DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ bidinosti-2016-1 rat Rattus norvegicus (Rat) Rat anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Bidinosti M., Botta P., Krüttner S., Proenca CC., Stoehr N., Bernhard M., Fruh I., Mueller M., Bonenfant D., Voshol H., Carbone W., Neal SJ., McTighe SM., Roma G., Dolmetsch RE., Porter JA., Caroni P., Bouwmeester T., Lüthi A., Galimberti I. DIP original experiment: DIP-269023X Science (New York, N.Y.) 2016 IMEx CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency. Bidinosti M., Botta P., Krüttner S., Proenca CC., Stoehr N., Bernhard M., Fruh I., Mueller M., Bonenfant D., Voshol H., Carbone W., Neal SJ., McTighe SM., Roma G., Dolmetsch RE., Porter JA., Caroni P., Bouwmeester T., Lüthi A., Galimberti I. Only protein-protein interactions imex curation ubiq_rat Ubiquitin Rps27a Uba80 Ubcep1 Uba52 Ubcep2 Ubb protein protein rat Rattus norvegicus (Rat) Rat MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair mint clk2_human Dual specificity protein kinase CLK2 CDC-like kinase 2 CLK2 protein protein human Homo sapiens Human MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR clk2-ub-1 3288770 N/A 3288771 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat N/A 3288772 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false rat Rattus norvegicus (Rat) Rat physical association physical association false false false