DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ saotome-2016-1 human Homo sapiens Human molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Saotome K., Singh AK., Yelshanskaya MV., Sobolevsky AI. DIP original experiment: DIP-269104X Nature 2016 IMEx Crystal structure of the epithelial calcium channel TRPV6. Saotome K., Singh AK., Yelshanskaya MV., Sobolevsky AI. Only protein-protein interactions imex curation saotome-2016-2 human Homo sapiens Human x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Saotome K., Singh AK., Yelshanskaya MV., Sobolevsky AI. DIP original experiment: DIP-269105X Nature 2016 IMEx Crystal structure of the epithelial calcium channel TRPV6. Saotome K., Singh AK., Yelshanskaya MV., Sobolevsky AI. Only protein-protein interactions imex curation saotome-2016-3 human Homo sapiens Human crosslink cross-linking study crosslink weight by comassie molecular weight estimation by coomasie staining weight by comassie Saotome K., Singh AK., Yelshanskaya MV., Sobolevsky AI. DIP original experiment: DIP-269106X Nature 2016 IMEx Crystal structure of the epithelial calcium channel TRPV6. Saotome K., Singh AK., Yelshanskaya MV., Sobolevsky AI. Only protein-protein interactions imex curation trpv6_rat Transient receptor potential cation channel subfamily V member 6 Trpv6 Epithelial calcium channel 2 Calcium transport protein 1 protein protein rat Rattus norvegicus (Rat) Rat MGPLQREGRPALGDANVAPGSSPGGVWHQPQPPKDSAFHPMGWSLPKEKGLILCLWNKFCRWFHRRESWAQSRDEQNLLQQKRIWESPLLLAAKENNVQALIKLLKFEGCEVHQKGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGGDHLKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQKRKHIQWTYGPLTSTLYDLTEIDSSGDDQSLLELIVTTKKREARQILDQTPVKELVSLKWKRYGRPYFCVLGAIYVLYIICFTMCCVYRPLKPRITNRTNPRDNTLLQQKLLQEAYVTPKDDLRLVGELVSIVGAVIILLVEIPDIFRLGVTRFFGQTILGGPFHVIIVTYAFMVLVTMVMRLTNSDGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPDELGHFYDYPMALFSTFELFLTIIDGPANYDVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQVVATTVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQRIRRYAQAFQQQDDLYSEDLEKDSGEKLEMARPFGAYLSFPTPSVSRSTSRSSTNWDRLRQGALRKDLQGIINRGLEDGEGWEYQI mint Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating trpv6-4 3292132 N/A 3292135 unspecified role unspecified role unspecified role unspecified role Region 41-700 Region 41-700 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false trpv6-5 3292133 N/A 3292135 unspecified role unspecified role unspecified role unspecified role Region 41-700 Region 41-700 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false trpv6-3 3292134 N/A 3292135 unspecified role unspecified role unspecified role unspecified role Region 41-700 Region 41-700 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Q9R186:p.[Asp74Cys;Arg671Cys] D74C/R671C mutation mutation certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false