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    <entry>
        <source releaseDate="2017-08-31+01:00">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
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            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3292313">
                <names>
                    <shortLabel>jones-1989-1</shortLabel>
                </names>
                <bibref>
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                <hostOrganismList>
                    <hostOrganism ncbiTaxId="562">
                        <names>
                            <shortLabel>ecolx</shortLabel>
                            <fullName>Escherichia coli</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>x-ray diffraction</shortLabel>
                        <fullName>x-ray crystallography</fullName>
                        <alias typeAc="MI:0303" type="go synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">x-ray diffraction</alias>
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                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
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                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Jones EY., Stuart DI., Walker NP.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-263710X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Nature</attribute>
                    <attribute name="publication year" nameAc="MI:0886">1989</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">Structure of tumour necrosis factor.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Jones EY.,  Stuart DI.,  Walker NP.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3292314">
                <names>
                    <shortLabel>tnfa_human</shortLabel>
                    <fullName>Tumor necrosis factor</fullName>
                    <alias typeAc="MI:0301" type="gene name">TNF</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">TNFA</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">TNFSF2</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">TNF-alpha</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Tumor necrosis factor ligand superfamily member 2</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Cachectin</alias>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0150078" secondary="positive regulation of neuroinflammatory response" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007254" secondary="JNK cascade" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048661" secondary="positive regulation of smooth muscle cell proliferation" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001819" secondary="positive regulation of cytokine production" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001937" secondary="negative regulation of endothelial cell proliferation" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903799" secondary="negative regulation of production of miRNAs involved in gene silencing by miRNA" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008630" secondary="intrinsic apoptotic signaling pathway in response to DNA damage" version="SP_261"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7KPA" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2001240" secondary="negative regulation of extrinsic apoptotic signaling pathway in absence of ligand" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071230" secondary="cellular response to amino acid stimulus" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051798" secondary="positive regulation of hair follicle development" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032722" secondary="positive regulation of chemokine production" version="SP_261"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1TNF" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0072659" secondary="protein localization to plasma membrane" version="SP_261"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4TWT" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000272" secondary="negative regulation of signaling receptor activity" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010693" secondary="negative regulation of alkaline phosphatase activity" version="SP_261"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6X82" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071677" secondary="positive regulation of mononuclear cell migration" version="SP_261"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1A8M" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035509" secondary="negative regulation of myosin-light-chain-phosphatase activity" version="SP_261"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5WUX" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000122" secondary="negative regulation of transcription by RNA polymerase II" version="SP_261"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7ASY" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045668" secondary="negative regulation of osteoblast differentiation" version="SP_261"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3IT8" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050807" secondary="regulation of synapse organization" version="SP_261"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051966" secondary="regulation of synaptic transmission, glutamatergic" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002637" secondary="regulation of immunoglobulin production" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071316" secondary="cellular response to nicotine" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008625" secondary="extrinsic apoptotic signaling pathway via death domain receptors" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031334" secondary="positive regulation of protein-containing complex assembly" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006954" secondary="inflammatory response" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045893" secondary="positive regulation of transcription, DNA-templated" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1902004" secondary="positive regulation of amyloid-beta formation" version="SP_261"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6OOZ" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051091" secondary="positive regulation of DNA-binding transcription factor activity" version="SP_261"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000365290" version="SP_261" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048566" secondary="embryonic digestive tract development" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045892" secondary="negative regulation of transcription, DNA-templated" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031622" secondary="positive regulation of fever generation" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006919" secondary="activation of cysteine-type endopeptidase activity involved in apoptotic process" version="SP_261"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000372988" version="SP_261" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3WD5" version="SP_261"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6X86" version="SP_261"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_000585.2"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032729" secondary="positive regulation of interferon-gamma production" version="SP_261"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7AT7" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032991" secondary="protein-containing complex" version="SP_261"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5UUI" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045121" secondary="membrane raft" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034116" secondary="positive regulation of heterotypic cell-cell adhesion" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005615" secondary="extracellular space" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1902895" secondary="positive regulation of pri-miRNA transcription by RNA polymerase II" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005164" secondary="tumor necrosis factor receptor binding" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032715" secondary="negative regulation of interleukin-6 production" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903347" secondary="negative regulation of bicellular tight junction assembly" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1904996" secondary="positive regulation of leukocyte adhesion to vascular endothelial cell" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060559" secondary="positive regulation of calcidiol 1-monooxygenase activity" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" secondary="positive regulation of transcription by RNA polymerase II" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009615" secondary="response to virus" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050729" secondary="positive regulation of inflammatory response" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032724" secondary="positive regulation of fractalkine production" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043280" secondary="positive regulation of cysteine-type endopeptidase activity involved in apoptotic process" version="SP_261"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5357905" version="SP_261"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070886" secondary="positive regulation of calcineurin-NFAT signaling cascade" version="SP_261"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7JRA" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009651" secondary="response to salt stress" version="SP_261"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000376122" version="SP_261" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030198" secondary="extracellular matrix organization" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071407" secondary="cellular response to organic cyclic compound" version="SP_261"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5MU8" version="SP_261"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-2895N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033138" secondary="positive regulation of peptidyl-serine phosphorylation" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043123" secondary="positive regulation of I-kappaB kinase/NF-kappaB signaling" version="SP_261"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6X81" version="SP_261"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5357786" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005125" secondary="cytokine activity" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032755" secondary="positive regulation of interleukin-6 production" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002020" secondary="protease binding" version="SP_261"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000165" secondary="MAPK cascade" version="SP_261"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2ZPX" version="SP_261"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-23878-1" id="3292315">
                <names>
                    <shortLabel>tnf-2</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-3911E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-23878-1" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16208923" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>3292313</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3292316">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-16208927" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3292314</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="562">
                                <names>
                                    <shortLabel>ecolx</shortLabel>
                                    <fullName>Escherichia coli</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
