IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ tian-2014-8 human-293ft Homo sapiens HEK293FT cell line 293ft HEK293FT cell line mirna interference luciferase assay miRNA interference luciferase reporter assay miRNA interference luciferase assay tag luciferase tag visualisation by luciferase assay tag luciferase Tian FJ, Tian FJ., An LN., Wang GK., Zhu JQ., Li Q., Zhang YY., Zeng A., Zou J., Zhu RF., Han XS., Shen N., Yang HT., Zhao XX., Huang S., Qin YW., Jing Q. qjing@sibs.ac.cn Cardiovascular research 2014 Only protein-protein interactions imex curation imex curation tian-2014-9 mouse-raw264_7 Mus musculus monocyte macrophage cell line RAW264 raw264_7 Mouse monocyte macrophage cellline RAW264.7 ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Tian FJ, Tian FJ., An LN., Wang GK., Zhu JQ., Li Q., Zhang YY., Zeng A., Zou J., Zhu RF., Han XS., Shen N., Yang HT., Zhao XX., Huang S., Qin YW., Jing Q. Cells were treated with oxidized low density lipoprotein. qjing@sibs.ac.cn Cardiovascular research 2014 Only protein-protein interactions imex curation imex curation tian-2014-10 mouse-raw264_7 Mus musculus monocyte macrophage cell line RAW264 raw264_7 Mouse monocyte macrophage cellline RAW264.7 ch-ip chromatin immunoprecipitation assay ch-ip qrt-pcr quantitative reverse transcription pcr QRT-PCR Tian FJ, Tian FJ., An LN., Wang GK., Zhu JQ., Li Q., Zhang YY., Zeng A., Zou J., Zhu RF., Han XS., Shen N., Yang HT., Zhao XX., Huang S., Qin YW., Jing Q. Cells were treated with oxidized low density lipoprotein. qjing@sibs.ac.cn Cardiovascular research 2014 Only protein-protein interactions imex curation imex curation tian-2014-11 in vitro In vitro emsa supershift electrophoretic mobility supershift assay emsa supershift tag visualisation tag visualisation Tian FJ, Tian FJ., An LN., Wang GK., Zhu JQ., Li Q., Zhang YY., Zeng A., Zou J., Zhu RF., Han XS., Shen N., Yang HT., Zhao XX., Huang S., Qin YW., Jing Q. qjing@sibs.ac.cn Cardiovascular research 2014 Only protein-protein interactions imex curation imex curation mrna_hbp1 HMG-box transcription factor 1 mRNA mrna messenger rna mRNA mrna mouse Mus musculus Mouse GGGGAGGGGGAAGACGAAGCTTGAAAGACTTGGTAATGGCGACGGGTTTGTCGGAGCACCATAACATGGTGTGGGAAGTGAAGACAAATCAGATGCCTAATGCAGTACAGAAACTCCTGCTGGTGATGGACAAGAGAGCACCAGGGATGAGTGACTCGCTGGAGTTGCTGCAGTGTAATGAGAATTTGCCATCCTCTCCAGGATACAACTCCTGTGATGAGCACATGGAGCTTGATGACCTTCCTGAACTTCAGGCTGTTCAAAGTGACCCTACCCAATCTGCCATATACCAGCTAAGTTCAGATGTATCTCATCAAGAATATCCAAGATCATCTTGGAGCCAGAATACCTCAGATATACCGGAAAATACTCACCGTGAAGATGAGGTGGACTGGCTAACAGAGTTAGCAAATATTGCCACTAGTCCACAAAGTCCCCTGATGCAGTGCTCATTTTATAACAGATCATCTCCTGTACACATCATAGCTACTAGCAAAAGTTTACATTCCTATGCACGCCCACCACCAGTGTCCTCTTCTTCAAAAAGTGGGCCAGCCTTCCCTCATGACCACTGGAAGGAAGAAACACCAGTAAGACATGAAAGGGCAAACAGTGAGTCAGAGTCAGGCATTTTCTGTATGTCCTCCCTGTCAGATGATGATGATCTGGGCTGGTGCAATTCCTGGCCATCCACCATTTGGCACTGCTTTCTGAAAGGCACGCGGCTGTGCTTCCATAAGGAAAGCAATAAGGAATGGCAAGATGTGGAAGACTTTGCTAGAGCCGCCAGCTGTGATAATGAGGAAGAGATCCAAATGGGCACTCACAAGGGCTATGGGTCTGATGGTCTAAAGTTGTTATCCCATGAAGAGAGTGTGTCATTCGGTGAGTCTGTACTGAAGTTGACATTTGATCCTGGTACAGTAGAAGATGGCTTGCTCACTGTAGAGTGCAAGCTGGACCACCCTTTCTATGTTAAAAATAAAGGTTGGTCGTCATTTTATCCAAGCTTGACTGTGGTACAGCATGGCATTCCATGTTGTGAAATTCATATTGGTGACGTATGTCTACCTCCTGGACACCCTGATGCCATTAATTTCGATGATTCAGGTGTTTTTGATACATTTAAAAGCTATGACTTCACACCTATGGACTCTTCTGCGGTCTATGTTTTGAGTAGTATGGCTCGTCAGCGCCGTGCATCTCTGTCTTGTGGAGGAGGACCTGGTACTGGTCAAGAGTTTTCGGGATCTGAATTCAGTAAAAGCTGTGGTTCACCTGGATCATCACAGCTCTCTTCTAGTTCTTTGTATGCTAAAGCTGTCAAAAGCCACAGCTCAGGGACTGTGAGTGCCACTTCTCCTAATAAGTGCAAAAGACCAATGAATGCCTTCATGCTTTTTGCCAAAAAATACAGAGTTGAATATACTCAGATGTATCCAGGGAAAGATAACAGAGCCATAAGTGTGATCCTTGGTGACAGGTGGAAAAAAATGAAGAACGAAGAAAGGAGGATGTACACATTAGAAGCAAAGGCTTTGGCTGAAGAACAAAAGCGTTTAAATCCTGACTGTTGGAAAAGGAAAAGAACCAACTCAGGCTCTCAACAGCATTAAACCTGATGCTTGTGTTTGTAAGTCTGCATCTGCATAAGTACTGACTCTGGATGGAAAAGCTTGGAAGACCTTGGTCTCACCATTTGTCTACATTTGTGTGACCATAAAATGCTGGGAGCATTGAGTTTTGTAATGATTTAATGGGTGAGGATTGCTTTCTCCATTAGAGCATTAAGCTATAACTATCAACATTGTAAACCAAATTGCCTTATTTTCCTTCCAAACTTCATATATCTATCAGGTAATATAGGCTTGAAAATTGATATCCTGTGGTGCTAAAGTACAGTAGAAAGATGTGTATACGTTTTATTTTAAATTGTACGAAGGGGAATTTAAAAATACGTAACTGCTGTTTATACATCAGCTCCTTACTGCTTATTAATCTGTATTGTACCCACGATATCAGGAGTGAAGCAGACGCTGGCCTTTCCATGAATAGCCACCACATGGCCCAGCATCTCTGCCAAACACAGTTGCTTCTAGTCTGGCCAGTGCCAAGAGACAACATAACATGGCAGGTGGATGGTGTCGGTGTCATTGTCTCAGCTCAAAGAGCCACCTGCTTCAGATACCATGGGCATGTGCTGAGTGGATGCACCAGGGGGCAGCACAGCTCCATGATTCCCAGTGGGGCCCAAGCCAGGCCAAGGTGCAGTCAGTTAATAGCATTGGGACAGTCATTGTAATGGTGCTGTTACCAGTCGACACCATTGTGTTTGACCGCGTTCCTGTCTCCTCAGCCACATACCCTCATCTGTGCTGTCAGTGTGTCTCTGGTGGGGCAGACTTTGCACTTACTGCAGTGCACCACTTGCACTTTACTCCCTCCGGCTTCTGAGACAGAGCAAGTACTTCAGCAGTCCTGCTGCTCTTGCTCTGAGCTACAATCATGGCTTCTCATGTTACTTACCAAGTGAGAGTTTTGGTTAGTAATCACAGCTGTAAAATTGATTTACACTTGTTAAACATATTGCCCCTCAATTTTGCACACTATATTCTTGTATATTATTTCAAATAAAAGGAAAAAAAAGGTCT mmu-mir-155 5p miR-155 5p mirna micro rna micro RNA micro-RNA micro-rna mirna miRNA mouse Mus musculus Mouse UUAAUGCUAAUUGUGAUAGGGGU gene_mir155 gene gene mouse Mus musculus Mouse tyy1_mouse Transcriptional repressor protein YY1 Yy1 Ucrbp Delta transcription factor NF-E1 UCR-motif DNA-binding protein Yin and yang 1 protein protein mouse Mus musculus Mouse MASGDTLYIATDGSEMPAEIVELHEIEVETIPVETIETTVVGEEEEEDDDDEDGGGGDHGGGGGGHGHAGHHHHHHHHHHHHPPMIALQPLVTDDPTQVHHHQEVILVQTREEVVGGDDSDGLRAEDGFEDQILIPVPAPAGGDDDYIEQTLVTVAAAGKSGGGASSGGGRVKKGGGKKSGKKSYLGGGAGAAGGGGADPGNKKWEQKQVQIKTLEGEFSVTMWSSDEKKDIDHETVVEEQIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARMKPRKIKEDDAPRTIACPHKGCTKMFRDNSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHILTHAKAKNNQ site_c_probe_mir-155_promoter dna deoxyribonucleic acid DNA deoxyribonucleic acid dna DNA deoxyribonucleic acid mouse Mus musculus Mouse CTCCTTCTGCACCCGCCATGTTCTTTTTATAAGGACATC mir_155-mrna_hbp1-1 3434170 N/A 3434174 regulator target regulator target regulator target modulator target neutral component neutral component over-expressed over expressed level over-expressed living cell living cell engineered engineered tag luciferase tag luciferase tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false r.1786_1790delinsggcct mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false human-293ft Homo sapiens HEK293FT cell line 293ft HEK293FT cell line N/A 3434175 regulator regulator modulator regulator neutral component neutral component over-expressed over expressed level over-expressed living cell living cell engineered engineered human-293ft Homo sapiens HEK293FT cell line 293ft HEK293FT cell line physical association physical association false false false Fig 2C, Suppl Fig 5 yy1-gene_mir155-1 3434171 N/A 3434176 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level site_C_promoter_region sufficient to bind sufficient binding region sufficient to bind undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 3434177 antibody detection identification by antibody antibody detection unspecified role unspecified role bait bait physiological level physiological level endogenous level endogenous endogenous endogenous level association association false false false Suppl. Fig 9D yy1-gene_mir155-2 3434172 N/A 3434176 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level site_C_promoter_region sufficient to bind sufficient binding region sufficient to bind undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 3434177 antibody detection identification by antibody antibody detection unspecified role unspecified role bait bait physiological level physiological level endogenous level endogenous endogenous endogenous level association association false false false Fig 4C yy1-gene_mir155-3 3434173 N/A 3434177 unspecified role unspecified role prey prey subcellular prep subcellular preparation subcellular prep mouse-raw264_7 Mus musculus monocyte macrophage cell line RAW264 raw264_7 Mouse monocyte macrophage cellline RAW264.7 N/A 3434178 unspecified role unspecified role bait bait purified purified region biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false synthetic construct synthetic construct physical association physical association false false false Fig 4B