DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ zak-2015-1 in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Zak KM., Kitel R., Przetocka S., Golik P., Guzik K., Musielak B., Dömling A., Dubin G., Holak TA. DIP original experiment: DIP-267816X Structure (London, England : 1993) 2015 IMEx Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1. Zak KM., Kitel R., Przetocka S., Golik P., Guzik K., Musielak B., Dömling A., Dubin G., Holak TA. Only protein-protein interactions imex curation zak-2015-2 in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Zak KM., Kitel R., Przetocka S., Golik P., Guzik K., Musielak B., Dömling A., Dubin G., Holak TA. DIP original experiment: DIP-267817X Structure (London, England : 1993) 2015 IMEx Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1. Zak KM., Kitel R., Przetocka S., Golik P., Guzik K., Musielak B., Dömling A., Dubin G., Holak TA. Only protein-protein interactions imex curation pdcd1_human Programmed cell death protein 1 PDCD1 PD1 protein protein human Homo sapiens Human MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGSLVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVPCVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL q9nzq7-1 Programmed cell death 1 ligand 1 CD274 B7H1 PDCD1L1 PDCD1LG1 PDL1 PD-L1I B7 homolog 1 protein protein human Homo sapiens Human MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET cd274-pdcd1-4 3286202 N/A 3286204 unspecified role unspecified role unspecified role unspecified role Region 33-150 Region 33-150 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3286205 unspecified role unspecified role unspecified role unspecified role Region 18-134 Region 18-134 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false cd274-pdcd1-5 3286203 N/A 3286204 unspecified role unspecified role unspecified role unspecified role Region 33-150 Region 33-150 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3286205 unspecified role unspecified role unspecified role unspecified role Region 18-134 Region 18-134 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false