DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ song-2015-16 in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Song W., Wang J., Han Z., Zhang Y., Zhang H., Wang W., Chang J., Xia B., Fan S., Zhang D., Wang J., Wang HW., Chai J. DIP original experiment: DIP-267916X Nature structural & molecular biology 2015 IMEx Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13. Song W., Wang J., Han Z., Zhang Y., Zhang H., Wang W., Chang J., Xia B., Fan S., Zhang D., Wang J., Wang HW., Chai J. Only protein-protein interactions imex curation song-2015-17 in vitro In vitro tem transmission electron microscopy tem predetermined predetermined participant predetermined Song W., Wang J., Han Z., Zhang Y., Zhang H., Wang W., Chang J., Xia B., Fan S., Zhang D., Wang J., Wang HW., Chai J. DIP original experiment: DIP-267919X Nature structural & molecular biology 2015 IMEx Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13. Song W., Wang J., Han Z., Zhang Y., Zhang H., Wang W., Chang J., Xia B., Fan S., Zhang D., Wang J., Wang HW., Chai J. Only protein-protein interactions imex curation song-2015-18 in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Song W., Wang J., Han Z., Zhang Y., Zhang H., Wang W., Chang J., Xia B., Fan S., Zhang D., Wang J., Wang HW., Chai J. DIP original experiment: DIP-267917X Nature structural & molecular biology 2015 IMEx Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13. Song W., Wang J., Han Z., Zhang Y., Zhang H., Wang W., Chang J., Xia B., Fan S., Zhang D., Wang J., Wang HW., Chai J. Only protein-protein interactions imex curation song-2015-19 in vitro In vitro 3d-em 3D electron microscopy 3D-EM electron tomog predetermined predetermined participant predetermined Song W., Wang J., Han Z., Zhang Y., Zhang H., Wang W., Chang J., Xia B., Fan S., Zhang D., Wang J., Wang HW., Chai J. DIP original experiment: DIP-267918X Nature structural & molecular biology 2015 IMEx Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13. Song W., Wang J., Han Z., Zhang Y., Zhang H., Wang W., Chang J., Xia B., Fan S., Zhang D., Wang J., Wang HW., Chai J. Only protein-protein interactions imex curation tlr13_mouse Toll-like receptor 13 Tlr13 protein protein mouse Mus musculus Mouse MSGLYRILVQLEQSPYVKTVPLNMRRDFFFLVVTWMPKTVKMNGSSFVPSLQLLLMLVGFSLPPVAETYGFNKCTQYEFDIHHVLCIRKKITNLTEAISDIPRYTTHLNLTHNEIQVLPPWSFTNLSALVDLRLEWNSIWKIDEGAFRGLENLTLLNLVENKIQSVNNSFEGLSSLKTLLLSHNQITHIHKDAFTPLIKLKYLSLSRNNISDFSGILEAVQHLPCLERLDLTNNSIMYLDHSPRSLVSLTHLSFEGNKLRELNFSALSLPNLTNLSASRNGNKVIQNVYLKTLPQLKSLNLSGTVIKLENLSAKHLQNLRAMDLSNWELRHGHLDMKTVCHLLGNLPKLETLVFQKNVTNAEGIKQLAKCTRLLFLDLGQNSDLIYLNDSEFNALPSLQKLNLNKCQLSFINNRTWSSLQNLTSLDLSHNKFKSFPDFAFSPLKHLEFLSLSRNPITELNNLAFSGLFALKELNLAACWIVTIDRYSFTQFPNLEVLDLGDNNIRTLNHGTFRPLKKLQSLILSHNCLKILEPNSFSGLTNLRSLDLMYNSLSYFHEHLFSGLEKLLILKLGFNKITYETTRTLQYPPFIKLKSLKQLNLEGQRHGIQVVPSNFFQGLGSLQELLLGKNPSVFLDHHQFDPLINLTKLDISGTKDGDRSLYLNASLFQNLKRLKILRLENNNLESLVPDMFSSLQSLQVFSLRFNNLKVINQSHLKNLKSLMFFDVYGNKLQCTCDNLWFKNWSMNTEEVHIPFLRSYPCQQPGSQSLLIDFDDAMCNFDLGKVYFLCSFSMVLSTMVFSWFSTKMIASLWYGLYICRAWYLTKWHKTEKKFLYDAFVSFSATDEAWVYKELVPALEQGSQTTFKLCLHQRDFEPGIDIFENIQNAINTSRKTLCVVSNHYLHSEWCRLEVQLASMKMFYEHKDVIILIFLEEIPNYKLSSYHRLRKLINKQTFITWPDSVHQQPLFWARIRNALGKETVEKENTHLIVVE tlr13-1 3283210 N/A 3283214 unspecified role unspecified role unspecified role unspecified role Region 1-785 Region 1-785 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Q6R5N8:p.[Glu579Ala;Thr580Tyr] E579A/T580Y mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false Q6R5N8:p.Glu601Arg E601R mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q6R5N8:p.Val609Tyr V609Y mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q6R5N8:p.[Asp649Tyr;Ser651Arg] D649Y/S651R mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false trini Trichoplusia ni (Cabbage looper) Cabbage looper direct interaction direct interaction false false false tlr13-2 3283211 N/A 3283214 unspecified role unspecified role unspecified role unspecified role Region 1-785 Region 1-785 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false trini Trichoplusia ni (Cabbage looper) Cabbage looper direct interaction direct interaction false false false tlr13-3 3283212 N/A 3283214 unspecified role unspecified role unspecified role unspecified role Region 1-785 Region 1-785 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false trini Trichoplusia ni (Cabbage looper) Cabbage looper direct interaction direct interaction false false false tlr13-4 3283213 N/A 3283214 unspecified role unspecified role unspecified role unspecified role Region 1-785 Region 1-785 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false trini Trichoplusia ni (Cabbage looper) Cabbage looper direct interaction direct interaction false false false