DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ cohen-2015-1 in vitro In vitro tem transmission electron microscopy tem predetermined predetermined participant predetermined Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S. Alzheimers - Interactions investigated in the context of Alzheimers disease DIP original experiment: DIP-265696X Nature structural & molecular biology 2015 IMEx A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers. Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S., Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S. Only protein-protein interactions imex curation cohen-2015-2 in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S. Alzheimers - Interactions investigated in the context of Alzheimers disease DIP original experiment: DIP-265690X Nature structural & molecular biology 2015 IMEx A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers. Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S., Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S. Only protein-protein interactions imex curation cohen-2015-3 in vitro In vitro fluorescence spectr classical fluorescence spectroscopy fluorescence spectr predetermined predetermined participant predetermined Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S. Alzheimers - Interactions investigated in the context of Alzheimers disease DIP original experiment: DIP-265691X Nature structural & molecular biology 2015 IMEx A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers. Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S., Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S. Only protein-protein interactions imex curation cohen-2015-4 in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S. Alzheimers - Interactions investigated in the context of Alzheimers disease DIP original experiment: DIP-265694X Nature structural & molecular biology 2015 IMEx A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers. Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S., Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S. Only protein-protein interactions imex curation cohen-2015-5 in vitro In vitro 3d-em 3D electron microscopy 3D-EM electron tomog predetermined predetermined participant predetermined Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S. Alzheimers - Interactions investigated in the context of Alzheimers disease DIP original experiment: DIP-265692X Nature structural & molecular biology 2015 IMEx A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers. Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S., Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S. Only protein-protein interactions imex curation cohen-2015-6 in vitro In vitro fluorescence spectr classical fluorescence spectroscopy fluorescence spectr predetermined predetermined participant predetermined Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S. Alzheimers - Interactions investigated in the context of Alzheimers disease DIP original experiment: DIP-265695X Nature structural & molecular biology 2015 IMEx A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers. Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S., Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S. Only protein-protein interactions imex curation cohen-2015-7 in vitro In vitro tem transmission electron microscopy tem predetermined predetermined participant predetermined Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S. Alzheimers - Interactions investigated in the context of Alzheimers disease DIP original experiment: DIP-265697X Nature structural & molecular biology 2015 IMEx A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers. Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S., Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S. Only protein-protein interactions imex curation cohen-2015-8 in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S. Alzheimers - Interactions investigated in the context of Alzheimers disease DIP original experiment: DIP-265693X Nature structural & molecular biology 2015 IMEx A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers. Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S., Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S. Only protein-protein interactions imex curation cohen-2015-9 in vitro In vitro 3d-em 3D electron microscopy 3D-EM electron tomog predetermined predetermined participant predetermined Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S. Alzheimers - Interactions investigated in the context of Alzheimers disease DIP original experiment: DIP-265698X Nature structural & molecular biology 2015 IMEx A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers. Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S., Cohen SI., Arosio P., Presto J., Kurudenkandy FR., Biverstål H., Dolfe L., Dunning C., Yang X., Frohm B., Vendruscolo M., Johansson J., Dobson CM., Fisahn A., Knowles TP., Linse S. Only protein-protein interactions imex curation p11686-1 Pulmonary surfactant-associated protein C SFTPC SFTP2 Pulmonary surfactant-associated proteolipid SPL(Val) SP5 protein protein human Homo sapiens Human MDVGSKEVLMESPPDYSAAPRGRFGIPCCPVHLKRLLIVVVVVVLIVVVIVGALLMGLHMSQKHTEMVLEMSIGAPEAQQRLALSEHLVTTATFSIGSTGLVVYDYQQLLIAYKPAPGTCCYIMKIAPESIPSLEALNRKVHNFQMECSLQAKPAVPTSKLGQAEGRDAGSAPSGGDPAFLGMAVNTLCGEVPLYYI p05067-pro_0000000092 Amyloid-beta protein 42 Alzheimer disease amyloid protein Cerebral vascular amyloid peptide APP A4 AD1 ABPP PreA4 Protease nexin-II APPI Amyloid precursor protein Amyloid-beta A4 protein Alzheimer disease amyloid A4 protein homolog Amyloid-beta (A4) precursor protein protein protein human Homo sapiens Human DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA 672 713 app-sftpc-1 3275499 N/A 3275508 unspecified role unspecified role unspecified role unspecified role Region 88-197 Region 88-197 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3275509 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false app-app-103 3275500 N/A 3275509 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli N/A 3275509 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false app-app-104 3275501 N/A 3275509 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli N/A 3275509 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false abeta(142)-sftpc-2 3275502 N/A 3275508 unspecified role unspecified role unspecified role unspecified role Region 88-197 Region 88-197 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3275509 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false app-app-105 3275503 N/A 3275509 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli N/A 3275509 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false app-sftpc-2 3275504 N/A 3275508 unspecified role unspecified role unspecified role unspecified role Region 88-197 Region 88-197 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3275509 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false app-app-106 3275505 N/A 3275509 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli N/A 3275509 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false app-sftpc-3 3275506 N/A 3275508 unspecified role unspecified role prey prey Region 88-197 Region 88-197 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3275509 unspecified role unspecified role bait bait ecolx Escherichia coli direct interaction direct interaction false false false abeta(142)-sftpc-5 3275507 N/A 3275508 unspecified role unspecified role unspecified role unspecified role Region 88-197 Region 88-197 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3275509 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false