCCGACCGCGTCGCTGCCGCTCTGCTCTCTCATACGCGTGTATGTTTGGTTCCATGTCACAGCCCCCTAGGAGCCAGTGATGCTCGGCCTTGCGCCCGTTCCACCTCCCAGGCCACCCTTCCTGGGCTTCTGGGCCACCTGCCCTCGGGGGGCCCCTGCGAGGGTGCCTGGAGTTCCCACGTGTCCCGGGGCTTTTCCAGGAAGCCCGAGCCCAGGACCTGTTGGCAGAGTTGCCAGGGTTACATTTTTGAAGCACCTGCTCCTTTTCTTGCAGTGTATTTTCTACAACCAGATTGTATTAATATTTTTTACTTTGCCCTTTTAAAAAATATACCTAATACAATATATTTAATTTTTAATTAAACTCTTAAACTTTTCTTCCAAAAAAAAAAAAAAA hsa-mir-7-5p microRNA hsa-miR-7-5p mirna micro rna micro RNA micro-RNA micro-rna mirna miRNA human Homo sapiens Human UGGAAGACUAGUGAUUUUGUUGU gp130 gene interleukin 6 signal transducer gp130 gene gene human Homo sapiens Human sox18_human Transcription factor SOX-18 SOX18 protein protein human Homo sapiens Human MQRSPPGYGAQDDPPARRDCAWAPGHGAAADTRGLAAGPAALAAPAAPASPPSPQRSPPRSPEPGRYGLSPAGRGERQAADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQARKARRLEPGLLLPGLAPPQPPPEPFPAASGSARAFRELPPLGAEFDGLGLPTPERSPLDGLEPGEAAFFPPPAAPEDCALRPFRAPYAPTELSRDPGGCYGAPLAEALRTAPPAAPLAGLYYGTLGTPGPYPGPLSPPPEAPPLESAEPLGPAADLWADVDLTEFDQYLNCSRTRPDAPGLPYHVALAKLGPRAMSCPEESSLISALSDASSAVYYSACISG hsa_mir_7_5p-mrna_sox18-1 3437295 N/A 3437297 regulator target regulator target regulator target modulator target neutral component neutral component over-expressed over expressed level over-expressed living cell living cell engineered engineered tag luciferase tag luciferase tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false r.1698_1703delinsctcctt mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false N/A 3437298 predetermined predetermined participant predetermined regulator regulator modulator regulator neutral component neutral component engineered engineered purified purified physical association physical association false false false Fig 1D, E sox18-1 3437296 N/A 3437299 unspecified role unspecified role prey prey living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 3437300 unspecified role unspecified role bait bait living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level physical association physical association false false false Fig 4 D